Hub : Traits :

Ever depressed for a whole week

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 20 47031920 48503461 1 1 2.7e-07 5.6e-06 0.021 74 STAU1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depression (Nagel 2018) 3.52 1 0 0.0 0 1 STAU1
Intelligence (Savage-Jansen 2018) 12.84 1 1 2.2 0 1 STAU1
Schizophrenia vs Biploar Disorder 6.73 1 0 0.0 0 1 STAU1
Alzheimer’s Disease (in father) 4.67 1 0 0.0 0 1 STAU1
Crohns Disease (2017) 4.54 1 0 0.0 0 1 STAU1
Major Depression (MDD) 6.36 1 0 0.0 0 1 STAU1
Reaction Time 8.78 1 0 0.0 0 1 STAU1
Verbal and Numeric Reasoning (VNR) 13.40 1 1 2.2 0 1 STAU1
Ovarian Cancer 4.88 1 0 0.0 0 1 STAU1
Bipolar Disorder (2011) 5.23 1 0 0.0 0 1 STAU1
Crohns Disease (2012) 2.78 1 0 0.0 0 1 STAU1
HDL Cholesterol 3.05 1 0 0.0 0 1 STAU1
Rheumatoid Arthritis 3.05 1 0 0.0 0 1 STAU1
Blood Platelet Count 0.40 1 0 0.0 0 1 STAU1
BMI 5.93 1 1 2.2 0 1 STAU1
Height 2.15 1 1 2.2 0 1 STAU1
Systolic Blood Pressure 1.08 1 0 0.0 0 1 STAU1
Allergy or Eczema 1.50 1 0 0.0 0 1 STAU1
Cardiovascular Disease 3.73 1 0 0.0 0 1 STAU1
Hypothyroidism (self reported) 2.77 1 0 0.0 0 1 STAU1
Lung FVC 2.59 1 0 0.0 0 1 STAU1
Hand grip strength (left) 2.19 1 0 0.0 0 1 STAU1
Frequency of depressed mood in last 2 weeks 4.76 1 0 0.0 0 1 STAU1
Diabetes (father) 3.70 1 0 0.0 0 1 STAU1
Pack years adult smoking proportion 3.04 1 0 0.0 0 1 STAU1
Trunk fat percentage 5.43 1 0 0.0 0 1 STAU1
Hand grip strength (right) 3.63 1 0 0.0 0 1 STAU1
Average weekly fortified wine intake 4.65 1 0 0.0 0 1 STAU1
Frequency of unenthusiasm / disinterest in last 2 weeks 5.23 1 0 0.0 0 1 STAU1
Serious illness, injury or assault to yourself 4.74 1 0 0.0 0 1 STAU1
Sitting height 2.46 1 0 0.0 0 1 STAU1
Body mass index (BMI) 5.20 1 0 0.0 0 1 STAU1
Trunk fat mass 3.73 1 0 0.0 0 1 STAU1
Waist circumference 1.49 1 0 0.0 0 1 STAU1
Forced vital capacity (FVC) 3.94 1 0 0.0 0 1 STAU1
Ever unenthusiastic/disinterested for a whole week 13.45 1 0 0.0 0 1 STAU1
Qualifications: None of the above 3.66 1 0 0.0 0 1 STAU1
Mouth/teeth dental problems 4.81 1 0 0.0 0 1 STAU1
Fluid intelligence score 5.86 1 0 0.0 0 1 STAU1
Weight 0.95 1 0 0.0 0 1 STAU1
Arm fat percentage (right) 6.50 1 0 0.0 0 1 STAU1
Time employed in main current job 5.23 1 0 0.0 0 1 STAU1
Father's age at death 3.65 1 0 0.0 0 1 STAU1
Frequency of tiredness / lethargy in last 2 weeks 5.22 1 0 0.0 0 1 STAU1
Hair/balding pattern: Pattern 3 3.27 1 0 0.0 0 1 STAU1
Forced expiratory volume in 1-second (FEV1) 3.54 1 0 0.0 0 1 STAU1
Qualifications: A levels/AS levels or equivalent 3.70 1 0 0.0 0 1 STAU1
Forced expiratory volume in 1-second (FEV1), Best measure 4.31 1 0 0.0 0 1 STAU1
Arm fat mass (right) 3.77 1 0 0.0 0 1 STAU1
Standing height 2.86 1 1 2.2 0 1 STAU1
Tense / 'highly strung' 3.71 1 0 0.0 0 1 STAU1
Pulse wave reflection index 3.34 1 0 0.0 0 1 STAU1
Mouth/teeth dental problems: Bleeding gums 7.15 1 0 0.0 0 1 STAU1
Medication: Paracetamol 2.78 1 0 0.0 0 1 STAU1
Medication: Ventolin 100micrograms inhaler 3.05 1 0 0.0 0 1 STAU1
Forced vital capacity (FVC), Best measure 6.01 1 0 0.0 0 1 STAU1
Body fat percentage 6.57 1 0 0.0 0 1 STAU1
Leg fat percentage (right) 8.59 1 1 2.2 0 1 STAU1
Comparative body size at age 10 1.76 1 0 0.0 0 1 STAU1
Wheeze or whistling in the chest in last year 3.97 1 0 0.0 0 1 STAU1
Number of children fathered 7.34 1 0 0.0 0 1 STAU1
Qualifications: College or University degree 7.49 1 0 0.0 0 1 STAU1
Medication: Ibuprofen 3.27 1 0 0.0 0 1 STAU1
Mean time to correctly identify matches 8.62 1 0 0.0 0 1 STAU1
Whole body fat mass 4.37 1 0 0.0 0 1 STAU1
Leg fat mass (right) 5.11 1 0 0.0 0 1 STAU1
Comparative height size at age 10 1.87 1 0 0.0 0 1 STAU1
Knee pain experienced in last month 5.53 1 0 0.0 0 1 STAU1
Hypertension (Self-reported) 1.64 1 0 0.0 0 1 STAU1
Arm fat percentage (left) 6.48 1 0 0.0 0 1 STAU1
Handedness (chirality/laterality): Left-handed 3.82 1 0 0.0 0 1 STAU1
Friendships satisfaction 5.25 1 0 0.0 0 1 STAU1
Qualifications: nursing, teaching 3.74 1 0 0.0 0 1 STAU1
Smoking status: Current 3.05 1 0 0.0 0 1 STAU1
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.68 1 0 0.0 0 1 STAU1
Arm fat mass (left) 4.19 1 0 0.0 0 1 STAU1
Mother's age at death 3.20 1 0 0.0 0 1 STAU1
High cholesterol (Self-reported) 4.09 1 0 0.0 0 1 STAU1
Medication: Paracetamol 4.92 1 0 0.0 0 1 STAU1
Leg fat percentage (left) 8.85 1 1 2.2 0 1 STAU1
Commuting to job workplace: Cycle 3.24 1 0 0.0 0 1 STAU1
Pain experienced in last month 3.15 1 0 0.0 0 1 STAU1
Leg fat mass (left) 5.44 1 0 0.0 0 1 STAU1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.4
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 1 0.019 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1