TWAS hub - CLPTM1L

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Skin Sun Exposed Lower leg	0.0890	0.0350	0.0096	-0.003	NA	-0.003	NA	-0.003	0.9600	NA	0.82	NA	0.700
2	METSIM	Adipose	0.0414	0.0167	0.0056	0.011	0.01	0.001	0.009	0.004	0.0072	0.0096	0.22	0.012	0.069

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Lung cancer (father)	17.1	20.0	36.0	6.0	2.0
Basal cell carcinoma (self-reported)	14.7	17.5	31.2	5.6	1.9
Ever had prostate specific antigen (PSA) test	12.2	14.1	24.0	4.9	2.0
Depression (self-reported)	9.5	11.4	11.4	3.4	3.4
Prostate Cancer	9.0	12.7	13.7	3.4	3.7
Alcohol drinker status: Never	4.0	4.8	9.0	-3.0	-0.7
Medication: Atorvastatin	3.7	4.5	7.9	-2.8	-1.1
Number of children fathered	3.6	4.1	5.2	-1.7	-2.3
Breast cancer (self-reported)	3.5	4.2	5.7	-2.4	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.4	8.1	0.8	2.8
Diabetes diagnosed by doctor	3.2	5.3	9.8	-0.9	-3.1
Allergy or Eczema	3.0	7.8	8.5	2.7	2.9
Hearing difficulty/problems: Yes	2.9	4.4	5.0	2.2	2.0
Number of live births	2.9	4.1	8.2	2.9	0.3
Tinnitus: Yes, now most or all of the time	2.7	3.1	5.7	0.8	2.4
Average weekly fortified wine intake	2.6	3.0	6.0	-0.2	2.4
High blood pressure (siblings)	2.5	3.6	6.4	-2.5	0.9
Forced vital capacity (FVC), Best measure	2.4	8.7	14.0	3.7	1.8
Diabetes (mother)	2.2	2.8	4.1	1.2	2.0
High blood pressure	2.1	5.8	10.7	-3.3	-0.9
Diabetes (self-reported)	2.1	3.2	5.8	-0.8	-2.4
Medication: Amlodipine	2.1	2.9	4.8	-2.2	-1.0
Medication: Ventolin 100micrograms inhaler	2.1	2.7	4.6	-2.1	-0.9
Osteoarthritis (self-reported)	2.1	2.7	5.5	-0.1	2.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	11.5	3.4	1.1
Hypertension (Self-reported)	2.0	5.7	11.1	-3.3	-0.5
Illnesses of father: Heart disease	2.0	2.8	4.0	-1.3	-2.0
Medication: Lisinopril	2.0	2.5	4.2	-2.0	-1.0
High blood pressure (mother)	1.9	2.7	3.4	1.4	1.8
Medication: Blood pressure	1.9	3.4	5.1	-2.2	-1.3
Number of self-reported non-cancer illnesses	1.9	3.2	6.2	-2.5	-0.5
Fractured/broken bones in last 5 years	1.9	2.5	4.4	-2.1	0.8
Heart disease (siblings)	1.9	2.4	4.7	2.2	-0.0
Hayfever, allergic rhinitis or eczema	1.8	3.8	4.3	2.1	1.8
Impedance of leg (left)	1.8	8.6	13.8	3.7	1.8
Age at last live birth	1.7	2.5	3.2	1.8	-1.4
Vascular/heart problems diagnosed by doctor	1.7	4.6	8.1	2.8	1.0
Medication: Metformin	1.6	2.3	3.0	-1.3	-1.7
Diabetes (father)	1.6	2.0	3.5	-1.9	-0.8
Severe depression (siblings)	1.6	1.7	2.7	1.6	0.9
Pain all over the body in last month	1.6	1.8	2.8	0.9	1.7
Number of full sisters	1.6	1.9	2.1	1.3	1.4
Knee pain experienced in last month	1.6	2.5	4.9	-0.3	-2.2
Alzheimer’s Disease (in father)	1.5	1.6	2.6	1.6	0.8
Respiratory disease	1.5	3.2	4.3	-1.5	-2.1
Impedance of leg (right)	1.5	7.1	9.4	3.1	2.2
Stomach or abdominal pain in last month	1.5	1.9	3.7	-1.9	-0.3
Falls in the last year	1.5	2.0	2.7	-1.6	1.1
Myopia	1.5	2.1	3.9	2.0	0.6
Supplements: Calcium	1.5	1.7	1.9	-1.4	-1.2
Number of treatments/medications taken	1.4	2.4	4.5	-2.1	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	3.6	-0.3	1.9
Birth weight of first child	1.4	2.5	3.1	1.8	1.4
Glaucoma (self-reported)	1.4	1.7	3.3	-0.0	1.8
Emphysema/chronic bronchitis	1.4	1.5	2.8	-1.7	-0.6
Medication: Omeprazole	1.4	1.6	3.3	-0.0	-1.8
Eye problems/disorders: Glaucoma	1.4	1.7	3.3	0.3	1.8
Age started oral contraceptive pill	1.4	1.8	3.4	0.3	1.9
Diastolic blood pressure, automated reading	1.4	4.3	8.3	-2.9	0.5
Cardiovascular Disease	1.3	4.3	8.3	-2.9	-0.6
Body mass index (BMI)	1.3	5.5	10.4	-3.2	-0.8
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	4.1	-2.0	0.3
Illnesses of mother	1.3	1.6	3.1	-0.4	-1.8
Wheeze or whistling in the chest in last year	1.3	2.4	3.9	-2.0	-0.9
Shortness of breath walking on level ground	1.3	1.5	2.7	-0.5	-1.7
Mineral and other dietary supplements	1.3	1.8	3.5	1.9	-0.3
Ever taken oral contraceptive pill	1.3	1.4	2.7	0.4	1.6
Ulcerative Colitis	1.2	1.8	3.3	-0.6	-1.8
Systolic Blood Pressure	1.2	6.0	11.5	-3.4	-0.7
Lung FVC	1.2	6.3	12.5	3.5	-0.3
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	1.9	-1.0	-1.4
Forced vital capacity (FVC)	1.2	4.8	9.3	3.1	0.5
Overall health rating	1.2	2.5	4.4	-2.1	-0.8
Mouth/teeth dental problems: Mouth ulcers	1.2	1.8	2.4	-1.6	-1.1
Miserableness	1.2	2.0	2.9	1.1	1.7
Wears glasses or contact lenses	1.2	1.3	1.8	1.3	0.9
Depression (Nagel 2018)	1.1	1.7	3.2	0.5	1.8
Ulcerative Colitis (UC)	1.1	2.1	4.0	-0.5	-2.0
Lupus	1.1	1.7	3.1	-0.4	1.8
Type 2 Diabetes (T2D) (2018)	1.1	2.0	3.6	0.6	-1.9
Systolic blood pressure, automated reading	1.1	3.1	6.2	-2.5	0.0
Past tobacco smoking	1.1	2.0	2.3	-1.5	-1.3
Forced expiratory volume in 1-second (FEV1)	1.1	3.7	7.4	2.7	0.0
Medication: Gliclazide	1.1	1.2	2.3	-1.5	0.2
Illnesses of father: None of the above (group 1)	1.1	1.4	1.6	1.3	1.1
Medication: Omeprazole (e.g. Zanprol)	1.1	1.4	2.8	-0.0	-1.7
Impedance of whole body	1.1	5.8	10.4	3.2	1.1
Alzheimer’s Disease (in mother)	1.0	1.1	1.8	-1.3	0.7
Mean Putamen Volume	1.0	1.1	1.3	-1.2	-1.0
Fasting Glucose	1.0	1.3	2.5	0.0	1.6
HbA1C	1.0	1.1	1.6	1.3	0.7
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	2.2	-1.5	-0.1
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	1.3	-1.0	-1.2
Multivitamins +/- minerals	1.0	1.3	2.6	-0.2	1.6
Waist circumference	1.0	3.7	7.3	-2.7	-0.4
Asthma	1.0	1.9	2.1	-1.5	-1.3
Peak expiratory flow (PEF)	1.0	2.3	4.1	2.0	0.7
Medication for cholesterol, blood pressure or diabetes	1.0	1.7	2.8	1.7	0.8
Illness, injury, bereavement, stress in last 2 years	1.0	1.2	2.3	0.4	1.5
Commuting to job workplace: Walk	1.0	1.1	2.0	-1.4	0.5
Average weekly spirits intake	0.9	1.1	2.1	-1.4	0.2
Qualifications: CSEs or equivalent	0.9	1.2	2.3	-0.4	1.5
Breastfed as a baby	0.9	1.1	1.6	-0.8	1.3
Health satisfaction	0.9	1.2	2.2	-1.5	-0.3
Ovarian Cancer	0.8	1.1	1.1	-1.0	1.1
Primary Biliary Cirrhosis	0.8	1.2	1.2	1.1	1.1
Blood Eosinophil Count	0.8	6.5	12.8	-3.6	-0.4
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.6	-1.3	-0.6
Father’s age at death	0.8	1.0	2.0	-1.4	0.2
Mouth/teeth dental problems: Dentures	0.8	1.4	2.7	0.2	1.6
Length of working week for main job	0.8	0.9	1.6	-1.3	0.3
Family relationship satisfaction	0.8	1.0	1.4	1.2	0.7
Average weekly red wine intake	0.8	1.1	2.0	-0.4	-1.4
Ever had bowel cancer screening	0.8	1.0	1.4	0.7	-1.2
Medication: Aspirin	0.8	1.1	2.0	-1.4	-0.3
Supplements: Fish oil (including cod liver oil)	0.8	1.1	1.9	-1.4	0.5
High cholesterol (Self-reported)	0.8	1.4	2.7	-1.6	-0.3
HDL Cholesterol	0.7	1.2	2.4	0.1	1.5
Leg fat-free mass (left)	0.7	3.9	7.5	-2.7	-0.5
Relative age voice broke	0.7	1.1	2.2	1.5	-0.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	3.2	1.8	0.4
Leg predicted mass (left)	0.7	3.9	7.5	-2.7	-0.5
Weight	0.7	3.5	7.0	-2.6	-0.2
Impedance of arm (right)	0.7	3.3	6.1	2.5	0.7
Alcohol intake versus 10 years previously	0.7	1.0	2.0	0.1	-1.4
Impedance of arm (left)	0.7	3.2	6.2	2.5	0.5
Number of full brothers	0.7	0.8	1.0	1.0	-0.8
Mean time to correctly identify matches	0.7	1.4	2.7	0.3	-1.6
Medication: Aspirin	0.7	0.9	1.6	-1.3	-0.5
Loneliness, isolation	0.7	0.9	1.5	-0.6	1.2
Ever smoked	0.7	1.2	1.4	1.0	1.2
Leg fat mass (left)	0.7	2.7	5.3	-2.3	-0.2
Body Mass Index (BMI) (2010)	0.6	0.8	1.1	-1.0	-0.8
BMI	0.6	3.4	5.0	-2.2	-1.4
Relative age of first facial hair	0.6	1.2	2.2	1.5	0.5
Vitamin and mineral supplements	0.6	0.9	1.0	1.0	-0.8
Medication: Co-codamol	0.6	0.7	1.3	0.3	1.1
Current tobacco smoking	0.6	1.0	1.3	0.8	-1.1
Hearing difficulty/problems with background noise	0.6	1.0	1.2	1.1	0.9
Illnesses of siblings	0.6	0.8	1.5	1.2	0.2
Medication: Cholesterol lowering	0.6	0.9	1.0	-1.0	-0.9
Arm fat mass (right)	0.6	2.4	4.8	-2.2	-0.2
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.3	-1.2	-0.5
Gout (self-reported)	0.6	0.9	1.7	-1.3	0.3
Qualifications: College or University degree	0.6	1.8	3.6	-1.9	0.2
Neck or shoulder pain in last month	0.6	0.8	0.9	-0.9	-0.9
Leg fat mass (right)	0.6	2.5	4.9	-2.2	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.1	2.2	-0.4	1.5
Leg fat-free mass (right)	0.6	3.2	5.9	-2.4	-0.8
Friendships satisfaction	0.6	0.7	1.4	1.2	-0.1
Asthma (self-reported)	0.6	1.3	1.4	-1.2	-1.1
Osteoporosis (self-reported)	0.6	0.7	1.4	-0.1	-1.2
Leg predicted mass (right)	0.6	3.4	6.2	-2.5	-0.8
Arm fat mass (left)	0.6	2.5	5.1	-2.2	0.1
Medication: Blood pressure	0.6	1.1	1.1	-1.1	1.0
Illnesses of father: High blood pressure	0.6	0.7	0.8	-0.9	0.8
Average weekly beer plus cider intake	0.6	0.9	1.6	-0.3	-1.3
Worry (Nagel 2018)	0.5	1.0	1.9	1.4	-0.3
Alzheimer’s Disease (including proxy)	0.5	0.8	1.3	-1.1	0.5
Blood Platelet Count	0.5	6.1	8.4	2.0	2.9
Blood White Count	0.5	3.9	5.9	1.4	2.4
Neuroticism	0.5	1.2	1.4	1.2	-1.0
Tanning	0.5	5.7	6.0	2.5	2.3
Ever used hormone-replacement therapy (HRT)	0.5	0.7	1.1	1.0	-0.5
Supplements: Zinc	0.5	0.5	1.1	-0.1	-1.0
Taking other prescription medications	0.5	0.8	1.3	-1.2	-0.6
Arm fat percentage (right)	0.5	1.9	3.7	-1.9	-0.1
Hip circumference	0.5	2.1	4.2	-2.0	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.1	-0.2	-1.0
Medication: Allopurinol	0.5	0.7	1.0	-1.0	-0.6
Pulse rate, automated reading	0.5	1.5	2.5	-0.7	-1.6
Arm fat percentage (left)	0.5	2.1	4.0	-2.0	-0.4
Long-standing illness, disability or infirmity	0.5	0.8	1.3	-1.2	0.5
Qualifications: nursing, teaching	0.5	0.8	1.4	-0.4	1.2
Smoking status: Current	0.5	0.8	0.8	0.8	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	1.8	1.4	-0.7
Whole body water mass	0.5	2.6	5.1	-2.3	0.2
Pain type(s) experienced in last month: Hip pain	0.5	0.6	0.9	0.6	0.9
Medication: Bendroflumethiazide	0.5	0.8	1.5	-1.2	-0.1
Basal metabolic rate	0.5	3.0	5.9	-2.4	0.2
Irritability	0.5	0.8	1.1	1.0	0.7
Breast Cancer	0.4	1.1	1.6	0.7	1.3
Schizophrenia (2014)	0.4	0.8	1.0	1.0	-0.7
Angina	0.4	0.5	0.8	-0.5	-0.9
Financial difficulties in last 2 years	0.4	0.6	0.8	0.6	-0.9
Trunk fat-free mass	0.4	2.4	4.4	-2.1	0.6
Hair/balding pattern: Pattern 3	0.4	0.6	0.7	0.9	-0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	0.8	-0.9	-0.5
Medication: Lansoprazole	0.4	0.4	0.5	-0.6	0.7
Trunk predicted mass	0.4	2.5	4.6	-2.1	0.6
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.9	0.3	1.0
Loud music exposure frequency	0.4	0.5	0.6	0.6	0.7
Headache pain in last month	0.4	0.6	1.1	-0.4	-1.0
Leg fat percentage (right)	0.4	1.3	2.5	-1.6	0.4
Arm fat-free mass (right)	0.4	1.9	3.7	-1.9	0.2
Exposure to tobacco smoke outside home	0.4	0.5	0.5	-0.7	-0.7
Age at first live birth	0.4	0.6	1.3	-0.0	-1.1
Angina (self-reported)	0.4	0.5	0.7	-0.4	-0.9
Migraine (self-reported)	0.4	0.6	0.6	0.7	-0.8
Heart disease (mother)	0.4	0.5	0.9	-1.0	0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	0.7	-0.8	-0.6
Had major operations	0.4	0.4	0.8	-0.2	-0.9
Supplements: Vitamin C	0.4	0.5	1.0	-1.0	0.1
Smoking status: Previous	0.4	0.6	0.9	0.6	0.9
Whole body fat-free mass	0.4	2.6	5.1	-2.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	1.0	0.0
Medication for cholesterol	0.4	0.6	0.8	0.7	-0.9
Arm fat-free mass (left)	0.4	2.1	3.8	-1.9	0.6
Number of operations (self-reported)	0.4	0.6	1.2	1.1	-0.0
Cholesterol lowering medication	0.4	0.5	0.8	-0.9	0.5
Arm predicted mass (left)	0.4	2.2	4.0	-2.0	0.6
Bipolar Disorder or Schizophrenia	0.3	0.7	0.8	0.9	-0.7
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.4	0.8
Irritable Bowel Disease (IBD)	0.3	0.8	1.5	-0.1	-1.2
Reaction Time	0.3	0.6	0.9	0.5	-0.9
Coronary Artery Disease (CAD)	0.3	0.4	0.7	-0.8	0.3
Crohns Disease (2012)	0.3	0.4	0.8	-0.0	0.9
LDL Cholesterol	0.3	0.5	0.7	-0.5	-0.8
Rheumatoid Arthritis	0.3	0.4	0.8	0.2	-0.9
Heel T-Score	0.3	2.5	5.1	-2.2	-0.0
Hypothyroidism (self reported)	0.3	0.6	0.7	-0.8	0.7
Hair Pigment	0.3	8.9	16.6	-4.1	-1.1
Ever had hysterectomy (womb removed)	0.3	0.3	0.4	-0.6	-0.5
Townsend deprivation index at recruitment	0.3	0.4	0.7	-0.3	-0.9
Maternal smoking around birth	0.3	0.4	0.4	0.7	-0.6
Age when periods started (menarche)	0.3	0.6	1.2	-0.3	1.1
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	0.4	0.7	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	0.0	1.0
Qualifications: None of the above	0.3	0.7	1.0	1.0	-0.7
Mouth/teeth dental problems	0.3	0.5	1.0	1.0	-0.1
Worrier / anxious feelings	0.3	0.6	0.7	0.8	-0.8
Pulse rate	0.3	0.5	0.9	-0.3	-0.9
Noisy workplace	0.3	0.4	0.8	0.1	-0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.5	0.7	-0.2
Prospective memory result	0.3	0.3	0.6	-0.8	0.2
Pulse wave Arterial Stiffness index	0.3	0.4	0.5	-0.5	0.7
Pulse wave peak to peak time	0.3	0.3	0.5	0.4	-0.7
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.5	-0.7	-0.3
Medication for pain relief, constipation, heartburn	0.3	0.5	0.9	1.0	0.4
Whole body fat mass	0.3	1.3	2.6	-1.6	0.2
Arm predicted mass (right)	0.3	1.3	2.6	-1.6	0.3
Leg pain on walking	0.3	0.4	0.7	-0.9	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.5	0.5	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.5	-0.7	-0.5
Financial situation satisfaction	0.3	0.4	0.8	-0.9	-0.1
Leg fat percentage (left)	0.3	0.9	1.8	-1.4	0.2
Commuting to job workplace: Cycle	0.3	0.3	0.5	0.7	-0.4
Depressed Affect (Nagel 2018)	0.2	0.5	0.7	0.6	0.8
Neuroticism (Nagel 2018)	0.2	0.4	0.8	0.9	0.2
Schizophrenia (2018)	0.2	0.5	0.6	0.6	-0.8
Crohns Disease (2017)	0.2	0.5	0.8	0.5	0.9
Verbal and Numeric Reasoning (VNR)	0.2	0.4	0.6	0.5	-0.8
Blood Red Count	0.2	2.1	2.9	-1.7	-1.1
Waist Hip Ratio (WHR)	0.2	0.8	1.5	-1.2	-0.3
Smoking Status	0.2	0.4	0.6	0.8	-0.6
Lung FEV1/FVC ratio	0.2	0.9	1.8	-0.0	-1.3
Serious illness, injury or assault to yourself	0.2	0.3	0.3	-0.5	-0.6
Supplements: Glucosamine	0.2	0.2	0.5	-0.7	0.0
Medication: Levothyroxine sodium	0.2	0.3	0.4	-0.4	0.7
Sitting height	0.2	1.5	3.0	-0.1	1.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	-0.6	0.3
Trunk fat mass	0.2	0.9	1.8	-1.3	0.1
Alcohol usually taken with meals	0.2	0.4	0.7	0.8	0.2
Hair/balding pattern: Pattern 2	0.2	0.3	0.5	-0.7	0.3
Had menopause	0.2	0.3	0.5	0.1	-0.7
Had other major operations	0.2	0.2	0.3	0.4	0.5
Allergy	0.2	0.4	0.6	-0.8	-0.5
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.6	0.8	0.1
Fluid intelligence score	0.2	0.4	0.7	0.8	-0.3
Time employed in main current job	0.2	0.2	0.3	-0.3	-0.5
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.8	-0.9	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	0.6	-0.1	0.8
Hair/balding pattern: Pattern 4	0.2	0.5	1.1	0.0	1.0
Pulse wave reflection index	0.2	0.3	0.6	0.8	0.2
Birth weight	0.2	0.5	0.8	0.9	-0.5
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	0.6	-0.0
Body fat percentage	0.2	0.8	1.6	-1.3	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.3	-0.3	-0.5
Suffer from ‘nerves’	0.2	0.3	0.4	0.6	-0.5
Commuting to job workplace: Car/motor vehicle	0.2	0.2	0.4	-0.7	0.2
Average weekly champagne plus white wine intake	0.2	0.3	0.4	-0.4	0.6
Risk taking	0.2	0.3	0.7	-0.2	0.8
Unable to work because of sickness or disability	0.2	0.3	0.6	-0.8	-0.2
Alcohol drinker status: Previous	0.2	0.3	0.3	0.5	0.5
Bipolar Disorder (2018)	0.1	0.2	0.4	0.6	0.2
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.3	-0.5
Chronotype (morning person)	0.1	0.3	0.3	0.5	-0.5
Hand grip strength (left)	0.1	0.2	0.3	-0.5	-0.3
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.3	-0.3	0.5
Medication for hormone replacement therapy	0.1	0.1	0.2	-0.3	0.4
Pack years adult smoking proportion	0.1	0.1	0.1	0.3	-0.2
Trunk fat percentage	0.1	0.3	0.6	-0.8	0.0
Hand grip strength (right)	0.1	0.1	0.3	-0.2	-0.5
Fed-up feelings	0.1	0.2	0.2	-0.4	-0.4
Medication: Atenolol	0.1	0.2	0.3	0.6	0.2
Number of incorrect matches in round	0.1	0.2	0.4	0.6	-0.1
Nervous feelings	0.1	0.2	0.4	0.6	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.4	0.5	0.6
Medication: Ramipril	0.1	0.1	0.2	-0.2	-0.4
Neuroticism score	0.1	0.1	0.2	0.3	-0.4
Standing height	0.1	1.4	2.1	0.9	1.5
Exposure to tobacco smoke at home	0.1	0.1	0.3	-0.1	-0.5
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.2	-0.5	0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.1	0.2	-0.3	0.4
Worry too long after embarrassment	0.1	0.2	0.4	0.1	-0.6
Eye problems/disorders: None of the above	0.1	0.1	0.3	0.5	-0.1
Alcohol intake frequency.	0.1	0.2	0.4	0.0	0.6
Comparative height size at age 10	0.1	0.8	0.9	0.9	0.9
Chest pain or discomfort	0.1	0.1	0.1	-0.4	-0.2
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.4	0.2
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.4	0.2
Eye problems/disorders: Cataract	0.1	0.1	0.1	0.4	-0.3
Back pain experienced in last month	0.1	0.1	0.1	0.3	0.3
Guilty feelings	0.1	0.2	0.4	0.6	-0.0
Mother’s age at death	0.1	0.2	0.2	-0.4	0.5
Medication: Paracetamol	0.1	0.1	0.2	-0.3	-0.5
Ever depressed for a whole week	0.1	0.1	0.1	-0.3	-0.3
Pain experienced in last month	0.1	0.1	0.3	0.1	-0.5
Pack years of smoking	0.1	0.2	0.3	0.6	0.1
Intelligence (Savage-Jansen 2018)	0.0	0.0	0.0	-0.1	0.0
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.0	0.1	0.1	-0.3
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.0	0.0	0.0	-0.1
Triglycerides	0.0	0.0	0.0	0.1	-0.1
Height	0.0	0.1	0.1	-0.2	0.3
Sensitivity / hurt feelings	0.0	0.1	0.1	-0.2	-0.3
Ever unenthusiastic/disinterested for a whole week	0.0	0.0	0.1	0.2	-0.2
Heart attack	0.0	0.0	0.0	0.1	0.0
Medication: Simvastatin	0.0	0.0	0.0	0.2	0.1
Happiness	0.0	0.0	0.0	-0.2	-0.2
Tense / ‘highly strung’	0.0	0.0	0.1	-0.1	0.3
Blood clot in the leg (DVT)	0.0	0.0	0.0	0.2	0.2
Medication: Paracetamol	0.0	0.1	0.1	-0.4	0.2
Comparative body size at age 10	0.0	0.1	0.2	-0.1	-0.5
Medication: Ibuprofen	0.0	0.0	0.0	0.0	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.1	0.1	-0.1	0.3
Mood swings	0.0	0.0	0.0	0.0	0.2
Hearing aid user	0.0	0.0	0.1	-0.3	-0.1
Commuting to job workplace: Public transport	0.0	0.0	0.1	-0.3	0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	-0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	0.1	0.1

Hub : Genes

CLPTM1L

Models

Trait associations