Hub : Traits :

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1 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	17	44788310	45088455	1	1	1.9e-07	7.8e-06	0.15	90	WNT3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Hair/balding pattern: Pattern 4	104.36	1	1	2.2	1	WNT3
Hair/balding pattern: Pattern 3	68.48	1	1	2.2	1	WNT3
Relative age of first facial hair	55.64	1	1	2.2	1	WNT3
Neuroticism (Nagel 2018)	53.81	1	1	2.2	1	WNT3
Sensitivity / hurt feelings	52.15	1	1	2.2	1	WNT3
Neuroticism	50.18	1	1	2.2	1	WNT3
Lung FVC	47.83	1	1	2.2	1	WNT3
Forced vital capacity (FVC), Best measure	46.20	1	1	2.2	1	WNT3
Forced vital capacity (FVC)	45.93	1	1	2.2	1	WNT3
Depressed Affect (Nagel 2018)	45.76	1	1	2.2	1	WNT3
Blood Red Count	45.65	1	1	2.2	1	WNT3
Forced expiratory volume in 1-second (FEV1)	45.61	1	1	2.2	1	WNT3
Neuroticism score	43.91	1	1	2.2	1	WNT3
Forced expiratory volume in 1-second (FEV1), Best measure	42.19	1	1	2.2	1	WNT3
Headache pain in last month	40.52	1	1	2.2	1	WNT3
Mood swings	39.60	1	1	2.2	1	WNT3
Relative age voice broke	37.44	1	1	2.2	1	WNT3
Forced expiratory volume in 1-second (FEV1), predicted percentage	34.11	1	1	2.2	1	WNT3
Handedness (chirality/laterality): Left-handed	33.01	1	1	2.2	1	WNT3
Frequency of tenseness / restlessness in last 2 weeks	30.98	1	1	2.2	1	WNT3
Hair/balding pattern: Pattern 2	29.27	1	1	2.2	1	WNT3
Ovarian Cancer	29.06	1	1	2.2	1	WNT3
Worry (Nagel 2018)	27.41	1	1	2.2	1	WNT3
Irritability	27.10	1	1	2.2	1	WNT3
Mouth/teeth dental problems: Mouth ulcers	26.90	1	1	2.2	1	WNT3
Medication: Paracetamol	26.83	1	1	2.2	1	WNT3
Medication: Paracetamol	25.87	1	1	2.2	1	WNT3
Peak expiratory flow (PEF)	24.63	1	1	2.2	1	WNT3
Hand grip strength (left)	23.70	1	1	2.2	1	WNT3
Fed-up feelings	22.39	1	1	2.2	1	WNT3
Nervous feelings	21.84	1	1	2.2	1	WNT3
Miserableness	20.72	1	1	2.2	1	WNT3
Sitting height	19.61	1	1	2.2	1	WNT3
Alcohol intake frequency.	19.47	1	1	2.2	1	WNT3
Neuroticism (2016)	18.40	1	1	2.2	1	WNT3
Worrier / anxious feelings	17.92	1	1	2.2	1	WNT3
Frequency of depressed mood in last 2 weeks	17.50	1	0	0.0	1	WNT3
Hand grip strength (right)	17.05	1	1	2.2	1	WNT3
Average weekly champagne plus white wine intake	16.95	1	0	0.0	1	WNT3
Waist Hip Ratio (WHR)	16.45	1	1	2.2	1	WNT3
Primary Biliary Cirrhosis	16.29	1	0	0.0	1	WNT3
Depression (Nagel 2018)	16.15	1	0	0.0	1	WNT3
Medication for pain relief, constipation, heartburn	16.00	1	1	2.2	1	WNT3
Blood Eosinophil Count	15.71	1	1	2.2	1	WNT3
Guilty feelings	15.23	1	0	0.0	1	WNT3
Ever unenthusiastic/disinterested for a whole week	15.15	1	0	0.0	1	WNT3
Leg pain on walking	14.86	1	0	0.0	1	WNT3
Mean Putamen Volume	14.76	1	0	0.0	1	WNT3
Supplements: Vitamin C	14.45	1	0	0.0	1	WNT3
Emphysema/chronic bronchitis	14.39	1	0	0.0	1	WNT3
Loneliness, isolation	14.08	1	0	0.0	1	WNT3
Qualifications: College or University degree	13.96	1	1	2.2	1	WNT3
Fractured/broken bones in last 5 years	13.93	1	0	0.0	1	WNT3
Worry too long after embarrassment	13.80	1	0	0.0	1	WNT3
Number of live births	13.74	1	0	0.0	1	WNT3
Number of full brothers	13.55	1	0	0.0	1	WNT3
Breast Cancer	13.44	1	1	2.2	1	WNT3
Ever depressed for a whole week	12.39	1	0	0.0	1	WNT3
Reproduciblity of spirometry measurement using ERS/ATS criteria	12.36	1	0	0.0	1	WNT3
Qualifications: CSEs or equivalent	12.29	1	0	0.0	1	WNT3
Illnesses of father: Heart disease	12.19	1	0	0.0	1	WNT3
Mouth/teeth dental problems	11.96	1	0	0.0	1	WNT3
Diverticular disease/diverticulitis (self-reported)	11.95	1	0	0.0	1	WNT3
Impedance of arm (left)	11.21	1	1	2.2	1	WNT3
Impedance of arm (right)	10.98	1	1	2.2	1	WNT3
Exposure to tobacco smoke outside home	10.88	1	0	0.0	1	WNT3
Hearing difficulty/problems with background noise	10.61	1	0	0.0	1	WNT3
Suffer from 'nerves'	10.35	1	0	0.0	1	WNT3
Medication: Ibuprofen (e.g. Nurofen)	10.27	1	0	0.0	1	WNT3
Intelligence (Savage-Jansen 2018)	9.98	1	1	2.2	1	WNT3
Eye problems/disorders: Glaucoma	9.94	1	0	0.0	1	WNT3
Pain experienced in last month	9.59	1	0	0.0	1	WNT3
Impedance of whole body	9.44	1	1	2.2	1	WNT3
Heel T-Score	9.38	1	1	2.2	1	WNT3
Medication: Ibuprofen	9.33	1	0	0.0	1	WNT3
Crohns Disease (2012)	9.30	1	0	0.0	1	WNT3
Trunk fat percentage	8.88	1	1	2.2	1	WNT3
Past tobacco smoking	8.74	1	0	0.0	1	WNT3
Smoking Status	8.33	1	0	0.0	1	WNT3
Tense / 'highly strung'	8.03	1	0	0.0	1	WNT3
Myopia	8.02	1	0	0.0	1	WNT3
Height	7.98	1	1	2.2	1	WNT3
Smoking status: Previous	7.92	1	0	0.0	1	WNT3
Ever had bowel cancer screening	7.84	1	0	0.0	1	WNT3
Ever smoked	7.81	1	0	0.0	1	WNT3
Vitamin and mineral supplements	7.79	1	0	0.0	1	WNT3
Heart disease (siblings)	7.68	1	0	0.0	1	WNT3
Noisy workplace	7.66	1	0	0.0	1	WNT3
Schizophrenia vs Biploar Disorder	7.42	1	0	0.0	1	WNT3
Age at first live birth	7.30	1	0	0.0	1	WNT3
Illnesses of father: None of the above (group 1)	7.19	1	0	0.0	1	WNT3
Diabetes (father)	7.07	1	0	0.0	1	WNT3
Fluid intelligence score	7.06	1	0	0.0	1	WNT3
Glaucoma (self-reported)	7.04	1	0	0.0	1	WNT3
Schizophrenia (2014)	7.03	1	0	0.0	1	WNT3
Lupus	6.92	1	0	0.0	1	WNT3
Frequency of tiredness / lethargy in last 2 weeks	6.90	1	0	0.0	1	WNT3
Comparative height size at age 10	6.89	1	1	2.2	1	WNT3
Supplements: Zinc	6.65	1	0	0.0	1	WNT3
Falls in the last year	6.65	1	0	0.0	1	WNT3
Osteoporosis (self-reported)	6.62	1	0	0.0	1	WNT3
Trunk fat mass	6.48	1	1	2.2	1	WNT3
Qualifications: A levels/AS levels or equivalent	6.42	1	0	0.0	1	WNT3
Ever highly irritable/argumentative for 2 days	6.41	1	0	0.0	1	WNT3
Standing height	6.24	1	1	2.2	1	WNT3
Verbal and Numeric Reasoning (VNR)	6.02	1	0	0.0	1	WNT3
Breast cancer (self-reported)	6.02	1	0	0.0	1	WNT3
Mouth/teeth dental problems: Bleeding gums	5.89	1	0	0.0	1	WNT3
Medication: Blood pressure	5.76	1	0	0.0	1	WNT3
Schizophrenia (2018)	5.59	1	0	0.0	1	WNT3
Wheeze or whistling in the chest in last year	5.56	1	0	0.0	1	WNT3
Medication for hormone replacement therapy	5.46	1	0	0.0	1	WNT3
Age at last live birth	5.40	1	0	0.0	1	WNT3
LDL Cholesterol	5.24	1	0	0.0	1	WNT3
Systolic blood pressure, automated reading	5.22	1	0	0.0	1	WNT3
Age when periods started (menarche)	5.09	1	0	0.0	1	WNT3
Medication for cholesterol	5.06	1	0	0.0	1	WNT3
Pain type(s) experienced in last month: Hip pain	5.05	1	0	0.0	1	WNT3
Qualifications: nursing, teaching	5.02	1	0	0.0	1	WNT3
Number of operations (self-reported)	4.82	1	0	0.0	1	WNT3
Frequency of unenthusiasm / disinterest in last 2 weeks	4.76	1	0	0.0	1	WNT3
Financial difficulties in last 2 years	4.73	1	0	0.0	1	WNT3
Heart disease (mother)	4.73	1	0	0.0	1	WNT3
Number of incorrect matches in round	4.59	1	0	0.0	1	WNT3
Average weekly red wine intake	4.37	1	0	0.0	1	WNT3
Hearing aid user	4.35	1	0	0.0	1	WNT3
Commuting to job workplace: Car/motor vehicle	4.33	1	0	0.0	1	WNT3
Body fat percentage	4.28	1	0	0.0	1	WNT3
Eye problems/disorders: None of the above	4.26	1	0	0.0	1	WNT3
Hearing difficulty/problems: Yes	4.25	1	0	0.0	1	WNT3
Severe depression (siblings)	4.17	1	0	0.0	1	WNT3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	4.08	1	0	0.0	1	WNT3
Average weekly fortified wine intake	4.03	1	0	0.0	1	WNT3
Average weekly beer plus cider intake	4.02	1	0	0.0	1	WNT3
Commuting to job workplace: Public transport	3.99	1	0	0.0	1	WNT3
Impedance of leg (left)	3.97	1	0	0.0	1	WNT3
High blood pressure (siblings)	3.96	1	0	0.0	1	WNT3
Prospective memory result	3.92	1	0	0.0	1	WNT3
Coronary Artery Disease (CAD)	3.77	1	0	0.0	1	WNT3
Chronic bronchitis/emphysema (mother)	3.77	1	0	0.0	1	WNT3
Alcohol drinker status: Never	3.75	1	0	0.0	1	WNT3
Current tobacco smoking	3.49	1	0	0.0	1	WNT3
Prostate Cancer	3.44	1	0	0.0	1	WNT3
Illness, injury, bereavement, stress in last 2 years	3.34	1	0	0.0	1	WNT3
Multivitamins +/- minerals	3.33	1	0	0.0	1	WNT3
Other serious medical condition/disability diagnosed by doctor	3.29	1	0	0.0	1	WNT3
Stomach or abdominal pain in last month	3.21	1	0	0.0	1	WNT3
Whole body fat mass	3.21	1	0	0.0	1	WNT3
Medication: Lisinopril	3.18	1	0	0.0	1	WNT3
Smoking status: Current	3.11	1	0	0.0	1	WNT3
Heel bone mineral density (BMD) T-score, automated (left)	3.09	1	0	0.0	1	WNT3
Impedance of leg (right)	2.99	1	0	0.0	1	WNT3
Birth weight of first child	2.96	1	0	0.0	1	WNT3
Gout (self-reported)	2.92	1	0	0.0	1	WNT3
Medication: Amlodipine	2.92	1	0	0.0	1	WNT3
Qualifications: None of the above	2.87	1	0	0.0	1	WNT3
Lung FEV1/FVC ratio	2.79	1	0	0.0	1	WNT3
Age at First Birth	2.75	1	0	0.0	1	WNT3
Reaction Time	2.73	1	0	0.0	1	WNT3
Heel bone mineral density (BMD) T-score, automated (right)	2.62	1	0	0.0	1	WNT3
Qualifications: O levels/GCSEs or equivalent	2.62	1	0	0.0	1	WNT3
Hypothyroidism/myxoedema (self-reported)	2.31	1	0	0.0	1	WNT3
Crohns Disease (2017)	2.27	1	0	0.0	1	WNT3
Blood White Count	2.20	1	0	0.0	1	WNT3
Hip circumference	2.13	1	0	0.0	1	WNT3
Systolic Blood Pressure	2.06	1	0	0.0	1	WNT3
High blood pressure	1.96	1	0	0.0	1	WNT3
Irritable Bowel Disease (IBD)	1.94	1	0	0.0	1	WNT3
Arm fat percentage (left)	1.80	1	0	0.0	1	WNT3
Hypertension (Self-reported)	1.65	1	0	0.0	1	WNT3
Diastolic blood pressure, automated reading	1.65	1	0	0.0	1	WNT3
Bipolar Disorder or Schizophrenia	1.61	1	0	0.0	1	WNT3
Arm fat percentage (right)	1.45	1	0	0.0	1	WNT3
Blood Platelet Count	1.36	1	0	0.0	1	WNT3
Weight	1.21	1	0	0.0	1	WNT3
Arm fat mass (right)	1.12	1	0	0.0	1	WNT3
Leg fat mass (left)	1.07	1	0	0.0	1	WNT3
Arm fat mass (left)	1.02	1	0	0.0	1	WNT3
Tanning	1.01	1	0	0.0	1	WNT3
Hair Pigment	0.61	1	0	0.0	1	WNT3

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Uterus	0	0.000	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
METSIM	Adipose	0	0.000	1.1
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.1
YFS	Blood	0	0.000	1.1
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.1
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.0