Hub : Traits :

Family relationship satisfaction

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 48072855 49519654 1 1 1.9e-07 1.1e-06 2e-05 23 STON1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Age at First Birth 3.80 1 0 0 0 1 STON1
Coronary Artery Disease (CAD) 8.96 1 0 0 0 1 STON1
Crohns Disease (2012) 2.69 1 0 0 0 1 STON1
Type 2 Diabetes (T2D) (2012) 4.52 1 0 0 0 1 STON1
BMI 1.03 1 0 0 0 1 STON1
Height 0.47 1 0 0 0 1 STON1
Waist Hip Ratio (WHR) 1.37 1 0 0 0 1 STON1
Lung FEV1/FVC ratio 5.01 1 0 0 0 1 STON1
Hand grip strength (left) 2.57 1 0 0 0 1 STON1
Other serious medical condition/disability diagnosed by doctor 3.53 1 0 0 0 1 STON1
Ever used hormone-replacement therapy (HRT) 11.60 1 0 0 0 1 STON1
Ever had hysterectomy (womb removed) 10.31 1 0 0 0 1 STON1
Vitamin and mineral supplements 11.92 1 0 0 0 1 STON1
Hand grip strength (right) 3.25 1 0 0 0 1 STON1
Current tobacco smoking 3.77 1 0 0 0 1 STON1
Bilateral oophorectomy (both ovaries removed) 4.19 1 0 0 0 1 STON1
Multivitamins +/- minerals 12.09 1 0 0 0 1 STON1
Stomach or abdominal pain in last month 5.05 1 0 0 0 1 STON1
High blood pressure (mother) 2.74 1 0 0 0 1 STON1
Frequency of tenseness / restlessness in last 2 weeks 5.15 1 0 0 0 1 STON1
Had other major operations 5.93 1 0 0 0 1 STON1
Qualifications: None of the above 1.92 1 0 0 0 1 STON1
Father's age at death 5.01 1 0 0 0 1 STON1
Number of live births 5.00 1 0 0 0 1 STON1
Happiness 17.29 1 0 0 0 1 STON1
Exposure to tobacco smoke at home 5.93 1 0 0 0 1 STON1
Loud music exposure frequency 3.92 1 0 0 0 1 STON1
Exposure to tobacco smoke outside home 4.78 1 0 0 0 1 STON1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.99 1 0 0 0 1 STON1
Number of children fathered 4.45 1 0 0 0 1 STON1
Health satisfaction 5.51 1 0 0 0 1 STON1
Qualifications: College or University degree 1.96 1 0 0 0 1 STON1
Pulse rate, automated reading 1.48 1 0 0 0 1 STON1
Number of full sisters 4.23 1 0 0 0 1 STON1
Overall health rating 2.53 1 0 0 0 1 STON1
Loneliness, isolation 2.93 1 0 0 0 1 STON1
Ever had stillbirth, spontaneous miscarriage or termination 6.37 1 0 0 0 1 STON1
Friendships satisfaction 8.85 1 0 0 0 1 STON1
Smoking status: Current 4.48 1 0 0 0 1 STON1
Financial situation satisfaction 4.59 1 0 0 0 1 STON1
Commuting to job workplace: Public transport 3.99 1 0 0 0 1 STON1
Number of operations (self-reported) 5.36 1 0 0 0 1 STON1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.00 1.2
GTEx Adipose Visceral Omentum 0 0.00 1.3
GTEx Adrenal Gland 0 0.00 1.3
GTEx Artery Aorta 0 0.00 1.2
GTEx Artery Coronary 0 0.00 1.3
GTEx Artery Tibial 0 0.00 1.2
GTEx Brain Caudate basal ganglia 0 0.00 1.2
GTEx Brain Cerebellar Hemisphere 0 0.00 1.2
GTEx Brain Cerebellum 0 0.00 1.2
GTEx Brain Cortex 0 0.00 1.3
GTEx Brain Frontal Cortex BA9 0 0.00 1.2
GTEx Brain Hippocampus 0 0.00 1.3
GTEx Brain Hypothalamus 0 0.00 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.00 1.3
GTEx Brain Putamen basal ganglia 0 0.00 1.3
GTEx Breast Mammary Tissue 0 0.00 1.3
GTEx Breast Mammary Tissue (Male) 0 0.00 1.2
GTEx Breast Mammary Tissue (Female) 0 0.00 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.00 1.3
GTEx Cells Transformed fibroblasts 0 0.00 1.2
GTEx Colon Sigmoid 0 0.00 1.3
GTEx Colon Transverse 0 0.00 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.00 1.2
GTEx Esophagus Mucosa 0 0.00 1.3
GTEx Esophagus Muscularis 0 0.00 1.2
GTEx Heart Atrial Appendage 0 0.00 1.3
GTEx Heart Left Ventricle 0 0.00 1.2
GTEx Liver 0 0.00 1.4
GTEx Lung 0 0.00 1.3
GTEx Muscle Skeletal 0 0.00 1.3
GTEx Nerve Tibial 0 0.00 1.2
GTEx Ovary 0 0.00 1.3
GTEx Pancreas 0 0.00 1.3
GTEx Pituitary 0 0.00 1.2
GTEx Prostate 0 0.00 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.00 1.3
GTEx Skin Sun Exposed Lower leg 0 0.00 1.3
GTEx Small Intestine Terminal Ileum 0 0.00 1.4
GTEx Spleen 0 0.00 1.4
GTEx Stomach 0 0.00 1.3
GTEx Testis 0 0.00 1.3
GTEx Thyroid 0 0.00 1.2
GTEx Uterus 0 0.00 1.2
GTEx Vagina 0 0.00 1.3
GTEx Whole Blood 1 0.05 1.3
METSIM Adipose 0 0.00 1.3
NTR Blood 0 0.00 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.00 1.3
YFS Blood 0 0.00 1.2
CommonMind Brain Pre-frontal Cortex 0 0.00 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.00 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.00 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.00 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.00 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.00 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.00 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.00 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.00 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.00 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.00 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.00 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.00 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.00 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.00 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.00 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.00 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.00 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.00 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.00 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.00 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.00 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.00 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.00 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.00 1.2