Hub : Traits :

Frequency of depressed mood in last 2 weeks

6 significantly associated models · 5 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 135726679 136715468 2 1 2.3e-08 3.5e-07 7.8e-02 88 PCCB
2 9 95518076 96913764 1 1 1.6e-07 2.4e-08 4.8e-04 61 FAM120AOS
3 10 64531160 65911294 1 1 2.0e-07 1.0e-05 9.2e-01 100 JMJD1C-AS1
4 18 34124783 35844220 1 1 9.5e-08 1.5e-10 7.2e-06 51 CELF4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 2.38 1 0 0.0 0.00 1.00000 FAM120AOS
Depressed Affect (Nagel 2018) 9.76 4 0 0.0 1.00 0.00039 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Depression (Nagel 2018) 21.22 4 4 8.9 1.00 0.00154 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Intelligence (Savage-Jansen 2018) 4.55 2 1 2.2 0.00 1.00000 JMJD1C-AS1 PCCB
Neuroticism (Nagel 2018) 12.55 4 3 6.7 0.97 0.02759 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Schizophrenia (2018) 4.51 2 0 0.0 0.00 1.00000 FAM120AOS PCCB
Schizophrenia vs Biploar Disorder 2.25 1 0 0.0 0.00 1.00000 PCCB
Worry (Nagel 2018) 11.21 3 1 2.2 0.00 1.00000 CELF4 FAM120AOS PCCB
Alzheimer’s Disease (in father) 2.86 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Major Depression (MDD) 3.00 1 0 0.0 0.00 1.00000 FAM120AOS
Reaction Time 2.82 1 0 0.0 0.00 1.00000 PCCB
Verbal and Numeric Reasoning (VNR) 4.92 3 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 PCCB
Breast Cancer 1.62 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Bipolar Disorder (2011) 2.48 1 0 0.0 0.00 1.00000 FAM120AOS
HDL Cholesterol 2.16 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Neuroticism (2016) 5.80 3 0 0.0 0.00 1.00000 CELF4 FAM120AOS PCCB
Rheumatoid Arthritis 2.44 1 0 0.0 0.00 1.00000 PCCB
Schizophrenia (2014) 4.26 2 0 0.0 0.00 1.00000 FAM120AOS PCCB
Triglycerides 2.89 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Blood Platelet Count 2.22 3 2 4.4 0.00 1.00000 FAM120AOS JMJD1C-AS1 PCCB
Blood Red Count 0.50 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Blood White Count 2.47 2 1 2.2 0.00 1.00000 JMJD1C-AS1 PCCB
BMI 1.32 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Height 0.72 3 1 2.2 0.00 1.00000 FAM120AOS JMJD1C-AS1 PCCB
Waist Hip Ratio (WHR) 1.85 2 0 0.0 0.00 1.00000 JMJD1C-AS1 PCCB
Systolic Blood Pressure 1.26 1 0 0.0 0.00 1.00000 PCCB
Cardiovascular Disease 1.90 1 0 0.0 0.00 1.00000 PCCB
Lung FEV1/FVC ratio 1.55 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Lung FVC 1.25 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Neuroticism 10.56 3 2 4.4 0.00 1.00000 CELF4 FAM120AOS PCCB
Chronotype (morning person) 1.93 1 0 0.0 0.00 1.00000 CELF4
Hair Pigment 0.19 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Hand grip strength (left) 1.57 1 0 0.0 0.00 1.00000 FAM120AOS
Sensitivity / hurt feelings 6.46 3 0 0.0 0.00 1.00000 CELF4 FAM120AOS PCCB
Hearing difficulty/problems: Yes 2.92 1 0 0.0 0.00 1.00000 PCCB
Vitamin and mineral supplements 2.03 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Pack years adult smoking proportion 6.19 1 1 2.2 0.00 1.00000 JMJD1C-AS1
Impedance of leg (right) 2.02 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Trunk fat percentage 0.99 1 0 0.0 0.00 1.00000 CELF4
Townsend deprivation index at recruitment 3.18 1 0 0.0 0.00 1.00000 FAM120AOS
Current tobacco smoking 2.84 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Fed-up feelings 9.12 4 1 2.2 0.99 0.01499 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Frequency of unenthusiasm / disinterest in last 2 weeks 17.57 4 1 2.2 0.99 0.00816 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Relative age voice broke 2.16 1 0 0.0 0.00 1.00000 PCCB
Taking other prescription medications 2.00 1 0 0.0 0.00 1.00000 CELF4
Age when periods started (menarche) 1.89 1 0 0.0 0.00 1.00000 FAM120AOS
Qualifications: CSEs or equivalent 3.29 1 0 0.0 0.00 1.00000 JMJD1C-AS1
High blood pressure 1.33 1 0 0.0 0.00 1.00000 PCCB
Stomach or abdominal pain in last month 8.34 3 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 PCCB
Body mass index (BMI) 1.45 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Impedance of leg (left) 1.96 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Trunk fat mass 0.95 1 0 0.0 0.00 1.00000 CELF4
Waist circumference 1.85 2 0 0.0 0.00 1.00000 JMJD1C-AS1 PCCB
Nervous feelings 6.98 2 1 2.2 0.00 1.00000 CELF4 PCCB
Frequency of tenseness / restlessness in last 2 weeks 14.19 4 1 2.2 1.00 0.00058 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Had other major operations 3.48 1 0 0.0 0.00 1.00000 FAM120AOS
Ever unenthusiastic/disinterested for a whole week 2.63 1 0 0.0 0.00 1.00000 FAM120AOS
Qualifications: None of the above 7.01 3 1 2.2 0.00 1.00000 CELF4 FAM120AOS JMJD1C-AS1
Financial difficulties in last 2 years 3.11 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Pain all over the body in last month 2.80 1 0 0.0 0.00 1.00000 FAM120AOS
Fluid intelligence score 4.84 2 0 0.0 0.00 1.00000 JMJD1C-AS1 PCCB
Neuroticism score 12.19 4 3 6.7 0.99 0.01081 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Impedance of arm (right) 2.01 1 1 2.2 0.00 1.00000 JMJD1C-AS1
Arm fat percentage (right) 1.17 1 0 0.0 0.00 1.00000 FAM120AOS
Trunk fat-free mass 0.46 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Worrier / anxious feelings 6.21 2 1 2.2 0.00 1.00000 FAM120AOS PCCB
Frequency of tiredness / lethargy in last 2 weeks 10.34 4 0 0.0 0.99 0.01030 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Falls in the last year 3.92 1 0 0.0 0.00 1.00000 FAM120AOS
Qualifications: A levels/AS levels or equivalent 4.18 3 0 0.0 0.00 1.00000 CELF4 FAM120AOS JMJD1C-AS1
Mouth/teeth dental problems: Dentures 3.32 1 0 0.0 0.00 1.00000 PCCB
Medication: Ibuprofen (e.g. Nurofen) 2.81 1 0 0.0 0.00 1.00000 FAM120AOS
Forced expiratory volume in 1-second (FEV1), Best measure 1.79 1 0 0.0 0.00 1.00000 FAM120AOS
Impedance of arm (left) 2.47 1 1 2.2 0.00 1.00000 JMJD1C-AS1
Trunk predicted mass 0.46 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Standing height 0.67 3 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1 PCCB
Tense / 'highly strung' 9.83 3 1 2.2 0.00 1.00000 CELF4 FAM120AOS PCCB
Seen doctor (GP) for nerves, anxiety, tension or depression 3.11 1 0 0.0 0.00 1.00000 CELF4
Ever highly irritable/argumentative for 2 days 4.53 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Loud music exposure frequency 3.15 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Qualifications: O levels/GCSEs or equivalent 2.10 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Medication: Paracetamol 3.84 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Headache pain in last month 4.45 2 0 0.0 0.00 1.00000 FAM120AOS PCCB
Forced vital capacity (FVC), Best measure 0.90 1 0 0.0 0.00 1.00000 FAM120AOS
Body fat percentage 1.10 1 0 0.0 0.00 1.00000 CELF4
Leg fat percentage (right) 1.29 1 0 0.0 0.00 1.00000 CELF4
Arm fat-free mass (right) 0.74 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Exposure to tobacco smoke outside home 3.19 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Comparative body size at age 10 5.47 1 1 2.2 0.00 1.00000 FAM120AOS
Worry too long after embarrassment 5.66 2 0 0.0 0.00 1.00000 CELF4 PCCB
Wheeze or whistling in the chest in last year 2.36 1 0 0.0 0.00 1.00000 FAM120AOS
Reason for reducing amount of alcohol drunk: Health precaution 1.95 1 0 0.0 0.00 1.00000 CELF4
Age at first live birth 3.14 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Pulse wave peak to peak time 2.31 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Qualifications: College or University degree 5.90 3 1 2.2 0.00 1.00000 CELF4 FAM120AOS JMJD1C-AS1
Medication for pain relief, constipation, heartburn 4.20 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Mean time to correctly identify matches 1.92 1 0 0.0 0.00 1.00000 PCCB
Whole body fat mass 0.94 1 0 0.0 0.00 1.00000 CELF4
Arm predicted mass (right) 0.63 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Pulse rate, automated reading 1.19 2 0 0.0 0.00 1.00000 CELF4 PCCB
Comparative height size at age 10 1.25 1 0 0.0 0.00 1.00000 PCCB
Suffer from 'nerves' 3.75 1 0 0.0 0.00 1.00000 CELF4
Overall health rating 5.06 3 0 0.0 0.00 1.00000 CELF4 FAM120AOS JMJD1C-AS1
Illness, injury, bereavement, stress in last 2 years 4.04 1 0 0.0 0.00 1.00000 FAM120AOS
Hypertension (Self-reported) 1.41 1 0 0.0 0.00 1.00000 PCCB
Whole body fat-free mass 0.46 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Arm fat percentage (left) 1.20 2 0 0.0 0.00 1.00000 CELF4 FAM120AOS
Mood swings 6.95 4 0 0.0 0.99 0.01493 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Loneliness, isolation 11.87 4 0 0.0 0.99 0.01408 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Long-standing illness, disability or infirmity 1.69 1 0 0.0 0.00 1.00000 FAM120AOS
Qualifications: nursing, teaching 5.26 2 0 0.0 0.00 1.00000 CELF4 JMJD1C-AS1
Eye problems/disorders: Cataract 2.53 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Back pain experienced in last month 3.29 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Osteoarthritis (self-reported) 2.40 1 0 0.0 0.00 1.00000 FAM120AOS
Smoking status: Current 2.69 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.72 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Whole body water mass 0.47 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Miserableness 7.17 4 0 0.0 1.00 0.00230 CELF4 FAM120AOS JMJD1C-AS1 PCCB
Guilty feelings 4.39 3 0 0.0 0.00 1.00000 CELF4 FAM120AOS PCCB
Hearing aid user 1.89 1 0 0.0 0.00 1.00000 PCCB
Financial situation satisfaction 3.72 1 0 0.0 0.00 1.00000 CELF4
Medication: Blood pressure 2.23 1 0 0.0 0.00 1.00000 PCCB
Pain type(s) experienced in last month: Hip pain 3.32 1 0 0.0 0.00 1.00000 FAM120AOS
Medication: Bendroflumethiazide 1.62 1 0 0.0 0.00 1.00000 PCCB
Medication: Paracetamol 2.45 1 0 0.0 0.00 1.00000 FAM120AOS
Basal metabolic rate 0.49 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Leg fat percentage (left) 1.28 1 0 0.0 0.00 1.00000 CELF4
Arm fat-free mass (left) 0.79 1 0 0.0 0.00 1.00000 JMJD1C-AS1
Number of operations (self-reported) 4.73 2 0 0.0 0.00 1.00000 FAM120AOS PCCB
Irritability 3.10 2 0 0.0 0.00 1.00000 CELF4 FAM120AOS
Risk taking 3.16 1 0 0.0 0.00 1.00000 PCCB
Unable to work because of sickness or disability 3.65 2 0 0.0 0.00 1.00000 FAM120AOS JMJD1C-AS1
Vascular/heart problems diagnosed by doctor 1.25 1 0 0.0 0.00 1.00000 PCCB
Pain experienced in last month 5.28 2 0 0.0 0.00 1.00000 CELF4 FAM120AOS
Pack years of smoking 5.19 1 1 2.2 0.00 1.00000 JMJD1C-AS1
Impedance of whole body 2.13 2 1 2.2 0.00 1.00000 FAM120AOS JMJD1C-AS1
Leg fat mass (left) 0.92 1 0 0.0 0.00 1.00000 CELF4
Arm predicted mass (left) 0.77 1 0 0.0 0.00 1.00000 JMJD1C-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.5
GTEx Adrenal Gland 0 0.000 1.4
GTEx Artery Aorta 0 0.000 1.4
GTEx Artery Coronary 0 0.000 1.6
GTEx Artery Tibial 0 0.000 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.5
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.5
GTEx Brain Hypothalamus 0 0.000 1.5
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 0 0.000 1.5
GTEx Breast Mammary Tissue (Male) 0 0.000 1.5
GTEx Breast Mammary Tissue (Female) 0 0.000 1.5
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.5
GTEx Cells Transformed fibroblasts 0 0.000 1.5
GTEx Colon Sigmoid 0 0.000 1.5
GTEx Colon Transverse 0 0.000 1.5
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.5
GTEx Esophagus Mucosa 0 0.000 1.4
GTEx Esophagus Muscularis 0 0.000 1.5
GTEx Heart Atrial Appendage 0 0.000 1.6
GTEx Heart Left Ventricle 0 0.000 1.5
GTEx Liver 0 0.000 1.5
GTEx Lung 0 0.000 1.5
GTEx Muscle Skeletal 0 0.000 1.5
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.5
GTEx Prostate 0 0.000 1.5
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.5
GTEx Skin Sun Exposed Lower leg 0 0.000 1.4
GTEx Small Intestine Terminal Ileum 0 0.000 1.6
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.5
GTEx Testis 1 0.032 1.4
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.6
GTEx Vagina 0 0.000 1.5
GTEx Whole Blood 0 0.000 1.5
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.4
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.4
YFS Blood 1 0.022 1.3
CommonMind Brain Pre-frontal Cortex 1 0.019 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.4
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 2 0.073 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.4
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3