Hub : Traits :

Illnesses of father: None of the above (group 1)

20 significantly associated models · 2 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	9	21303958	22705094	1	1	7.7e-08	2.0e-13	2.2e-07	50	CDKN2B
2	15	90730363	92135418	1	1	5.7e-14	3.9e-10	5.2e-01	99	FES

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Coronary Artery Disease (CAD)	73.87	1	1	2.2	1	CDKN2B
Illnesses of father: Heart disease	48.55	2	2	4.4	1	CDKN2B FES
Angina	48.53	2	2	4.4	1	CDKN2B FES
Angina (self-reported)	48.11	2	2	4.4	1	CDKN2B FES
Heart attack/myocardial infarction (self-reported)	34.76	2	1	2.2	1	CDKN2B FES
Heart attack	34.14	2	1	2.2	1	CDKN2B FES
Eye problems/disorders: Glaucoma	27.73	1	1	2.2	1	CDKN2B
Vascular/heart problems diagnosed by doctor	26.65	2	1	2.2	1	CDKN2B FES
Medication: Aspirin	26.58	2	2	4.4	1	CDKN2B FES
Medication: Aspirin	26.54	2	2	4.4	1	CDKN2B FES
High blood pressure (mother)	23.04	1	1	2.2	1	FES
Hypertension (Self-reported)	22.24	1	1	2.2	1	FES
High blood pressure	21.79	1	1	2.2	1	FES
Medication for cholesterol, blood pressure or diabetes	20.94	1	1	2.2	1	FES
Medication: Blood pressure	20.33	1	1	2.2	1	FES
Glaucoma (self-reported)	20.27	1	1	2.2	1	CDKN2B
Heart disease (mother)	20.26	2	1	2.2	1	CDKN2B FES
Systolic Blood Pressure	20.00	1	1	2.2	1	FES
Illnesses of father: High blood pressure	19.31	1	1	2.2	1	FES
Illnesses of mother	18.23	2	1	2.2	1	CDKN2B FES
Cardiovascular Disease	17.75	1	1	2.2	1	FES
Medication: Cholesterol lowering	17.41	2	1	2.2	1	CDKN2B FES
Medication: Atenolol	16.44	2	1	2.2	1	CDKN2B FES
Systolic blood pressure, automated reading	15.46	1	1	2.2	1	FES
Medication: Blood pressure	15.17	1	1	2.2	1	FES
Diastolic blood pressure, automated reading	14.78	2	1	2.2	1	CDKN2B FES
Birth weight of first child	14.66	1	1	2.2	1	FES
Father's age at death	14.00	2	0	0.0	1	CDKN2B FES
Schizophrenia (2018)	13.64	1	1	2.2	1	FES
Medication: Atorvastatin	13.47	1	1	2.2	1	CDKN2B
Medication: Amlodipine	13.36	1	1	2.2	1	FES
Bipolar Disorder or Schizophrenia	12.62	1	1	2.2	1	FES
Type 2 Diabetes (T2D) (2012)	12.41	1	0	0.0	1	CDKN2B
Schizophrenia (2014)	12.40	1	1	2.2	1	FES
Medication: Simvastatin	12.35	2	0	0.0	1	CDKN2B FES
Breast Cancer	11.23	2	1	2.2	1	CDKN2B FES
Medication: Ramipril	10.46	1	0	0.0	1	FES
Heart disease (siblings)	10.27	2	0	0.0	1	CDKN2B FES
Basal cell carcinoma (self-reported)	9.90	1	0	0.0	1	CDKN2B
Medication for cholesterol	8.91	1	0	0.0	1	FES
High blood pressure (siblings)	8.74	1	0	0.0	1	FES
Pulse wave peak to peak time	8.46	2	0	0.0	1	CDKN2B FES
Number of treatments/medications taken	8.18	1	1	2.2	1	FES
Pulse wave Arterial Stiffness index	8.05	2	0	0.0	1	CDKN2B FES
Illnesses of siblings	7.87	1	0	0.0	1	FES
Birth weight	7.46	1	1	2.2	1	FES
Chest pain or discomfort	7.01	1	0	0.0	1	CDKN2B
Medication: Bendroflumethiazide	6.94	1	0	0.0	1	FES
Medication: Gliclazide	6.67	1	0	0.0	1	CDKN2B
Breast cancer (self-reported)	5.42	1	0	0.0	1	CDKN2B
Cholesterol lowering medication	5.29	1	0	0.0	1	CDKN2B
Medication: Metformin	5.27	1	0	0.0	1	CDKN2B
Number of self-reported non-cancer illnesses	5.27	1	0	0.0	1	FES
Long-standing illness, disability or infirmity	5.17	1	0	0.0	1	CDKN2B
Ovarian Cancer	5.04	1	0	0.0	1	FES
Mineral and other dietary supplements	5.01	1	0	0.0	1	FES
Medication: Lisinopril	4.93	1	0	0.0	1	FES
Risk taking	4.43	1	0	0.0	1	FES
Supplements: Fish oil (including cod liver oil)	4.31	1	0	0.0	1	FES
Ever smoked	4.22	1	0	0.0	1	FES
Sensitivity / hurt feelings	4.10	1	0	0.0	1	FES
Alcohol usually taken with meals	3.91	1	0	0.0	1	FES
Mouth/teeth dental problems	3.52	1	0	0.0	1	CDKN2B
Blood White Count	3.39	2	1	2.2	1	CDKN2B FES
Hair/balding pattern: Pattern 4	3.34	1	0	0.0	1	FES
Smoking Status	3.05	1	0	0.0	1	FES
Type 2 Diabetes (T2D) (2018)	3.00	1	0	0.0	1	CDKN2B
Allergy or Eczema	2.64	1	0	0.0	1	FES
Mean time to correctly identify matches	2.62	1	0	0.0	1	FES
Hand grip strength (left)	2.11	1	0	0.0	1	FES
Impedance of leg (right)	2.06	1	0	0.0	1	FES
Hair Pigment	1.97	2	2	4.4	1	CDKN2B FES
Impedance of leg (left)	1.88	1	0	0.0	1	FES
Comparative height size at age 10	1.67	1	0	0.0	1	FES
Leg predicted mass (right)	1.27	1	0	0.0	1	FES
Leg fat-free mass (right)	1.23	1	0	0.0	1	FES
Impedance of arm (right)	1.20	1	0	0.0	1	CDKN2B
Blood Platelet Count	1.16	1	0	0.0	1	CDKN2B
Leg fat-free mass (left)	1.05	1	0	0.0	1	FES
Leg predicted mass (left)	0.99	1	0	0.0	1	FES
Blood Red Count	0.95	1	0	0.0	1	CDKN2B
Height	0.92	1	1	2.2	1	FES
Standing height	0.53	1	0	0.0	1	FES

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Putamen basal ganglia	0	0.000	1.4
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Adipose Visceral Omentum	1	0.049	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Tibial	1	0.027	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Uterus	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	1	0.024	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	1	0.035	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	1	0.022	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2