Hub : Traits :

Family relationship satisfaction

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 48072855 49519654 1 1 1.9e-07 1.1e-06 2e-05 23 STON1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Age at First Birth 3.75 1 0 0 0 1 STON1
Coronary Artery Disease (CAD) 8.78 1 0 0 0 1 STON1
Crohns Disease (2012) 2.66 1 0 0 0 1 STON1
Type 2 Diabetes (T2D) 4.43 1 0 0 0 1 STON1
BMI 1.01 1 0 0 0 1 STON1
Height 0.46 1 0 0 0 1 STON1
Waist Hip Ratio (WHR) 1.34 1 0 0 0 1 STON1
Lung FEV1/FVC ratio 5.02 1 0 0 0 1 STON1
Hand grip strength (left) 2.54 1 0 0 0 1 STON1
Other serious medical condition/disability diagnosed by doctor 3.52 1 0 0 0 1 STON1
Ever used hormone-replacement therapy (HRT) 11.59 1 0 0 0 1 STON1
Ever had hysterectomy (womb removed) 10.34 1 0 0 0 1 STON1
Vitamin and mineral supplements 11.84 1 0 0 0 1 STON1
Hand grip strength (right) 3.23 1 0 0 0 1 STON1
Current tobacco smoking 3.78 1 0 0 0 1 STON1
Bilateral oophorectomy (both ovaries removed) 4.21 1 0 0 0 1 STON1
Multivitamins +/- minerals 12.11 1 0 0 0 1 STON1
Stomach or abdominal pain in last month 5.02 1 0 0 0 1 STON1
High blood pressure (mother) 2.74 1 0 0 0 1 STON1
Frequency of tenseness / restlessness in last 2 weeks 5.07 1 0 0 0 1 STON1
Had other major operations 5.90 1 0 0 0 1 STON1
Qualifications: None of the above 1.90 1 0 0 0 1 STON1
Father's age at death 4.97 1 0 0 0 1 STON1
Number of live births 4.98 1 0 0 0 1 STON1
Happiness 17.22 1 0 0 0 1 STON1
Exposure to tobacco smoke at home 5.92 1 0 0 0 1 STON1
Loud music exposure frequency 3.93 1 0 0 0 1 STON1
Exposure to tobacco smoke outside home 4.78 1 0 0 0 1 STON1
Seen a psychiatrist for nerves, anxiety, tension or depression 2.99 1 0 0 0 1 STON1
Number of children fathered 4.43 1 0 0 0 1 STON1
Health satisfaction 5.51 1 0 0 0 1 STON1
Qualifications: College or University degree 1.93 1 0 0 0 1 STON1
Pulse rate, automated reading 1.47 1 0 0 0 1 STON1
Number of full sisters 4.23 1 0 0 0 1 STON1
Overall health rating 2.51 1 0 0 0 1 STON1
Loneliness, isolation 2.93 1 0 0 0 1 STON1
Ever had stillbirth, spontaneous miscarriage or termination 6.35 1 0 0 0 1 STON1
Friendships satisfaction 8.85 1 0 0 0 1 STON1
Smoking status: Current 4.50 1 0 0 0 1 STON1
Financial situation satisfaction 4.57 1 0 0 0 1 STON1
Commuting to job workplace: Public transport 3.98 1 0 0 0 1 STON1
Number of operations (self-reported) 5.28 1 0 0 0 1 STON1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.25
GTEx Adipose Visceral Omentum 0 0.0000 1.28
GTEx Adrenal Gland 0 0.0000 1.27
GTEx Artery Aorta 0 0.0000 1.25
GTEx Artery Coronary 0 0.0000 1.28
GTEx Artery Tibial 0 0.0000 1.23
GTEx Brain Caudate basal ganglia 0 0.0000 1.22
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.24
GTEx Brain Cerebellum 0 0.0000 1.22
GTEx Brain Cortex 0 0.0000 1.30
GTEx Brain Frontal Cortex BA9 0 0.0000 1.17
GTEx Brain Hippocampus 0 0.0000 1.33
GTEx Brain Hypothalamus 0 0.0000 1.16
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.27
GTEx Brain Putamen basal ganglia 0 0.0000 1.32
GTEx Breast Mammary Tissue 0 0.0000 1.26
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.21
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.28
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.25
GTEx Cells Transformed fibroblasts 0 0.0000 1.23
GTEx Colon Sigmoid 0 0.0000 1.28
GTEx Colon Transverse 0 0.0000 1.29
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.24
GTEx Esophagus Mucosa 0 0.0000 1.27
GTEx Esophagus Muscularis 0 0.0000 1.21
GTEx Heart Atrial Appendage 0 0.0000 1.26
GTEx Heart Left Ventricle 0 0.0000 1.24
GTEx Liver 0 0.0000 1.36
GTEx Lung 0 0.0000 1.26
GTEx Muscle Skeletal 0 0.0000 1.27
GTEx Nerve Tibial 0 0.0000 1.24
GTEx Ovary 0 0.0000 1.26
GTEx Pancreas 0 0.0000 1.27
GTEx Pituitary 0 0.0000 1.18
GTEx Prostate 0 0.0000 1.29
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.26
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.26
GTEx Small Intestine Terminal Ileum 0 0.0000 1.44
GTEx Spleen 0 0.0000 1.35
GTEx Stomach 0 0.0000 1.26
GTEx Testis 0 0.0000 1.26
GTEx Thyroid 0 0.0000 1.21
GTEx Uterus 0 0.0000 1.15
GTEx Vagina 0 0.0000 1.31
GTEx Whole Blood 1 0.0502 1.29
METSIM Adipose 0 0.0000 1.29
NTR Blood 0 0.0000 1.23
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.26
YFS Blood 0 0.0000 1.20
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.22
TCGA Breast Tumor 0 0.0000 1.15
TCGA Breast Normal 0 0.0000 1.19
TCGA Ovarian Tumor 0 0.0000 1.14
TCGA Prostate Tumor 0 0.0000 1.20