Hub : Traits :

Breastfed as a baby

11 significantly associated models · 6 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	752566	2051513	5	2	4.8e-08	3.1e-07	0.90	100	LOC441869 PUSL1
2	11	119947402	120446830	1	1	8.3e-08	6.2e-06	0.23	93	TMEM136

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Systolic blood pressure, automated reading	9.65	3	2	4.4	1	LOC441869 PUSL1 TMEM136
Medication: Levothyroxine sodium	8.52	1	1	2.2	1	PUSL1
Systolic Blood Pressure	8.30	3	2	4.4	1	LOC441869 PUSL1 TMEM136
Ulcerative Colitis	7.85	1	0	0.0	1	TMEM136
Peak expiratory flow (PEF)	7.68	2	1	2.2	1	LOC441869 PUSL1
Eye problems/disorders: Glaucoma	7.61	1	0	0.0	1	TMEM136
Birth weight of first child	7.45	2	0	0.0	1	LOC441869 PUSL1
Hypothyroidism/myxoedema (self-reported)	6.90	2	0	0.0	1	LOC441869 PUSL1
Glaucoma (self-reported)	5.72	1	0	0.0	1	TMEM136
Illnesses of siblings	5.58	1	0	0.0	1	LOC441869
High blood pressure (siblings)	5.05	1	0	0.0	1	LOC441869
Hypothyroidism (self reported)	4.95	1	0	0.0	1	PUSL1
High blood pressure (mother)	4.47	1	0	0.0	1	LOC441869
Medication: Cholesterol lowering	4.14	1	0	0.0	1	TMEM136
Ulcerative Colitis (UC)	4.08	2	0	0.0	1	LOC441869 TMEM136
Medication for cholesterol, blood pressure or diabetes	3.90	2	0	0.0	1	LOC441869 TMEM136
Had other major operations	3.77	1	0	0.0	1	LOC441869
Irritable Bowel Disease (IBD)	3.59	1	0	0.0	1	LOC441869
Number of operations (self-reported)	3.12	1	0	0.0	1	PUSL1
Medication: Ramipril	3.03	1	0	0.0	1	TMEM136
Angina	2.89	1	0	0.0	1	TMEM136
Medication: Lisinopril	2.82	1	0	0.0	1	LOC441869
Forced expiratory volume in 1-second (FEV1)	2.64	2	0	0.0	1	LOC441869 TMEM136
Angina (self-reported)	2.59	1	0	0.0	1	TMEM136
Loneliness, isolation	2.51	1	0	0.0	1	LOC441869
Overall health rating	2.41	1	0	0.0	1	TMEM136
Forced vital capacity (FVC)	2.34	2	0	0.0	1	LOC441869 TMEM136
Intelligence (Savage-Jansen 2018)	2.18	1	0	0.0	1	TMEM136
Vascular/heart problems diagnosed by doctor	2.15	1	0	0.0	1	TMEM136
Forced expiratory volume in 1-second (FEV1), Best measure	2.14	1	0	0.0	1	TMEM136
Crohns Disease (2017)	2.12	1	0	0.0	1	LOC441869
Number of treatments/medications taken	2.02	1	0	0.0	1	TMEM136
Mouth/teeth dental problems: Dentures	1.91	1	0	0.0	1	LOC441869
Forced vital capacity (FVC), Best measure	1.88	1	0	0.0	1	TMEM136
Fed-up feelings	1.85	1	0	0.0	1	PUSL1
Depressed Affect (Nagel 2018)	1.76	1	0	0.0	1	PUSL1
Heel T-Score	1.68	2	0	0.0	1	PUSL1 TMEM136
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.67	1	0	0.0	1	TMEM136
Lung FVC	1.65	2	0	0.0	1	LOC441869 TMEM136
Type 2 Diabetes (T2D) (2018)	1.63	1	0	0.0	1	TMEM136
Cardiovascular Disease	1.56	1	0	0.0	1	PUSL1
Breast Cancer	1.54	1	0	0.0	1	TMEM136
Arm fat mass (right)	1.51	2	0	0.0	1	PUSL1 TMEM136
Leg fat mass (left)	1.49	1	0	0.0	1	TMEM136
Body mass index (BMI)	1.48	1	0	0.0	1	TMEM136
Arm fat mass (left)	1.48	1	0	0.0	1	PUSL1
Leg fat percentage (left)	1.46	1	0	0.0	1	TMEM136
Leg fat mass (right)	1.43	1	0	0.0	1	TMEM136
Arm fat percentage (right)	1.42	1	0	0.0	1	TMEM136
Leg fat percentage (right)	1.35	1	0	0.0	1	TMEM136
Hip circumference	1.33	1	0	0.0	1	PUSL1
Arm fat percentage (left)	1.29	1	0	0.0	1	TMEM136
Blood Platelet Count	1.28	1	1	2.2	1	TMEM136
Weight	1.15	1	0	0.0	1	PUSL1
Trunk fat-free mass	1.06	1	0	0.0	1	PUSL1
Trunk predicted mass	1.06	1	0	0.0	1	PUSL1
Comparative height size at age 10	1.06	1	0	0.0	1	LOC441869
Basal metabolic rate	1.05	1	0	0.0	1	PUSL1
Whole body water mass	1.02	1	0	0.0	1	PUSL1
Blood Eosinophil Count	1.01	1	0	0.0	1	TMEM136
BMI	0.98	1	0	0.0	1	TMEM136
Whole body fat-free mass	0.96	1	0	0.0	1	PUSL1
Blood White Count	0.95	1	0	0.0	1	TMEM136
Arm fat-free mass (right)	0.92	1	0	0.0	1	PUSL1
Arm predicted mass (left)	0.92	1	0	0.0	1	PUSL1
Arm predicted mass (right)	0.88	1	0	0.0	1	PUSL1
Arm fat-free mass (left)	0.87	1	0	0.0	1	PUSL1
Leg predicted mass (right)	0.86	1	0	0.0	1	PUSL1
Leg fat-free mass (left)	0.85	1	0	0.0	1	PUSL1
Leg predicted mass (left)	0.84	1	0	0.0	1	PUSL1
Leg fat-free mass (right)	0.79	1	0	0.0	1	PUSL1
Standing height	0.75	1	0	0.0	1	TMEM136
Height	0.61	2	0	0.0	1	PUSL1 TMEM136
Hair Pigment	0.29	2	0	0.0	1	LOC441869 PUSL1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Testis	1	0.032	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
NTR	Blood	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	1	0.023	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Transverse	1	0.048	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	2	0.039	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.1
GTEx	Brain Hippocampus	0	0.000	1.1
GTEx	Uterus	0	0.000	1.1