Hub : Traits :

Number of children fathered

2 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 84767271 86367480 1 1 9e-10 5.4e-11 0.019 87 CADM2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 7.5 1 0 0.0 0 1 CADM2
Intelligence (Savage-Jansen 2018) 2.8 1 0 0.0 0 1 CADM2
Neuroticism (Nagel 2018) 7.6 1 0 0.0 0 1 CADM2
Schizophrenia vs Biploar Disorder 4.1 1 0 0.0 0 1 CADM2
Worry (Nagel 2018) 36.0 1 1 2.2 0 1 CADM2
Irritable Bowel Disease (IBD) 3.7 1 0 0.0 0 1 CADM2
Ulcerative Colitis (UC) 3.5 1 0 0.0 0 1 CADM2
Verbal and Numeric Reasoning (VNR) 3.3 1 0 0.0 0 1 CADM2
Bipolar Disorder (2011) 6.2 1 0 0.0 0 1 CADM2
Body Mass Index (BMI) (2010) 8.2 1 0 0.0 0 1 CADM2
Neuroticism (2016) 5.8 1 0 0.0 0 1 CADM2
BMI 13.0 1 1 2.2 0 1 CADM2
Systolic Blood Pressure 8.4 1 1 2.2 0 1 CADM2
Smoking Status 31.8 1 1 2.2 0 1 CADM2
Allergy or Eczema 2.7 1 0 0.0 0 1 CADM2
Lung FEV1/FVC ratio 1.5 1 0 0.0 0 1 CADM2
Neuroticism 11.0 1 1 2.2 0 1 CADM2
Tanning 7.5 1 1 2.2 0 1 CADM2
Hand grip strength (left) 14.1 1 1 2.2 0 1 CADM2
Hearing difficulty/problems: Yes 3.6 1 0 0.0 0 1 CADM2
Other serious medical condition/disability diagnosed by doctor 4.5 1 0 0.0 0 1 CADM2
Systolic blood pressure, automated reading 4.1 1 0 0.0 0 1 CADM2
Vitamin and mineral supplements 4.3 1 0 0.0 0 1 CADM2
Impedance of leg (right) 9.2 1 1 2.2 0 1 CADM2
Leg fat-free mass (left) 11.6 1 1 2.2 0 1 CADM2
Hand grip strength (right) 6.9 1 0 0.0 0 1 CADM2
Townsend deprivation index at recruitment 4.4 1 0 0.0 0 1 CADM2
Current tobacco smoking 6.3 1 0 0.0 0 1 CADM2
Taking other prescription medications 6.6 1 0 0.0 0 1 CADM2
Hayfever, allergic rhinitis or eczema 2.5 1 0 0.0 0 1 CADM2
Supplements: Glucosamine 5.8 1 0 0.0 0 1 CADM2
Body mass index (BMI) 13.5 1 1 2.2 0 1 CADM2
Impedance of leg (left) 9.4 1 1 2.2 0 1 CADM2
Leg predicted mass (left) 11.5 1 1 2.2 0 1 CADM2
Trunk fat mass 4.7 1 0 0.0 0 1 CADM2
Waist circumference 10.1 1 1 2.2 0 1 CADM2
Past tobacco smoking 34.5 1 1 2.2 0 1 CADM2
Alcohol usually taken with meals 3.4 1 0 0.0 0 1 CADM2
Nervous feelings 37.5 1 1 2.2 0 1 CADM2
Neuroticism score 7.1 1 0 0.0 0 1 CADM2
Weight 12.3 1 1 2.2 0 1 CADM2
Impedance of arm (right) 21.9 1 1 2.2 0 1 CADM2
Arm fat percentage (right) 4.0 1 0 0.0 0 1 CADM2
Trunk fat-free mass 13.8 1 1 2.2 0 1 CADM2
Hip circumference 7.3 1 1 2.2 0 1 CADM2
Worrier / anxious feelings 32.6 1 1 2.2 0 1 CADM2
Number of live births 17.4 1 0 0.0 0 1 CADM2
Qualifications: A levels/AS levels or equivalent 4.0 1 0 0.0 0 1 CADM2
Impedance of arm (left) 22.0 1 1 2.2 0 1 CADM2
Arm fat mass (right) 9.7 1 1 2.2 0 1 CADM2
Trunk predicted mass 13.8 1 1 2.2 0 1 CADM2
Length of working week for main job 4.7 1 0 0.0 0 1 CADM2
Tense / 'highly strung' 14.0 1 0 0.0 0 1 CADM2
Seen doctor (GP) for nerves, anxiety, tension or depression 7.3 1 0 0.0 0 1 CADM2
Peak expiratory flow (PEF) 3.7 1 0 0.0 0 1 CADM2
Qualifications: O levels/GCSEs or equivalent 5.3 1 0 0.0 0 1 CADM2
Glaucoma (self-reported) 5.4 1 0 0.0 0 1 CADM2
Body fat percentage 2.8 1 0 0.0 0 1 CADM2
Leg fat percentage (right) 6.3 1 0 0.0 0 1 CADM2
Arm fat-free mass (right) 17.7 1 1 2.2 0 1 CADM2
Comparative body size at age 10 24.1 1 1 2.2 0 1 CADM2
Number of full brothers 9.7 1 0 0.0 0 1 CADM2
Worry too long after embarrassment 7.9 1 0 0.0 0 1 CADM2
Qualifications: College or University degree 7.2 1 0 0.0 0 1 CADM2
Eye problems/disorders: None of the above 6.6 1 0 0.0 0 1 CADM2
Mouth/teeth dental problems: Loose teeth 5.2 1 0 0.0 0 1 CADM2
Migraine (self-reported) 5.5 1 0 0.0 0 1 CADM2
Whole body fat mass 7.9 1 1 2.2 0 1 CADM2
Leg fat mass (right) 12.7 1 1 2.2 0 1 CADM2
Arm predicted mass (right) 17.2 1 1 2.2 0 1 CADM2
Alcohol intake frequency. 13.3 1 1 2.2 0 1 CADM2
Number of full sisters 18.0 1 0 0.0 0 1 CADM2
Suffer from 'nerves' 27.3 1 1 2.2 0 1 CADM2
Chest pain or discomfort 3.9 1 0 0.0 0 1 CADM2
Age at last live birth 5.4 1 0 0.0 0 1 CADM2
Commuting to job workplace: Car/motor vehicle 4.8 1 0 0.0 0 1 CADM2
Smoking status: Previous 31.2 1 1 2.2 0 1 CADM2
Whole body fat-free mass 13.9 1 1 2.2 0 1 CADM2
Leg fat-free mass (right) 10.8 1 1 2.2 0 1 CADM2
Arm fat percentage (left) 3.9 1 0 0.0 0 1 CADM2
Average weekly red wine intake 3.6 1 0 0.0 0 1 CADM2
Long-standing illness, disability or infirmity 5.6 1 0 0.0 0 1 CADM2
Ever had stillbirth, spontaneous miscarriage or termination 11.0 1 0 0.0 0 1 CADM2
Qualifications: nursing, teaching 8.3 1 0 0.0 0 1 CADM2
Mouth/teeth dental problems: Mouth ulcers 7.3 1 0 0.0 0 1 CADM2
Smoking status: Current 8.8 1 0 0.0 0 1 CADM2
Whole body water mass 14.1 1 1 2.2 0 1 CADM2
Leg predicted mass (right) 10.7 1 1 2.2 0 1 CADM2
Arm fat mass (left) 10.6 1 1 2.2 0 1 CADM2
Average weekly champagne plus white wine intake 3.7 1 0 0.0 0 1 CADM2
Wears glasses or contact lenses 13.2 1 0 0.0 0 1 CADM2
Financial situation satisfaction 7.0 1 0 0.0 0 1 CADM2
Commuting to job workplace: Public transport 9.6 1 0 0.0 0 1 CADM2
Eye problems/disorders: Glaucoma 6.5 1 0 0.0 0 1 CADM2
Alcohol drinker status: Never 13.0 1 0 0.0 0 1 CADM2
Ever smoked 29.3 1 1 2.2 0 1 CADM2
Basal metabolic rate 14.2 1 1 2.2 0 1 CADM2
Leg fat percentage (left) 6.5 1 0 0.0 0 1 CADM2
Arm fat-free mass (left) 18.2 1 1 2.2 0 1 CADM2
Average weekly beer plus cider intake 9.8 1 0 0.0 0 1 CADM2
Irritability 3.5 1 0 0.0 0 1 CADM2
Risk taking 52.1 1 1 2.2 0 1 CADM2
Age started oral contraceptive pill 6.6 1 0 0.0 0 1 CADM2
Commuting to job workplace: Cycle 6.8 1 0 0.0 0 1 CADM2
Myopia 4.3 1 0 0.0 0 1 CADM2
Impedance of whole body 18.6 1 1 2.2 0 1 CADM2
Leg fat mass (left) 12.8 1 1 2.2 0 1 CADM2
Arm predicted mass (left) 17.6 1 1 2.2 0 1 CADM2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.1
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.1
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.1
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.1
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.1
GTEx Cells Transformed fibroblasts 0 0.000 1.1
GTEx Colon Sigmoid 0 0.000 1.1
GTEx Colon Transverse 0 0.000 1.1
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.1
GTEx Esophagus Mucosa 0 0.000 1.1
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.1
GTEx Heart Left Ventricle 0 0.000 1.1
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.1
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.1
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.1
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.1
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.0
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.0
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2