Hub : Traits :

Eye problems/disorders: Cataract

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 20 18506005 20398583 1 1 5.4e-08 6.7e-11 0.00013 66 SLC24A3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Body Mass Index (BMI) (2010) 3.66 1 0 0.0 0 1 SLC24A3
Blood Platelet Count 0.70 1 0 0.0 0 1 SLC24A3
Blood White Count 1.44 1 0 0.0 0 1 SLC24A3
Height 0.96 1 0 0.0 0 1 SLC24A3
Systolic Blood Pressure 5.50 1 1 2.2 0 1 SLC24A3
Respiratory disease 3.28 1 0 0.0 0 1 SLC24A3
Lung FEV1/FVC ratio 8.06 1 1 2.2 0 1 SLC24A3
Sensitivity / hurt feelings 2.60 1 0 0.0 0 1 SLC24A3
Systolic blood pressure, automated reading 2.89 1 0 0.0 0 1 SLC24A3
Diabetes (mother) 4.18 1 0 0.0 0 1 SLC24A3
Pack years adult smoking proportion 3.13 1 0 0.0 0 1 SLC24A3
Trunk fat percentage 1.39 1 0 0.0 0 1 SLC24A3
Fed-up feelings 2.33 1 0 0.0 0 1 SLC24A3
Diverticular disease/diverticulitis (self-reported) 3.83 1 0 0.0 0 1 SLC24A3
High blood pressure (mother) 4.40 1 0 0.0 0 1 SLC24A3
Ever unenthusiastic/disinterested for a whole week 3.35 1 0 0.0 0 1 SLC24A3
Arm fat percentage (right) 1.35 1 0 0.0 0 1 SLC24A3
Father's age at death 7.89 1 0 0.0 0 1 SLC24A3
Frequency of tiredness / lethargy in last 2 weeks 2.43 1 0 0.0 0 1 SLC24A3
Hair/balding pattern: Pattern 3 3.33 1 0 0.0 0 1 SLC24A3
Asthma 3.15 1 0 0.0 0 1 SLC24A3
Medication: Ibuprofen (e.g. Nurofen) 9.66 1 0 0.0 0 1 SLC24A3
Mouth/teeth dental problems: Bleeding gums 3.54 1 0 0.0 0 1 SLC24A3
Medication: Paracetamol 7.19 1 0 0.0 0 1 SLC24A3
Headache pain in last month 12.14 1 0 0.0 0 1 SLC24A3
High blood pressure (siblings) 2.66 1 0 0.0 0 1 SLC24A3
Body fat percentage 1.38 1 0 0.0 0 1 SLC24A3
Leg fat percentage (right) 1.15 1 0 0.0 0 1 SLC24A3
Comparative body size at age 10 1.42 1 0 0.0 0 1 SLC24A3
Number of full brothers 7.26 1 0 0.0 0 1 SLC24A3
Eye problems/disorders: None of the above 8.89 1 0 0.0 0 1 SLC24A3
Medication for pain relief, constipation, heartburn 4.43 1 0 0.0 0 1 SLC24A3
Migraine (self-reported) 18.48 1 0 0.0 0 1 SLC24A3
Medication: Ibuprofen 10.97 1 0 0.0 0 1 SLC24A3
Arm fat percentage (left) 1.55 1 0 0.0 0 1 SLC24A3
Mood swings 4.33 1 0 0.0 0 1 SLC24A3
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.82 1 0 0.0 0 1 SLC24A3
Asthma (self-reported) 3.27 1 0 0.0 0 1 SLC24A3
Illnesses of father: None of the above (group 1) 3.37 1 0 0.0 0 1 SLC24A3
Pain type(s) experienced in last month: Hip pain 4.64 1 0 0.0 0 1 SLC24A3
Medication: Paracetamol 6.78 1 0 0.0 0 1 SLC24A3
Diastolic blood pressure, automated reading 11.17 1 1 2.2 0 1 SLC24A3
Medication: Omeprazole (e.g. Zanprol) 4.24 1 0 0.0 0 1 SLC24A3
Pain experienced in last month 2.64 1 0 0.0 0 1 SLC24A3
Pack years of smoking 3.04 1 0 0.0 0 1 SLC24A3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 1 0.027 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.1
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.1
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.1
GTEx Thyroid 0 0.000 1.1
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2