Hub : Traits :

Financial situation satisfaction

2 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48702606 50085153 1 1 9.4e-09 5.4e-07 0.22 94 GPX1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 28.66 1 1 2.2 0 1 GPX1
Depression (Nagel 2018) 4.36 1 0 0.0 0 1 GPX1
Intelligence (Savage-Jansen 2018) 22.21 1 1 2.2 0 1 GPX1
Neuroticism (Nagel 2018) 10.26 1 0 0.0 0 1 GPX1
Crohns Disease (2017) 16.02 1 1 2.2 0 1 GPX1
Irritable Bowel Disease (IBD) 24.45 1 1 2.2 0 1 GPX1
Ulcerative Colitis (UC) 22.06 1 1 2.2 0 1 GPX1
Major Depression (MDD) 14.18 1 0 0.0 0 1 GPX1
Verbal and Numeric Reasoning (VNR) 13.38 1 1 2.2 0 1 GPX1
Breast Cancer 2.92 1 0 0.0 0 1 GPX1
Prostate Cancer 14.86 1 0 0.0 0 1 GPX1
Age at First Birth 25.01 1 1 2.2 0 1 GPX1
Crohns Disease (2012) 6.36 1 0 0.0 0 1 GPX1
Neuroticism (2016) 14.87 1 0 0.0 0 1 GPX1
Ulcerative Colitis 19.26 1 1 2.2 0 1 GPX1
Blood Eosinophil Count 2.59 1 0 0.0 0 1 GPX1
Blood Platelet Count 0.72 1 0 0.0 0 1 GPX1
Blood White Count 2.66 1 0 0.0 0 1 GPX1
Heel T-Score 0.80 1 0 0.0 0 1 GPX1
BMI 12.93 1 1 2.2 0 1 GPX1
Height 3.84 1 1 2.2 0 1 GPX1
Waist Hip Ratio (WHR) 6.68 1 1 2.2 0 1 GPX1
Systolic Blood Pressure 4.78 1 0 0.0 0 1 GPX1
Smoking Status 13.86 1 1 2.2 0 1 GPX1
Cardiovascular Disease 3.45 1 0 0.0 0 1 GPX1
Hypothyroidism (self reported) 2.49 1 0 0.0 0 1 GPX1
Lung FVC 5.13 1 0 0.0 0 1 GPX1
Neuroticism 15.05 1 1 2.2 0 1 GPX1
Chronotype (morning person) 5.36 1 0 0.0 0 1 GPX1
Number of treatments/medications taken 12.32 1 0 0.0 0 1 GPX1
Average weekly spirits intake 5.29 1 0 0.0 0 1 GPX1
Frequency of depressed mood in last 2 weeks 4.22 1 0 0.0 0 1 GPX1
Relative age of first facial hair 2.82 1 0 0.0 0 1 GPX1
Systolic blood pressure, automated reading 11.37 1 1 2.2 0 1 GPX1
Medication: Co-codamol 11.82 1 0 0.0 0 1 GPX1
Pack years adult smoking proportion 15.48 1 0 0.0 0 1 GPX1
Impedance of leg (right) 5.58 1 1 2.2 0 1 GPX1
Leg fat-free mass (left) 2.97 1 0 0.0 0 1 GPX1
Trunk fat percentage 4.52 1 0 0.0 0 1 GPX1
Townsend deprivation index at recruitment 3.85 1 0 0.0 0 1 GPX1
Current tobacco smoking 7.62 1 0 0.0 0 1 GPX1
Maternal smoking around birth 7.35 1 0 0.0 0 1 GPX1
Fed-up feelings 28.21 1 1 2.2 0 1 GPX1
Frequency of unenthusiasm / disinterest in last 2 weeks 11.47 1 0 0.0 0 1 GPX1
Taking other prescription medications 16.49 1 0 0.0 0 1 GPX1
Age when periods started (menarche) 16.32 1 1 2.2 0 1 GPX1
Tinnitus: Yes, but not now, but have in the past 6.68 1 0 0.0 0 1 GPX1
Qualifications: CSEs or equivalent 9.06 1 0 0.0 0 1 GPX1
High blood pressure 2.30 1 0 0.0 0 1 GPX1
Stomach or abdominal pain in last month 4.63 1 0 0.0 0 1 GPX1
Body mass index (BMI) 18.17 1 1 2.2 0 1 GPX1
Impedance of leg (left) 5.38 1 0 0.0 0 1 GPX1
Leg predicted mass (left) 2.95 1 0 0.0 0 1 GPX1
Trunk fat mass 5.61 1 0 0.0 0 1 GPX1
Waist circumference 4.14 1 0 0.0 0 1 GPX1
Past tobacco smoking 4.71 1 0 0.0 0 1 GPX1
Alcohol usually taken with meals 5.30 1 0 0.0 0 1 GPX1
Frequency of tenseness / restlessness in last 2 weeks 14.89 1 0 0.0 0 1 GPX1
Had menopause 4.69 1 0 0.0 0 1 GPX1
Forced vital capacity (FVC) 7.02 1 1 2.2 0 1 GPX1
Ever unenthusiastic/disinterested for a whole week 8.65 1 0 0.0 0 1 GPX1
Qualifications: None of the above 23.20 1 1 2.2 0 1 GPX1
Financial difficulties in last 2 years 8.66 1 0 0.0 0 1 GPX1
Mouth/teeth dental problems 4.03 1 0 0.0 0 1 GPX1
Heart attack 4.78 1 0 0.0 0 1 GPX1
Pain all over the body in last month 13.63 1 0 0.0 0 1 GPX1
Fluid intelligence score 7.70 1 0 0.0 0 1 GPX1
Illnesses of siblings 4.49 1 0 0.0 0 1 GPX1
Neuroticism score 15.00 1 1 2.2 0 1 GPX1
Weight 7.01 1 1 2.2 0 1 GPX1
Impedance of arm (right) 17.37 1 1 2.2 0 1 GPX1
Arm fat percentage (right) 9.59 1 1 2.2 0 1 GPX1
Trunk fat-free mass 2.07 1 0 0.0 0 1 GPX1
Hip circumference 8.57 1 1 2.2 0 1 GPX1
Alcohol intake versus 10 years previously 7.95 1 0 0.0 0 1 GPX1
Father's age at death 16.84 1 0 0.0 0 1 GPX1
Frequency of tiredness / lethargy in last 2 weeks 14.37 1 0 0.0 0 1 GPX1
Forced expiratory volume in 1-second (FEV1) 9.47 1 1 2.2 0 1 GPX1
Pulse rate 4.00 1 0 0.0 0 1 GPX1
Noisy workplace 8.88 1 0 0.0 0 1 GPX1
Qualifications: A levels/AS levels or equivalent 26.43 1 1 2.2 0 1 GPX1
Mouth/teeth dental problems: Dentures 13.21 1 0 0.0 0 1 GPX1
Lung cancer (father) 12.37 1 0 0.0 0 1 GPX1
Forced expiratory volume in 1-second (FEV1), Best measure 10.04 1 1 2.2 0 1 GPX1
Impedance of arm (left) 18.81 1 1 2.2 0 1 GPX1
Arm fat mass (right) 10.90 1 1 2.2 0 1 GPX1
Trunk predicted mass 1.92 1 0 0.0 0 1 GPX1
Standing height 3.04 1 1 2.2 0 1 GPX1
Exposure to tobacco smoke at home 13.07 1 0 0.0 0 1 GPX1
Tense / 'highly strung' 4.63 1 0 0.0 0 1 GPX1
Seen doctor (GP) for nerves, anxiety, tension or depression 10.55 1 0 0.0 0 1 GPX1
Hair/balding pattern: Pattern 4 2.51 1 0 0.0 0 1 GPX1
Ever highly irritable/argumentative for 2 days 10.93 1 0 0.0 0 1 GPX1
Qualifications: O levels/GCSEs or equivalent 18.45 1 1 2.2 0 1 GPX1
Medication: Paracetamol 16.35 1 1 2.2 0 1 GPX1
Forced vital capacity (FVC), Best measure 8.34 1 1 2.2 0 1 GPX1
Body fat percentage 8.13 1 1 2.2 0 1 GPX1
Leg fat percentage (right) 15.36 1 1 2.2 0 1 GPX1
Arm fat-free mass (right) 4.84 1 0 0.0 0 1 GPX1
Exposure to tobacco smoke outside home 5.83 1 0 0.0 0 1 GPX1
Comparative body size at age 10 2.21 1 0 0.0 0 1 GPX1
Number of full brothers 11.98 1 0 0.0 0 1 GPX1
Seen a psychiatrist for nerves, anxiety, tension or depression 7.32 1 0 0.0 0 1 GPX1
Wheeze or whistling in the chest in last year 9.38 1 0 0.0 0 1 GPX1
Age at first live birth 22.33 1 1 2.2 0 1 GPX1
Health satisfaction 12.13 1 0 0.0 0 1 GPX1
Qualifications: College or University degree 34.99 1 1 2.2 0 1 GPX1
Emphysema/chronic bronchitis 7.11 1 0 0.0 0 1 GPX1
Medication for pain relief, constipation, heartburn 12.29 1 0 0.0 0 1 GPX1
Neck or shoulder pain in last month 14.96 1 0 0.0 0 1 GPX1
Medication: Omeprazole 5.77 1 0 0.0 0 1 GPX1
Medication: Seretide 50 evohaler 10.26 1 0 0.0 0 1 GPX1
Whole body fat mass 9.54 1 1 2.2 0 1 GPX1
Leg fat mass (right) 14.43 1 1 2.2 0 1 GPX1
Arm predicted mass (right) 4.91 1 0 0.0 0 1 GPX1
Pulse rate, automated reading 3.90 1 0 0.0 0 1 GPX1
Comparative height size at age 10 4.87 1 1 2.2 0 1 GPX1
Number of full sisters 4.97 1 0 0.0 0 1 GPX1
Overall health rating 25.00 1 1 2.2 0 1 GPX1
Chest pain or discomfort 10.88 1 0 0.0 0 1 GPX1
Had major operations 12.14 1 0 0.0 0 1 GPX1
Age at last live birth 23.50 1 1 2.2 0 1 GPX1
Leg pain on walking 7.09 1 0 0.0 0 1 GPX1
Commuting to job workplace: Car/motor vehicle 5.27 1 0 0.0 0 1 GPX1
Knee pain experienced in last month 7.14 1 0 0.0 0 1 GPX1
Hypertension (Self-reported) 1.95 1 0 0.0 0 1 GPX1
Illnesses of siblings: Diabetes 6.11 1 0 0.0 0 1 GPX1
Whole body fat-free mass 2.76 1 0 0.0 0 1 GPX1
Leg fat-free mass (right) 2.52 1 0 0.0 0 1 GPX1
Arm fat percentage (left) 9.02 1 1 2.2 0 1 GPX1
Mood swings 27.78 1 1 2.2 0 1 GPX1
Loneliness, isolation 19.13 1 1 2.2 0 1 GPX1
Qualifications: nursing, teaching 5.83 1 0 0.0 0 1 GPX1
Medication: Laxatives (e.g. Dulcolax, Senokot) 10.96 1 0 0.0 0 1 GPX1
Back pain experienced in last month 6.26 1 0 0.0 0 1 GPX1
Osteoarthritis (self-reported) 6.98 1 0 0.0 0 1 GPX1
Smoking status: Current 7.37 1 0 0.0 0 1 GPX1
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.75 1 0 0.0 0 1 GPX1
Whole body water mass 2.97 1 0 0.0 0 1 GPX1
Leg predicted mass (right) 2.43 1 0 0.0 0 1 GPX1
Arm fat mass (left) 10.23 1 1 2.2 0 1 GPX1
Number of self-reported non-cancer illnesses 5.78 1 0 0.0 0 1 GPX1
Miserableness 35.84 1 1 2.2 0 1 GPX1
Guilty feelings 8.62 1 0 0.0 0 1 GPX1
Mother's age at death 6.53 1 0 0.0 0 1 GPX1
Commuting to job workplace: Public transport 6.17 1 0 0.0 0 1 GPX1
Medication: Paracetamol 16.54 1 0 0.0 0 1 GPX1
Ever smoked 5.42 1 0 0.0 0 1 GPX1
Basal metabolic rate 3.89 1 0 0.0 0 1 GPX1
Leg fat percentage (left) 15.96 1 1 2.2 0 1 GPX1
Arm fat-free mass (left) 5.83 1 1 2.2 0 1 GPX1
Number of operations (self-reported) 11.80 1 0 0.0 0 1 GPX1
Average weekly beer plus cider intake 7.67 1 0 0.0 0 1 GPX1
Irritability 13.67 1 0 0.0 0 1 GPX1
Age started oral contraceptive pill 11.29 1 0 0.0 0 1 GPX1
Diastolic blood pressure, automated reading 6.66 1 0 0.0 0 1 GPX1
Ever depressed for a whole week 9.05 1 0 0.0 0 1 GPX1
Vascular/heart problems diagnosed by doctor 3.87 1 0 0.0 0 1 GPX1
Pain experienced in last month 18.71 1 1 2.2 0 1 GPX1
Heart attack/myocardial infarction (self-reported) 4.75 1 0 0.0 0 1 GPX1
Heart disease (siblings) 5.25 1 0 0.0 0 1 GPX1
Pack years of smoking 12.67 1 0 0.0 0 1 GPX1
Impedance of whole body 13.90 1 1 2.2 0 1 GPX1
Leg fat mass (left) 15.30 1 1 2.2 0 1 GPX1
Arm predicted mass (left) 5.61 1 1 2.2 0 1 GPX1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 1 0.108 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 1 0.035 1.3
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1