Hub : Traits :

Number of full sisters

1 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	84767271	86367480	1	1	1.3e-07	8.3e-07	1	100	CADM2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Risk taking	50.93	1	1	2.2	1	CADM2
Past tobacco smoking	37.69	1	1	2.2	1	CADM2
Worrier / anxious feelings	35.60	1	1	2.2	1	CADM2
Smoking Status	35.21	1	1	2.2	1	CADM2
Nervous feelings	34.37	1	1	2.2	1	CADM2
Smoking status: Previous	34.23	1	1	2.2	1	CADM2
Number of children fathered	33.06	1	1	2.2	1	CADM2
Ever smoked	33.06	1	1	2.2	1	CADM2
Worry (Nagel 2018)	32.33	1	1	2.2	1	CADM2
Suffer from 'nerves'	23.40	1	1	2.2	1	CADM2
Impedance of arm (left)	22.92	1	1	2.2	1	CADM2
Impedance of arm (right)	22.75	1	1	2.2	1	CADM2
Number of live births	19.41	1	1	2.2	1	CADM2
Comparative body size at age 10	18.72	1	1	2.2	1	CADM2
Impedance of whole body	18.30	1	1	2.2	1	CADM2
Arm fat-free mass (left)	18.24	1	1	2.2	1	CADM2
Arm fat-free mass (right)	17.83	1	1	2.2	1	CADM2
Arm predicted mass (left)	17.82	1	1	2.2	1	CADM2
Arm predicted mass (right)	17.72	1	1	2.2	1	CADM2
Hand grip strength (left)	14.46	1	1	2.2	1	CADM2
Wears glasses or contact lenses	14.05	1	0	0.0	1	CADM2
Basal metabolic rate	13.96	1	1	2.2	1	CADM2
Whole body water mass	13.78	1	1	2.2	1	CADM2
Alcohol drinker status: Never	13.63	1	0	0.0	1	CADM2
Whole body fat-free mass	13.61	1	1	2.2	1	CADM2
Trunk fat-free mass	13.38	1	1	2.2	1	CADM2
Body mass index (BMI)	13.27	1	1	2.2	1	CADM2
Trunk predicted mass	13.27	1	1	2.2	1	CADM2
Leg fat mass (left)	12.58	1	1	2.2	1	CADM2
Leg fat mass (right)	12.32	1	1	2.2	1	CADM2
Weight	12.22	1	1	2.2	1	CADM2
Commuting to job workplace: Public transport	12.03	1	0	0.0	1	CADM2
BMI	11.71	1	1	2.2	1	CADM2
Number of full brothers	11.44	1	0	0.0	1	CADM2
Leg fat-free mass (left)	11.34	1	1	2.2	1	CADM2
Leg predicted mass (left)	11.28	1	1	2.2	1	CADM2
Tense / 'highly strung'	10.96	1	0	0.0	1	CADM2
Alcohol intake frequency.	10.76	1	0	0.0	1	CADM2
Leg fat-free mass (right)	10.71	1	1	2.2	1	CADM2
Average weekly beer plus cider intake	10.62	1	0	0.0	1	CADM2
Leg predicted mass (right)	10.58	1	1	2.2	1	CADM2
Age started oral contraceptive pill	10.41	1	0	0.0	1	CADM2
Qualifications: nursing, teaching	10.34	1	0	0.0	1	CADM2
Waist circumference	10.30	1	1	2.2	1	CADM2
Ever had stillbirth, spontaneous miscarriage or termination	10.02	1	0	0.0	1	CADM2
Arm fat mass (left)	9.91	1	1	2.2	1	CADM2
Qualifications: College or University degree	9.78	1	1	2.2	1	CADM2
Smoking status: Current	9.39	1	0	0.0	1	CADM2
Arm fat mass (right)	9.19	1	1	2.2	1	CADM2
Impedance of leg (right)	8.83	1	1	2.2	1	CADM2
Impedance of leg (left)	8.75	1	1	2.2	1	CADM2
Worry too long after embarrassment	8.61	1	0	0.0	1	CADM2
Financial situation satisfaction	8.59	1	0	0.0	1	CADM2
Neuroticism	8.46	1	0	0.0	1	CADM2
Seen doctor (GP) for nerves, anxiety, tension or depression	8.28	1	0	0.0	1	CADM2
Mouth/teeth dental problems: Mouth ulcers	7.97	1	0	0.0	1	CADM2
Hip circumference	7.92	1	1	2.2	1	CADM2
Whole body fat mass	7.67	1	1	2.2	1	CADM2
Bipolar Disorder (2018)	7.48	1	0	0.0	1	CADM2
Hand grip strength (right)	7.44	1	0	0.0	1	CADM2
Migraine (self-reported)	7.35	1	0	0.0	1	CADM2
Tanning	7.32	1	1	2.2	1	CADM2
Systolic Blood Pressure	7.19	1	1	2.2	1	CADM2
Length of working week for main job	6.69	1	0	0.0	1	CADM2
Other serious medical condition/disability diagnosed by doctor	6.63	1	0	0.0	1	CADM2
Current tobacco smoking	6.62	1	0	0.0	1	CADM2
Leg fat percentage (left)	6.50	1	0	0.0	1	CADM2
Qualifications: A levels/AS levels or equivalent	6.35	1	0	0.0	1	CADM2
Leg fat percentage (right)	6.33	1	0	0.0	1	CADM2
Neuroticism (2016)	6.12	1	0	0.0	1	CADM2
Bipolar Disorder (2011)	5.91	1	0	0.0	1	CADM2
Qualifications: O levels/GCSEs or equivalent	5.76	1	0	0.0	1	CADM2
Commuting to job workplace: Cycle	5.64	1	0	0.0	1	CADM2
Commuting to job workplace: Car/motor vehicle	5.47	1	0	0.0	1	CADM2
Neuroticism score	5.39	1	0	0.0	1	CADM2
Neuroticism (Nagel 2018)	5.38	1	0	0.0	1	CADM2
Mouth/teeth dental problems: Loose teeth	5.33	1	0	0.0	1	CADM2
Body Mass Index (BMI) (2010)	5.17	1	0	0.0	1	CADM2
Long-standing illness, disability or infirmity	5.12	1	0	0.0	1	CADM2
Eye problems/disorders: None of the above	5.11	1	0	0.0	1	CADM2
Illness, injury, bereavement, stress in last 2 years	4.99	1	0	0.0	1	CADM2
Taking other prescription medications	4.91	1	0	0.0	1	CADM2
Trunk fat mass	4.74	1	0	0.0	1	CADM2
Myopia	4.72	1	0	0.0	1	CADM2
Medication: Metformin	4.47	1	0	0.0	1	CADM2
Time employed in main current job	4.36	1	0	0.0	1	CADM2
Ever taken oral contraceptive pill	4.31	1	0	0.0	1	CADM2
Systolic blood pressure, automated reading	4.17	1	0	0.0	1	CADM2
Diabetes (self-reported)	4.13	1	0	0.0	1	CADM2
Gout (self-reported)	4.06	1	0	0.0	1	CADM2
Eye problems/disorders: Glaucoma	4.05	1	0	0.0	1	CADM2
Wheeze or whistling in the chest in last year	4.00	1	0	0.0	1	CADM2
Vitamin and mineral supplements	3.97	1	0	0.0	1	CADM2
Average weekly fortified wine intake	3.95	1	0	0.0	1	CADM2
Townsend deprivation index at recruitment	3.94	1	0	0.0	1	CADM2
Alcohol usually taken with meals	3.90	1	0	0.0	1	CADM2
Pulse wave Arterial Stiffness index	3.89	1	0	0.0	1	CADM2
Schizophrenia vs Biploar Disorder	3.83	1	0	0.0	1	CADM2
High cholesterol (Self-reported)	3.83	1	0	0.0	1	CADM2
Osteoporosis (self-reported)	3.79	1	0	0.0	1	CADM2
Supplements: Glucosamine	3.69	1	0	0.0	1	CADM2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.66	1	0	0.0	1	CADM2
Pulse wave peak to peak time	3.62	1	0	0.0	1	CADM2
Supplements: Vitamin C	3.59	1	0	0.0	1	CADM2
Verbal and Numeric Reasoning (VNR)	3.57	1	0	0.0	1	CADM2
Age at last live birth	3.49	1	0	0.0	1	CADM2
Arm fat percentage (left)	3.44	1	0	0.0	1	CADM2
Arm fat percentage (right)	3.39	1	0	0.0	1	CADM2
Peak expiratory flow (PEF)	3.32	1	0	0.0	1	CADM2
Hearing difficulty/problems: Yes	3.30	1	0	0.0	1	CADM2
Chest pain or discomfort	3.24	1	0	0.0	1	CADM2
Irritable Bowel Disease (IBD)	3.15	1	0	0.0	1	CADM2
Diabetes diagnosed by doctor	3.08	1	0	0.0	1	CADM2
Allergy or Eczema	2.95	1	0	0.0	1	CADM2
Body fat percentage	2.81	1	0	0.0	1	CADM2
Intelligence (Savage-Jansen 2018)	2.76	1	0	0.0	1	CADM2
Qualifications: None of the above	2.62	1	0	0.0	1	CADM2
Hayfever, allergic rhinitis or eczema	2.37	1	0	0.0	1	CADM2
Number of self-reported non-cancer illnesses	2.34	1	0	0.0	1	CADM2
Ulcerative Colitis (UC)	2.33	1	0	0.0	1	CADM2
Type 2 Diabetes (T2D) (2018)	2.27	1	0	0.0	1	CADM2
Allergy	2.17	1	0	0.0	1	CADM2
Crohns Disease (2017)	2.07	1	0	0.0	1	CADM2
Pulse rate, automated reading	1.30	1	0	0.0	1	CADM2
Lung FEV1/FVC ratio	1.20	1	0	0.0	1	CADM2
Trunk fat percentage	1.20	1	0	0.0	1	CADM2
Blood Red Count	0.45	1	0	0.0	1	CADM2
Height	0.26	1	0	0.0	1	CADM2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
YFS	Blood	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.1
GTEx	Spleen	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1