Hub : Traits :

Financial situation satisfaction

2 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	48702606	50085153	1	1	9.4e-09	5.4e-07	0.22	94	GPX1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Miserableness	35.84	1	1	2.2	1	GPX1
Qualifications: College or University degree	34.99	1	1	2.2	1	GPX1
Depressed Affect (Nagel 2018)	28.66	1	1	2.2	1	GPX1
Fed-up feelings	28.21	1	1	2.2	1	GPX1
Mood swings	27.78	1	1	2.2	1	GPX1
Qualifications: A levels/AS levels or equivalent	26.43	1	1	2.2	1	GPX1
Age at First Birth	25.01	1	1	2.2	1	GPX1
Overall health rating	25.00	1	1	2.2	1	GPX1
Irritable Bowel Disease (IBD)	24.45	1	1	2.2	1	GPX1
Age at last live birth	23.50	1	1	2.2	1	GPX1
Qualifications: None of the above	23.20	1	1	2.2	1	GPX1
Age at first live birth	22.33	1	1	2.2	1	GPX1
Intelligence (Savage-Jansen 2018)	22.21	1	1	2.2	1	GPX1
Ulcerative Colitis (UC)	22.06	1	1	2.2	1	GPX1
Ulcerative Colitis	19.26	1	1	2.2	1	GPX1
Loneliness, isolation	19.13	1	1	2.2	1	GPX1
Impedance of arm (left)	18.81	1	1	2.2	1	GPX1
Pain experienced in last month	18.71	1	1	2.2	1	GPX1
Qualifications: O levels/GCSEs or equivalent	18.45	1	1	2.2	1	GPX1
Body mass index (BMI)	18.17	1	1	2.2	1	GPX1
Impedance of arm (right)	17.37	1	1	2.2	1	GPX1
Father's age at death	16.84	1	0	0.0	1	GPX1
Medication: Paracetamol	16.54	1	0	0.0	1	GPX1
Taking other prescription medications	16.49	1	0	0.0	1	GPX1
Medication: Paracetamol	16.35	1	1	2.2	1	GPX1
Age when periods started (menarche)	16.32	1	1	2.2	1	GPX1
Crohns Disease (2017)	16.02	1	1	2.2	1	GPX1
Leg fat percentage (left)	15.96	1	1	2.2	1	GPX1
Pack years adult smoking proportion	15.48	1	0	0.0	1	GPX1
Leg fat percentage (right)	15.36	1	1	2.2	1	GPX1
Leg fat mass (left)	15.30	1	1	2.2	1	GPX1
Neuroticism	15.05	1	1	2.2	1	GPX1
Neuroticism score	15.00	1	1	2.2	1	GPX1
Neck or shoulder pain in last month	14.96	1	0	0.0	1	GPX1
Frequency of tenseness / restlessness in last 2 weeks	14.89	1	0	0.0	1	GPX1
Neuroticism (2016)	14.87	1	0	0.0	1	GPX1
Prostate Cancer	14.86	1	0	0.0	1	GPX1
Leg fat mass (right)	14.43	1	1	2.2	1	GPX1
Frequency of tiredness / lethargy in last 2 weeks	14.37	1	0	0.0	1	GPX1
Major Depression (MDD)	14.18	1	0	0.0	1	GPX1
Impedance of whole body	13.90	1	1	2.2	1	GPX1
Smoking Status	13.86	1	1	2.2	1	GPX1
Irritability	13.67	1	0	0.0	1	GPX1
Pain all over the body in last month	13.63	1	0	0.0	1	GPX1
Verbal and Numeric Reasoning (VNR)	13.38	1	1	2.2	1	GPX1
Mouth/teeth dental problems: Dentures	13.21	1	0	0.0	1	GPX1
Exposure to tobacco smoke at home	13.07	1	0	0.0	1	GPX1
BMI	12.93	1	1	2.2	1	GPX1
Pack years of smoking	12.67	1	0	0.0	1	GPX1
Lung cancer (father)	12.37	1	0	0.0	1	GPX1
Number of treatments/medications taken	12.32	1	0	0.0	1	GPX1
Medication for pain relief, constipation, heartburn	12.29	1	0	0.0	1	GPX1
Had major operations	12.14	1	0	0.0	1	GPX1
Health satisfaction	12.13	1	0	0.0	1	GPX1
Number of full brothers	11.98	1	0	0.0	1	GPX1
Medication: Co-codamol	11.82	1	0	0.0	1	GPX1
Number of operations (self-reported)	11.80	1	0	0.0	1	GPX1
Frequency of unenthusiasm / disinterest in last 2 weeks	11.47	1	0	0.0	1	GPX1
Systolic blood pressure, automated reading	11.37	1	1	2.2	1	GPX1
Age started oral contraceptive pill	11.29	1	0	0.0	1	GPX1
Medication: Laxatives (e.g. Dulcolax, Senokot)	10.96	1	0	0.0	1	GPX1
Ever highly irritable/argumentative for 2 days	10.93	1	0	0.0	1	GPX1
Arm fat mass (right)	10.90	1	1	2.2	1	GPX1
Chest pain or discomfort	10.88	1	0	0.0	1	GPX1
Seen doctor (GP) for nerves, anxiety, tension or depression	10.55	1	0	0.0	1	GPX1
Neuroticism (Nagel 2018)	10.26	1	0	0.0	1	GPX1
Medication: Seretide 50 evohaler	10.26	1	0	0.0	1	GPX1
Arm fat mass (left)	10.23	1	1	2.2	1	GPX1
Forced expiratory volume in 1-second (FEV1), Best measure	10.04	1	1	2.2	1	GPX1
Arm fat percentage (right)	9.59	1	1	2.2	1	GPX1
Whole body fat mass	9.54	1	1	2.2	1	GPX1
Forced expiratory volume in 1-second (FEV1)	9.47	1	1	2.2	1	GPX1
Wheeze or whistling in the chest in last year	9.38	1	0	0.0	1	GPX1
Qualifications: CSEs or equivalent	9.06	1	0	0.0	1	GPX1
Ever depressed for a whole week	9.05	1	0	0.0	1	GPX1
Arm fat percentage (left)	9.02	1	1	2.2	1	GPX1
Noisy workplace	8.88	1	0	0.0	1	GPX1
Financial difficulties in last 2 years	8.66	1	0	0.0	1	GPX1
Ever unenthusiastic/disinterested for a whole week	8.65	1	0	0.0	1	GPX1
Guilty feelings	8.62	1	0	0.0	1	GPX1
Hip circumference	8.57	1	1	2.2	1	GPX1
Forced vital capacity (FVC), Best measure	8.34	1	1	2.2	1	GPX1
Body fat percentage	8.13	1	1	2.2	1	GPX1
Alcohol intake versus 10 years previously	7.95	1	0	0.0	1	GPX1
Fluid intelligence score	7.70	1	0	0.0	1	GPX1
Average weekly beer plus cider intake	7.67	1	0	0.0	1	GPX1
Current tobacco smoking	7.62	1	0	0.0	1	GPX1
Smoking status: Current	7.37	1	0	0.0	1	GPX1
Maternal smoking around birth	7.35	1	0	0.0	1	GPX1
Seen a psychiatrist for nerves, anxiety, tension or depression	7.32	1	0	0.0	1	GPX1
Knee pain experienced in last month	7.14	1	0	0.0	1	GPX1
Emphysema/chronic bronchitis	7.11	1	0	0.0	1	GPX1
Leg pain on walking	7.09	1	0	0.0	1	GPX1
Forced vital capacity (FVC)	7.02	1	1	2.2	1	GPX1
Weight	7.01	1	1	2.2	1	GPX1
Osteoarthritis (self-reported)	6.98	1	0	0.0	1	GPX1
Waist Hip Ratio (WHR)	6.68	1	1	2.2	1	GPX1
Tinnitus: Yes, but not now, but have in the past	6.68	1	0	0.0	1	GPX1
Diastolic blood pressure, automated reading	6.66	1	0	0.0	1	GPX1
Mother's age at death	6.53	1	0	0.0	1	GPX1
Crohns Disease (2012)	6.36	1	0	0.0	1	GPX1
Back pain experienced in last month	6.26	1	0	0.0	1	GPX1
Commuting to job workplace: Public transport	6.17	1	0	0.0	1	GPX1
Illnesses of siblings: Diabetes	6.11	1	0	0.0	1	GPX1
Exposure to tobacco smoke outside home	5.83	1	0	0.0	1	GPX1
Qualifications: nursing, teaching	5.83	1	0	0.0	1	GPX1
Arm fat-free mass (left)	5.83	1	1	2.2	1	GPX1
Number of self-reported non-cancer illnesses	5.78	1	0	0.0	1	GPX1
Medication: Omeprazole	5.77	1	0	0.0	1	GPX1
Trunk fat mass	5.61	1	0	0.0	1	GPX1
Arm predicted mass (left)	5.61	1	1	2.2	1	GPX1
Impedance of leg (right)	5.58	1	1	2.2	1	GPX1
Ever smoked	5.42	1	0	0.0	1	GPX1
Impedance of leg (left)	5.38	1	0	0.0	1	GPX1
Chronotype (morning person)	5.36	1	0	0.0	1	GPX1
Alcohol usually taken with meals	5.30	1	0	0.0	1	GPX1
Average weekly spirits intake	5.29	1	0	0.0	1	GPX1
Commuting to job workplace: Car/motor vehicle	5.27	1	0	0.0	1	GPX1
Heart disease (siblings)	5.25	1	0	0.0	1	GPX1
Lung FVC	5.13	1	0	0.0	1	GPX1
Number of full sisters	4.97	1	0	0.0	1	GPX1
Arm predicted mass (right)	4.91	1	0	0.0	1	GPX1
Comparative height size at age 10	4.87	1	1	2.2	1	GPX1
Arm fat-free mass (right)	4.84	1	0	0.0	1	GPX1
Systolic Blood Pressure	4.78	1	0	0.0	1	GPX1
Heart attack	4.78	1	0	0.0	1	GPX1
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.75	1	0	0.0	1	GPX1
Heart attack/myocardial infarction (self-reported)	4.75	1	0	0.0	1	GPX1
Past tobacco smoking	4.71	1	0	0.0	1	GPX1
Had menopause	4.69	1	0	0.0	1	GPX1
Stomach or abdominal pain in last month	4.63	1	0	0.0	1	GPX1
Tense / 'highly strung'	4.63	1	0	0.0	1	GPX1
Trunk fat percentage	4.52	1	0	0.0	1	GPX1
Illnesses of siblings	4.49	1	0	0.0	1	GPX1
Depression (Nagel 2018)	4.36	1	0	0.0	1	GPX1
Frequency of depressed mood in last 2 weeks	4.22	1	0	0.0	1	GPX1
Waist circumference	4.14	1	0	0.0	1	GPX1
Mouth/teeth dental problems	4.03	1	0	0.0	1	GPX1
Pulse rate	4.00	1	0	0.0	1	GPX1
Pulse rate, automated reading	3.90	1	0	0.0	1	GPX1
Basal metabolic rate	3.89	1	0	0.0	1	GPX1
Vascular/heart problems diagnosed by doctor	3.87	1	0	0.0	1	GPX1
Townsend deprivation index at recruitment	3.85	1	0	0.0	1	GPX1
Height	3.84	1	1	2.2	1	GPX1
Cardiovascular Disease	3.45	1	0	0.0	1	GPX1
Standing height	3.04	1	1	2.2	1	GPX1
Leg fat-free mass (left)	2.97	1	0	0.0	1	GPX1
Whole body water mass	2.97	1	0	0.0	1	GPX1
Leg predicted mass (left)	2.95	1	0	0.0	1	GPX1
Breast Cancer	2.92	1	0	0.0	1	GPX1
Relative age of first facial hair	2.82	1	0	0.0	1	GPX1
Whole body fat-free mass	2.76	1	0	0.0	1	GPX1
Blood White Count	2.66	1	0	0.0	1	GPX1
Blood Eosinophil Count	2.59	1	0	0.0	1	GPX1
Leg fat-free mass (right)	2.52	1	0	0.0	1	GPX1
Hair/balding pattern: Pattern 4	2.51	1	0	0.0	1	GPX1
Hypothyroidism (self reported)	2.49	1	0	0.0	1	GPX1
Leg predicted mass (right)	2.43	1	0	0.0	1	GPX1
High blood pressure	2.30	1	0	0.0	1	GPX1
Comparative body size at age 10	2.21	1	0	0.0	1	GPX1
Trunk fat-free mass	2.07	1	0	0.0	1	GPX1
Hypertension (Self-reported)	1.95	1	0	0.0	1	GPX1
Trunk predicted mass	1.92	1	0	0.0	1	GPX1
Heel T-Score	0.80	1	0	0.0	1	GPX1
Blood Platelet Count	0.72	1	0	0.0	1	GPX1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	1	0.108	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Lung	1	0.035	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1