Hub : Traits :

Breastfed as a baby

11 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 2051513 5 2 4.8e-08 3.1e-07 0.90 100 LOC441869 PUSL1
2 11 119947402 120446830 1 1 8.3e-08 6.2e-06 0.23 93 TMEM136

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 1.76 1 0 0.0 0 1 PUSL1
Intelligence (Savage-Jansen 2018) 2.18 1 0 0.0 0 1 TMEM136
Crohns Disease (2017) 2.12 1 0 0.0 0 1 LOC441869
Irritable Bowel Disease (IBD) 3.59 1 0 0.0 0 1 LOC441869
Ulcerative Colitis (UC) 4.08 2 0 0.0 0 1 LOC441869 TMEM136
Breast Cancer 1.54 1 0 0.0 0 1 TMEM136
Ulcerative Colitis 7.85 1 0 0.0 0 1 TMEM136
Blood Eosinophil Count 1.01 1 0 0.0 0 1 TMEM136
Blood Platelet Count 1.28 1 1 2.2 0 1 TMEM136
Blood White Count 0.95 1 0 0.0 0 1 TMEM136
Heel T-Score 1.68 2 0 0.0 0 1 PUSL1 TMEM136
BMI 0.98 1 0 0.0 0 1 TMEM136
Height 0.61 2 0 0.0 0 1 PUSL1 TMEM136
Systolic Blood Pressure 8.30 3 2 4.4 0 1 LOC441869 PUSL1 TMEM136
Cardiovascular Disease 1.56 1 0 0.0 0 1 PUSL1
Hypothyroidism (self reported) 4.95 1 0 0.0 0 1 PUSL1
Type 2 Diabetes (T2D) (2018) 1.63 1 0 0.0 0 1 TMEM136
Lung FVC 1.65 2 0 0.0 0 1 LOC441869 TMEM136
Hair Pigment 0.29 2 0 0.0 0 1 LOC441869 PUSL1
Number of treatments/medications taken 2.02 1 0 0.0 0 1 TMEM136
Systolic blood pressure, automated reading 9.65 3 2 4.4 0 1 LOC441869 PUSL1 TMEM136
Angina 2.89 1 0 0.0 0 1 TMEM136
Leg fat-free mass (left) 0.85 1 0 0.0 0 1 PUSL1
Fed-up feelings 1.85 1 0 0.0 0 1 PUSL1
Medication: Levothyroxine sodium 8.52 1 1 2.2 0 1 PUSL1
High blood pressure (mother) 4.47 1 0 0.0 0 1 LOC441869
Body mass index (BMI) 1.48 1 0 0.0 0 1 TMEM136
Leg predicted mass (left) 0.84 1 0 0.0 0 1 PUSL1
Had other major operations 3.77 1 0 0.0 0 1 LOC441869
Forced vital capacity (FVC) 2.34 2 0 0.0 0 1 LOC441869 TMEM136
Medication: Ramipril 3.03 1 0 0.0 0 1 TMEM136
Illnesses of siblings 5.58 1 0 0.0 0 1 LOC441869
Weight 1.15 1 0 0.0 0 1 PUSL1
Arm fat percentage (right) 1.42 1 0 0.0 0 1 TMEM136
Trunk fat-free mass 1.06 1 0 0.0 0 1 PUSL1
Hip circumference 1.33 1 0 0.0 0 1 PUSL1
Forced expiratory volume in 1-second (FEV1) 2.64 2 0 0.0 0 1 LOC441869 TMEM136
Mouth/teeth dental problems: Dentures 1.91 1 0 0.0 0 1 LOC441869
Medication: Cholesterol lowering 4.14 1 0 0.0 0 1 TMEM136
Forced expiratory volume in 1-second (FEV1), Best measure 2.14 1 0 0.0 0 1 TMEM136
Arm fat mass (right) 1.51 2 0 0.0 0 1 PUSL1 TMEM136
Trunk predicted mass 1.06 1 0 0.0 0 1 PUSL1
Standing height 0.75 1 0 0.0 0 1 TMEM136
Birth weight of first child 7.45 2 0 0.0 0 1 LOC441869 PUSL1
Peak expiratory flow (PEF) 7.68 2 1 2.2 0 1 LOC441869 PUSL1
Medication for cholesterol, blood pressure or diabetes 3.90 2 0 0.0 0 1 LOC441869 TMEM136
Glaucoma (self-reported) 5.72 1 0 0.0 0 1 TMEM136
Hypothyroidism/myxoedema (self-reported) 6.90 2 0 0.0 0 1 LOC441869 PUSL1
High blood pressure (siblings) 5.05 1 0 0.0 0 1 LOC441869
Forced vital capacity (FVC), Best measure 1.88 1 0 0.0 0 1 TMEM136
Leg fat percentage (right) 1.35 1 0 0.0 0 1 TMEM136
Arm fat-free mass (right) 0.92 1 0 0.0 0 1 PUSL1
Angina (self-reported) 2.59 1 0 0.0 0 1 TMEM136
Leg fat mass (right) 1.43 1 0 0.0 0 1 TMEM136
Arm predicted mass (right) 0.88 1 0 0.0 0 1 PUSL1
Comparative height size at age 10 1.06 1 0 0.0 0 1 LOC441869
Overall health rating 2.41 1 0 0.0 0 1 TMEM136
Whole body fat-free mass 0.96 1 0 0.0 0 1 PUSL1
Leg fat-free mass (right) 0.79 1 0 0.0 0 1 PUSL1
Arm fat percentage (left) 1.29 1 0 0.0 0 1 TMEM136
Loneliness, isolation 2.51 1 0 0.0 0 1 LOC441869
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.67 1 0 0.0 0 1 TMEM136
Whole body water mass 1.02 1 0 0.0 0 1 PUSL1
Leg predicted mass (right) 0.86 1 0 0.0 0 1 PUSL1
Arm fat mass (left) 1.48 1 0 0.0 0 1 PUSL1
Eye problems/disorders: Glaucoma 7.61 1 0 0.0 0 1 TMEM136
Medication: Lisinopril 2.82 1 0 0.0 0 1 LOC441869
Basal metabolic rate 1.05 1 0 0.0 0 1 PUSL1
Leg fat percentage (left) 1.46 1 0 0.0 0 1 TMEM136
Arm fat-free mass (left) 0.87 1 0 0.0 0 1 PUSL1
Number of operations (self-reported) 3.12 1 0 0.0 0 1 PUSL1
Vascular/heart problems diagnosed by doctor 2.15 1 0 0.0 0 1 TMEM136
Leg fat mass (left) 1.49 1 0 0.0 0 1 TMEM136
Arm predicted mass (left) 0.92 1 0 0.0 0 1 PUSL1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.1
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 1 0.048 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 1 0.032 1.3
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.1
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.3
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.2
The Cancer Genome Atlas Thyroid Carcinoma 2 0.039 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2