Hub : Traits :

Time employed in main current job

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 17 44788310 45088455 1 1 1.9e-07 7.8e-06 0.15 90 WNT3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 1.61 1 0 0.0 0 1 WNT3
Depressed Affect (Nagel 2018) 45.76 1 1 2.2 0 1 WNT3
Depression (Nagel 2018) 16.15 1 0 0.0 0 1 WNT3
Intelligence (Savage-Jansen 2018) 9.98 1 1 2.2 0 1 WNT3
Neuroticism (Nagel 2018) 53.81 1 1 2.2 0 1 WNT3
Schizophrenia (2018) 5.59 1 0 0.0 0 1 WNT3
Schizophrenia vs Biploar Disorder 7.42 1 0 0.0 0 1 WNT3
Worry (Nagel 2018) 27.41 1 1 2.2 0 1 WNT3
Crohns Disease (2017) 2.27 1 0 0.0 0 1 WNT3
Irritable Bowel Disease (IBD) 1.94 1 0 0.0 0 1 WNT3
Reaction Time 2.73 1 0 0.0 0 1 WNT3
Verbal and Numeric Reasoning (VNR) 6.02 1 0 0.0 0 1 WNT3
Breast Cancer 13.44 1 1 2.2 0 1 WNT3
Ovarian Cancer 29.06 1 1 2.2 0 1 WNT3
Prostate Cancer 3.44 1 0 0.0 0 1 WNT3
Age at First Birth 2.75 1 0 0.0 0 1 WNT3
Coronary Artery Disease (CAD) 3.77 1 0 0.0 0 1 WNT3
Crohns Disease (2012) 9.30 1 0 0.0 0 1 WNT3
Mean Putamen Volume 14.76 1 0 0.0 0 1 WNT3
LDL Cholesterol 5.24 1 0 0.0 0 1 WNT3
Lupus 6.92 1 0 0.0 0 1 WNT3
Neuroticism (2016) 18.40 1 1 2.2 0 1 WNT3
Primary Biliary Cirrhosis 16.29 1 0 0.0 0 1 WNT3
Schizophrenia (2014) 7.03 1 0 0.0 0 1 WNT3
Blood Eosinophil Count 15.71 1 1 2.2 0 1 WNT3
Blood Platelet Count 1.36 1 0 0.0 0 1 WNT3
Blood Red Count 45.65 1 1 2.2 0 1 WNT3
Blood White Count 2.20 1 0 0.0 0 1 WNT3
Heel T-Score 9.38 1 1 2.2 0 1 WNT3
Height 7.98 1 1 2.2 0 1 WNT3
Waist Hip Ratio (WHR) 16.45 1 1 2.2 0 1 WNT3
Systolic Blood Pressure 2.06 1 0 0.0 0 1 WNT3
Smoking Status 8.33 1 0 0.0 0 1 WNT3
Lung FEV1/FVC ratio 2.79 1 0 0.0 0 1 WNT3
Lung FVC 47.83 1 1 2.2 0 1 WNT3
Neuroticism 50.18 1 1 2.2 0 1 WNT3
Hair Pigment 0.61 1 0 0.0 0 1 WNT3
Tanning 1.01 1 0 0.0 0 1 WNT3
Hand grip strength (left) 23.70 1 1 2.2 0 1 WNT3
Sensitivity / hurt feelings 52.15 1 1 2.2 0 1 WNT3
Frequency of depressed mood in last 2 weeks 17.50 1 0 0.0 0 1 WNT3
Hearing difficulty/problems: Yes 4.25 1 0 0.0 0 1 WNT3
Relative age of first facial hair 55.64 1 1 2.2 0 1 WNT3
Other serious medical condition/disability diagnosed by doctor 3.29 1 0 0.0 0 1 WNT3
Systolic blood pressure, automated reading 5.22 1 0 0.0 0 1 WNT3
Medication for hormone replacement therapy 5.46 1 0 0.0 0 1 WNT3
Vitamin and mineral supplements 7.79 1 0 0.0 0 1 WNT3
Supplements: Zinc 6.65 1 0 0.0 0 1 WNT3
Diabetes (father) 7.07 1 0 0.0 0 1 WNT3
Severe depression (siblings) 4.17 1 0 0.0 0 1 WNT3
Impedance of leg (right) 2.99 1 0 0.0 0 1 WNT3
Trunk fat percentage 8.88 1 1 2.2 0 1 WNT3
Hand grip strength (right) 17.05 1 1 2.2 0 1 WNT3
Current tobacco smoking 3.49 1 0 0.0 0 1 WNT3
Average weekly fortified wine intake 4.03 1 0 0.0 0 1 WNT3
Fed-up feelings 22.39 1 1 2.2 0 1 WNT3
Frequency of unenthusiasm / disinterest in last 2 weeks 4.76 1 0 0.0 0 1 WNT3
Relative age voice broke 37.44 1 1 2.2 0 1 WNT3
Age when periods started (menarche) 5.09 1 0 0.0 0 1 WNT3
Heel bone mineral density (BMD) T-score, automated (left) 3.09 1 0 0.0 0 1 WNT3
Qualifications: CSEs or equivalent 12.29 1 0 0.0 0 1 WNT3
High blood pressure 1.96 1 0 0.0 0 1 WNT3
Multivitamins +/- minerals 3.33 1 0 0.0 0 1 WNT3
Stomach or abdominal pain in last month 3.21 1 0 0.0 0 1 WNT3
Diverticular disease/diverticulitis (self-reported) 11.95 1 0 0.0 0 1 WNT3
Sitting height 19.61 1 1 2.2 0 1 WNT3
Impedance of leg (left) 3.97 1 0 0.0 0 1 WNT3
Trunk fat mass 6.48 1 1 2.2 0 1 WNT3
Number of incorrect matches in round 4.59 1 0 0.0 0 1 WNT3
Past tobacco smoking 8.74 1 0 0.0 0 1 WNT3
Nervous feelings 21.84 1 1 2.2 0 1 WNT3
Frequency of tenseness / restlessness in last 2 weeks 30.98 1 1 2.2 0 1 WNT3
Hearing difficulty/problems with background noise 10.61 1 0 0.0 0 1 WNT3
Hair/balding pattern: Pattern 2 29.27 1 1 2.2 0 1 WNT3
Forced vital capacity (FVC) 45.93 1 1 2.2 0 1 WNT3
Heel bone mineral density (BMD) T-score, automated (right) 2.62 1 0 0.0 0 1 WNT3
Ever unenthusiastic/disinterested for a whole week 15.15 1 0 0.0 0 1 WNT3
Qualifications: None of the above 2.87 1 0 0.0 0 1 WNT3
Financial difficulties in last 2 years 4.73 1 0 0.0 0 1 WNT3
Mouth/teeth dental problems 11.96 1 0 0.0 0 1 WNT3
Fluid intelligence score 7.06 1 0 0.0 0 1 WNT3
Neuroticism score 43.91 1 1 2.2 0 1 WNT3
Weight 1.21 1 0 0.0 0 1 WNT3
Impedance of arm (right) 10.98 1 1 2.2 0 1 WNT3
Arm fat percentage (right) 1.45 1 0 0.0 0 1 WNT3
Hip circumference 2.13 1 0 0.0 0 1 WNT3
Worrier / anxious feelings 17.92 1 1 2.2 0 1 WNT3
Frequency of tiredness / lethargy in last 2 weeks 6.90 1 0 0.0 0 1 WNT3
Falls in the last year 6.65 1 0 0.0 0 1 WNT3
Hair/balding pattern: Pattern 3 68.48 1 1 2.2 0 1 WNT3
Number of live births 13.74 1 0 0.0 0 1 WNT3
Forced expiratory volume in 1-second (FEV1) 45.61 1 1 2.2 0 1 WNT3
Noisy workplace 7.66 1 0 0.0 0 1 WNT3
Qualifications: A levels/AS levels or equivalent 6.42 1 0 0.0 0 1 WNT3
Medication: Ibuprofen (e.g. Nurofen) 10.27 1 0 0.0 0 1 WNT3
Prospective memory result 3.92 1 0 0.0 0 1 WNT3
Forced expiratory volume in 1-second (FEV1), Best measure 42.19 1 1 2.2 0 1 WNT3
Impedance of arm (left) 11.21 1 1 2.2 0 1 WNT3
Arm fat mass (right) 1.12 1 0 0.0 0 1 WNT3
Standing height 6.24 1 1 2.2 0 1 WNT3
Tense / 'highly strung' 8.03 1 0 0.0 0 1 WNT3
Hair/balding pattern: Pattern 4 104.36 1 1 2.2 0 1 WNT3
Birth weight of first child 2.96 1 0 0.0 0 1 WNT3
Peak expiratory flow (PEF) 24.63 1 1 2.2 0 1 WNT3
Ever highly irritable/argumentative for 2 days 6.41 1 0 0.0 0 1 WNT3
Qualifications: O levels/GCSEs or equivalent 2.62 1 0 0.0 0 1 WNT3
Mouth/teeth dental problems: Bleeding gums 5.89 1 0 0.0 0 1 WNT3
Medication: Paracetamol 26.83 1 1 2.2 0 1 WNT3
Headache pain in last month 40.52 1 1 2.2 0 1 WNT3
Glaucoma (self-reported) 7.04 1 0 0.0 0 1 WNT3
Gout (self-reported) 2.92 1 0 0.0 0 1 WNT3
Hypothyroidism/myxoedema (self-reported) 2.31 1 0 0.0 0 1 WNT3
Medication: Amlodipine 2.92 1 0 0.0 0 1 WNT3
Chronic bronchitis/emphysema (mother) 3.77 1 0 0.0 0 1 WNT3
High blood pressure (siblings) 3.96 1 0 0.0 0 1 WNT3
Forced vital capacity (FVC), Best measure 46.20 1 1 2.2 0 1 WNT3
Body fat percentage 4.28 1 0 0.0 0 1 WNT3
Exposure to tobacco smoke outside home 10.88 1 0 0.0 0 1 WNT3
Number of full brothers 13.55 1 0 0.0 0 1 WNT3
Worry too long after embarrassment 13.80 1 0 0.0 0 1 WNT3
Wheeze or whistling in the chest in last year 5.56 1 0 0.0 0 1 WNT3
Age at first live birth 7.30 1 0 0.0 0 1 WNT3
Qualifications: College or University degree 13.96 1 1 2.2 0 1 WNT3
Eye problems/disorders: None of the above 4.26 1 0 0.0 0 1 WNT3
Emphysema/chronic bronchitis 14.39 1 0 0.0 0 1 WNT3
Medication for pain relief, constipation, heartburn 16.00 1 1 2.2 0 1 WNT3
Medication: Ibuprofen 9.33 1 0 0.0 0 1 WNT3
Heart disease (mother) 4.73 1 0 0.0 0 1 WNT3
Reproduciblity of spirometry measurement using ERS/ATS criteria 12.36 1 0 0.0 0 1 WNT3
Whole body fat mass 3.21 1 0 0.0 0 1 WNT3
Alcohol intake frequency. 19.47 1 1 2.2 0 1 WNT3
Comparative height size at age 10 6.89 1 1 2.2 0 1 WNT3
Suffer from 'nerves' 10.35 1 0 0.0 0 1 WNT3
Age at last live birth 5.40 1 0 0.0 0 1 WNT3
Leg pain on walking 14.86 1 0 0.0 0 1 WNT3
Commuting to job workplace: Car/motor vehicle 4.33 1 0 0.0 0 1 WNT3
Illness, injury, bereavement, stress in last 2 years 3.34 1 0 0.0 0 1 WNT3
Supplements: Vitamin C 14.45 1 0 0.0 0 1 WNT3
Hypertension (Self-reported) 1.65 1 0 0.0 0 1 WNT3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 4.08 1 0 0.0 0 1 WNT3
Illnesses of father: Heart disease 12.19 1 0 0.0 0 1 WNT3
Smoking status: Previous 7.92 1 0 0.0 0 1 WNT3
Arm fat percentage (left) 1.80 1 0 0.0 0 1 WNT3
Average weekly red wine intake 4.37 1 0 0.0 0 1 WNT3
Handedness (chirality/laterality): Left-handed 33.01 1 1 2.2 0 1 WNT3
Mood swings 39.60 1 1 2.2 0 1 WNT3
Loneliness, isolation 14.08 1 0 0.0 0 1 WNT3
Ever had bowel cancer screening 7.84 1 0 0.0 0 1 WNT3
Qualifications: nursing, teaching 5.02 1 0 0.0 0 1 WNT3
Mouth/teeth dental problems: Mouth ulcers 26.90 1 1 2.2 0 1 WNT3
Medication for cholesterol 5.06 1 0 0.0 0 1 WNT3
Breast cancer (self-reported) 6.02 1 0 0.0 0 1 WNT3
Osteoporosis (self-reported) 6.62 1 0 0.0 0 1 WNT3
Illnesses of father: None of the above (group 1) 7.19 1 0 0.0 0 1 WNT3
Smoking status: Current 3.11 1 0 0.0 0 1 WNT3
Forced expiratory volume in 1-second (FEV1), predicted percentage 34.11 1 1 2.2 0 1 WNT3
Arm fat mass (left) 1.02 1 0 0.0 0 1 WNT3
Average weekly champagne plus white wine intake 16.95 1 0 0.0 0 1 WNT3
Miserableness 20.72 1 1 2.2 0 1 WNT3
Guilty feelings 15.23 1 0 0.0 0 1 WNT3
Hearing aid user 4.35 1 0 0.0 0 1 WNT3
Commuting to job workplace: Public transport 3.99 1 0 0.0 0 1 WNT3
Eye problems/disorders: Glaucoma 9.94 1 0 0.0 0 1 WNT3
Medication: Blood pressure 5.76 1 0 0.0 0 1 WNT3
Pain type(s) experienced in last month: Hip pain 5.05 1 0 0.0 0 1 WNT3
Medication: Paracetamol 25.87 1 1 2.2 0 1 WNT3
Medication: Lisinopril 3.18 1 0 0.0 0 1 WNT3
Alcohol drinker status: Never 3.75 1 0 0.0 0 1 WNT3
Ever smoked 7.81 1 0 0.0 0 1 WNT3
Number of operations (self-reported) 4.82 1 0 0.0 0 1 WNT3
Average weekly beer plus cider intake 4.02 1 0 0.0 0 1 WNT3
Irritability 27.10 1 1 2.2 0 1 WNT3
Fractured/broken bones in last 5 years 13.93 1 0 0.0 0 1 WNT3
Diastolic blood pressure, automated reading 1.65 1 0 0.0 0 1 WNT3
Ever depressed for a whole week 12.39 1 0 0.0 0 1 WNT3
Myopia 8.02 1 0 0.0 0 1 WNT3
Pain experienced in last month 9.59 1 0 0.0 0 1 WNT3
Heart disease (siblings) 7.68 1 0 0.0 0 1 WNT3
Impedance of whole body 9.44 1 1 2.2 0 1 WNT3
Leg fat mass (left) 1.07 1 0 0.0 0 1 WNT3

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.1
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.0
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1