Hub : Traits :

Mouth/teeth dental problems: Bleeding gums

5 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 46180005 47977454 3 1 7.2e-11 1.7e-07 0.93 100 C11orf49

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 5.5 1 0 0.0 0 1 C11orf49
Depression (Nagel 2018) 7.8 1 0 0.0 0 1 C11orf49
Intelligence (Savage-Jansen 2018) 4.2 1 0 0.0 0 1 C11orf49
Reaction Time 6.7 1 0 0.0 0 1 C11orf49
Verbal and Numeric Reasoning (VNR) 7.9 1 0 0.0 0 1 C11orf49
HDL Cholesterol 12.5 1 0 0.0 0 1 C11orf49
Lupus 5.6 1 0 0.0 0 1 C11orf49
Blood Platelet Count 4.1 1 1 2.2 0 1 C11orf49
Blood White Count 2.0 1 0 0.0 0 1 C11orf49
BMI 5.6 1 1 2.2 0 1 C11orf49
Height 2.3 1 1 2.2 0 1 C11orf49
Waist Hip Ratio (WHR) 2.3 1 0 0.0 0 1 C11orf49
Cardiovascular Disease 2.7 1 0 0.0 0 1 C11orf49
Neuroticism 4.4 1 0 0.0 0 1 C11orf49
Chronotype (morning person) 3.3 1 0 0.0 0 1 C11orf49
Hair Pigment 0.4 1 0 0.0 0 1 C11orf49
Frequency of depressed mood in last 2 weeks 5.2 1 0 0.0 0 1 C11orf49
Trunk fat percentage 3.7 1 0 0.0 0 1 C11orf49
Fed-up feelings 5.8 1 0 0.0 0 1 C11orf49
Frequency of unenthusiasm / disinterest in last 2 weeks 8.1 1 0 0.0 0 1 C11orf49
Sitting height 1.3 1 0 0.0 0 1 C11orf49
Body mass index (BMI) 2.9 1 0 0.0 0 1 C11orf49
Trunk fat mass 2.2 1 0 0.0 0 1 C11orf49
Forced vital capacity (FVC) 2.5 1 0 0.0 0 1 C11orf49
Mouth/teeth dental problems 10.8 1 0 0.0 0 1 C11orf49
Fluid intelligence score 5.8 1 0 0.0 0 1 C11orf49
Neuroticism score 4.3 1 0 0.0 0 1 C11orf49
Arm fat percentage (right) 5.9 1 0 0.0 0 1 C11orf49
Arm fat mass (right) 2.8 1 0 0.0 0 1 C11orf49
Standing height 2.2 1 0 0.0 0 1 C11orf49
Body fat percentage 4.1 1 0 0.0 0 1 C11orf49
Leg fat percentage (right) 4.1 1 0 0.0 0 1 C11orf49
Comparative body size at age 10 2.6 1 0 0.0 0 1 C11orf49
Age at first live birth 5.6 1 0 0.0 0 1 C11orf49
Migraine (self-reported) 16.5 1 0 0.0 0 1 C11orf49
Mean time to correctly identify matches 7.8 1 0 0.0 0 1 C11orf49
Whole body fat mass 2.2 1 0 0.0 0 1 C11orf49
Leg fat mass (right) 1.9 1 0 0.0 0 1 C11orf49
Pulse rate, automated reading 3.3 1 0 0.0 0 1 C11orf49
Comparative height size at age 10 1.5 1 0 0.0 0 1 C11orf49
Suffer from 'nerves' 7.0 1 0 0.0 0 1 C11orf49
Overall health rating 3.2 1 0 0.0 0 1 C11orf49
Age at last live birth 5.2 1 0 0.0 0 1 C11orf49
Hypertension (Self-reported) 2.7 1 0 0.0 0 1 C11orf49
Arm fat percentage (left) 5.8 1 0 0.0 0 1 C11orf49
Loneliness, isolation 6.4 1 0 0.0 0 1 C11orf49
Medication: Laxatives (e.g. Dulcolax, Senokot) 9.3 1 0 0.0 0 1 C11orf49
Arm fat mass (left) 2.4 1 0 0.0 0 1 C11orf49
Medication: Blood pressure 6.7 1 0 0.0 0 1 C11orf49
Leg fat percentage (left) 4.7 1 0 0.0 0 1 C11orf49
Leg fat mass (left) 2.2 1 0 0.0 0 1 C11orf49

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.4
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 1 0.071 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 1 0.025 1.3
GTEx Uterus 1 0.176 1.2
GTEx Vagina 0 0.000 1.4
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.4
YFS Blood 1 0.022 1.3
CommonMind Brain Pre-frontal Cortex 0 0.000 1.3
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.4
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2