Hub : Traits :

Eye problems/disorders: Cataract

1 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	20	18506005	20398583	1	1	5.4e-08	6.7e-11	0.00013	66	SLC24A3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Migraine (self-reported)	18.48	1	0	0.0	1	SLC24A3
Headache pain in last month	12.14	1	0	0.0	1	SLC24A3
Diastolic blood pressure, automated reading	11.17	1	1	2.2	1	SLC24A3
Medication: Ibuprofen	10.97	1	0	0.0	1	SLC24A3
Medication: Ibuprofen (e.g. Nurofen)	9.66	1	0	0.0	1	SLC24A3
Eye problems/disorders: None of the above	8.89	1	0	0.0	1	SLC24A3
Lung FEV1/FVC ratio	8.06	1	1	2.2	1	SLC24A3
Father's age at death	7.89	1	0	0.0	1	SLC24A3
Number of full brothers	7.26	1	0	0.0	1	SLC24A3
Medication: Paracetamol	7.19	1	0	0.0	1	SLC24A3
Medication: Paracetamol	6.78	1	0	0.0	1	SLC24A3
Systolic Blood Pressure	5.50	1	1	2.2	1	SLC24A3
Pain type(s) experienced in last month: Hip pain	4.64	1	0	0.0	1	SLC24A3
Medication for pain relief, constipation, heartburn	4.43	1	0	0.0	1	SLC24A3
High blood pressure (mother)	4.40	1	0	0.0	1	SLC24A3
Mood swings	4.33	1	0	0.0	1	SLC24A3
Medication: Omeprazole (e.g. Zanprol)	4.24	1	0	0.0	1	SLC24A3
Diabetes (mother)	4.18	1	0	0.0	1	SLC24A3
Diverticular disease/diverticulitis (self-reported)	3.83	1	0	0.0	1	SLC24A3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.82	1	0	0.0	1	SLC24A3
Body Mass Index (BMI) (2010)	3.66	1	0	0.0	1	SLC24A3
Mouth/teeth dental problems: Bleeding gums	3.54	1	0	0.0	1	SLC24A3
Illnesses of father: None of the above (group 1)	3.37	1	0	0.0	1	SLC24A3
Ever unenthusiastic/disinterested for a whole week	3.35	1	0	0.0	1	SLC24A3
Hair/balding pattern: Pattern 3	3.33	1	0	0.0	1	SLC24A3
Respiratory disease	3.28	1	0	0.0	1	SLC24A3
Asthma (self-reported)	3.27	1	0	0.0	1	SLC24A3
Asthma	3.15	1	0	0.0	1	SLC24A3
Pack years adult smoking proportion	3.13	1	0	0.0	1	SLC24A3
Pack years of smoking	3.04	1	0	0.0	1	SLC24A3
Systolic blood pressure, automated reading	2.89	1	0	0.0	1	SLC24A3
High blood pressure (siblings)	2.66	1	0	0.0	1	SLC24A3
Pain experienced in last month	2.64	1	0	0.0	1	SLC24A3
Sensitivity / hurt feelings	2.60	1	0	0.0	1	SLC24A3
Frequency of tiredness / lethargy in last 2 weeks	2.43	1	0	0.0	1	SLC24A3
Fed-up feelings	2.33	1	0	0.0	1	SLC24A3
Arm fat percentage (left)	1.55	1	0	0.0	1	SLC24A3
Blood White Count	1.44	1	0	0.0	1	SLC24A3
Comparative body size at age 10	1.42	1	0	0.0	1	SLC24A3
Trunk fat percentage	1.39	1	0	0.0	1	SLC24A3
Body fat percentage	1.38	1	0	0.0	1	SLC24A3
Arm fat percentage (right)	1.35	1	0	0.0	1	SLC24A3
Leg fat percentage (right)	1.15	1	0	0.0	1	SLC24A3
Height	0.96	1	0	0.0	1	SLC24A3
Blood Platelet Count	0.70	1	0	0.0	1	SLC24A3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	1	0.027	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.1
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.1
GTEx	Brain Hippocampus	0	0.000	1.1
GTEx	Pancreas	0	0.000	1.1
GTEx	Testis	0	0.000	1.1
GTEx	Thyroid	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
YFS	Blood	0	0.000	1.1
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.1
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.1