Hub : Traits :

Heart disease (siblings)

3 significantly associated models · 3 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	6	12595275	13990267	1	1	2.5e-07	2.0e-06	1.0e+00	100	RP1-257A7.5
2	6	160071844	161571560	1	1	6.4e-08	3.3e-08	3.8e-08	1	SLC22A3
3	10	90726364	91424024	1	1	5.6e-08	6.8e-07	5.8e-01	99	LIPA

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Heart attack/myocardial infarction (self-reported)	26.10	3	1	2.2	1	LIPA RP1-257A7.5 SLC22A3
Heart attack	25.40	3	1	2.2	1	LIPA RP1-257A7.5 SLC22A3
Coronary Artery Disease (CAD)	22.68	3	1	2.2	1	LIPA RP1-257A7.5 SLC22A3
Illnesses of father: Heart disease	20.56	3	2	4.4	1	LIPA RP1-257A7.5 SLC22A3
Migraine (self-reported)	17.85	2	1	2.2	1	RP1-257A7.5 SLC22A3
Angina (self-reported)	16.85	3	1	2.2	1	LIPA RP1-257A7.5 SLC22A3
Angina	16.03	3	1	2.2	1	LIPA RP1-257A7.5 SLC22A3
Heart disease (mother)	15.82	3	0	0.0	1	LIPA RP1-257A7.5 SLC22A3
Headache pain in last month	11.87	1	1	2.2	1	RP1-257A7.5
Medication: Ibuprofen (e.g. Nurofen)	11.52	2	1	2.2	1	RP1-257A7.5 SLC22A3
Cholesterol lowering medication	11.02	1	1	2.2	1	SLC22A3
High cholesterol (Self-reported)	10.70	1	1	2.2	1	SLC22A3
Medication: Ibuprofen	10.49	2	1	2.2	1	RP1-257A7.5 SLC22A3
Medication: Aspirin	8.43	3	0	0.0	1	LIPA RP1-257A7.5 SLC22A3
Medication: Aspirin	7.32	2	0	0.0	1	RP1-257A7.5 SLC22A3
Medication: Paracetamol	6.46	1	1	2.2	1	RP1-257A7.5
Had major operations	6.46	2	0	0.0	1	LIPA RP1-257A7.5
Triglycerides	6.11	1	0	0.0	1	SLC22A3
Medication: Atorvastatin	5.92	1	0	0.0	1	SLC22A3
Waist Hip Ratio (WHR)	5.56	1	1	2.2	1	SLC22A3
Illnesses of father: None of the above (group 1)	5.32	2	0	0.0	1	RP1-257A7.5 SLC22A3
Pulse wave Arterial Stiffness index	5.18	1	0	0.0	1	RP1-257A7.5
Medication: Cholesterol lowering	5.13	1	0	0.0	1	SLC22A3
Medication for pain relief, constipation, heartburn	4.97	2	0	0.0	1	LIPA RP1-257A7.5
Medication: Paracetamol	4.94	1	0	0.0	1	RP1-257A7.5
Alcohol intake frequency.	4.93	2	0	0.0	1	RP1-257A7.5 SLC22A3
LDL Cholesterol	4.85	1	0	0.0	1	SLC22A3
Pulse wave peak to peak time	4.79	1	0	0.0	1	RP1-257A7.5
Medication: Ramipril	4.55	1	0	0.0	1	SLC22A3
Supplements: Fish oil (including cod liver oil)	4.50	1	0	0.0	1	SLC22A3
Medication: Simvastatin	4.49	1	0	0.0	1	SLC22A3
Mineral and other dietary supplements	4.47	1	0	0.0	1	SLC22A3
High blood pressure (mother)	4.22	1	0	0.0	1	RP1-257A7.5
Medication for cholesterol	3.98	1	0	0.0	1	SLC22A3
Lung cancer (father)	3.86	1	0	0.0	1	SLC22A3
Hand grip strength (left)	3.75	1	1	2.2	1	RP1-257A7.5
Frequency of tenseness / restlessness in last 2 weeks	3.67	2	0	0.0	1	LIPA SLC22A3
Health satisfaction	3.65	2	0	0.0	1	LIPA SLC22A3
Illnesses of siblings	3.64	1	0	0.0	1	SLC22A3
Diabetes (father)	3.54	1	0	0.0	1	RP1-257A7.5
Medication: Bendroflumethiazide	3.49	1	0	0.0	1	RP1-257A7.5
Pain experienced in last month	3.29	1	0	0.0	1	RP1-257A7.5
Breastfed as a baby	3.27	1	0	0.0	1	SLC22A3
Pulse wave reflection index	3.12	1	0	0.0	1	SLC22A3
Blood White Count	3.08	2	1	2.2	1	LIPA RP1-257A7.5
Hip circumference	3.02	1	1	2.2	1	SLC22A3
Hand grip strength (right)	2.93	2	0	0.0	1	RP1-257A7.5 SLC22A3
Number of treatments/medications taken	2.82	2	0	0.0	1	RP1-257A7.5 SLC22A3
Medication: Lansoprazole	2.81	1	0	0.0	1	SLC22A3
Serious illness, injury or assault to yourself	2.78	1	0	0.0	1	LIPA
Systolic blood pressure, automated reading	2.77	1	0	0.0	1	RP1-257A7.5
Weight	2.68	1	1	2.2	1	SLC22A3
Chronic bronchitis/emphysema (father)	2.66	1	0	0.0	1	SLC22A3
Trunk fat mass	2.63	2	1	2.2	1	RP1-257A7.5 SLC22A3
Length of working week for main job	2.60	1	0	0.0	1	LIPA
Leg predicted mass (left)	2.59	1	1	2.2	1	SLC22A3
Whole body fat mass	2.58	1	1	2.2	1	SLC22A3
Irritability	2.58	1	0	0.0	1	SLC22A3
Illness, injury, bereavement, stress in last 2 years	2.56	1	0	0.0	1	LIPA
Diastolic blood pressure, automated reading	2.55	2	0	0.0	1	RP1-257A7.5 SLC22A3
Leg fat-free mass (left)	2.52	1	1	2.2	1	SLC22A3
Leg predicted mass (right)	2.52	1	1	2.2	1	SLC22A3
Leg fat-free mass (right)	2.51	1	1	2.2	1	SLC22A3
Basal metabolic rate	2.46	1	1	2.2	1	SLC22A3
Leg pain on walking	2.44	1	0	0.0	1	SLC22A3
Arm fat mass (right)	2.35	1	0	0.0	1	SLC22A3
Arm fat mass (left)	2.31	2	0	0.0	1	RP1-257A7.5 SLC22A3
Illnesses of siblings: Diabetes	2.30	1	0	0.0	1	SLC22A3
Arm predicted mass (left)	2.25	1	1	2.2	1	SLC22A3
Whole body fat-free mass	2.22	1	1	2.2	1	SLC22A3
Systolic Blood Pressure	2.18	1	1	2.2	1	RP1-257A7.5
Arm predicted mass (right)	2.18	1	1	2.2	1	SLC22A3
Alcohol drinker status: Never	2.16	1	0	0.0	1	RP1-257A7.5
Whole body water mass	2.15	1	1	2.2	1	SLC22A3
Illnesses of mother	2.13	1	0	0.0	1	LIPA
Leg fat mass (right)	2.11	1	0	0.0	1	SLC22A3
Hair/balding pattern: Pattern 2	2.09	1	0	0.0	1	SLC22A3
Arm fat-free mass (left)	2.09	1	1	2.2	1	SLC22A3
Cardiovascular Disease	2.08	1	0	0.0	1	SLC22A3
Trunk fat percentage	2.08	2	0	0.0	1	RP1-257A7.5 SLC22A3
Leg fat mass (left)	2.04	1	0	0.0	1	SLC22A3
Trunk fat-free mass	2.01	1	1	2.2	1	SLC22A3
Arm fat-free mass (right)	2.00	1	1	2.2	1	SLC22A3
Trunk predicted mass	1.95	1	1	2.2	1	SLC22A3
Body Mass Index (BMI) (2010)	1.91	1	0	0.0	1	SLC22A3
Financial difficulties in last 2 years	1.88	1	0	0.0	1	LIPA
Knee pain experienced in last month	1.88	1	0	0.0	1	RP1-257A7.5
Number of self-reported non-cancer illnesses	1.84	1	0	0.0	1	SLC22A3
Pulse rate, automated reading	1.83	1	0	0.0	1	RP1-257A7.5
BMI	1.78	1	0	0.0	1	SLC22A3
Body fat percentage	1.76	2	0	0.0	1	RP1-257A7.5 SLC22A3
Alcohol usually taken with meals	1.67	1	0	0.0	1	RP1-257A7.5
Qualifications: College or University degree	1.55	1	0	0.0	1	LIPA
Arm fat percentage (right)	1.53	2	0	0.0	1	RP1-257A7.5 SLC22A3
Guilty feelings	1.53	1	0	0.0	1	RP1-257A7.5
Forced expiratory volume in 1-second (FEV1), predicted	1.52	1	0	0.0	1	SLC22A3
Arm fat percentage (left)	1.52	2	0	0.0	1	RP1-257A7.5 SLC22A3
Standing height	1.50	1	1	2.2	1	SLC22A3
Birth weight	1.43	1	0	0.0	1	RP1-257A7.5
Chronotype (morning person)	1.41	1	0	0.0	1	RP1-257A7.5
Hypertension (Self-reported)	1.41	1	0	0.0	1	RP1-257A7.5
Comparative height size at age 10	1.39	1	0	0.0	1	SLC22A3
Body mass index (BMI)	1.34	2	0	0.0	1	RP1-257A7.5 SLC22A3
High blood pressure	1.31	1	0	0.0	1	RP1-257A7.5
Breast Cancer	1.28	1	0	0.0	1	LIPA
Height	1.24	1	1	2.2	1	SLC22A3
Sitting height	1.21	1	0	0.0	1	SLC22A3
Peak expiratory flow (PEF)	1.20	1	0	0.0	1	RP1-257A7.5
Type 2 Diabetes (T2D) (2018)	1.13	1	0	0.0	1	SLC22A3
Leg fat percentage (right)	1.13	1	0	0.0	1	RP1-257A7.5
Leg fat percentage (left)	1.09	1	0	0.0	1	RP1-257A7.5
Forced vital capacity (FVC), Best measure	0.98	1	0	0.0	1	LIPA
Forced expiratory volume in 1-second (FEV1), Best measure	0.84	1	0	0.0	1	LIPA
Lung FEV1/FVC ratio	0.75	1	0	0.0	1	SLC22A3
Blood Platelet Count	0.67	2	0	0.0	1	LIPA RP1-257A7.5
Blood Red Count	0.66	1	0	0.0	1	RP1-257A7.5
Lung FVC	0.62	1	0	0.0	1	SLC22A3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	1	0.108	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Artery Aorta	1	0.034	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.1