Hub : Traits :

Chronic bronchitis/emphysema (mother)

6 significantly associated models · 5 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 15 78032707 79886142 5 2 1.7e-10 3.9e-10 0.12 94 PSMA4 RNU6-415P

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Alzheimer’s Disease (including proxy) 3.10 1 0 0.0 0 1 RNU6-415P
HbA1C 4.95 1 0 0.0 0 1 RNU6-415P
Schizophrenia 7.44 1 1 3.0 0 1 PSMA4
Blood Platelet Count 0.67 1 0 0.0 0 1 RNU6-415P
Blood Red Count 0.85 2 0 0.0 0 1 PSMA4 RNU6-415P
Blood White Count 0.66 1 0 0.0 0 1 PSMA4
Allergy or Eczema 3.86 1 0 0.0 0 1 PSMA4
Cardiovascular Disease 1.97 1 0 0.0 0 1 RNU6-415P
Lung FEV1/FVC ratio 3.41 1 1 3.0 0 1 PSMA4
Lung FVC 3.98 1 1 3.0 0 1 PSMA4
Angina 9.32 1 0 0.0 0 1 RNU6-415P
Vitamin and mineral supplements 6.34 2 0 0.0 0 1 PSMA4 RNU6-415P
Pack years adult smoking proportion 149.61 2 2 6.1 0 1 PSMA4 RNU6-415P
Current tobacco smoking 5.08 1 0 0.0 0 1 PSMA4
Maternal smoking around birth 13.73 2 0 0.0 0 1 PSMA4 RNU6-415P
Frequency of unenthusiasm / disinterest in last 2 weeks 2.82 1 0 0.0 0 1 PSMA4
Age when periods started (menarche) 4.11 2 0 0.0 0 1 PSMA4 RNU6-415P
Qualifications: CSEs or equivalent 6.78 2 0 0.0 0 1 PSMA4 RNU6-415P
Hayfever, allergic rhinitis or eczema 3.78 1 0 0.0 0 1 PSMA4
Multivitamins +/- minerals 7.98 2 0 0.0 0 1 PSMA4 RNU6-415P
Chronic bronchitis/emphysema (father) 34.71 2 2 6.1 0 1 PSMA4 RNU6-415P
Forced vital capacity (FVC) 3.66 1 1 3.0 0 1 PSMA4
Hayfever/allergic rhinitis (self-reported) 4.34 1 0 0.0 0 1 PSMA4
Father's age at death 17.58 1 1 3.0 0 1 PSMA4
Number of live births 3.66 1 0 0.0 0 1 PSMA4
Forced expiratory volume in 1-second (FEV1) 7.14 1 1 3.0 0 1 PSMA4
Mouth/teeth dental problems: Dentures 11.09 2 0 0.0 0 1 PSMA4 RNU6-415P
Lung cancer (father) 41.34 2 2 6.1 0 1 PSMA4 RNU6-415P
Forced expiratory volume in 1-second (FEV1), Best measure 8.23 2 1 3.0 0 1 PSMA4 RNU6-415P
Exposure to tobacco smoke at home 5.04 1 0 0.0 0 1 PSMA4
Peak expiratory flow (PEF) 3.37 1 0 0.0 0 1 PSMA4
Birth weight 2.74 1 0 0.0 0 1 PSMA4
Forced vital capacity (FVC), Best measure 4.41 2 0 0.0 0 1 PSMA4 RNU6-415P
Comparative body size at age 10 3.09 2 0 0.0 0 1 PSMA4 RNU6-415P
Wheeze or whistling in the chest in last year 4.45 1 0 0.0 0 1 PSMA4
Mouth/teeth dental problems: Loose teeth 4.46 1 0 0.0 0 1 PSMA4
Emphysema/chronic bronchitis 9.90 1 0 0.0 0 1 PSMA4
Medication: Blood pressure 2.58 1 0 0.0 0 1 RNU6-415P
Angina (self-reported) 8.94 1 0 0.0 0 1 RNU6-415P
Heart disease (mother) 12.07 2 0 0.0 0 1 PSMA4 RNU6-415P
Alcohol intake frequency. 3.06 1 0 0.0 0 1 PSMA4
Overall health rating 6.23 2 0 0.0 0 1 PSMA4 RNU6-415P
Qualifications: NVQ or HND or HNC or equivalent 4.60 1 0 0.0 0 1 RNU6-415P
Knee pain experienced in last month 3.65 1 0 0.0 0 1 PSMA4
Illnesses of father: Heart disease 6.98 1 0 0.0 0 1 RNU6-415P
Smoking status: Previous 3.81 1 0 0.0 0 1 PSMA4
Average weekly red wine intake 3.21 1 0 0.0 0 1 PSMA4
Long-standing illness, disability or infirmity 2.89 1 0 0.0 0 1 PSMA4
Commuting to job workplace: Walk 3.58 1 0 0.0 0 1 PSMA4
Forced expiratory volume in 1-second (FEV1), predicted percentage 22.67 2 2 6.1 0 1 PSMA4 RNU6-415P
Average weekly champagne plus white wine intake 4.24 1 0 0.0 0 1 PSMA4
Mother's age at death 6.59 1 0 0.0 0 1 PSMA4
Medication: Bendroflumethiazide 4.30 1 0 0.0 0 1 RNU6-415P
Ever smoked 5.09 1 0 0.0 0 1 PSMA4
Risk taking 7.95 1 0 0.0 0 1 PSMA4
Unable to work because of sickness or disability 8.00 2 0 0.0 0 1 PSMA4 RNU6-415P
Pack years of smoking 138.13 2 2 6.1 0 1 PSMA4 RNU6-415P

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.20
GTEx Adipose Visceral Omentum 0 0.0000 1.17
GTEx Adrenal Gland 0 0.0000 1.11
GTEx Artery Aorta 0 0.0000 1.17
GTEx Artery Coronary 0 0.0000 1.17
GTEx Artery Tibial 0 0.0000 1.15
GTEx Brain Caudate basal ganglia 0 0.0000 1.14
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.18
GTEx Brain Cerebellum 0 0.0000 1.23
GTEx Brain Cortex 0 0.0000 1.21
GTEx Brain Frontal Cortex BA9 0 0.0000 1.24
GTEx Brain Hippocampus 0 0.0000 1.11
GTEx Brain Hypothalamus 0 0.0000 1.27
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.22
GTEx Brain Putamen basal ganglia 0 0.0000 1.19
GTEx Breast Mammary Tissue 0 0.0000 1.17
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.20
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.13
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.19
GTEx Cells Transformed fibroblasts 0 0.0000 1.18
GTEx Colon Sigmoid 0 0.0000 1.19
GTEx Colon Transverse 0 0.0000 1.20
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.29
GTEx Esophagus Mucosa 0 0.0000 1.18
GTEx Esophagus Muscularis 0 0.0000 1.17
GTEx Heart Atrial Appendage 0 0.0000 1.18
GTEx Heart Left Ventricle 0 0.0000 1.17
GTEx Liver 1 0.1395 1.20
GTEx Lung 0 0.0000 1.18
GTEx Muscle Skeletal 0 0.0000 1.21
GTEx Nerve Tibial 0 0.0000 1.20
GTEx Ovary 0 0.0000 1.23
GTEx Pancreas 0 0.0000 1.15
GTEx Pituitary 0 0.0000 1.26
GTEx Prostate 0 0.0000 1.12
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.25
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.21
GTEx Small Intestine Terminal Ileum 0 0.0000 1.13
GTEx Spleen 0 0.0000 1.24
GTEx Stomach 0 0.0000 1.18
GTEx Testis 1 0.0317 1.16
GTEx Thyroid 0 0.0000 1.18
GTEx Uterus 0 0.0000 1.31
GTEx Vagina 0 0.0000 1.26
GTEx Whole Blood 0 0.0000 1.17
METSIM Adipose 0 0.0000 1.14
NTR Blood 0 0.0000 1.16
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.13
YFS Blood 2 0.0433 1.13
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.12
TCGA Breast Tumor 0 0.0000 1.21
TCGA Breast Normal 0 0.0000 1.12
TCGA Ovarian Tumor 1 0.0342 1.20
TCGA Prostate Tumor 1 0.0289 1.17