Hub : Traits :

Frequency of depressed mood in last 2 weeks

6 significantly associated models · 5 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	135726679	136715468	2	1	2.3e-08	3.5e-07	7.8e-02	88	PCCB
2	9	95518076	96913764	1	1	1.6e-07	2.4e-08	4.8e-04	61	FAM120AOS
3	10	64531160	65911294	1	1	2.0e-07	1.0e-05	9.2e-01	100	JMJD1C-AS1
4	18	34124783	35844220	1	1	9.5e-08	1.5e-10	7.2e-06	51	CELF4

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Depression (Nagel 2018)	21.22	4	4	8.9	1.00	0.00154	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Frequency of unenthusiasm / disinterest in last 2 weeks	17.57	4	1	2.2	0.99	0.00816	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Frequency of tenseness / restlessness in last 2 weeks	14.19	4	1	2.2	1.00	0.00058	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Neuroticism (Nagel 2018)	12.55	4	3	6.7	0.97	0.02759	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Neuroticism score	12.19	4	3	6.7	0.99	0.01081	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Loneliness, isolation	11.87	4	0	0.0	0.99	0.01408	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Worry (Nagel 2018)	11.21	3	1	2.2	0.00	1.00000	CELF4 FAM120AOS PCCB
Neuroticism	10.56	3	2	4.4	0.00	1.00000	CELF4 FAM120AOS PCCB
Frequency of tiredness / lethargy in last 2 weeks	10.34	4	0	0.0	0.99	0.01030	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Tense / 'highly strung'	9.83	3	1	2.2	0.00	1.00000	CELF4 FAM120AOS PCCB
Depressed Affect (Nagel 2018)	9.76	4	0	0.0	1.00	0.00039	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Fed-up feelings	9.12	4	1	2.2	0.99	0.01499	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Stomach or abdominal pain in last month	8.34	3	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1 PCCB
Miserableness	7.17	4	0	0.0	1.00	0.00230	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Qualifications: None of the above	7.01	3	1	2.2	0.00	1.00000	CELF4 FAM120AOS JMJD1C-AS1
Nervous feelings	6.98	2	1	2.2	0.00	1.00000	CELF4 PCCB
Mood swings	6.95	4	0	0.0	0.99	0.01493	CELF4 FAM120AOS JMJD1C-AS1 PCCB
Sensitivity / hurt feelings	6.46	3	0	0.0	0.00	1.00000	CELF4 FAM120AOS PCCB
Worrier / anxious feelings	6.21	2	1	2.2	0.00	1.00000	FAM120AOS PCCB
Pack years adult smoking proportion	6.19	1	1	2.2	0.00	1.00000	JMJD1C-AS1
Qualifications: College or University degree	5.90	3	1	2.2	0.00	1.00000	CELF4 FAM120AOS JMJD1C-AS1
Neuroticism (2016)	5.80	3	0	0.0	0.00	1.00000	CELF4 FAM120AOS PCCB
Worry too long after embarrassment	5.66	2	0	0.0	0.00	1.00000	CELF4 PCCB
Comparative body size at age 10	5.47	1	1	2.2	0.00	1.00000	FAM120AOS
Pain experienced in last month	5.28	2	0	0.0	0.00	1.00000	CELF4 FAM120AOS
Qualifications: nursing, teaching	5.26	2	0	0.0	0.00	1.00000	CELF4 JMJD1C-AS1
Pack years of smoking	5.19	1	1	2.2	0.00	1.00000	JMJD1C-AS1
Overall health rating	5.06	3	0	0.0	0.00	1.00000	CELF4 FAM120AOS JMJD1C-AS1
Verbal and Numeric Reasoning (VNR)	4.92	3	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1 PCCB
Fluid intelligence score	4.84	2	0	0.0	0.00	1.00000	JMJD1C-AS1 PCCB
Number of operations (self-reported)	4.73	2	0	0.0	0.00	1.00000	FAM120AOS PCCB
Intelligence (Savage-Jansen 2018)	4.55	2	1	2.2	0.00	1.00000	JMJD1C-AS1 PCCB
Ever highly irritable/argumentative for 2 days	4.53	2	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1
Schizophrenia (2018)	4.51	2	0	0.0	0.00	1.00000	FAM120AOS PCCB
Headache pain in last month	4.45	2	0	0.0	0.00	1.00000	FAM120AOS PCCB
Guilty feelings	4.39	3	0	0.0	0.00	1.00000	CELF4 FAM120AOS PCCB
Schizophrenia (2014)	4.26	2	0	0.0	0.00	1.00000	FAM120AOS PCCB
Medication for pain relief, constipation, heartburn	4.20	2	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1
Qualifications: A levels/AS levels or equivalent	4.18	3	0	0.0	0.00	1.00000	CELF4 FAM120AOS JMJD1C-AS1
Illness, injury, bereavement, stress in last 2 years	4.04	1	0	0.0	0.00	1.00000	FAM120AOS
Falls in the last year	3.92	1	0	0.0	0.00	1.00000	FAM120AOS
Medication: Paracetamol	3.84	2	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1
Suffer from 'nerves'	3.75	1	0	0.0	0.00	1.00000	CELF4
Financial situation satisfaction	3.72	1	0	0.0	0.00	1.00000	CELF4
Unable to work because of sickness or disability	3.65	2	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1
Had other major operations	3.48	1	0	0.0	0.00	1.00000	FAM120AOS
Mouth/teeth dental problems: Dentures	3.32	1	0	0.0	0.00	1.00000	PCCB
Pain type(s) experienced in last month: Hip pain	3.32	1	0	0.0	0.00	1.00000	FAM120AOS
Qualifications: CSEs or equivalent	3.29	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Back pain experienced in last month	3.29	2	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1
Exposure to tobacco smoke outside home	3.19	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Townsend deprivation index at recruitment	3.18	1	0	0.0	0.00	1.00000	FAM120AOS
Risk taking	3.16	1	0	0.0	0.00	1.00000	PCCB
Loud music exposure frequency	3.15	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Age at first live birth	3.14	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Financial difficulties in last 2 years	3.11	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Seen doctor (GP) for nerves, anxiety, tension or depression	3.11	1	0	0.0	0.00	1.00000	CELF4
Irritability	3.10	2	0	0.0	0.00	1.00000	CELF4 FAM120AOS
Major Depression (MDD)	3.00	1	0	0.0	0.00	1.00000	FAM120AOS
Hearing difficulty/problems: Yes	2.92	1	0	0.0	0.00	1.00000	PCCB
Triglycerides	2.89	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Alzheimer’s Disease (in father)	2.86	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Current tobacco smoking	2.84	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Reaction Time	2.82	1	0	0.0	0.00	1.00000	PCCB
Medication: Ibuprofen (e.g. Nurofen)	2.81	1	0	0.0	0.00	1.00000	FAM120AOS
Pain all over the body in last month	2.80	1	0	0.0	0.00	1.00000	FAM120AOS
Smoking status: Current	2.69	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Ever unenthusiastic/disinterested for a whole week	2.63	1	0	0.0	0.00	1.00000	FAM120AOS
Eye problems/disorders: Cataract	2.53	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Bipolar Disorder (2011)	2.48	1	0	0.0	0.00	1.00000	FAM120AOS
Blood White Count	2.47	2	1	2.2	0.00	1.00000	JMJD1C-AS1 PCCB
Impedance of arm (left)	2.47	1	1	2.2	0.00	1.00000	JMJD1C-AS1
Medication: Paracetamol	2.45	1	0	0.0	0.00	1.00000	FAM120AOS
Rheumatoid Arthritis	2.44	1	0	0.0	0.00	1.00000	PCCB
Osteoarthritis (self-reported)	2.40	1	0	0.0	0.00	1.00000	FAM120AOS
Bipolar Disorder or Schizophrenia	2.38	1	0	0.0	0.00	1.00000	FAM120AOS
Wheeze or whistling in the chest in last year	2.36	1	0	0.0	0.00	1.00000	FAM120AOS
Pulse wave peak to peak time	2.31	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Schizophrenia vs Biploar Disorder	2.25	1	0	0.0	0.00	1.00000	PCCB
Medication: Blood pressure	2.23	1	0	0.0	0.00	1.00000	PCCB
Blood Platelet Count	2.22	3	2	4.4	0.00	1.00000	FAM120AOS JMJD1C-AS1 PCCB
HDL Cholesterol	2.16	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Relative age voice broke	2.16	1	0	0.0	0.00	1.00000	PCCB
Impedance of whole body	2.13	2	1	2.2	0.00	1.00000	FAM120AOS JMJD1C-AS1
Qualifications: O levels/GCSEs or equivalent	2.10	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Vitamin and mineral supplements	2.03	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Impedance of leg (right)	2.02	2	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1
Impedance of arm (right)	2.01	1	1	2.2	0.00	1.00000	JMJD1C-AS1
Taking other prescription medications	2.00	1	0	0.0	0.00	1.00000	CELF4
Impedance of leg (left)	1.96	2	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1
Reason for reducing amount of alcohol drunk: Health precaution	1.95	1	0	0.0	0.00	1.00000	CELF4
Chronotype (morning person)	1.93	1	0	0.0	0.00	1.00000	CELF4
Mean time to correctly identify matches	1.92	1	0	0.0	0.00	1.00000	PCCB
Cardiovascular Disease	1.90	1	0	0.0	0.00	1.00000	PCCB
Age when periods started (menarche)	1.89	1	0	0.0	0.00	1.00000	FAM120AOS
Hearing aid user	1.89	1	0	0.0	0.00	1.00000	PCCB
Waist Hip Ratio (WHR)	1.85	2	0	0.0	0.00	1.00000	JMJD1C-AS1 PCCB
Waist circumference	1.85	2	0	0.0	0.00	1.00000	JMJD1C-AS1 PCCB
Forced expiratory volume in 1-second (FEV1), Best measure	1.79	1	0	0.0	0.00	1.00000	FAM120AOS
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.72	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Long-standing illness, disability or infirmity	1.69	1	0	0.0	0.00	1.00000	FAM120AOS
Breast Cancer	1.62	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Medication: Bendroflumethiazide	1.62	1	0	0.0	0.00	1.00000	PCCB
Hand grip strength (left)	1.57	1	0	0.0	0.00	1.00000	FAM120AOS
Lung FEV1/FVC ratio	1.55	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Body mass index (BMI)	1.45	2	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1
Hypertension (Self-reported)	1.41	1	0	0.0	0.00	1.00000	PCCB
High blood pressure	1.33	1	0	0.0	0.00	1.00000	PCCB
BMI	1.32	2	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1
Leg fat percentage (right)	1.29	1	0	0.0	0.00	1.00000	CELF4
Leg fat percentage (left)	1.28	1	0	0.0	0.00	1.00000	CELF4
Systolic Blood Pressure	1.26	1	0	0.0	0.00	1.00000	PCCB
Lung FVC	1.25	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Comparative height size at age 10	1.25	1	0	0.0	0.00	1.00000	PCCB
Vascular/heart problems diagnosed by doctor	1.25	1	0	0.0	0.00	1.00000	PCCB
Arm fat percentage (left)	1.20	2	0	0.0	0.00	1.00000	CELF4 FAM120AOS
Pulse rate, automated reading	1.19	2	0	0.0	0.00	1.00000	CELF4 PCCB
Arm fat percentage (right)	1.17	1	0	0.0	0.00	1.00000	FAM120AOS
Body fat percentage	1.10	1	0	0.0	0.00	1.00000	CELF4
Trunk fat percentage	0.99	1	0	0.0	0.00	1.00000	CELF4
Trunk fat mass	0.95	1	0	0.0	0.00	1.00000	CELF4
Whole body fat mass	0.94	1	0	0.0	0.00	1.00000	CELF4
Leg fat mass (left)	0.92	1	0	0.0	0.00	1.00000	CELF4
Forced vital capacity (FVC), Best measure	0.90	1	0	0.0	0.00	1.00000	FAM120AOS
Arm fat-free mass (left)	0.79	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Arm predicted mass (left)	0.77	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Arm fat-free mass (right)	0.74	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Height	0.72	3	1	2.2	0.00	1.00000	FAM120AOS JMJD1C-AS1 PCCB
Standing height	0.67	3	0	0.0	0.00	1.00000	FAM120AOS JMJD1C-AS1 PCCB
Arm predicted mass (right)	0.63	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Blood Red Count	0.50	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Basal metabolic rate	0.49	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Whole body water mass	0.47	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Trunk fat-free mass	0.46	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Trunk predicted mass	0.46	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Whole body fat-free mass	0.46	1	0	0.0	0.00	1.00000	JMJD1C-AS1
Hair Pigment	0.19	1	0	0.0	0.00	1.00000	JMJD1C-AS1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Artery Coronary	0	0.000	1.6
GTEx	Heart Atrial Appendage	0	0.000	1.6
GTEx	Small Intestine Terminal Ileum	0	0.000	1.6
GTEx	Uterus	0	0.000	1.6
GTEx	Adipose Visceral Omentum	0	0.000	1.5
GTEx	Brain Cortex	0	0.000	1.5
GTEx	Brain Hippocampus	0	0.000	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Breast Mammary Tissue	0	0.000	1.5
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.5
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.5
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.5
GTEx	Cells Transformed fibroblasts	0	0.000	1.5
GTEx	Colon Sigmoid	0	0.000	1.5
GTEx	Colon Transverse	0	0.000	1.5
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.5
GTEx	Esophagus Muscularis	0	0.000	1.5
GTEx	Heart Left Ventricle	0	0.000	1.5
GTEx	Liver	0	0.000	1.5
GTEx	Lung	0	0.000	1.5
GTEx	Muscle Skeletal	0	0.000	1.5
GTEx	Ovary	0	0.000	1.5
GTEx	Pituitary	0	0.000	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.5
GTEx	Spleen	0	0.000	1.5
GTEx	Stomach	0	0.000	1.5
GTEx	Vagina	0	0.000	1.5
GTEx	Whole Blood	0	0.000	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Adrenal Gland	0	0.000	1.4
GTEx	Artery Aorta	0	0.000	1.4
GTEx	Artery Tibial	0	0.000	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Esophagus Mucosa	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Testis	1	0.032	1.4
GTEx	Thyroid	0	0.000	1.4
NTR	Blood	0	0.000	1.4
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.4
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.4
METSIM	Adipose	0	0.000	1.3
YFS	Blood	1	0.022	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2