Hub : Traits :

Falls in the last year

3 significantly associated models · 3 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	49615624	50998816	1	1	1.4e-08	5.4e-04	0.00049	-1	SEMA3B-AS1
2	16	69586228	70978362	1	1	5.2e-08	2.1e-06	0.00217	58	EXOSC6

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Worrier / anxious feelings	15.54	2	1	2.2	1	EXOSC6 SEMA3B-AS1
BMI	11.12	1	1	2.2	1	EXOSC6
Fractured/broken bones in last 5 years	10.01	1	0	0.0	1	SEMA3B-AS1
Arm fat percentage (left)	9.95	1	1	2.2	1	EXOSC6
Arm fat percentage (right)	9.75	1	1	2.2	1	EXOSC6
Body mass index (BMI)	9.66	1	1	2.2	1	EXOSC6
Had menopause	8.36	1	0	0.0	1	SEMA3B-AS1
Body fat percentage	7.86	1	1	2.2	1	EXOSC6
Alzheimer’s Disease (in father)	7.78	1	0	0.0	1	EXOSC6
Arm fat mass (right)	7.73	1	1	2.2	1	EXOSC6
Arm fat mass (left)	7.66	1	1	2.2	1	EXOSC6
Impedance of leg (right)	7.56	2	2	4.4	1	EXOSC6 SEMA3B-AS1
Impedance of leg (left)	7.43	2	2	4.4	1	EXOSC6 SEMA3B-AS1
Neuroticism score	7.38	1	0	0.0	1	SEMA3B-AS1
Leg fat percentage (right)	7.22	1	1	2.2	1	EXOSC6
Leg fat mass (right)	7.21	1	1	2.2	1	EXOSC6
Whole body fat mass	7.17	1	1	2.2	1	EXOSC6
Leg fat percentage (left)	7.11	1	1	2.2	1	EXOSC6
Serious illness, injury or assault to yourself	7.09	1	0	0.0	1	EXOSC6
Leg fat mass (left)	6.86	1	1	2.2	1	EXOSC6
Trunk fat percentage	6.81	1	1	2.2	1	EXOSC6
Commuting to job workplace: Car/motor vehicle	6.80	1	0	0.0	1	SEMA3B-AS1
Alcohol drinker status: Previous	6.79	1	0	0.0	1	SEMA3B-AS1
Tense / 'highly strung'	6.69	1	0	0.0	1	SEMA3B-AS1
Waist circumference	6.53	1	1	2.2	1	EXOSC6
Hip circumference	6.52	1	1	2.2	1	EXOSC6
Nervous feelings	6.33	1	0	0.0	1	SEMA3B-AS1
Medication for cholesterol, blood pressure or diabetes	6.19	1	0	0.0	1	EXOSC6
Trunk fat mass	6.13	1	1	2.2	1	EXOSC6
Body Mass Index (BMI) (2010)	5.75	2	0	0.0	1	EXOSC6 SEMA3B-AS1
Happiness	5.72	1	0	0.0	1	SEMA3B-AS1
Bipolar Disorder (2018)	5.41	2	0	0.0	1	EXOSC6 SEMA3B-AS1
Worry (Nagel 2018)	5.36	1	0	0.0	1	SEMA3B-AS1
Ever used hormone-replacement therapy (HRT)	5.11	1	0	0.0	1	SEMA3B-AS1
Commuting to job workplace: Public transport	5.09	1	0	0.0	1	SEMA3B-AS1
Impedance of whole body	5.09	2	1	2.2	1	EXOSC6 SEMA3B-AS1
Neuroticism (2016)	4.70	1	0	0.0	1	SEMA3B-AS1
Medication: Atenolol	4.70	1	0	0.0	1	EXOSC6
Shortness of breath walking on level ground	4.69	1	0	0.0	1	SEMA3B-AS1
Comparative body size at age 10	4.68	2	0	0.0	1	EXOSC6 SEMA3B-AS1
Neuroticism	4.44	1	0	0.0	1	SEMA3B-AS1
Sensitivity / hurt feelings	4.44	1	0	0.0	1	SEMA3B-AS1
Ever highly irritable/argumentative for 2 days	4.31	1	0	0.0	1	SEMA3B-AS1
Breastfed as a baby	4.21	1	0	0.0	1	SEMA3B-AS1
Diastolic blood pressure, automated reading	4.02	1	0	0.0	1	EXOSC6
Number of treatments/medications taken	4.01	1	0	0.0	1	EXOSC6
Mood swings	3.97	1	0	0.0	1	SEMA3B-AS1
Stomach or abdominal pain in last month	3.85	1	0	0.0	1	EXOSC6
Pulse rate, automated reading	3.69	2	0	0.0	1	EXOSC6 SEMA3B-AS1
Medication: Cholesterol lowering	3.64	1	0	0.0	1	EXOSC6
Number of self-reported non-cancer illnesses	3.58	1	0	0.0	1	EXOSC6
Weight	3.57	1	1	2.2	1	EXOSC6
Eye problems/disorders: Cataract	3.56	1	0	0.0	1	EXOSC6
Health satisfaction	3.55	1	0	0.0	1	SEMA3B-AS1
Overall health rating	3.53	1	0	0.0	1	SEMA3B-AS1
Cardiovascular Disease	3.51	1	0	0.0	1	EXOSC6
Diabetes diagnosed by doctor	3.50	1	0	0.0	1	EXOSC6
Medication: Blood pressure	3.49	1	0	0.0	1	EXOSC6
Height	3.46	2	2	4.4	1	EXOSC6 SEMA3B-AS1
Diabetes (self-reported)	3.42	1	0	0.0	1	EXOSC6
Ever had prostate specific antigen (PSA) test	3.41	1	0	0.0	1	SEMA3B-AS1
Pack years of smoking	3.37	1	0	0.0	1	EXOSC6
High cholesterol (Self-reported)	3.33	1	0	0.0	1	EXOSC6
Impedance of arm (right)	3.20	2	0	0.0	1	EXOSC6 SEMA3B-AS1
Medication: Amlodipine	3.06	1	0	0.0	1	EXOSC6
High blood pressure	3.05	1	0	0.0	1	EXOSC6
Crohns Disease (2017)	3.04	2	0	0.0	1	EXOSC6 SEMA3B-AS1
Pack years adult smoking proportion	3.03	1	0	0.0	1	EXOSC6
Lung FVC	3.01	1	1	2.2	1	SEMA3B-AS1
Standing height	2.99	2	2	4.4	1	EXOSC6 SEMA3B-AS1
Hypertension (Self-reported)	2.97	1	0	0.0	1	EXOSC6
Relative age voice broke	2.89	1	0	0.0	1	EXOSC6
Maternal smoking around birth	2.81	1	0	0.0	1	EXOSC6
Impedance of arm (left)	2.80	2	0	0.0	1	EXOSC6 SEMA3B-AS1
Forced expiratory volume in 1-second (FEV1), predicted	2.79	1	0	0.0	1	SEMA3B-AS1
Irritable Bowel Disease (IBD)	2.76	1	0	0.0	1	EXOSC6
Frequency of depressed mood in last 2 weeks	2.74	1	0	0.0	1	SEMA3B-AS1
Neuroticism (Nagel 2018)	2.68	1	0	0.0	1	SEMA3B-AS1
Depression (Nagel 2018)	2.66	1	0	0.0	1	SEMA3B-AS1
Frequency of tenseness / restlessness in last 2 weeks	2.66	1	0	0.0	1	SEMA3B-AS1
Systolic blood pressure, automated reading	2.64	1	0	0.0	1	EXOSC6
Type 2 Diabetes (T2D) (2018)	2.59	1	0	0.0	1	SEMA3B-AS1
Smoking Status	2.57	1	0	0.0	1	SEMA3B-AS1
Medication: Simvastatin	2.48	1	0	0.0	1	EXOSC6
Taking other prescription medications	2.45	1	0	0.0	1	EXOSC6
Diabetes (mother)	2.41	1	0	0.0	1	EXOSC6
Vascular/heart problems diagnosed by doctor	2.41	1	0	0.0	1	EXOSC6
High blood pressure (siblings)	2.40	1	0	0.0	1	EXOSC6
Frequency of unenthusiasm / disinterest in last 2 weeks	2.39	1	0	0.0	1	SEMA3B-AS1
Past tobacco smoking	2.37	1	0	0.0	1	SEMA3B-AS1
Heel bone mineral density (BMD) T-score, automated (left)	2.35	1	0	0.0	1	SEMA3B-AS1
Wheeze or whistling in the chest in last year	2.26	1	0	0.0	1	EXOSC6
Breast Cancer	2.25	1	0	0.0	1	EXOSC6
Hand grip strength (right)	2.21	1	0	0.0	1	SEMA3B-AS1
Pulse rate	2.16	1	0	0.0	1	EXOSC6
Fed-up feelings	2.09	1	0	0.0	1	SEMA3B-AS1
Current tobacco smoking	2.08	1	0	0.0	1	SEMA3B-AS1
Knee pain experienced in last month	2.00	1	0	0.0	1	EXOSC6
Ever smoked	1.91	1	0	0.0	1	SEMA3B-AS1
Forced vital capacity (FVC), Best measure	1.81	1	0	0.0	1	EXOSC6
Age when periods started (menarche)	1.64	1	0	0.0	1	EXOSC6
Heel bone mineral density (BMD) T-score, automated (right)	1.62	1	0	0.0	1	SEMA3B-AS1
Leg fat-free mass (left)	1.56	1	0	0.0	1	EXOSC6
Leg predicted mass (left)	1.55	1	0	0.0	1	EXOSC6
Leg predicted mass (right)	1.28	1	0	0.0	1	EXOSC6
Forced vital capacity (FVC)	1.24	1	0	0.0	1	EXOSC6
Forced expiratory volume in 1-second (FEV1), Best measure	1.23	1	0	0.0	1	EXOSC6
Leg fat-free mass (right)	1.19	1	0	0.0	1	EXOSC6
Blood White Count	1.11	1	0	0.0	1	EXOSC6
Systolic Blood Pressure	1.09	1	0	0.0	1	EXOSC6
Basal metabolic rate	1.09	1	0	0.0	1	EXOSC6
Blood Eosinophil Count	1.03	2	0	0.0	1	EXOSC6 SEMA3B-AS1
Heel T-Score	0.99	1	0	0.0	1	SEMA3B-AS1
Blood Red Count	0.77	1	0	0.0	1	SEMA3B-AS1
Whole body fat-free mass	0.55	1	0	0.0	1	EXOSC6
Whole body water mass	0.53	1	0	0.0	1	EXOSC6
Blood Platelet Count	0.35	1	0	0.0	1	SEMA3B-AS1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Artery Coronary	0	0.000	1.5
GTEx	Brain Cerebellum	0	0.000	1.5
GTEx	Liver	0	0.000	1.5
GTEx	Ovary	0	0.000	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Spleen	0	0.000	1.5
GTEx	Stomach	0	0.000	1.5
GTEx	Uterus	0	0.000	1.5
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Artery Aorta	1	0.034	1.4
GTEx	Artery Tibial	0	0.000	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.4
GTEx	Cells Transformed fibroblasts	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Colon Transverse	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Esophagus Muscularis	0	0.000	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Muscle Skeletal	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Testis	0	0.000	1.4
GTEx	Thyroid	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
NTR	Blood	0	0.000	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	1	0.061	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
YFS	Blood	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3