Hub : Traits :

Mouth/teeth dental problems: Bleeding gums

5 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 46180005 47977454 3 1 7.2e-11 1.7e-07 0.93 100 C11orf49

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Reaction Time 6.58 1 0 0 0 1 C11orf49
Verbal and Numeric Reasoning (VNR) 7.83 1 0 0 0 1 C11orf49
HDL Cholesterol 12.66 1 0 0 0 1 C11orf49
Lupus 5.66 1 0 0 0 1 C11orf49
Blood Platelet Count 4.06 1 1 3 0 1 C11orf49
Blood White Count 2.02 1 0 0 0 1 C11orf49
BMI 5.51 1 1 3 0 1 C11orf49
Height 2.28 1 1 3 0 1 C11orf49
Waist Hip Ratio (WHR) 2.23 1 0 0 0 1 C11orf49
Cardiovascular Disease 2.72 1 0 0 0 1 C11orf49
Neuroticism 4.36 1 0 0 0 1 C11orf49
Chronotype (morning person) 3.26 1 0 0 0 1 C11orf49
Hair Pigment 0.37 1 0 0 0 1 C11orf49
Frequency of depressed mood in last 2 weeks 5.16 1 0 0 0 1 C11orf49
Trunk fat percentage 3.57 1 0 0 0 1 C11orf49
Fed-up feelings 5.70 1 0 0 0 1 C11orf49
Frequency of unenthusiasm / disinterest in last 2 weeks 8.07 1 0 0 0 1 C11orf49
Sitting height 1.26 1 0 0 0 1 C11orf49
Body mass index (BMI) 2.82 1 0 0 0 1 C11orf49
Trunk fat mass 2.16 1 0 0 0 1 C11orf49
Forced vital capacity (FVC) 2.43 1 0 0 0 1 C11orf49
Mouth/teeth dental problems 10.81 1 0 0 0 1 C11orf49
Fluid intelligence score 5.73 1 0 0 0 1 C11orf49
Neuroticism score 4.19 1 0 0 0 1 C11orf49
Arm fat percentage (right) 5.80 1 0 0 0 1 C11orf49
Arm fat mass (right) 2.75 1 0 0 0 1 C11orf49
Standing height 2.20 1 0 0 0 1 C11orf49
Body fat percentage 4.04 1 0 0 0 1 C11orf49
Leg fat percentage (right) 4.04 1 0 0 0 1 C11orf49
Comparative body size at age 10 2.57 1 0 0 0 1 C11orf49
Age at first live birth 5.54 1 0 0 0 1 C11orf49
Migraine (self-reported) 16.42 1 0 0 0 1 C11orf49
Mean time to correctly identify matches 7.72 1 0 0 0 1 C11orf49
Whole body fat mass 2.13 1 0 0 0 1 C11orf49
Leg fat mass (right) 1.87 1 0 0 0 1 C11orf49
Pulse rate, automated reading 3.29 1 0 0 0 1 C11orf49
Comparative height size at age 10 1.51 1 0 0 0 1 C11orf49
Suffer from 'nerves' 6.88 1 0 0 0 1 C11orf49
Overall health rating 3.16 1 0 0 0 1 C11orf49
Age at last live birth 5.13 1 0 0 0 1 C11orf49
Hypertension (Self-reported) 2.66 1 0 0 0 1 C11orf49
Arm fat percentage (left) 5.64 1 0 0 0 1 C11orf49
Loneliness, isolation 6.43 1 0 0 0 1 C11orf49
Medication: Laxatives (e.g. Dulcolax, Senokot) 9.23 1 0 0 0 1 C11orf49
Arm fat mass (left) 2.35 1 0 0 0 1 C11orf49
Medication: Blood pressure 6.58 1 0 0 0 1 C11orf49
Leg fat percentage (left) 4.63 1 0 0 0 1 C11orf49
Leg fat mass (left) 2.13 1 0 0 0 1 C11orf49

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.29
GTEx Adipose Visceral Omentum 0 0.0000 1.31
GTEx Adrenal Gland 0 0.0000 1.35
GTEx Artery Aorta 0 0.0000 1.32
GTEx Artery Coronary 0 0.0000 1.27
GTEx Artery Tibial 0 0.0000 1.33
GTEx Brain Caudate basal ganglia 0 0.0000 1.28
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.43
GTEx Brain Cerebellum 0 0.0000 1.36
GTEx Brain Cortex 0 0.0000 1.38
GTEx Brain Frontal Cortex BA9 0 0.0000 1.34
GTEx Brain Hippocampus 0 0.0000 1.21
GTEx Brain Hypothalamus 0 0.0000 1.33
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.28
GTEx Brain Putamen basal ganglia 0 0.0000 1.20
GTEx Breast Mammary Tissue 0 0.0000 1.37
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.27
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.34
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.28
GTEx Cells Transformed fibroblasts 0 0.0000 1.31
GTEx Colon Sigmoid 0 0.0000 1.34
GTEx Colon Transverse 0 0.0000 1.32
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.29
GTEx Esophagus Mucosa 0 0.0000 1.33
GTEx Esophagus Muscularis 0 0.0000 1.31
GTEx Heart Atrial Appendage 0 0.0000 1.35
GTEx Heart Left Ventricle 0 0.0000 1.33
GTEx Liver 0 0.0000 1.20
GTEx Lung 0 0.0000 1.27
GTEx Muscle Skeletal 0 0.0000 1.31
GTEx Nerve Tibial 0 0.0000 1.29
GTEx Ovary 0 0.0000 1.26
GTEx Pancreas 0 0.0000 1.28
GTEx Pituitary 0 0.0000 1.26
GTEx Prostate 0 0.0000 1.33
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.34
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.33
GTEx Small Intestine Terminal Ileum 0 0.0000 1.29
GTEx Spleen 1 0.0709 1.33
GTEx Stomach 0 0.0000 1.30
GTEx Testis 0 0.0000 1.30
GTEx Thyroid 1 0.0250 1.30
GTEx Uterus 1 0.1764 1.18
GTEx Vagina 0 0.0000 1.40
GTEx Whole Blood 0 0.0000 1.33
METSIM Adipose 0 0.0000 1.25
NTR Blood 0 0.0000 1.24
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.36
YFS Blood 1 0.0217 1.29
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.31
TCGA Breast Tumor 0 0.0000 1.30
TCGA Breast Normal 0 0.0000 1.20
TCGA Ovarian Tumor 0 0.0000 1.23
TCGA Prostate Tumor 0 0.0000 1.20