Hub : Traits :

Number of children fathered

2 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	84767271	86367480	1	1	9e-10	5.4e-11	0.019	87	CADM2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Risk taking	52.1	1	1	2.2	1	CADM2
Nervous feelings	37.5	1	1	2.2	1	CADM2
Worry (Nagel 2018)	36.0	1	1	2.2	1	CADM2
Past tobacco smoking	34.5	1	1	2.2	1	CADM2
Worrier / anxious feelings	32.6	1	1	2.2	1	CADM2
Smoking Status	31.8	1	1	2.2	1	CADM2
Smoking status: Previous	31.2	1	1	2.2	1	CADM2
Ever smoked	29.3	1	1	2.2	1	CADM2
Suffer from 'nerves'	27.3	1	1	2.2	1	CADM2
Comparative body size at age 10	24.1	1	1	2.2	1	CADM2
Impedance of arm (left)	22.0	1	1	2.2	1	CADM2
Impedance of arm (right)	21.9	1	1	2.2	1	CADM2
Impedance of whole body	18.6	1	1	2.2	1	CADM2
Arm fat-free mass (left)	18.2	1	1	2.2	1	CADM2
Number of full sisters	18.0	1	0	0.0	1	CADM2
Arm fat-free mass (right)	17.7	1	1	2.2	1	CADM2
Arm predicted mass (left)	17.6	1	1	2.2	1	CADM2
Number of live births	17.4	1	0	0.0	1	CADM2
Arm predicted mass (right)	17.2	1	1	2.2	1	CADM2
Basal metabolic rate	14.2	1	1	2.2	1	CADM2
Hand grip strength (left)	14.1	1	1	2.2	1	CADM2
Whole body water mass	14.1	1	1	2.2	1	CADM2
Tense / 'highly strung'	14.0	1	0	0.0	1	CADM2
Whole body fat-free mass	13.9	1	1	2.2	1	CADM2
Trunk fat-free mass	13.8	1	1	2.2	1	CADM2
Trunk predicted mass	13.8	1	1	2.2	1	CADM2
Body mass index (BMI)	13.5	1	1	2.2	1	CADM2
Alcohol intake frequency.	13.3	1	1	2.2	1	CADM2
Wears glasses or contact lenses	13.2	1	0	0.0	1	CADM2
BMI	13.0	1	1	2.2	1	CADM2
Alcohol drinker status: Never	13.0	1	0	0.0	1	CADM2
Leg fat mass (left)	12.8	1	1	2.2	1	CADM2
Leg fat mass (right)	12.7	1	1	2.2	1	CADM2
Weight	12.3	1	1	2.2	1	CADM2
Leg fat-free mass (left)	11.6	1	1	2.2	1	CADM2
Leg predicted mass (left)	11.5	1	1	2.2	1	CADM2
Neuroticism	11.0	1	1	2.2	1	CADM2
Ever had stillbirth, spontaneous miscarriage or termination	11.0	1	0	0.0	1	CADM2
Leg fat-free mass (right)	10.8	1	1	2.2	1	CADM2
Leg predicted mass (right)	10.7	1	1	2.2	1	CADM2
Arm fat mass (left)	10.6	1	1	2.2	1	CADM2
Waist circumference	10.1	1	1	2.2	1	CADM2
Average weekly beer plus cider intake	9.8	1	0	0.0	1	CADM2
Arm fat mass (right)	9.7	1	1	2.2	1	CADM2
Number of full brothers	9.7	1	0	0.0	1	CADM2
Commuting to job workplace: Public transport	9.6	1	0	0.0	1	CADM2
Impedance of leg (left)	9.4	1	1	2.2	1	CADM2
Impedance of leg (right)	9.2	1	1	2.2	1	CADM2
Smoking status: Current	8.8	1	0	0.0	1	CADM2
Systolic Blood Pressure	8.4	1	1	2.2	1	CADM2
Qualifications: nursing, teaching	8.3	1	0	0.0	1	CADM2
Body Mass Index (BMI) (2010)	8.2	1	0	0.0	1	CADM2
Worry too long after embarrassment	7.9	1	0	0.0	1	CADM2
Whole body fat mass	7.9	1	1	2.2	1	CADM2
Neuroticism (Nagel 2018)	7.6	1	0	0.0	1	CADM2
Bipolar Disorder (2018)	7.5	1	0	0.0	1	CADM2
Tanning	7.5	1	1	2.2	1	CADM2
Hip circumference	7.3	1	1	2.2	1	CADM2
Seen doctor (GP) for nerves, anxiety, tension or depression	7.3	1	0	0.0	1	CADM2
Mouth/teeth dental problems: Mouth ulcers	7.3	1	0	0.0	1	CADM2
Qualifications: College or University degree	7.2	1	0	0.0	1	CADM2
Neuroticism score	7.1	1	0	0.0	1	CADM2
Financial situation satisfaction	7.0	1	0	0.0	1	CADM2
Hand grip strength (right)	6.9	1	0	0.0	1	CADM2
Commuting to job workplace: Cycle	6.8	1	0	0.0	1	CADM2
Taking other prescription medications	6.6	1	0	0.0	1	CADM2
Eye problems/disorders: None of the above	6.6	1	0	0.0	1	CADM2
Age started oral contraceptive pill	6.6	1	0	0.0	1	CADM2
Eye problems/disorders: Glaucoma	6.5	1	0	0.0	1	CADM2
Leg fat percentage (left)	6.5	1	0	0.0	1	CADM2
Current tobacco smoking	6.3	1	0	0.0	1	CADM2
Leg fat percentage (right)	6.3	1	0	0.0	1	CADM2
Bipolar Disorder (2011)	6.2	1	0	0.0	1	CADM2
Neuroticism (2016)	5.8	1	0	0.0	1	CADM2
Supplements: Glucosamine	5.8	1	0	0.0	1	CADM2
Long-standing illness, disability or infirmity	5.6	1	0	0.0	1	CADM2
Migraine (self-reported)	5.5	1	0	0.0	1	CADM2
Glaucoma (self-reported)	5.4	1	0	0.0	1	CADM2
Age at last live birth	5.4	1	0	0.0	1	CADM2
Qualifications: O levels/GCSEs or equivalent	5.3	1	0	0.0	1	CADM2
Mouth/teeth dental problems: Loose teeth	5.2	1	0	0.0	1	CADM2
Commuting to job workplace: Car/motor vehicle	4.8	1	0	0.0	1	CADM2
Trunk fat mass	4.7	1	0	0.0	1	CADM2
Length of working week for main job	4.7	1	0	0.0	1	CADM2
Other serious medical condition/disability diagnosed by doctor	4.5	1	0	0.0	1	CADM2
Townsend deprivation index at recruitment	4.4	1	0	0.0	1	CADM2
Vitamin and mineral supplements	4.3	1	0	0.0	1	CADM2
Myopia	4.3	1	0	0.0	1	CADM2
Schizophrenia vs Biploar Disorder	4.1	1	0	0.0	1	CADM2
Systolic blood pressure, automated reading	4.1	1	0	0.0	1	CADM2
Arm fat percentage (right)	4.0	1	0	0.0	1	CADM2
Qualifications: A levels/AS levels or equivalent	4.0	1	0	0.0	1	CADM2
Chest pain or discomfort	3.9	1	0	0.0	1	CADM2
Arm fat percentage (left)	3.9	1	0	0.0	1	CADM2
Irritable Bowel Disease (IBD)	3.7	1	0	0.0	1	CADM2
Peak expiratory flow (PEF)	3.7	1	0	0.0	1	CADM2
Average weekly champagne plus white wine intake	3.7	1	0	0.0	1	CADM2
Hearing difficulty/problems: Yes	3.6	1	0	0.0	1	CADM2
Average weekly red wine intake	3.6	1	0	0.0	1	CADM2
Ulcerative Colitis (UC)	3.5	1	0	0.0	1	CADM2
Irritability	3.5	1	0	0.0	1	CADM2
Alcohol usually taken with meals	3.4	1	0	0.0	1	CADM2
Verbal and Numeric Reasoning (VNR)	3.3	1	0	0.0	1	CADM2
Intelligence (Savage-Jansen 2018)	2.8	1	0	0.0	1	CADM2
Body fat percentage	2.8	1	0	0.0	1	CADM2
Allergy or Eczema	2.7	1	0	0.0	1	CADM2
Hayfever, allergic rhinitis or eczema	2.5	1	0	0.0	1	CADM2
Lung FEV1/FVC ratio	1.5	1	0	0.0	1	CADM2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Adipose Subcutaneous	0	0.000	1.1
GTEx	Adrenal Gland	0	0.000	1.1
GTEx	Artery Tibial	0	0.000	1.1
GTEx	Brain Caudate basal ganglia	0	0.000	1.1
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.1
GTEx	Brain Frontal Cortex BA9	0	0.000	1.1
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.1
GTEx	Breast Mammary Tissue	0	0.000	1.1
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.1
GTEx	Cells Transformed fibroblasts	0	0.000	1.1
GTEx	Colon Sigmoid	0	0.000	1.1
GTEx	Colon Transverse	0	0.000	1.1
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.1
GTEx	Esophagus Mucosa	0	0.000	1.1
GTEx	Heart Atrial Appendage	0	0.000	1.1
GTEx	Heart Left Ventricle	0	0.000	1.1
GTEx	Muscle Skeletal	0	0.000	1.1
GTEx	Small Intestine Terminal Ileum	0	0.000	1.1
GTEx	Stomach	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
NTR	Blood	0	0.000	1.1
YFS	Blood	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.0
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.0