Hub : Traits :

Falls in the last year

3 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49615624 50998816 1 1 1.4e-08 5.4e-04 0.00049 -1 SEMA3B-AS1
2 16 69586228 70978362 1 1 5.2e-08 2.1e-06 0.00217 58 EXOSC6

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 5.41 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Depression (Nagel 2018) 2.66 1 0 0.0 0 1 SEMA3B-AS1
Neuroticism (Nagel 2018) 2.68 1 0 0.0 0 1 SEMA3B-AS1
Worry (Nagel 2018) 5.36 1 0 0.0 0 1 SEMA3B-AS1
Alzheimer’s Disease (in father) 7.78 1 0 0.0 0 1 EXOSC6
Crohns Disease (2017) 3.04 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Irritable Bowel Disease (IBD) 2.76 1 0 0.0 0 1 EXOSC6
Breast Cancer 2.25 1 0 0.0 0 1 EXOSC6
Body Mass Index (BMI) (2010) 5.75 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Neuroticism (2016) 4.70 1 0 0.0 0 1 SEMA3B-AS1
Blood Eosinophil Count 1.03 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Blood Platelet Count 0.35 1 0 0.0 0 1 SEMA3B-AS1
Blood Red Count 0.77 1 0 0.0 0 1 SEMA3B-AS1
Blood White Count 1.11 1 0 0.0 0 1 EXOSC6
Heel T-Score 0.99 1 0 0.0 0 1 SEMA3B-AS1
BMI 11.12 1 1 2.2 0 1 EXOSC6
Height 3.46 2 2 4.4 0 1 EXOSC6 SEMA3B-AS1
Systolic Blood Pressure 1.09 1 0 0.0 0 1 EXOSC6
Smoking Status 2.57 1 0 0.0 0 1 SEMA3B-AS1
Cardiovascular Disease 3.51 1 0 0.0 0 1 EXOSC6
Type 2 Diabetes (T2D) (2018) 2.59 1 0 0.0 0 1 SEMA3B-AS1
Lung FVC 3.01 1 1 2.2 0 1 SEMA3B-AS1
Neuroticism 4.44 1 0 0.0 0 1 SEMA3B-AS1
Number of treatments/medications taken 4.01 1 0 0.0 0 1 EXOSC6
Sensitivity / hurt feelings 4.44 1 0 0.0 0 1 SEMA3B-AS1
Frequency of depressed mood in last 2 weeks 2.74 1 0 0.0 0 1 SEMA3B-AS1
Ever used hormone-replacement therapy (HRT) 5.11 1 0 0.0 0 1 SEMA3B-AS1
Systolic blood pressure, automated reading 2.64 1 0 0.0 0 1 EXOSC6
Diabetes (mother) 2.41 1 0 0.0 0 1 EXOSC6
Pack years adult smoking proportion 3.03 1 0 0.0 0 1 EXOSC6
Impedance of leg (right) 7.56 2 2 4.4 0 1 EXOSC6 SEMA3B-AS1
Leg fat-free mass (left) 1.56 1 0 0.0 0 1 EXOSC6
Trunk fat percentage 6.81 1 1 2.2 0 1 EXOSC6
Hand grip strength (right) 2.21 1 0 0.0 0 1 SEMA3B-AS1
Current tobacco smoking 2.08 1 0 0.0 0 1 SEMA3B-AS1
Maternal smoking around birth 2.81 1 0 0.0 0 1 EXOSC6
Fed-up feelings 2.09 1 0 0.0 0 1 SEMA3B-AS1
Frequency of unenthusiasm / disinterest in last 2 weeks 2.39 1 0 0.0 0 1 SEMA3B-AS1
Relative age voice broke 2.89 1 0 0.0 0 1 EXOSC6
Taking other prescription medications 2.45 1 0 0.0 0 1 EXOSC6
Age when periods started (menarche) 1.64 1 0 0.0 0 1 EXOSC6
Heel bone mineral density (BMD) T-score, automated (left) 2.35 1 0 0.0 0 1 SEMA3B-AS1
Serious illness, injury or assault to yourself 7.09 1 0 0.0 0 1 EXOSC6
High blood pressure 3.05 1 0 0.0 0 1 EXOSC6
Stomach or abdominal pain in last month 3.85 1 0 0.0 0 1 EXOSC6
Medication: Atenolol 4.70 1 0 0.0 0 1 EXOSC6
Body mass index (BMI) 9.66 1 1 2.2 0 1 EXOSC6
Impedance of leg (left) 7.43 2 2 4.4 0 1 EXOSC6 SEMA3B-AS1
Leg predicted mass (left) 1.55 1 0 0.0 0 1 EXOSC6
Trunk fat mass 6.13 1 1 2.2 0 1 EXOSC6
Waist circumference 6.53 1 1 2.2 0 1 EXOSC6
Past tobacco smoking 2.37 1 0 0.0 0 1 SEMA3B-AS1
Nervous feelings 6.33 1 0 0.0 0 1 SEMA3B-AS1
Frequency of tenseness / restlessness in last 2 weeks 2.66 1 0 0.0 0 1 SEMA3B-AS1
Had menopause 8.36 1 0 0.0 0 1 SEMA3B-AS1
Forced vital capacity (FVC) 1.24 1 0 0.0 0 1 EXOSC6
Heel bone mineral density (BMD) T-score, automated (right) 1.62 1 0 0.0 0 1 SEMA3B-AS1
Diabetes (self-reported) 3.42 1 0 0.0 0 1 EXOSC6
Medication: Simvastatin 2.48 1 0 0.0 0 1 EXOSC6
Neuroticism score 7.38 1 0 0.0 0 1 SEMA3B-AS1
Weight 3.57 1 1 2.2 0 1 EXOSC6
Impedance of arm (right) 3.20 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Arm fat percentage (right) 9.75 1 1 2.2 0 1 EXOSC6
Hip circumference 6.52 1 1 2.2 0 1 EXOSC6
Worrier / anxious feelings 15.54 2 1 2.2 0 1 EXOSC6 SEMA3B-AS1
Pulse rate 2.16 1 0 0.0 0 1 EXOSC6
Happiness 5.72 1 0 0.0 0 1 SEMA3B-AS1
Medication: Cholesterol lowering 3.64 1 0 0.0 0 1 EXOSC6
Forced expiratory volume in 1-second (FEV1), Best measure 1.23 1 0 0.0 0 1 EXOSC6
Impedance of arm (left) 2.80 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Arm fat mass (right) 7.73 1 1 2.2 0 1 EXOSC6
Standing height 2.99 2 2 4.4 0 1 EXOSC6 SEMA3B-AS1
Breastfed as a baby 4.21 1 0 0.0 0 1 SEMA3B-AS1
Tense / 'highly strung' 6.69 1 0 0.0 0 1 SEMA3B-AS1
Ever highly irritable/argumentative for 2 days 4.31 1 0 0.0 0 1 SEMA3B-AS1
Medication for cholesterol, blood pressure or diabetes 6.19 1 0 0.0 0 1 EXOSC6
Medication: Amlodipine 3.06 1 0 0.0 0 1 EXOSC6
High blood pressure (siblings) 2.40 1 0 0.0 0 1 EXOSC6
Forced vital capacity (FVC), Best measure 1.81 1 0 0.0 0 1 EXOSC6
Body fat percentage 7.86 1 1 2.2 0 1 EXOSC6
Leg fat percentage (right) 7.22 1 1 2.2 0 1 EXOSC6
Comparative body size at age 10 4.68 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Wheeze or whistling in the chest in last year 2.26 1 0 0.0 0 1 EXOSC6
Health satisfaction 3.55 1 0 0.0 0 1 SEMA3B-AS1
Shortness of breath walking on level ground 4.69 1 0 0.0 0 1 SEMA3B-AS1
Medication: Blood pressure 3.49 1 0 0.0 0 1 EXOSC6
Whole body fat mass 7.17 1 1 2.2 0 1 EXOSC6
Leg fat mass (right) 7.21 1 1 2.2 0 1 EXOSC6
Pulse rate, automated reading 3.69 2 0 0.0 0 1 EXOSC6 SEMA3B-AS1
Overall health rating 3.53 1 0 0.0 0 1 SEMA3B-AS1
Commuting to job workplace: Car/motor vehicle 6.80 1 0 0.0 0 1 SEMA3B-AS1
Knee pain experienced in last month 2.00 1 0 0.0 0 1 EXOSC6
Hypertension (Self-reported) 2.97 1 0 0.0 0 1 EXOSC6
Forced expiratory volume in 1-second (FEV1), predicted 2.79 1 0 0.0 0 1 SEMA3B-AS1
Whole body fat-free mass 0.55 1 0 0.0 0 1 EXOSC6
Leg fat-free mass (right) 1.19 1 0 0.0 0 1 EXOSC6
Arm fat percentage (left) 9.95 1 1 2.2 0 1 EXOSC6
Mood swings 3.97 1 0 0.0 0 1 SEMA3B-AS1
Diabetes diagnosed by doctor 3.50 1 0 0.0 0 1 EXOSC6
Eye problems/disorders: Cataract 3.56 1 0 0.0 0 1 EXOSC6
Whole body water mass 0.53 1 0 0.0 0 1 EXOSC6
Leg predicted mass (right) 1.28 1 0 0.0 0 1 EXOSC6
Arm fat mass (left) 7.66 1 1 2.2 0 1 EXOSC6
Number of self-reported non-cancer illnesses 3.58 1 0 0.0 0 1 EXOSC6
Commuting to job workplace: Public transport 5.09 1 0 0.0 0 1 SEMA3B-AS1
High cholesterol (Self-reported) 3.33 1 0 0.0 0 1 EXOSC6
Ever smoked 1.91 1 0 0.0 0 1 SEMA3B-AS1
Basal metabolic rate 1.09 1 0 0.0 0 1 EXOSC6
Leg fat percentage (left) 7.11 1 1 2.2 0 1 EXOSC6
Ever had prostate specific antigen (PSA) test 3.41 1 0 0.0 0 1 SEMA3B-AS1
Fractured/broken bones in last 5 years 10.01 1 0 0.0 0 1 SEMA3B-AS1
Diastolic blood pressure, automated reading 4.02 1 0 0.0 0 1 EXOSC6
Vascular/heart problems diagnosed by doctor 2.41 1 0 0.0 0 1 EXOSC6
Alcohol drinker status: Previous 6.79 1 0 0.0 0 1 SEMA3B-AS1
Pack years of smoking 3.37 1 0 0.0 0 1 EXOSC6
Impedance of whole body 5.09 2 1 2.2 0 1 EXOSC6 SEMA3B-AS1
Leg fat mass (left) 6.86 1 1 2.2 0 1 EXOSC6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 1 0.034 1.4
GTEx Artery Coronary 0 0.000 1.5
GTEx Artery Tibial 0 0.000 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.5
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 1 0.061 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 0 0.000 1.4
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.4
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 0 0.000 1.4
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.5
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.4
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.5
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.4
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.5
GTEx Testis 0 0.000 1.4
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.4
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.4
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.4
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3