Hub : Traits :

Number of full sisters

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 84767271 86367480 1 1 1.3e-07 8.3e-07 1 100 CADM2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 7.48 1 0 0.0 0 1 CADM2
Intelligence (Savage-Jansen 2018) 2.76 1 0 0.0 0 1 CADM2
Neuroticism (Nagel 2018) 5.38 1 0 0.0 0 1 CADM2
Schizophrenia vs Biploar Disorder 3.83 1 0 0.0 0 1 CADM2
Worry (Nagel 2018) 32.33 1 1 2.2 0 1 CADM2
Crohns Disease (2017) 2.07 1 0 0.0 0 1 CADM2
Irritable Bowel Disease (IBD) 3.15 1 0 0.0 0 1 CADM2
Ulcerative Colitis (UC) 2.33 1 0 0.0 0 1 CADM2
Verbal and Numeric Reasoning (VNR) 3.57 1 0 0.0 0 1 CADM2
Bipolar Disorder (2011) 5.91 1 0 0.0 0 1 CADM2
Body Mass Index (BMI) (2010) 5.17 1 0 0.0 0 1 CADM2
Neuroticism (2016) 6.12 1 0 0.0 0 1 CADM2
Blood Red Count 0.45 1 0 0.0 0 1 CADM2
BMI 11.71 1 1 2.2 0 1 CADM2
Height 0.26 1 0 0.0 0 1 CADM2
Systolic Blood Pressure 7.19 1 1 2.2 0 1 CADM2
Smoking Status 35.21 1 1 2.2 0 1 CADM2
Allergy or Eczema 2.95 1 0 0.0 0 1 CADM2
Type 2 Diabetes (T2D) (2018) 2.27 1 0 0.0 0 1 CADM2
Lung FEV1/FVC ratio 1.20 1 0 0.0 0 1 CADM2
Neuroticism 8.46 1 0 0.0 0 1 CADM2
Tanning 7.32 1 1 2.2 0 1 CADM2
Hand grip strength (left) 14.46 1 1 2.2 0 1 CADM2
Hearing difficulty/problems: Yes 3.30 1 0 0.0 0 1 CADM2
Other serious medical condition/disability diagnosed by doctor 6.63 1 0 0.0 0 1 CADM2
Systolic blood pressure, automated reading 4.17 1 0 0.0 0 1 CADM2
Vitamin and mineral supplements 3.97 1 0 0.0 0 1 CADM2
Medication: Metformin 4.47 1 0 0.0 0 1 CADM2
Impedance of leg (right) 8.83 1 1 2.2 0 1 CADM2
Leg fat-free mass (left) 11.34 1 1 2.2 0 1 CADM2
Trunk fat percentage 1.20 1 0 0.0 0 1 CADM2
Hand grip strength (right) 7.44 1 0 0.0 0 1 CADM2
Townsend deprivation index at recruitment 3.94 1 0 0.0 0 1 CADM2
Current tobacco smoking 6.62 1 0 0.0 0 1 CADM2
Average weekly fortified wine intake 3.95 1 0 0.0 0 1 CADM2
Taking other prescription medications 4.91 1 0 0.0 0 1 CADM2
Hayfever, allergic rhinitis or eczema 2.37 1 0 0.0 0 1 CADM2
Supplements: Glucosamine 3.69 1 0 0.0 0 1 CADM2
Body mass index (BMI) 13.27 1 1 2.2 0 1 CADM2
Impedance of leg (left) 8.75 1 1 2.2 0 1 CADM2
Leg predicted mass (left) 11.28 1 1 2.2 0 1 CADM2
Trunk fat mass 4.74 1 0 0.0 0 1 CADM2
Waist circumference 10.30 1 1 2.2 0 1 CADM2
Past tobacco smoking 37.69 1 1 2.2 0 1 CADM2
Alcohol usually taken with meals 3.90 1 0 0.0 0 1 CADM2
Nervous feelings 34.37 1 1 2.2 0 1 CADM2
Qualifications: None of the above 2.62 1 0 0.0 0 1 CADM2
Allergy 2.17 1 0 0.0 0 1 CADM2
Diabetes (self-reported) 4.13 1 0 0.0 0 1 CADM2
Neuroticism score 5.39 1 0 0.0 0 1 CADM2
Weight 12.22 1 1 2.2 0 1 CADM2
Impedance of arm (right) 22.75 1 1 2.2 0 1 CADM2
Arm fat percentage (right) 3.39 1 0 0.0 0 1 CADM2
Trunk fat-free mass 13.38 1 1 2.2 0 1 CADM2
Hip circumference 7.92 1 1 2.2 0 1 CADM2
Time employed in main current job 4.36 1 0 0.0 0 1 CADM2
Worrier / anxious feelings 35.60 1 1 2.2 0 1 CADM2
Number of live births 19.41 1 1 2.2 0 1 CADM2
Qualifications: A levels/AS levels or equivalent 6.35 1 0 0.0 0 1 CADM2
Pulse wave Arterial Stiffness index 3.89 1 0 0.0 0 1 CADM2
Impedance of arm (left) 22.92 1 1 2.2 0 1 CADM2
Arm fat mass (right) 9.19 1 1 2.2 0 1 CADM2
Trunk predicted mass 13.27 1 1 2.2 0 1 CADM2
Length of working week for main job 6.69 1 0 0.0 0 1 CADM2
Tense / 'highly strung' 10.96 1 0 0.0 0 1 CADM2
Seen doctor (GP) for nerves, anxiety, tension or depression 8.28 1 0 0.0 0 1 CADM2
Peak expiratory flow (PEF) 3.32 1 0 0.0 0 1 CADM2
Qualifications: O levels/GCSEs or equivalent 5.76 1 0 0.0 0 1 CADM2
Gout (self-reported) 4.06 1 0 0.0 0 1 CADM2
Body fat percentage 2.81 1 0 0.0 0 1 CADM2
Leg fat percentage (right) 6.33 1 0 0.0 0 1 CADM2
Arm fat-free mass (right) 17.83 1 1 2.2 0 1 CADM2
Comparative body size at age 10 18.72 1 1 2.2 0 1 CADM2
Number of full brothers 11.44 1 0 0.0 0 1 CADM2
Worry too long after embarrassment 8.61 1 0 0.0 0 1 CADM2
Wheeze or whistling in the chest in last year 4.00 1 0 0.0 0 1 CADM2
Number of children fathered 33.06 1 1 2.2 0 1 CADM2
Pulse wave peak to peak time 3.62 1 0 0.0 0 1 CADM2
Qualifications: College or University degree 9.78 1 1 2.2 0 1 CADM2
Eye problems/disorders: None of the above 5.11 1 0 0.0 0 1 CADM2
Mouth/teeth dental problems: Loose teeth 5.33 1 0 0.0 0 1 CADM2
Migraine (self-reported) 7.35 1 0 0.0 0 1 CADM2
Whole body fat mass 7.67 1 1 2.2 0 1 CADM2
Leg fat mass (right) 12.32 1 1 2.2 0 1 CADM2
Arm predicted mass (right) 17.72 1 1 2.2 0 1 CADM2
Pulse rate, automated reading 1.30 1 0 0.0 0 1 CADM2
Alcohol intake frequency. 10.76 1 0 0.0 0 1 CADM2
Suffer from 'nerves' 23.40 1 1 2.2 0 1 CADM2
Chest pain or discomfort 3.24 1 0 0.0 0 1 CADM2
Age at last live birth 3.49 1 0 0.0 0 1 CADM2
Commuting to job workplace: Car/motor vehicle 5.47 1 0 0.0 0 1 CADM2
Illness, injury, bereavement, stress in last 2 years 4.99 1 0 0.0 0 1 CADM2
Supplements: Vitamin C 3.59 1 0 0.0 0 1 CADM2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 3.66 1 0 0.0 0 1 CADM2
Smoking status: Previous 34.23 1 1 2.2 0 1 CADM2
Whole body fat-free mass 13.61 1 1 2.2 0 1 CADM2
Leg fat-free mass (right) 10.71 1 1 2.2 0 1 CADM2
Arm fat percentage (left) 3.44 1 0 0.0 0 1 CADM2
Long-standing illness, disability or infirmity 5.12 1 0 0.0 0 1 CADM2
Diabetes diagnosed by doctor 3.08 1 0 0.0 0 1 CADM2
Ever had stillbirth, spontaneous miscarriage or termination 10.02 1 0 0.0 0 1 CADM2
Qualifications: nursing, teaching 10.34 1 0 0.0 0 1 CADM2
Mouth/teeth dental problems: Mouth ulcers 7.97 1 0 0.0 0 1 CADM2
Osteoporosis (self-reported) 3.79 1 0 0.0 0 1 CADM2
Smoking status: Current 9.39 1 0 0.0 0 1 CADM2
Whole body water mass 13.78 1 1 2.2 0 1 CADM2
Leg predicted mass (right) 10.58 1 1 2.2 0 1 CADM2
Arm fat mass (left) 9.91 1 1 2.2 0 1 CADM2
Number of self-reported non-cancer illnesses 2.34 1 0 0.0 0 1 CADM2
Wears glasses or contact lenses 14.05 1 0 0.0 0 1 CADM2
Ever taken oral contraceptive pill 4.31 1 0 0.0 0 1 CADM2
Financial situation satisfaction 8.59 1 0 0.0 0 1 CADM2
Commuting to job workplace: Public transport 12.03 1 0 0.0 0 1 CADM2
Eye problems/disorders: Glaucoma 4.05 1 0 0.0 0 1 CADM2
High cholesterol (Self-reported) 3.83 1 0 0.0 0 1 CADM2
Alcohol drinker status: Never 13.63 1 0 0.0 0 1 CADM2
Ever smoked 33.06 1 1 2.2 0 1 CADM2
Basal metabolic rate 13.96 1 1 2.2 0 1 CADM2
Leg fat percentage (left) 6.50 1 0 0.0 0 1 CADM2
Arm fat-free mass (left) 18.24 1 1 2.2 0 1 CADM2
Average weekly beer plus cider intake 10.62 1 0 0.0 0 1 CADM2
Risk taking 50.93 1 1 2.2 0 1 CADM2
Age started oral contraceptive pill 10.41 1 0 0.0 0 1 CADM2
Commuting to job workplace: Cycle 5.64 1 0 0.0 0 1 CADM2
Myopia 4.72 1 0 0.0 0 1 CADM2
Impedance of whole body 18.30 1 1 2.2 0 1 CADM2
Leg fat mass (left) 12.58 1 1 2.2 0 1 CADM2
Arm predicted mass (left) 17.82 1 1 2.2 0 1 CADM2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.1
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.1
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2