Hub : Traits :

Ever depressed for a whole week

1 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	20	47031920	48503461	1	1	2.7e-07	5.6e-06	0.021	74	STAU1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Ever unenthusiastic/disinterested for a whole week	13.45	1	0	0.0	1	STAU1
Verbal and Numeric Reasoning (VNR)	13.40	1	1	2.2	1	STAU1
Intelligence (Savage-Jansen 2018)	12.84	1	1	2.2	1	STAU1
Leg fat percentage (left)	8.85	1	1	2.2	1	STAU1
Reaction Time	8.78	1	0	0.0	1	STAU1
Mean time to correctly identify matches	8.62	1	0	0.0	1	STAU1
Leg fat percentage (right)	8.59	1	1	2.2	1	STAU1
Qualifications: College or University degree	7.49	1	0	0.0	1	STAU1
Number of children fathered	7.34	1	0	0.0	1	STAU1
Mouth/teeth dental problems: Bleeding gums	7.15	1	0	0.0	1	STAU1
Schizophrenia vs Biploar Disorder	6.73	1	0	0.0	1	STAU1
Body fat percentage	6.57	1	0	0.0	1	STAU1
Arm fat percentage (right)	6.50	1	0	0.0	1	STAU1
Arm fat percentage (left)	6.48	1	0	0.0	1	STAU1
Major Depression (MDD)	6.36	1	0	0.0	1	STAU1
Forced vital capacity (FVC), Best measure	6.01	1	0	0.0	1	STAU1
BMI	5.93	1	1	2.2	1	STAU1
Fluid intelligence score	5.86	1	0	0.0	1	STAU1
Knee pain experienced in last month	5.53	1	0	0.0	1	STAU1
Leg fat mass (left)	5.44	1	0	0.0	1	STAU1
Trunk fat percentage	5.43	1	0	0.0	1	STAU1
Friendships satisfaction	5.25	1	0	0.0	1	STAU1
Bipolar Disorder (2011)	5.23	1	0	0.0	1	STAU1
Frequency of unenthusiasm / disinterest in last 2 weeks	5.23	1	0	0.0	1	STAU1
Time employed in main current job	5.23	1	0	0.0	1	STAU1
Frequency of tiredness / lethargy in last 2 weeks	5.22	1	0	0.0	1	STAU1
Body mass index (BMI)	5.20	1	0	0.0	1	STAU1
Leg fat mass (right)	5.11	1	0	0.0	1	STAU1
Medication: Paracetamol	4.92	1	0	0.0	1	STAU1
Ovarian Cancer	4.88	1	0	0.0	1	STAU1
Mouth/teeth dental problems	4.81	1	0	0.0	1	STAU1
Frequency of depressed mood in last 2 weeks	4.76	1	0	0.0	1	STAU1
Serious illness, injury or assault to yourself	4.74	1	0	0.0	1	STAU1
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.68	1	0	0.0	1	STAU1
Alzheimer’s Disease (in father)	4.67	1	0	0.0	1	STAU1
Average weekly fortified wine intake	4.65	1	0	0.0	1	STAU1
Crohns Disease (2017)	4.54	1	0	0.0	1	STAU1
Whole body fat mass	4.37	1	0	0.0	1	STAU1
Forced expiratory volume in 1-second (FEV1), Best measure	4.31	1	0	0.0	1	STAU1
Arm fat mass (left)	4.19	1	0	0.0	1	STAU1
High cholesterol (Self-reported)	4.09	1	0	0.0	1	STAU1
Wheeze or whistling in the chest in last year	3.97	1	0	0.0	1	STAU1
Forced vital capacity (FVC)	3.94	1	0	0.0	1	STAU1
Handedness (chirality/laterality): Left-handed	3.82	1	0	0.0	1	STAU1
Arm fat mass (right)	3.77	1	0	0.0	1	STAU1
Qualifications: nursing, teaching	3.74	1	0	0.0	1	STAU1
Cardiovascular Disease	3.73	1	0	0.0	1	STAU1
Trunk fat mass	3.73	1	0	0.0	1	STAU1
Tense / 'highly strung'	3.71	1	0	0.0	1	STAU1
Diabetes (father)	3.70	1	0	0.0	1	STAU1
Qualifications: A levels/AS levels or equivalent	3.70	1	0	0.0	1	STAU1
Qualifications: None of the above	3.66	1	0	0.0	1	STAU1
Father's age at death	3.65	1	0	0.0	1	STAU1
Hand grip strength (right)	3.63	1	0	0.0	1	STAU1
Forced expiratory volume in 1-second (FEV1)	3.54	1	0	0.0	1	STAU1
Depression (Nagel 2018)	3.52	1	0	0.0	1	STAU1
Pulse wave reflection index	3.34	1	0	0.0	1	STAU1
Hair/balding pattern: Pattern 3	3.27	1	0	0.0	1	STAU1
Medication: Ibuprofen	3.27	1	0	0.0	1	STAU1
Commuting to job workplace: Cycle	3.24	1	0	0.0	1	STAU1
Mother's age at death	3.20	1	0	0.0	1	STAU1
Pain experienced in last month	3.15	1	0	0.0	1	STAU1
HDL Cholesterol	3.05	1	0	0.0	1	STAU1
Rheumatoid Arthritis	3.05	1	0	0.0	1	STAU1
Medication: Ventolin 100micrograms inhaler	3.05	1	0	0.0	1	STAU1
Smoking status: Current	3.05	1	0	0.0	1	STAU1
Pack years adult smoking proportion	3.04	1	0	0.0	1	STAU1
Standing height	2.86	1	1	2.2	1	STAU1
Crohns Disease (2012)	2.78	1	0	0.0	1	STAU1
Medication: Paracetamol	2.78	1	0	0.0	1	STAU1
Hypothyroidism (self reported)	2.77	1	0	0.0	1	STAU1
Lung FVC	2.59	1	0	0.0	1	STAU1
Sitting height	2.46	1	0	0.0	1	STAU1
Hand grip strength (left)	2.19	1	0	0.0	1	STAU1
Height	2.15	1	1	2.2	1	STAU1
Comparative height size at age 10	1.87	1	0	0.0	1	STAU1
Comparative body size at age 10	1.76	1	0	0.0	1	STAU1
Hypertension (Self-reported)	1.64	1	0	0.0	1	STAU1
Allergy or Eczema	1.50	1	0	0.0	1	STAU1
Waist circumference	1.49	1	0	0.0	1	STAU1
Systolic Blood Pressure	1.08	1	0	0.0	1	STAU1
Weight	0.95	1	0	0.0	1	STAU1
Blood Platelet Count	0.40	1	0	0.0	1	STAU1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Spleen	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1