Hub : Genes

SLC24A3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1401 0.0446 0.00190 0.024 NA -0.003 NA 0.004 5.0e-03 NA 0.6300 NA 0.14000
2 GTEx Whole Blood 0.1310 0.0480 0.00620 0.059 NA 0.023 NA 0.030 4.1e-06 NA 0.0031 NA 0.00082
3 NTR Blood 0.0228 0.0091 0.00370 0.002 0.005 0.000 0.004 0.000 5.3e-02 0.00730 0.2600 0.012 0.24000
4 TCGA Kidney Renal Clear Cell Carcinoma 0.0705 0.0334 0.00830 0.000 0.004 -0.002 NA -0.002 3.5e-01 0.10000 0.8800 NA 0.68000
5 TCGA Thyroid Carcinoma 0.0650 0.0240 0.00029 0.042 0.028 0.022 NA 0.029 5.7e-05 0.00091 0.0026 NA 0.00080

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.4 0.7 2.9 1.7 -0.3 -0.6 -0.1 0.4
Bipolar Disorder or Schizophrenia 0.1 0.2 1.1 1.0 -0.1 0.3 0.2 -0.1
Depressed Affect (Nagel 2018) 0.4 0.8 2.6 -1.6 0.1 -0.3 -1.2 0.3
Depression (Nagel 2018) 0.4 0.7 1.7 0.1 0.5 1.3 -0.5 -1.0
Intelligence (Savage-Jansen 2018) 1.1 3.4 8.9 -1.0 -0.8 -1.7 -3.0 2.0
Neuroticism (Nagel 2018) 0.4 1.0 3.2 -1.2 -0.0 -1.8 -0.1 0.7
Schizophrenia (2018) 0.1 0.2 0.8 -0.0 0.0 0.9 0.3 -0.5
Schizophrenia vs Biploar Disorder 0.7 1.0 2.9 -1.7 0.6 -0.7 1.0 0.1
Worry (Nagel 2018) 0.5 1.0 3.6 -0.1 -1.1 -1.9 -0.1 0.4
Alzheimer’s Disease (in mother) 0.4 0.4 1.8 0.3 -0.5 -0.2 1.4 -0.0
Alzheimer’s Disease (in father) 0.4 0.5 1.5 -0.5 -1.2 0.3 0.0 0.7
Alzheimer’s Disease (including proxy) 0.3 0.4 1.0 0.2 -0.8 0.4 1.0 -0.4
Crohns Disease (2017) 0.1 0.2 0.7 -0.0 -0.0 -0.0 0.5 0.8
Irritable Bowel Disease (IBD) 0.2 0.5 1.9 -0.4 0.1 -0.4 -0.2 1.4
Ulcerative Colitis (UC) 0.4 0.7 2.6 -0.3 -0.0 -0.5 -0.6 1.6
Major Depression (MDD) 1.4 1.7 2.9 -0.6 1.6 -1.4 0.7 1.7
Reaction Time 0.4 0.7 2.2 0.3 -1.5 -0.9 0.6 0.3
Verbal and Numeric Reasoning (VNR) 1.4 3.3 12.0 -1.7 -0.7 -0.3 -3.5 1.0
Breast Cancer 1.1 2.6 5.0 1.0 2.2 2.2 1.3 -0.8
Ovarian Cancer 2.0 2.7 5.4 1.1 0.6 2.3 2.0 -1.5
Prostate Cancer 0.3 0.4 0.6 0.5 -0.6 -0.8 0.7 0.8
Age at First Birth 0.6 0.9 3.5 0.0 -0.0 -1.0 -0.4 -1.9
Bipolar Disorder (2011) 0.4 0.4 1.0 1.0 0.4 0.1 -0.7 0.6
Body Mass Index (BMI) (2010) 1.2 1.7 5.0 -2.2 0.5 -0.6 -1.6 0.5
Coronary Artery Disease (CAD) 0.9 1.1 2.4 0.9 -0.7 1.5 0.2 -1.2
Crohns Disease (2012) 0.2 0.4 0.7 -0.3 -0.9 0.5 0.7 -0.5
Mean Putamen Volume 0.2 0.2 0.4 -0.2 -0.0 0.4 0.6 0.7
Fasting Glucose 0.1 0.1 0.3 -0.3 0.3 0.1 -0.5 0.1
HbA1C 0.0 0.0 0.1 -0.0 0.0 0.3 -0.1 0.4
HDL Cholesterol 0.1 0.2 0.8 0.1 -0.9 0.0 -0.1 -0.6
LDL Cholesterol 0.9 1.5 2.3 0.9 -1.5 1.4 1.5 -0.5
Lupus 1.7 2.5 6.3 -1.4 0.5 -1.8 1.0 2.5
Neuroticism (2016) 0.2 0.3 1.0 -0.6 -0.0 -1.0 0.5 0.3
Primary Biliary Cirrhosis 0.6 0.9 2.6 -1.0 0.0 -0.8 -1.6 0.3
Rheumatoid Arthritis 0.2 0.3 0.6 -0.6 0.7 -0.4 0.6 -0.1
Schizophrenia (2014) 0.1 0.2 0.6 -0.4 0.7 0.4 0.1 -0.4
Triglycerides 0.4 0.7 2.4 -1.6 1.1 -0.1 -0.1 0.2
Type 2 Diabetes (T2D) (2012) 0.4 0.5 1.5 0.4 -0.0 -0.9 -0.1 1.2
Ulcerative Colitis 0.6 0.9 2.0 -0.8 0.2 -0.3 -1.3 1.4
Blood Eosinophil Count 0.1 0.8 2.0 0.6 -0.9 0.8 1.4 0.5
Blood Platelet Count 1.0 12.2 22.8 -2.8 0.9 4.8 -2.6 -4.7
Blood Red Count 0.2 2.4 4.5 -1.5 0.2 -2.1 -1.1 2.0
Blood White Count 0.8 5.8 11.0 -3.3 0.3 -1.8 -3.3 1.9
Heel T-Score 0.2 1.5 3.8 -0.8 0.2 1.7 -2.0 -0.4
BMI 0.2 1.2 2.5 -1.6 0.8 -1.1 -1.1 0.7
Height 0.5 9.3 18.6 4.3 2.4 1.1 3.8 -2.6
Waist Hip Ratio (WHR) 0.6 2.6 7.3 0.1 1.1 2.7 0.8 -1.9
Systolic Blood Pressure 1.9 9.7 27.5 -5.2 0.2 1.9 -4.0 -1.4
Smoking Status 0.2 0.6 2.3 -1.5 0.5 0.6 0.2 0.2
Allergy or Eczema 0.4 1.0 2.8 0.0 -0.8 1.0 -0.7 -1.7
Cardiovascular Disease 1.0 3.4 6.0 -1.9 0.3 2.1 -2.4 -1.6
Hypothyroidism (self reported) 0.2 0.4 0.9 -0.8 0.3 -0.9 -0.7 0.2
Respiratory disease 1.6 3.6 7.3 -2.7 -0.5 1.7 -2.4 -1.2
Type 2 Diabetes (T2D) (2018) 0.2 0.3 0.7 0.9 -0.4 -0.0 0.5 0.6
Lung FEV1/FVC ratio 2.9 14.6 40.9 6.4 -1.1 0.9 4.2 -3.5
Lung FVC 0.6 3.0 5.1 -1.3 -1.1 -1.8 -2.2 2.0
Neuroticism 0.5 1.3 3.1 -1.4 -0.1 -1.8 -0.7 0.9
Chronotype (morning person) 0.1 0.2 0.3 0.4 -0.6 -0.2 0.0 0.6
Hair Pigment 0.3 7.4 21.9 0.7 1.4 4.7 -0.2 -3.6
Tanning 0.0 0.3 1.0 -0.5 0.2 -0.1 1.0 0.6
Hand grip strength (left) 2.2 5.8 12.9 0.5 0.6 3.5 1.7 -3.6
Number of treatments/medications taken 0.7 1.2 2.2 -1.4 -1.1 -1.5 0.1 0.9
Average weekly spirits intake 0.4 0.5 1.6 0.3 0.5 -0.7 -1.3 -0.3
Sensitivity / hurt feelings 1.0 1.8 4.5 -2.1 -0.2 -2.0 -0.6 0.3
Frequency of depressed mood in last 2 weeks 0.4 0.5 1.1 0.2 1.1 -0.4 0.2 1.1
Hearing difficulty/problems: Yes 0.5 0.8 2.3 -1.5 0.3 1.3 0.1 -0.0
Relative age of first facial hair 0.4 0.8 3.3 0.0 0.8 1.8 0.5 -0.1
Other serious medical condition/disability diagnosed by doctor 1.0 1.3 3.6 -1.9 0.3 0.8 -0.6 -1.4
Ever used hormone-replacement therapy (HRT) 0.3 0.3 1.2 -1.1 0.1 0.1 0.5 -0.4
Ever had hysterectomy (womb removed) 0.4 0.5 1.5 0.7 0.3 0.2 0.6 -1.2
Systolic blood pressure, automated reading 1.0 2.8 8.4 -2.9 -0.3 -1.3 -1.4 1.4
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 1.9 1.4 0.3 -0.6 1.0 0.6
Angina 0.7 0.9 2.1 -1.0 -0.4 1.1 0.3 -1.4
Medication for hormone replacement therapy 0.6 0.7 1.2 0.7 1.1 0.6 1.0 -0.8
Vitamin and mineral supplements 1.2 1.7 3.5 1.3 -0.4 -0.0 1.7 1.9
Supplements: Zinc 1.2 1.3 3.3 -1.8 0.1 0.2 -1.5 -1.0
Medication: Co-codamol 0.8 0.9 2.4 1.0 -0.5 -0.9 1.5 0.3
Medication: Metformin 1.3 1.8 3.6 0.3 1.1 -1.8 0.9 1.9
Diabetes (father) 0.6 0.8 3.2 1.8 0.7 0.2 0.2 0.2
Diabetes (mother) 1.5 2.0 5.3 -2.3 -0.7 0.3 -2.0 0.2
Severe depression (siblings) 0.3 0.4 0.9 -0.1 0.5 0.0 0.9 -0.9
Pack years adult smoking proportion 1.4 2.1 4.8 -2.2 0.8 1.3 -1.9 0.0
Impedance of leg (right) 0.3 1.5 3.0 -1.0 -1.2 -1.7 -0.2 1.4
Leg fat-free mass (left) 0.5 2.5 6.2 0.0 2.5 1.7 1.0 -1.5
Trunk fat percentage 0.7 2.7 5.6 -2.4 1.6 -1.6 -0.2 1.7
Hand grip strength (right) 0.9 2.4 6.2 -0.4 -0.1 2.1 1.0 -2.5
Townsend deprivation index at recruitment 0.1 0.2 0.7 0.0 -0.3 0.8 0.1 -0.2
Current tobacco smoking 0.7 1.1 3.9 -1.0 0.6 0.4 -2.0 0.3
Average weekly fortified wine intake 0.5 0.5 1.8 -0.0 -1.3 -0.1 0.7 -0.6
Maternal smoking around birth 0.4 0.6 1.8 -0.2 0.4 -0.6 0.8 1.4
Fed-up feelings 1.0 1.8 4.2 -2.1 1.0 -0.6 -1.9 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.1 3.0 0.7 0.8 1.3 0.1 -1.7
Relative age voice broke 0.8 1.2 3.2 0.5 0.8 1.2 1.8 0.2
Taking other prescription medications 0.2 0.3 0.7 -0.3 -0.8 0.5 0.7 -0.1
Age when periods started (menarche) 1.9 4.5 14.6 0.0 -0.4 3.8 0.8 -2.6
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 1.1 -0.4 -1.1 -0.3 -0.5 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.2 2.7 7.5 0.1 1.3 2.7 -0.9 -1.9
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 1.2 -1.0 -0.4 0.1 0.2 -1.1
Qualifications: CSEs or equivalent 0.5 0.6 1.9 -0.5 1.0 -0.1 -0.1 1.4
Serious illness, injury or assault to yourself 0.9 1.1 3.7 1.9 0.5 -0.3 1.2 -0.1
High blood pressure 0.3 0.8 2.7 -0.1 -1.7 0.6 -0.2 -0.8
Hayfever, allergic rhinitis or eczema 0.6 1.2 1.9 -0.0 -1.2 1.4 -1.4 -0.9
Multivitamins +/- minerals 1.4 1.7 4.9 -1.2 0.8 -1.2 -2.2 -0.6
Stomach or abdominal pain in last month 0.5 0.6 1.7 0.8 0.6 -0.6 1.3 0.3
Supplements: Glucosamine 0.3 0.4 0.7 0.2 0.7 -0.8 0.4 -0.6
Diverticular disease/diverticulitis (self-reported) 2.0 2.4 5.2 -2.1 -1.0 -0.7 -2.3 -0.8
Medication: Atenolol 0.1 0.1 0.3 0.3 0.2 0.2 -0.5 0.2
Medication: Levothyroxine sodium 0.1 0.2 0.9 -0.3 0.0 0.3 0.2 -1.0
Sitting height 0.1 0.7 2.0 0.3 -0.4 0.7 1.4 -1.0
Chronic bronchitis/emphysema (father) 1.6 1.9 5.0 0.6 1.7 -0.1 2.2 1.0
High blood pressure (mother) 1.3 1.8 6.2 -2.5 -0.0 0.8 -0.5 -1.4
Body mass index (BMI) 0.3 1.1 1.9 -1.4 1.2 -1.1 -0.5 0.9
Impedance of leg (left) 0.5 2.4 5.7 -0.8 -1.3 -2.4 -0.0 2.0
Leg predicted mass (left) 0.5 2.5 6.0 0.0 2.5 1.8 1.1 -1.5
Trunk fat mass 0.5 2.1 3.6 -1.9 1.9 -1.3 0.2 1.3
Waist circumference 0.4 1.6 3.0 -1.2 1.7 -1.3 0.6 1.2
Number of incorrect matches in round 0.1 0.2 0.6 -0.5 0.4 -0.0 -0.8 0.4
Past tobacco smoking 1.0 1.8 5.1 0.6 -1.1 -1.5 -2.2 0.5
Alcohol usually taken with meals 0.9 1.4 3.0 1.7 -1.1 0.6 0.9 -1.3
Nervous feelings 0.4 0.7 2.7 0.6 -0.2 -1.6 0.5 0.5
Frequency of tenseness / restlessness in last 2 weeks 0.3 0.5 1.2 -0.9 -0.3 0.2 0.7 -1.1
Hearing difficulty/problems with background noise 0.3 0.4 0.8 -0.9 -0.9 0.2 -0.6 -0.5
Hair/balding pattern: Pattern 2 1.2 1.5 3.7 -1.9 -1.2 -0.5 -1.2 1.0
Had menopause 1.0 1.2 3.9 1.4 0.4 -0.2 2.0 0.2
Had other major operations 0.9 1.1 3.6 0.4 0.3 -1.1 1.9 0.6
Forced vital capacity (FVC) 0.2 0.9 1.5 -1.2 -0.4 1.2 -1.0 -0.8
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.7 5.4 -0.5 0.7 2.3 -0.6 -1.4
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 4.1 -2.0 1.3 0.1 0.1 -0.3
Qualifications: None of the above 0.6 1.3 4.0 -0.2 -1.2 -0.7 2.0 0.6
Financial difficulties in last 2 years 0.7 0.9 4.0 -0.4 2.0 0.5 -0.0 0.2
Mouth/teeth dental problems 0.3 0.5 1.6 1.3 0.0 0.1 -0.4 0.7
Heart attack 1.0 1.2 2.4 1.5 0.7 0.9 1.2 -1.0
Allergy 0.9 2.1 4.7 0.6 0.8 -2.2 1.6 1.5
Pain all over the body in last month 1.0 1.1 3.5 0.6 -1.9 0.6 -0.5 -0.9
Diabetes (self-reported) 1.0 1.5 3.9 1.2 0.5 -0.9 2.0 1.1
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.5 0.3 -0.7 -0.1 -0.2 -0.3
Medication: Ramipril 1.0 1.3 3.4 0.1 -0.6 -1.8 -0.6 1.5
Medication: Simvastatin 0.4 0.6 1.8 0.0 -0.2 -0.8 1.3 0.9
Fluid intelligence score 1.8 3.7 5.9 -1.7 -0.5 -2.1 -2.2 2.4
Illnesses of siblings 0.2 0.3 1.0 1.0 0.5 -0.4 -0.1 0.5
Neuroticism score 0.9 1.9 3.8 -2.0 0.5 -1.8 -0.7 1.2
Weight 0.2 1.1 4.1 -0.9 2.0 -0.2 0.6 0.2
Impedance of arm (right) 0.2 0.8 2.6 -0.9 0.0 1.6 0.2 -0.6
Arm fat percentage (right) 0.4 1.6 5.3 -2.3 1.2 -0.6 -0.3 0.8
Trunk fat-free mass 0.3 1.6 3.1 1.1 1.8 0.6 1.5 -1.1
Hip circumference 0.8 3.2 6.5 -1.5 1.5 -2.5 0.6 2.2
Time employed in main current job 1.7 1.9 7.7 0.9 0.6 -2.8 0.3 0.9
Alcohol intake versus 10 years previously 0.8 1.2 2.9 -1.7 -1.5 -0.4 -0.5 0.8
Father’s age at death 2.1 2.8 10.6 3.3 0.4 0.1 1.6 -1.0
Worrier / anxious feelings 1.2 2.3 6.0 -1.2 0.1 -2.4 -1.1 1.6
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 3.9 -2.0 2.0 -1.0 -0.5 1.1
Falls in the last year 0.2 0.3 1.5 0.1 1.2 0.3 -0.2 0.3
Hair/balding pattern: Pattern 3 0.8 1.2 5.0 2.2 0.5 0.7 -0.1 -0.6
Number of live births 0.5 0.7 1.8 -0.6 -0.4 1.3 1.1 -0.1
Forced expiratory volume in 1-second (FEV1) 0.4 1.5 3.9 0.3 -0.4 1.8 -0.1 -2.0
Pulse rate 0.3 0.5 1.7 -0.1 -1.3 0.0 -0.8 -0.6
Happiness 0.1 0.2 0.4 0.1 0.4 -0.4 0.6 -0.3
Noisy workplace 0.6 0.8 2.7 -0.5 -0.0 0.8 0.6 -1.6
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.0 0.7 -0.6 0.3 0.5 -1.0
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.3 0.4 0.8 -0.2 1.5 0.3
Mouth/teeth dental problems: Dentures 0.8 1.3 3.4 -1.9 0.2 -1.4 -0.9 0.3
Asthma 0.9 1.7 6.2 -2.5 -0.0 0.7 -1.4 -0.4
Medication: Ibuprofen (e.g. Nurofen) 3.9 5.0 12.3 -3.5 2.0 0.3 -2.9 -0.1
Medication: Cholesterol lowering 0.5 0.7 1.5 -0.4 -1.2 0.4 1.2 -0.5
Depression (self-reported) 0.4 0.5 0.9 0.5 -0.4 -0.8 0.9 0.6
Medication: Lansoprazole 0.2 0.2 0.6 0.0 0.3 0.5 0.0 0.8
Prospective memory result 0.9 1.1 4.9 0.1 -0.6 0.0 2.2 -0.1
Lung cancer (father) 0.9 1.0 3.0 -0.3 -1.7 -0.9 0.1 1.0
Illnesses of mother 0.6 0.8 2.9 1.7 0.5 -0.4 -0.5 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 8.1 0.5 0.2 2.1 -0.1 -2.8
Pulse wave Arterial Stiffness index 1.4 1.6 2.6 0.1 1.6 1.0 -1.5 -1.5
Impedance of arm (left) 0.1 0.5 1.5 -1.2 0.2 1.0 -0.2 -0.0
Arm fat mass (right) 0.2 0.9 2.3 -1.5 1.5 -0.3 0.1 0.3
Trunk predicted mass 0.3 1.5 2.8 0.9 1.7 0.7 1.4 -1.2
Standing height 0.3 2.7 4.7 1.0 2.0 1.3 2.2 -1.4
Length of working week for main job 0.1 0.1 0.4 0.2 -0.5 0.6 0.3 0.1
Exposure to tobacco smoke at home 0.4 0.5 1.8 0.4 -0.2 -0.2 1.3 -0.6
Breastfed as a baby 0.3 0.4 1.4 0.6 0.3 0.3 0.3 1.2
Tense / ‘highly strung’ 1.1 1.8 6.8 0.1 0.3 -2.6 1.2 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.3 0.0 0.6 -1.5 -0.1 1.4
Hair/balding pattern: Pattern 4 0.1 0.2 0.6 0.2 -0.3 -0.8 0.3 0.6
Birth weight of first child 0.3 0.6 1.1 0.9 -1.1 -0.3 0.8 -0.3
Peak expiratory flow (PEF) 2.0 4.6 11.2 1.7 -0.2 3.0 0.4 -3.3
Pulse wave reflection index 1.3 1.6 3.2 0.2 1.3 1.8 -0.8 -1.6
Ever highly irritable/argumentative for 2 days 1.0 1.2 3.0 -1.7 0.4 -1.4 0.4 0.9
Loud music exposure frequency 0.6 0.7 1.4 -0.8 0.1 -0.2 1.2 -1.2
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.9 0.4 1.0 0.1 0.2 0.9
Mouth/teeth dental problems: Bleeding gums 1.1 1.4 4.6 -2.1 -0.5 -0.6 0.6 1.2
Blood clot in the leg (DVT) 0.5 0.7 1.7 0.9 0.7 0.6 0.3 -1.3
Medication: Paracetamol 1.8 3.0 11.9 -3.5 1.4 0.4 -0.9 -0.3
Headache pain in last month 3.0 5.2 20.9 -4.6 1.7 0.9 -1.0 -0.6
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.2 -0.3 1.1 0.0 0.0 0.2
Glaucoma (self-reported) 1.1 1.2 2.3 -1.3 -1.5 0.9 -0.0 -1.2
Gout (self-reported) 1.1 1.5 4.4 -1.0 0.3 2.1 0.1 -1.3
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 1.1 0.2 -0.1 -1.0 0.5 0.1
Medication: Amlodipine 1.6 2.2 4.0 -0.2 -2.0 1.6 -1.0 -1.8
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.7 -0.2 -0.2 1.3 0.3 -1.0
Birth weight 0.5 1.2 4.7 -0.5 0.3 0.7 -2.2 -0.5
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.4 -0.6 0.4 0.5 1.2 0.8
High blood pressure (siblings) 0.7 1.0 3.8 -2.0 0.7 0.4 -0.7 0.0
Forced vital capacity (FVC), Best measure 0.2 0.9 1.8 -1.0 0.4 1.0 -0.7 -1.4
Body fat percentage 0.7 2.6 5.4 -2.3 1.2 -1.8 -0.1 1.7
Leg fat percentage (right) 0.9 3.1 7.1 -2.0 0.6 -2.7 -0.4 1.9
Arm fat-free mass (right) 0.2 1.0 3.1 0.6 1.8 -0.1 1.2 -0.4
Exposure to tobacco smoke outside home 0.6 0.7 2.6 0.3 0.3 -0.9 0.2 1.6
Comparative body size at age 10 1.8 5.0 9.9 -2.0 1.3 1.7 -3.2 -2.6
Number of full brothers 3.0 3.8 9.1 -3.0 -0.5 1.0 -2.7 1.1
Worry too long after embarrassment 0.5 0.8 1.7 -1.3 0.6 -1.3 -0.4 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.3 6.9 0.0 -0.4 -2.1 0.3 2.6
Wheeze or whistling in the chest in last year 0.6 1.0 2.3 -1.5 -0.0 1.2 -1.1 -0.3
Number of children fathered 1.0 1.1 1.7 -1.0 -1.3 0.0 -1.1 -1.3
Reason for reducing amount of alcohol drunk: Health precaution 0.7 0.8 2.6 -0.1 -0.9 -0.6 1.6 -0.6
Age at first live birth 1.3 2.2 8.6 0.8 -2.9 -1.1 0.7 -0.3
Pulse wave peak to peak time 1.3 1.5 2.7 -0.1 -1.5 -0.9 1.6 1.3
Health satisfaction 1.0 1.3 3.0 0.4 1.3 -1.2 -0.6 1.7
Shortness of breath walking on level ground 1.3 1.5 6.6 0.6 2.6 0.1 -0.1 0.9
Qualifications: College or University degree 0.9 2.7 9.0 1.2 -1.1 1.4 0.2 -3.0
Eye problems/disorders: None of the above 2.0 2.3 10.3 3.2 0.8 0.2 0.5 0.4
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.6 -0.9 0.3 -0.5 0.6 1.3
Emphysema/chronic bronchitis 0.8 0.9 3.2 -0.5 0.9 -0.3 0.6 1.8
Medication for pain relief, constipation, heartburn 2.0 3.5 7.6 2.8 -2.6 -0.8 1.5 0.5
Neck or shoulder pain in last month 0.2 0.3 0.6 -0.1 0.5 -0.7 0.3 0.7
Medication: Blood pressure 0.5 0.9 3.0 0.5 -1.7 0.0 -0.6 -0.9
Angina (self-reported) 0.5 0.7 1.6 -1.1 -0.5 0.6 -0.0 -1.3
Migraine (self-reported) 5.8 7.2 22.9 -4.8 2.2 1.2 -2.6 0.2
Medication: Ibuprofen 3.8 4.6 13.1 -3.6 2.1 -0.5 -2.3 0.1
Medication: Allopurinol 2.2 3.0 7.4 -0.9 -0.5 2.7 0.1 -2.5
Medication: Omeprazole 0.5 0.6 1.3 1.1 0.7 -0.1 -0.6 -0.8
Medication: Seretide 50 evohaler 0.3 0.4 1.2 -0.2 -1.1 -0.6 0.6 -0.0
Mean time to correctly identify matches 0.8 1.6 4.2 0.5 -1.5 -2.1 0.1 1.1
Heart disease (mother) 0.8 0.9 2.5 -1.6 -1.4 -0.1 -0.0 0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.1 3.7 6.9 1.7 -1.6 2.6 1.6 -2.0
Whole body fat mass 0.3 1.4 2.5 -1.6 1.6 -1.1 0.3 0.9
Leg fat mass (right) 0.4 1.5 3.7 -1.9 1.6 -1.1 -0.1 0.6
Arm predicted mass (right) 0.2 1.0 3.9 0.6 2.0 -0.2 0.9 -0.2
Pulse rate, automated reading 0.3 1.0 2.0 1.1 -0.4 -1.4 -0.7 1.2
Alcohol intake frequency. 1.2 2.9 7.4 -0.8 1.5 -2.0 0.4 2.7
Comparative height size at age 10 0.1 0.7 3.0 -0.3 1.7 0.3 0.4 0.1
Number of full sisters 0.6 0.7 2.1 -1.4 -0.2 0.9 -0.8 0.4
Suffer from ‘nerves’ 0.8 1.3 3.9 0.2 -2.0 -1.5 0.4 -0.3
Overall health rating 0.3 0.6 1.7 0.3 0.4 -0.7 -0.6 1.3
Chest pain or discomfort 0.3 0.4 1.5 -0.6 1.2 0.5 -0.0 -0.3
Had major operations 0.5 0.6 1.2 0.9 -1.1 0.6 -0.3 -0.8
Age at last live birth 0.8 1.2 3.7 -0.1 -1.9 -0.1 0.6 -1.4
Family relationship satisfaction 0.4 0.5 1.9 0.1 0.9 1.4 -0.1 -0.1
Leg pain on walking 2.0 2.5 6.8 -1.5 1.8 -0.0 -2.6 -0.2
Qualifications: NVQ or HND or HNC or equivalent 1.3 1.5 4.2 0.3 2.1 0.7 -1.7 -0.1
Commuting to job workplace: Car/motor vehicle 1.7 2.0 3.5 -1.6 0.3 -1.9 0.9 1.7
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.8 -1.2 -1.4 -0.3 -1.0 0.4
Medication: Aspirin 0.1 0.1 0.5 0.1 0.7 -0.3 0.1 0.2
Supplements: Vitamin C 0.9 1.1 2.7 -0.6 -1.1 1.1 -0.4 -1.6
Knee pain experienced in last month 1.3 2.0 4.9 0.9 1.0 -2.2 1.4 1.1
Hypertension (Self-reported) 0.3 0.7 1.9 0.1 -1.4 0.8 -0.5 -0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.0 0.4 -1.0 0.1 -0.6 -0.5
Illnesses of father: Heart disease 0.6 0.8 2.0 1.4 0.5 1.0 0.6 -0.1
Illnesses of siblings: Diabetes 0.3 0.4 1.4 -0.5 -1.2 -0.0 -0.3 -0.1
Smoking status: Previous 1.3 1.9 8.6 -0.2 0.8 0.5 2.9 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 5.0 -1.4 -0.3 2.2 0.1 -2.2
Whole body fat-free mass 0.3 1.7 3.9 0.7 2.0 1.0 1.4 -1.2
Leg fat-free mass (right) 0.4 2.4 5.9 0.2 2.4 1.7 1.1 -1.3
Arm fat percentage (left) 0.5 2.1 6.2 -2.5 1.5 -0.9 -0.6 1.1
Average weekly red wine intake 0.8 1.1 3.1 1.8 0.3 1.0 0.6 -1.0
Handedness (chirality/laterality): Left-handed 2.5 3.0 5.2 0.6 -1.9 2.0 -1.3 -2.3
Mood swings 1.1 2.0 7.8 -2.8 1.0 -0.5 -0.3 0.8
Loneliness, isolation 1.1 1.5 3.7 -1.0 0.4 -1.7 0.1 1.9
Long-standing illness, disability or infirmity 0.3 0.4 1.2 -0.3 0.7 -1.1 -0.0 0.4
Ever had bowel cancer screening 1.1 1.3 3.7 -1.2 -0.4 -1.9 -0.6 0.9
Diabetes diagnosed by doctor 0.9 1.6 4.1 1.6 0.1 -0.3 2.0 0.9
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 3.2 1.2 -0.2 -0.0 0.8 1.8
Friendships satisfaction 0.4 0.5 1.1 -1.1 0.8 0.3 -0.3 0.6
Qualifications: nursing, teaching 0.7 1.1 3.8 -0.1 -0.3 1.0 0.9 -1.9
Commuting to job workplace: Walk 0.3 0.3 0.8 0.1 0.0 0.9 -0.7 -0.5
Eye problems/disorders: Cataract 6.0 6.9 29.6 -5.4 0.1 -0.0 -2.2 0.4
Mouth/teeth dental problems: Mouth ulcers 1.4 2.2 7.1 -0.9 -0.1 1.5 -0.9 -2.7
Medication for cholesterol 0.3 0.4 1.1 -0.6 0.4 -1.0 0.2 0.7
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 4.5 2.1 -0.9 -0.6 1.1 0.1
Back pain experienced in last month 1.8 2.6 6.0 -0.7 1.0 -2.4 0.4 2.4
Mineral and other dietary supplements 0.3 0.4 0.9 0.4 -1.0 -0.1 -0.8 0.7
Breast cancer (self-reported) 0.7 0.8 1.6 1.0 1.3 -0.5 0.7 0.7
Asthma (self-reported) 1.1 2.1 6.5 -2.5 -0.2 0.9 -1.7 -0.6
Osteoporosis (self-reported) 0.2 0.3 0.9 0.7 -0.3 -0.3 -0.0 -0.9
Osteoarthritis (self-reported) 0.5 0.7 1.6 -0.6 0.0 -1.2 0.2 1.3
Medication: Aspirin 0.0 0.0 0.2 0.0 0.1 -0.1 -0.0 -0.4
Medication: Gliclazide 0.3 0.4 1.1 -1.0 0.2 -0.0 0.7 -0.5
Illnesses of father: None of the above (group 1) 1.2 1.4 4.2 -2.0 -0.8 -0.6 -1.4 -0.5
Smoking status: Current 0.7 1.2 3.7 -1.1 0.7 0.7 -1.9 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.0 -0.0 0.5 -0.9 -1.0 -0.7
Whole body water mass 0.3 1.8 4.1 0.7 2.0 1.1 1.4 -1.2
Leg predicted mass (right) 0.5 2.4 5.8 0.3 2.4 1.8 1.1 -1.4
Arm fat mass (left) 0.3 1.2 3.0 -1.6 1.7 -0.4 -0.1 0.5
Number of self-reported non-cancer illnesses 0.6 1.0 3.2 -1.8 -0.6 -0.2 -1.1 0.4
Average weekly champagne plus white wine intake 2.0 2.8 7.9 1.6 -2.8 0.2 1.4 -1.1
Miserableness 0.6 1.0 2.2 -1.5 1.1 0.5 -1.1 -0.2
Guilty feelings 0.2 0.3 0.7 -0.8 0.4 -0.3 0.8 0.2
Wears glasses or contact lenses 0.9 1.1 1.7 -1.2 -0.5 -1.3 -1.3 0.2
Ever taken oral contraceptive pill 0.8 0.9 2.2 0.1 -0.1 -1.4 0.5 1.5
Hearing aid user 0.8 0.9 3.0 -0.2 1.7 0.6 1.0 0.2
Mother’s age at death 0.3 0.4 0.7 0.7 0.8 0.6 0.3 -0.5
Financial situation satisfaction 0.2 0.3 0.8 -0.1 0.3 -0.1 -0.7 -0.9
Tinnitus: Yes, now most or all of the time 0.9 1.1 4.6 -0.1 0.1 2.1 -0.2 -0.9
Commuting to job workplace: Public transport 0.3 0.4 1.0 0.4 1.0 0.7 0.2 -0.5
Eye problems/disorders: Glaucoma 1.0 1.2 2.4 -0.7 -1.6 1.2 0.0 -1.3
Medication: Blood pressure 0.2 0.3 0.8 -0.2 -0.9 0.7 -0.4 -0.4
Pain type(s) experienced in last month: Hip pain 1.5 1.9 5.8 2.4 0.1 -0.6 1.8 0.4
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.7 -0.1 0.3 -0.1 0.3 -0.8
High cholesterol (Self-reported) 0.5 1.0 2.1 -1.5 -1.2 0.0 -0.2 1.2
Medication: Bendroflumethiazide 0.3 0.4 0.9 -0.7 -0.9 -0.8 0.1 0.2
Medication: Paracetamol 1.5 2.4 10.5 -3.2 0.0 -0.7 -0.9 -0.3
Medication: Lisinopril 0.3 0.4 1.4 -0.3 0.5 0.6 -1.2 -0.1
Medication: Atorvastatin 1.2 1.5 3.1 1.1 -0.8 1.5 0.7 -1.8
Illnesses of father: High blood pressure 0.5 0.6 1.4 0.2 0.9 -0.1 0.8 1.2
Alcohol drinker status: Never 0.8 0.9 2.7 1.7 0.6 0.8 0.0 -0.9
Ever smoked 1.2 2.1 5.1 -0.4 1.0 2.3 1.8 -0.9
Basal metabolic rate 0.3 1.5 4.6 0.2 2.1 0.8 1.2 -1.0
Leg fat percentage (left) 1.1 3.9 10.4 -1.7 0.6 -3.2 -0.3 2.4
Arm fat-free mass (left) 0.2 0.9 1.9 0.2 1.3 0.3 1.4 -0.8
Number of operations (self-reported) 0.2 0.2 0.5 -0.4 -0.1 -0.0 0.7 0.7
Average weekly beer plus cider intake 0.4 0.6 1.8 -0.2 1.0 -0.6 0.3 1.4
Irritability 1.0 1.7 3.6 -1.5 1.2 -1.9 0.5 0.8
Risk taking 1.6 2.4 6.2 -0.0 -0.2 2.5 0.8 -2.2
Ever had prostate specific antigen (PSA) test 1.0 1.1 3.5 1.9 0.4 -0.3 1.3 -0.5
Fractured/broken bones in last 5 years 0.5 0.6 2.5 -0.3 0.6 -0.3 -1.6 -0.3
Age started oral contraceptive pill 2.7 3.4 12.0 1.8 -3.5 -0.8 0.9 -0.7
Diastolic blood pressure, automated reading 2.6 8.0 34.6 5.9 -0.4 1.0 1.9 -0.7
Ever depressed for a whole week 0.8 1.0 2.9 -1.7 0.7 -0.6 -0.9 0.5
Unable to work because of sickness or disability 0.7 0.9 1.5 -1.2 -1.0 0.6 -0.5 -1.1
Commuting to job workplace: Cycle 1.3 1.6 5.9 -0.2 2.4 0.5 0.5 -1.2
Myopia 1.1 1.6 5.2 -0.9 1.2 0.8 -2.3 -0.1
Vascular/heart problems diagnosed by doctor 0.3 0.8 3.0 0.3 1.7 -0.7 0.2 0.8
Cholesterol lowering medication 0.0 0.0 0.1 0.3 0.2 0.1 -0.0 0.2
Medication: Omeprazole (e.g. Zanprol) 1.3 1.6 5.2 2.3 0.8 0.4 -0.9 -1.1
Pain experienced in last month 1.0 1.6 4.4 2.1 -0.9 0.9 0.2 -1.3
Supplements: Calcium 0.2 0.3 0.6 0.8 -0.2 -0.1 0.8 -0.2
Basal cell carcinoma (self-reported) 1.3 1.6 5.3 -0.2 -2.3 0.6 -0.4 -1.4
Heart attack/myocardial infarction (self-reported) 0.9 1.1 2.3 1.5 0.5 0.9 1.0 -1.1
Deep venous thrombosis (DVT) (self-reported) 0.3 0.3 0.9 0.6 0.5 0.3 0.1 -1.0
Heart disease (siblings) 0.4 0.5 1.5 0.6 -0.7 0.1 1.2 0.1
Alcohol drinker status: Previous 2.0 2.3 5.0 1.0 2.2 -1.3 0.7 1.8
Pack years of smoking 1.1 1.6 4.5 -2.1 0.3 0.9 -1.6 0.3
Impedance of whole body 0.2 0.9 2.7 -1.6 -0.5 -0.7 -0.5 0.9
Leg fat mass (left) 0.4 1.4 2.4 -1.6 1.4 -1.3 0.1 0.9
Arm predicted mass (left) 0.2 0.9 2.3 0.1 1.5 0.4 1.3 -0.7