Hub : Traits :

Mouth/teeth dental problems: Bleeding gums

5 significantly associated models · 3 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	11	46180005	47977454	3	1	7.2e-11	1.7e-07	0.93	100	C11orf49

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Migraine (self-reported)	16.5	1	0	0.0	1	C11orf49
HDL Cholesterol	12.5	1	0	0.0	1	C11orf49
Mouth/teeth dental problems	10.8	1	0	0.0	1	C11orf49
Medication: Laxatives (e.g. Dulcolax, Senokot)	9.3	1	0	0.0	1	C11orf49
Frequency of unenthusiasm / disinterest in last 2 weeks	8.1	1	0	0.0	1	C11orf49
Verbal and Numeric Reasoning (VNR)	7.9	1	0	0.0	1	C11orf49
Depression (Nagel 2018)	7.8	1	0	0.0	1	C11orf49
Mean time to correctly identify matches	7.8	1	0	0.0	1	C11orf49
Suffer from 'nerves'	7.0	1	0	0.0	1	C11orf49
Reaction Time	6.7	1	0	0.0	1	C11orf49
Medication: Blood pressure	6.7	1	0	0.0	1	C11orf49
Loneliness, isolation	6.4	1	0	0.0	1	C11orf49
Arm fat percentage (right)	5.9	1	0	0.0	1	C11orf49
Fed-up feelings	5.8	1	0	0.0	1	C11orf49
Fluid intelligence score	5.8	1	0	0.0	1	C11orf49
Arm fat percentage (left)	5.8	1	0	0.0	1	C11orf49
Lupus	5.6	1	0	0.0	1	C11orf49
BMI	5.6	1	1	2.2	1	C11orf49
Age at first live birth	5.6	1	0	0.0	1	C11orf49
Depressed Affect (Nagel 2018)	5.5	1	0	0.0	1	C11orf49
Frequency of depressed mood in last 2 weeks	5.2	1	0	0.0	1	C11orf49
Age at last live birth	5.2	1	0	0.0	1	C11orf49
Leg fat percentage (left)	4.7	1	0	0.0	1	C11orf49
Neuroticism	4.4	1	0	0.0	1	C11orf49
Neuroticism score	4.3	1	0	0.0	1	C11orf49
Intelligence (Savage-Jansen 2018)	4.2	1	0	0.0	1	C11orf49
Blood Platelet Count	4.1	1	1	2.2	1	C11orf49
Body fat percentage	4.1	1	0	0.0	1	C11orf49
Leg fat percentage (right)	4.1	1	0	0.0	1	C11orf49
Trunk fat percentage	3.7	1	0	0.0	1	C11orf49
Chronotype (morning person)	3.3	1	0	0.0	1	C11orf49
Pulse rate, automated reading	3.3	1	0	0.0	1	C11orf49
Overall health rating	3.2	1	0	0.0	1	C11orf49
Body mass index (BMI)	2.9	1	0	0.0	1	C11orf49
Arm fat mass (right)	2.8	1	0	0.0	1	C11orf49
Cardiovascular Disease	2.7	1	0	0.0	1	C11orf49
Hypertension (Self-reported)	2.7	1	0	0.0	1	C11orf49
Comparative body size at age 10	2.6	1	0	0.0	1	C11orf49
Forced vital capacity (FVC)	2.5	1	0	0.0	1	C11orf49
Arm fat mass (left)	2.4	1	0	0.0	1	C11orf49
Height	2.3	1	1	2.2	1	C11orf49
Waist Hip Ratio (WHR)	2.3	1	0	0.0	1	C11orf49
Trunk fat mass	2.2	1	0	0.0	1	C11orf49
Standing height	2.2	1	0	0.0	1	C11orf49
Whole body fat mass	2.2	1	0	0.0	1	C11orf49
Leg fat mass (left)	2.2	1	0	0.0	1	C11orf49
Blood White Count	2.0	1	0	0.0	1	C11orf49
Leg fat mass (right)	1.9	1	0	0.0	1	C11orf49
Comparative height size at age 10	1.5	1	0	0.0	1	C11orf49
Sitting height	1.3	1	0	0.0	1	C11orf49
Hair Pigment	0.4	1	0	0.0	1	C11orf49

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adrenal Gland	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Vagina	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Spleen	1	0.071	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Whole Blood	0	0.000	1.3
YFS	Blood	1	0.022	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Uterus	1	0.176	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2