Hub : Traits :

Illnesses of father: None of the above (group 1)

20 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 9 21303958 22705094 1 1 7.7e-08 2.0e-13 2.2e-07 50 CDKN2B
2 15 90730363 92135418 1 1 5.7e-14 3.9e-10 5.2e-01 99 FES

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 12.62 1 1 2.2 0 1 FES
Schizophrenia (2018) 13.64 1 1 2.2 0 1 FES
Breast Cancer 11.23 2 1 2.2 0 1 CDKN2B FES
Ovarian Cancer 5.04 1 0 0.0 0 1 FES
Coronary Artery Disease (CAD) 73.87 1 1 2.2 0 1 CDKN2B
Schizophrenia (2014) 12.40 1 1 2.2 0 1 FES
Type 2 Diabetes (T2D) (2012) 12.41 1 0 0.0 0 1 CDKN2B
Blood Platelet Count 1.16 1 0 0.0 0 1 CDKN2B
Blood Red Count 0.95 1 0 0.0 0 1 CDKN2B
Blood White Count 3.39 2 1 2.2 0 1 CDKN2B FES
Height 0.92 1 1 2.2 0 1 FES
Systolic Blood Pressure 20.00 1 1 2.2 0 1 FES
Smoking Status 3.05 1 0 0.0 0 1 FES
Allergy or Eczema 2.64 1 0 0.0 0 1 FES
Cardiovascular Disease 17.75 1 1 2.2 0 1 FES
Type 2 Diabetes (T2D) (2018) 3.00 1 0 0.0 0 1 CDKN2B
Hair Pigment 1.97 2 2 4.4 0 1 CDKN2B FES
Hand grip strength (left) 2.11 1 0 0.0 0 1 FES
Number of treatments/medications taken 8.18 1 1 2.2 0 1 FES
Sensitivity / hurt feelings 4.10 1 0 0.0 0 1 FES
Systolic blood pressure, automated reading 15.46 1 1 2.2 0 1 FES
Angina 48.53 2 2 4.4 0 1 CDKN2B FES
Medication: Metformin 5.27 1 0 0.0 0 1 CDKN2B
Impedance of leg (right) 2.06 1 0 0.0 0 1 FES
Leg fat-free mass (left) 1.05 1 0 0.0 0 1 FES
High blood pressure 21.79 1 1 2.2 0 1 FES
Medication: Atenolol 16.44 2 1 2.2 0 1 CDKN2B FES
High blood pressure (mother) 23.04 1 1 2.2 0 1 FES
Impedance of leg (left) 1.88 1 0 0.0 0 1 FES
Leg predicted mass (left) 0.99 1 0 0.0 0 1 FES
Alcohol usually taken with meals 3.91 1 0 0.0 0 1 FES
Mouth/teeth dental problems 3.52 1 0 0.0 0 1 CDKN2B
Heart attack 34.14 2 1 2.2 0 1 CDKN2B FES
Medication: Ramipril 10.46 1 0 0.0 0 1 FES
Medication: Simvastatin 12.35 2 0 0.0 0 1 CDKN2B FES
Illnesses of siblings 7.87 1 0 0.0 0 1 FES
Impedance of arm (right) 1.20 1 0 0.0 0 1 CDKN2B
Father's age at death 14.00 2 0 0.0 0 1 CDKN2B FES
Medication: Cholesterol lowering 17.41 2 1 2.2 0 1 CDKN2B FES
Illnesses of mother 18.23 2 1 2.2 0 1 CDKN2B FES
Pulse wave Arterial Stiffness index 8.05 2 0 0.0 0 1 CDKN2B FES
Standing height 0.53 1 0 0.0 0 1 FES
Hair/balding pattern: Pattern 4 3.34 1 0 0.0 0 1 FES
Birth weight of first child 14.66 1 1 2.2 0 1 FES
Medication for cholesterol, blood pressure or diabetes 20.94 1 1 2.2 0 1 FES
Glaucoma (self-reported) 20.27 1 1 2.2 0 1 CDKN2B
Medication: Amlodipine 13.36 1 1 2.2 0 1 FES
Birth weight 7.46 1 1 2.2 0 1 FES
High blood pressure (siblings) 8.74 1 0 0.0 0 1 FES
Pulse wave peak to peak time 8.46 2 0 0.0 0 1 CDKN2B FES
Medication: Blood pressure 20.33 1 1 2.2 0 1 FES
Angina (self-reported) 48.11 2 2 4.4 0 1 CDKN2B FES
Mean time to correctly identify matches 2.62 1 0 0.0 0 1 FES
Heart disease (mother) 20.26 2 1 2.2 0 1 CDKN2B FES
Comparative height size at age 10 1.67 1 0 0.0 0 1 FES
Chest pain or discomfort 7.01 1 0 0.0 0 1 CDKN2B
Medication: Aspirin 26.58 2 2 4.4 0 1 CDKN2B FES
Hypertension (Self-reported) 22.24 1 1 2.2 0 1 FES
Illnesses of father: Heart disease 48.55 2 2 4.4 0 1 CDKN2B FES
Leg fat-free mass (right) 1.23 1 0 0.0 0 1 FES
Long-standing illness, disability or infirmity 5.17 1 0 0.0 0 1 CDKN2B
Medication for cholesterol 8.91 1 0 0.0 0 1 FES
Mineral and other dietary supplements 5.01 1 0 0.0 0 1 FES
Breast cancer (self-reported) 5.42 1 0 0.0 0 1 CDKN2B
Medication: Aspirin 26.54 2 2 4.4 0 1 CDKN2B FES
Medication: Gliclazide 6.67 1 0 0.0 0 1 CDKN2B
Leg predicted mass (right) 1.27 1 0 0.0 0 1 FES
Number of self-reported non-cancer illnesses 5.27 1 0 0.0 0 1 FES
Eye problems/disorders: Glaucoma 27.73 1 1 2.2 0 1 CDKN2B
Medication: Blood pressure 15.17 1 1 2.2 0 1 FES
Supplements: Fish oil (including cod liver oil) 4.31 1 0 0.0 0 1 FES
Medication: Bendroflumethiazide 6.94 1 0 0.0 0 1 FES
Medication: Lisinopril 4.93 1 0 0.0 0 1 FES
Medication: Atorvastatin 13.47 1 1 2.2 0 1 CDKN2B
Illnesses of father: High blood pressure 19.31 1 1 2.2 0 1 FES
Ever smoked 4.22 1 0 0.0 0 1 FES
Risk taking 4.43 1 0 0.0 0 1 FES
Diastolic blood pressure, automated reading 14.78 2 1 2.2 0 1 CDKN2B FES
Vascular/heart problems diagnosed by doctor 26.65 2 1 2.2 0 1 CDKN2B FES
Cholesterol lowering medication 5.29 1 0 0.0 0 1 CDKN2B
Basal cell carcinoma (self-reported) 9.90 1 0 0.0 0 1 CDKN2B
Heart attack/myocardial infarction (self-reported) 34.76 2 1 2.2 0 1 CDKN2B FES
Heart disease (siblings) 10.27 2 0 0.0 0 1 CDKN2B FES

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 1 0.049 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 1 0.027 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.4
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.4
GTEx Cells Transformed fibroblasts 1 0.024 1.2
GTEx Colon Sigmoid 0 0.000 1.3
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 1 0.035 1.2
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 1 0.025 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 1 0.022 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 1 0.019 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.3
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2