Hub : Traits :

Heart disease (siblings)

3 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 12595275 13990267 1 1 2.5e-07 2.0e-06 1.0e+00 100 RP1-257A7.5
2 6 160071844 161571560 1 1 6.4e-08 3.3e-08 3.8e-08 1 SLC22A3
3 10 90726364 91424024 1 1 5.6e-08 6.8e-07 5.8e-01 99 LIPA

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Breast Cancer 1.28 1 0 0.0 0 1 LIPA
Body Mass Index (BMI) (2010) 1.91 1 0 0.0 0 1 SLC22A3
Coronary Artery Disease (CAD) 22.68 3 1 2.2 0 1 LIPA RP1-257A7.5 SLC22A3
LDL Cholesterol 4.85 1 0 0.0 0 1 SLC22A3
Triglycerides 6.11 1 0 0.0 0 1 SLC22A3
Blood Platelet Count 0.67 2 0 0.0 0 1 LIPA RP1-257A7.5
Blood Red Count 0.66 1 0 0.0 0 1 RP1-257A7.5
Blood White Count 3.08 2 1 2.2 0 1 LIPA RP1-257A7.5
BMI 1.78 1 0 0.0 0 1 SLC22A3
Height 1.24 1 1 2.2 0 1 SLC22A3
Waist Hip Ratio (WHR) 5.56 1 1 2.2 0 1 SLC22A3
Systolic Blood Pressure 2.18 1 1 2.2 0 1 RP1-257A7.5
Cardiovascular Disease 2.08 1 0 0.0 0 1 SLC22A3
Type 2 Diabetes (T2D) (2018) 1.13 1 0 0.0 0 1 SLC22A3
Lung FEV1/FVC ratio 0.75 1 0 0.0 0 1 SLC22A3
Lung FVC 0.62 1 0 0.0 0 1 SLC22A3
Chronotype (morning person) 1.41 1 0 0.0 0 1 RP1-257A7.5
Hand grip strength (left) 3.75 1 1 2.2 0 1 RP1-257A7.5
Number of treatments/medications taken 2.82 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Systolic blood pressure, automated reading 2.77 1 0 0.0 0 1 RP1-257A7.5
Angina 16.03 3 1 2.2 0 1 LIPA RP1-257A7.5 SLC22A3
Diabetes (father) 3.54 1 0 0.0 0 1 RP1-257A7.5
Leg fat-free mass (left) 2.52 1 1 2.2 0 1 SLC22A3
Trunk fat percentage 2.08 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Hand grip strength (right) 2.93 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Serious illness, injury or assault to yourself 2.78 1 0 0.0 0 1 LIPA
High blood pressure 1.31 1 0 0.0 0 1 RP1-257A7.5
Sitting height 1.21 1 0 0.0 0 1 SLC22A3
Chronic bronchitis/emphysema (father) 2.66 1 0 0.0 0 1 SLC22A3
High blood pressure (mother) 4.22 1 0 0.0 0 1 RP1-257A7.5
Body mass index (BMI) 1.34 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Leg predicted mass (left) 2.59 1 1 2.2 0 1 SLC22A3
Trunk fat mass 2.63 2 1 2.2 0 1 RP1-257A7.5 SLC22A3
Alcohol usually taken with meals 1.67 1 0 0.0 0 1 RP1-257A7.5
Frequency of tenseness / restlessness in last 2 weeks 3.67 2 0 0.0 0 1 LIPA SLC22A3
Hair/balding pattern: Pattern 2 2.09 1 0 0.0 0 1 SLC22A3
Financial difficulties in last 2 years 1.88 1 0 0.0 0 1 LIPA
Heart attack 25.40 3 1 2.2 0 1 LIPA RP1-257A7.5 SLC22A3
Medication: Ramipril 4.55 1 0 0.0 0 1 SLC22A3
Medication: Simvastatin 4.49 1 0 0.0 0 1 SLC22A3
Illnesses of siblings 3.64 1 0 0.0 0 1 SLC22A3
Weight 2.68 1 1 2.2 0 1 SLC22A3
Arm fat percentage (right) 1.53 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Trunk fat-free mass 2.01 1 1 2.2 0 1 SLC22A3
Hip circumference 3.02 1 1 2.2 0 1 SLC22A3
Medication: Ibuprofen (e.g. Nurofen) 11.52 2 1 2.2 0 1 RP1-257A7.5 SLC22A3
Medication: Cholesterol lowering 5.13 1 0 0.0 0 1 SLC22A3
Medication: Lansoprazole 2.81 1 0 0.0 0 1 SLC22A3
Lung cancer (father) 3.86 1 0 0.0 0 1 SLC22A3
Illnesses of mother 2.13 1 0 0.0 0 1 LIPA
Forced expiratory volume in 1-second (FEV1), Best measure 0.84 1 0 0.0 0 1 LIPA
Pulse wave Arterial Stiffness index 5.18 1 0 0.0 0 1 RP1-257A7.5
Arm fat mass (right) 2.35 1 0 0.0 0 1 SLC22A3
Trunk predicted mass 1.95 1 1 2.2 0 1 SLC22A3
Standing height 1.50 1 1 2.2 0 1 SLC22A3
Length of working week for main job 2.60 1 0 0.0 0 1 LIPA
Breastfed as a baby 3.27 1 0 0.0 0 1 SLC22A3
Peak expiratory flow (PEF) 1.20 1 0 0.0 0 1 RP1-257A7.5
Pulse wave reflection index 3.12 1 0 0.0 0 1 SLC22A3
Medication: Paracetamol 6.46 1 1 2.2 0 1 RP1-257A7.5
Headache pain in last month 11.87 1 1 2.2 0 1 RP1-257A7.5
Birth weight 1.43 1 0 0.0 0 1 RP1-257A7.5
Forced vital capacity (FVC), Best measure 0.98 1 0 0.0 0 1 LIPA
Body fat percentage 1.76 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Leg fat percentage (right) 1.13 1 0 0.0 0 1 RP1-257A7.5
Arm fat-free mass (right) 2.00 1 1 2.2 0 1 SLC22A3
Pulse wave peak to peak time 4.79 1 0 0.0 0 1 RP1-257A7.5
Health satisfaction 3.65 2 0 0.0 0 1 LIPA SLC22A3
Qualifications: College or University degree 1.55 1 0 0.0 0 1 LIPA
Medication for pain relief, constipation, heartburn 4.97 2 0 0.0 0 1 LIPA RP1-257A7.5
Angina (self-reported) 16.85 3 1 2.2 0 1 LIPA RP1-257A7.5 SLC22A3
Migraine (self-reported) 17.85 2 1 2.2 0 1 RP1-257A7.5 SLC22A3
Medication: Ibuprofen 10.49 2 1 2.2 0 1 RP1-257A7.5 SLC22A3
Heart disease (mother) 15.82 3 0 0.0 0 1 LIPA RP1-257A7.5 SLC22A3
Whole body fat mass 2.58 1 1 2.2 0 1 SLC22A3
Leg fat mass (right) 2.11 1 0 0.0 0 1 SLC22A3
Arm predicted mass (right) 2.18 1 1 2.2 0 1 SLC22A3
Pulse rate, automated reading 1.83 1 0 0.0 0 1 RP1-257A7.5
Alcohol intake frequency. 4.93 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Comparative height size at age 10 1.39 1 0 0.0 0 1 SLC22A3
Had major operations 6.46 2 0 0.0 0 1 LIPA RP1-257A7.5
Leg pain on walking 2.44 1 0 0.0 0 1 SLC22A3
Illness, injury, bereavement, stress in last 2 years 2.56 1 0 0.0 0 1 LIPA
Medication: Aspirin 8.43 3 0 0.0 0 1 LIPA RP1-257A7.5 SLC22A3
Knee pain experienced in last month 1.88 1 0 0.0 0 1 RP1-257A7.5
Hypertension (Self-reported) 1.41 1 0 0.0 0 1 RP1-257A7.5
Illnesses of father: Heart disease 20.56 3 2 4.4 0 1 LIPA RP1-257A7.5 SLC22A3
Illnesses of siblings: Diabetes 2.30 1 0 0.0 0 1 SLC22A3
Forced expiratory volume in 1-second (FEV1), predicted 1.52 1 0 0.0 0 1 SLC22A3
Whole body fat-free mass 2.22 1 1 2.2 0 1 SLC22A3
Leg fat-free mass (right) 2.51 1 1 2.2 0 1 SLC22A3
Arm fat percentage (left) 1.52 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Medication for cholesterol 3.98 1 0 0.0 0 1 SLC22A3
Mineral and other dietary supplements 4.47 1 0 0.0 0 1 SLC22A3
Medication: Aspirin 7.32 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Illnesses of father: None of the above (group 1) 5.32 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Whole body water mass 2.15 1 1 2.2 0 1 SLC22A3
Leg predicted mass (right) 2.52 1 1 2.2 0 1 SLC22A3
Arm fat mass (left) 2.31 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Number of self-reported non-cancer illnesses 1.84 1 0 0.0 0 1 SLC22A3
Guilty feelings 1.53 1 0 0.0 0 1 RP1-257A7.5
Supplements: Fish oil (including cod liver oil) 4.50 1 0 0.0 0 1 SLC22A3
High cholesterol (Self-reported) 10.70 1 1 2.2 0 1 SLC22A3
Medication: Bendroflumethiazide 3.49 1 0 0.0 0 1 RP1-257A7.5
Medication: Paracetamol 4.94 1 0 0.0 0 1 RP1-257A7.5
Medication: Atorvastatin 5.92 1 0 0.0 0 1 SLC22A3
Alcohol drinker status: Never 2.16 1 0 0.0 0 1 RP1-257A7.5
Basal metabolic rate 2.46 1 1 2.2 0 1 SLC22A3
Leg fat percentage (left) 1.09 1 0 0.0 0 1 RP1-257A7.5
Arm fat-free mass (left) 2.09 1 1 2.2 0 1 SLC22A3
Irritability 2.58 1 0 0.0 0 1 SLC22A3
Diastolic blood pressure, automated reading 2.55 2 0 0.0 0 1 RP1-257A7.5 SLC22A3
Cholesterol lowering medication 11.02 1 1 2.2 0 1 SLC22A3
Pain experienced in last month 3.29 1 0 0.0 0 1 RP1-257A7.5
Heart attack/myocardial infarction (self-reported) 26.10 3 1 2.2 0 1 LIPA RP1-257A7.5 SLC22A3
Leg fat mass (left) 2.04 1 0 0.0 0 1 SLC22A3
Arm predicted mass (left) 2.25 1 1 2.2 0 1 SLC22A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 1 0.034 1.3
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 1 0.108 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2