Hub : Genes

SLC24A3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1401	0.0446	0.00190	0.024	NA	-0.003	NA	0.004	5.0e-03	NA	0.6300	NA	0.14000
2	GTEx	Whole Blood	0.1310	0.0480	0.00620	0.059	NA	0.023	NA	0.030	4.1e-06	NA	0.0031	NA	0.00082
3	NTR	Blood	0.0228	0.0091	0.00370	0.002	0.005	0.000	0.004	0.000	5.3e-02	0.00730	0.2600	0.012	0.24000
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0705	0.0334	0.00830	0.000	0.004	-0.002	NA	-0.002	3.5e-01	0.10000	0.8800	NA	0.68000
5	TCGA	Thyroid Carcinoma	0.0650	0.0240	0.00029	0.042	0.028	0.022	NA	0.029	5.7e-05	0.00091	0.0026	NA	0.00080

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.4	0.7	2.9	1.7	-0.3	-0.6	-0.1	0.4
Bipolar Disorder or Schizophrenia	0.1	0.2	1.1	1.0	-0.1	0.3	0.2	-0.1
Depressed Affect (Nagel 2018)	0.4	0.8	2.6	-1.6	0.1	-0.3	-1.2	0.3
Depression (Nagel 2018)	0.4	0.7	1.7	0.1	0.5	1.3	-0.5	-1.0
Intelligence (Savage-Jansen 2018)	1.1	3.4	8.9	-1.0	-0.8	-1.7	-3.0	2.0
Neuroticism (Nagel 2018)	0.4	1.0	3.2	-1.2	-0.0	-1.8	-0.1	0.7
Schizophrenia (2018)	0.1	0.2	0.8	-0.0	0.0	0.9	0.3	-0.5
Schizophrenia vs Biploar Disorder	0.7	1.0	2.9	-1.7	0.6	-0.7	1.0	0.1
Worry (Nagel 2018)	0.5	1.0	3.6	-0.1	-1.1	-1.9	-0.1	0.4
Alzheimer’s Disease (in mother)	0.4	0.4	1.8	0.3	-0.5	-0.2	1.4	-0.0
Alzheimer’s Disease (in father)	0.4	0.5	1.5	-0.5	-1.2	0.3	0.0	0.7
Alzheimer’s Disease (including proxy)	0.3	0.4	1.0	0.2	-0.8	0.4	1.0	-0.4
Crohns Disease (2017)	0.1	0.2	0.7	-0.0	-0.0	-0.0	0.5	0.8
Irritable Bowel Disease (IBD)	0.2	0.5	1.9	-0.4	0.1	-0.4	-0.2	1.4
Ulcerative Colitis (UC)	0.4	0.7	2.6	-0.3	-0.0	-0.5	-0.6	1.6
Major Depression (MDD)	1.4	1.7	2.9	-0.6	1.6	-1.4	0.7	1.7
Reaction Time	0.4	0.7	2.2	0.3	-1.5	-0.9	0.6	0.3
Verbal and Numeric Reasoning (VNR)	1.4	3.3	12.0	-1.7	-0.7	-0.3	-3.5	1.0
Breast Cancer	1.1	2.6	5.0	1.0	2.2	2.2	1.3	-0.8
Ovarian Cancer	2.0	2.7	5.4	1.1	0.6	2.3	2.0	-1.5
Prostate Cancer	0.3	0.4	0.6	0.5	-0.6	-0.8	0.7	0.8
Age at First Birth	0.6	0.9	3.5	0.0	-0.0	-1.0	-0.4	-1.9
Bipolar Disorder (2011)	0.4	0.4	1.0	1.0	0.4	0.1	-0.7	0.6
Body Mass Index (BMI) (2010)	1.2	1.7	5.0	-2.2	0.5	-0.6	-1.6	0.5
Coronary Artery Disease (CAD)	0.9	1.1	2.4	0.9	-0.7	1.5	0.2	-1.2
Crohns Disease (2012)	0.2	0.4	0.7	-0.3	-0.9	0.5	0.7	-0.5
Mean Putamen Volume	0.2	0.2	0.4	-0.2	-0.0	0.4	0.6	0.7
Fasting Glucose	0.1	0.1	0.3	-0.3	0.3	0.1	-0.5	0.1
HbA1C	0.0	0.0	0.1	-0.0	0.0	0.3	-0.1	0.4
HDL Cholesterol	0.1	0.2	0.8	0.1	-0.9	0.0	-0.1	-0.6
LDL Cholesterol	0.9	1.5	2.3	0.9	-1.5	1.4	1.5	-0.5
Lupus	1.7	2.5	6.3	-1.4	0.5	-1.8	1.0	2.5
Neuroticism (2016)	0.2	0.3	1.0	-0.6	-0.0	-1.0	0.5	0.3
Primary Biliary Cirrhosis	0.6	0.9	2.6	-1.0	0.0	-0.8	-1.6	0.3
Rheumatoid Arthritis	0.2	0.3	0.6	-0.6	0.7	-0.4	0.6	-0.1
Schizophrenia (2014)	0.1	0.2	0.6	-0.4	0.7	0.4	0.1	-0.4
Triglycerides	0.4	0.7	2.4	-1.6	1.1	-0.1	-0.1	0.2
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.5	0.4	-0.0	-0.9	-0.1	1.2
Ulcerative Colitis	0.6	0.9	2.0	-0.8	0.2	-0.3	-1.3	1.4
Blood Eosinophil Count	0.1	0.8	2.0	0.6	-0.9	0.8	1.4	0.5
Blood Platelet Count	1.0	12.2	22.8	-2.8	0.9	4.8	-2.6	-4.7
Blood Red Count	0.2	2.4	4.5	-1.5	0.2	-2.1	-1.1	2.0
Blood White Count	0.8	5.8	11.0	-3.3	0.3	-1.8	-3.3	1.9
Heel T-Score	0.2	1.5	3.8	-0.8	0.2	1.7	-2.0	-0.4
BMI	0.2	1.2	2.5	-1.6	0.8	-1.1	-1.1	0.7
Height	0.5	9.3	18.6	4.3	2.4	1.1	3.8	-2.6
Waist Hip Ratio (WHR)	0.6	2.6	7.3	0.1	1.1	2.7	0.8	-1.9
Systolic Blood Pressure	1.9	9.7	27.5	-5.2	0.2	1.9	-4.0	-1.4
Smoking Status	0.2	0.6	2.3	-1.5	0.5	0.6	0.2	0.2
Allergy or Eczema	0.4	1.0	2.8	0.0	-0.8	1.0	-0.7	-1.7
Cardiovascular Disease	1.0	3.4	6.0	-1.9	0.3	2.1	-2.4	-1.6
Hypothyroidism (self reported)	0.2	0.4	0.9	-0.8	0.3	-0.9	-0.7	0.2
Respiratory disease	1.6	3.6	7.3	-2.7	-0.5	1.7	-2.4	-1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.7	0.9	-0.4	-0.0	0.5	0.6
Lung FEV1/FVC ratio	2.9	14.6	40.9	6.4	-1.1	0.9	4.2	-3.5
Lung FVC	0.6	3.0	5.1	-1.3	-1.1	-1.8	-2.2	2.0
Neuroticism	0.5	1.3	3.1	-1.4	-0.1	-1.8	-0.7	0.9
Chronotype (morning person)	0.1	0.2	0.3	0.4	-0.6	-0.2	0.0	0.6
Hair Pigment	0.3	7.4	21.9	0.7	1.4	4.7	-0.2	-3.6
Tanning	0.0	0.3	1.0	-0.5	0.2	-0.1	1.0	0.6
Hand grip strength (left)	2.2	5.8	12.9	0.5	0.6	3.5	1.7	-3.6
Number of treatments/medications taken	0.7	1.2	2.2	-1.4	-1.1	-1.5	0.1	0.9
Average weekly spirits intake	0.4	0.5	1.6	0.3	0.5	-0.7	-1.3	-0.3
Sensitivity / hurt feelings	1.0	1.8	4.5	-2.1	-0.2	-2.0	-0.6	0.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.1	0.2	1.1	-0.4	0.2	1.1
Hearing difficulty/problems: Yes	0.5	0.8	2.3	-1.5	0.3	1.3	0.1	-0.0
Relative age of first facial hair	0.4	0.8	3.3	0.0	0.8	1.8	0.5	-0.1
Other serious medical condition/disability diagnosed by doctor	1.0	1.3	3.6	-1.9	0.3	0.8	-0.6	-1.4
Ever used hormone-replacement therapy (HRT)	0.3	0.3	1.2	-1.1	0.1	0.1	0.5	-0.4
Ever had hysterectomy (womb removed)	0.4	0.5	1.5	0.7	0.3	0.2	0.6	-1.2
Systolic blood pressure, automated reading	1.0	2.8	8.4	-2.9	-0.3	-1.3	-1.4	1.4
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.9	1.4	0.3	-0.6	1.0	0.6
Angina	0.7	0.9	2.1	-1.0	-0.4	1.1	0.3	-1.4
Medication for hormone replacement therapy	0.6	0.7	1.2	0.7	1.1	0.6	1.0	-0.8
Vitamin and mineral supplements	1.2	1.7	3.5	1.3	-0.4	-0.0	1.7	1.9
Supplements: Zinc	1.2	1.3	3.3	-1.8	0.1	0.2	-1.5	-1.0
Medication: Co-codamol	0.8	0.9	2.4	1.0	-0.5	-0.9	1.5	0.3
Medication: Metformin	1.3	1.8	3.6	0.3	1.1	-1.8	0.9	1.9
Diabetes (father)	0.6	0.8	3.2	1.8	0.7	0.2	0.2	0.2
Diabetes (mother)	1.5	2.0	5.3	-2.3	-0.7	0.3	-2.0	0.2
Severe depression (siblings)	0.3	0.4	0.9	-0.1	0.5	0.0	0.9	-0.9
Pack years adult smoking proportion	1.4	2.1	4.8	-2.2	0.8	1.3	-1.9	0.0
Impedance of leg (right)	0.3	1.5	3.0	-1.0	-1.2	-1.7	-0.2	1.4
Leg fat-free mass (left)	0.5	2.5	6.2	0.0	2.5	1.7	1.0	-1.5
Trunk fat percentage	0.7	2.7	5.6	-2.4	1.6	-1.6	-0.2	1.7
Hand grip strength (right)	0.9	2.4	6.2	-0.4	-0.1	2.1	1.0	-2.5
Townsend deprivation index at recruitment	0.1	0.2	0.7	0.0	-0.3	0.8	0.1	-0.2
Current tobacco smoking	0.7	1.1	3.9	-1.0	0.6	0.4	-2.0	0.3
Average weekly fortified wine intake	0.5	0.5	1.8	-0.0	-1.3	-0.1	0.7	-0.6
Maternal smoking around birth	0.4	0.6	1.8	-0.2	0.4	-0.6	0.8	1.4
Fed-up feelings	1.0	1.8	4.2	-2.1	1.0	-0.6	-1.9	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	3.0	0.7	0.8	1.3	0.1	-1.7
Relative age voice broke	0.8	1.2	3.2	0.5	0.8	1.2	1.8	0.2
Taking other prescription medications	0.2	0.3	0.7	-0.3	-0.8	0.5	0.7	-0.1
Age when periods started (menarche)	1.9	4.5	14.6	0.0	-0.4	3.8	0.8	-2.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.1	-0.4	-1.1	-0.3	-0.5	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	7.5	0.1	1.3	2.7	-0.9	-1.9
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.2	-1.0	-0.4	0.1	0.2	-1.1
Qualifications: CSEs or equivalent	0.5	0.6	1.9	-0.5	1.0	-0.1	-0.1	1.4
Serious illness, injury or assault to yourself	0.9	1.1	3.7	1.9	0.5	-0.3	1.2	-0.1
High blood pressure	0.3	0.8	2.7	-0.1	-1.7	0.6	-0.2	-0.8
Hayfever, allergic rhinitis or eczema	0.6	1.2	1.9	-0.0	-1.2	1.4	-1.4	-0.9
Multivitamins +/- minerals	1.4	1.7	4.9	-1.2	0.8	-1.2	-2.2	-0.6
Stomach or abdominal pain in last month	0.5	0.6	1.7	0.8	0.6	-0.6	1.3	0.3
Supplements: Glucosamine	0.3	0.4	0.7	0.2	0.7	-0.8	0.4	-0.6
Diverticular disease/diverticulitis (self-reported)	2.0	2.4	5.2	-2.1	-1.0	-0.7	-2.3	-0.8
Medication: Atenolol	0.1	0.1	0.3	0.3	0.2	0.2	-0.5	0.2
Medication: Levothyroxine sodium	0.1	0.2	0.9	-0.3	0.0	0.3	0.2	-1.0
Sitting height	0.1	0.7	2.0	0.3	-0.4	0.7	1.4	-1.0
Chronic bronchitis/emphysema (father)	1.6	1.9	5.0	0.6	1.7	-0.1	2.2	1.0
High blood pressure (mother)	1.3	1.8	6.2	-2.5	-0.0	0.8	-0.5	-1.4
Body mass index (BMI)	0.3	1.1	1.9	-1.4	1.2	-1.1	-0.5	0.9
Impedance of leg (left)	0.5	2.4	5.7	-0.8	-1.3	-2.4	-0.0	2.0
Leg predicted mass (left)	0.5	2.5	6.0	0.0	2.5	1.8	1.1	-1.5
Trunk fat mass	0.5	2.1	3.6	-1.9	1.9	-1.3	0.2	1.3
Waist circumference	0.4	1.6	3.0	-1.2	1.7	-1.3	0.6	1.2
Number of incorrect matches in round	0.1	0.2	0.6	-0.5	0.4	-0.0	-0.8	0.4
Past tobacco smoking	1.0	1.8	5.1	0.6	-1.1	-1.5	-2.2	0.5
Alcohol usually taken with meals	0.9	1.4	3.0	1.7	-1.1	0.6	0.9	-1.3
Nervous feelings	0.4	0.7	2.7	0.6	-0.2	-1.6	0.5	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.2	-0.9	-0.3	0.2	0.7	-1.1
Hearing difficulty/problems with background noise	0.3	0.4	0.8	-0.9	-0.9	0.2	-0.6	-0.5
Hair/balding pattern: Pattern 2	1.2	1.5	3.7	-1.9	-1.2	-0.5	-1.2	1.0
Had menopause	1.0	1.2	3.9	1.4	0.4	-0.2	2.0	0.2
Had other major operations	0.9	1.1	3.6	0.4	0.3	-1.1	1.9	0.6
Forced vital capacity (FVC)	0.2	0.9	1.5	-1.2	-0.4	1.2	-1.0	-0.8
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	5.4	-0.5	0.7	2.3	-0.6	-1.4
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.1	-2.0	1.3	0.1	0.1	-0.3
Qualifications: None of the above	0.6	1.3	4.0	-0.2	-1.2	-0.7	2.0	0.6
Financial difficulties in last 2 years	0.7	0.9	4.0	-0.4	2.0	0.5	-0.0	0.2
Mouth/teeth dental problems	0.3	0.5	1.6	1.3	0.0	0.1	-0.4	0.7
Heart attack	1.0	1.2	2.4	1.5	0.7	0.9	1.2	-1.0
Allergy	0.9	2.1	4.7	0.6	0.8	-2.2	1.6	1.5
Pain all over the body in last month	1.0	1.1	3.5	0.6	-1.9	0.6	-0.5	-0.9
Diabetes (self-reported)	1.0	1.5	3.9	1.2	0.5	-0.9	2.0	1.1
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.5	0.3	-0.7	-0.1	-0.2	-0.3
Medication: Ramipril	1.0	1.3	3.4	0.1	-0.6	-1.8	-0.6	1.5
Medication: Simvastatin	0.4	0.6	1.8	0.0	-0.2	-0.8	1.3	0.9
Fluid intelligence score	1.8	3.7	5.9	-1.7	-0.5	-2.1	-2.2	2.4
Illnesses of siblings	0.2	0.3	1.0	1.0	0.5	-0.4	-0.1	0.5
Neuroticism score	0.9	1.9	3.8	-2.0	0.5	-1.8	-0.7	1.2
Weight	0.2	1.1	4.1	-0.9	2.0	-0.2	0.6	0.2
Impedance of arm (right)	0.2	0.8	2.6	-0.9	0.0	1.6	0.2	-0.6
Arm fat percentage (right)	0.4	1.6	5.3	-2.3	1.2	-0.6	-0.3	0.8
Trunk fat-free mass	0.3	1.6	3.1	1.1	1.8	0.6	1.5	-1.1
Hip circumference	0.8	3.2	6.5	-1.5	1.5	-2.5	0.6	2.2
Time employed in main current job	1.7	1.9	7.7	0.9	0.6	-2.8	0.3	0.9
Alcohol intake versus 10 years previously	0.8	1.2	2.9	-1.7	-1.5	-0.4	-0.5	0.8
Father’s age at death	2.1	2.8	10.6	3.3	0.4	0.1	1.6	-1.0
Worrier / anxious feelings	1.2	2.3	6.0	-1.2	0.1	-2.4	-1.1	1.6
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.9	-2.0	2.0	-1.0	-0.5	1.1
Falls in the last year	0.2	0.3	1.5	0.1	1.2	0.3	-0.2	0.3
Hair/balding pattern: Pattern 3	0.8	1.2	5.0	2.2	0.5	0.7	-0.1	-0.6
Number of live births	0.5	0.7	1.8	-0.6	-0.4	1.3	1.1	-0.1
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	3.9	0.3	-0.4	1.8	-0.1	-2.0
Pulse rate	0.3	0.5	1.7	-0.1	-1.3	0.0	-0.8	-0.6
Happiness	0.1	0.2	0.4	0.1	0.4	-0.4	0.6	-0.3
Noisy workplace	0.6	0.8	2.7	-0.5	-0.0	0.8	0.6	-1.6
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	0.7	-0.6	0.3	0.5	-1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.3	0.4	0.8	-0.2	1.5	0.3
Mouth/teeth dental problems: Dentures	0.8	1.3	3.4	-1.9	0.2	-1.4	-0.9	0.3
Asthma	0.9	1.7	6.2	-2.5	-0.0	0.7	-1.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	3.9	5.0	12.3	-3.5	2.0	0.3	-2.9	-0.1
Medication: Cholesterol lowering	0.5	0.7	1.5	-0.4	-1.2	0.4	1.2	-0.5
Depression (self-reported)	0.4	0.5	0.9	0.5	-0.4	-0.8	0.9	0.6
Medication: Lansoprazole	0.2	0.2	0.6	0.0	0.3	0.5	0.0	0.8
Prospective memory result	0.9	1.1	4.9	0.1	-0.6	0.0	2.2	-0.1
Lung cancer (father)	0.9	1.0	3.0	-0.3	-1.7	-0.9	0.1	1.0
Illnesses of mother	0.6	0.8	2.9	1.7	0.5	-0.4	-0.5	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	8.1	0.5	0.2	2.1	-0.1	-2.8
Pulse wave Arterial Stiffness index	1.4	1.6	2.6	0.1	1.6	1.0	-1.5	-1.5
Impedance of arm (left)	0.1	0.5	1.5	-1.2	0.2	1.0	-0.2	-0.0
Arm fat mass (right)	0.2	0.9	2.3	-1.5	1.5	-0.3	0.1	0.3
Trunk predicted mass	0.3	1.5	2.8	0.9	1.7	0.7	1.4	-1.2
Standing height	0.3	2.7	4.7	1.0	2.0	1.3	2.2	-1.4
Length of working week for main job	0.1	0.1	0.4	0.2	-0.5	0.6	0.3	0.1
Exposure to tobacco smoke at home	0.4	0.5	1.8	0.4	-0.2	-0.2	1.3	-0.6
Breastfed as a baby	0.3	0.4	1.4	0.6	0.3	0.3	0.3	1.2
Tense / ‘highly strung’	1.1	1.8	6.8	0.1	0.3	-2.6	1.2	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.3	0.0	0.6	-1.5	-0.1	1.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.6	0.2	-0.3	-0.8	0.3	0.6
Birth weight of first child	0.3	0.6	1.1	0.9	-1.1	-0.3	0.8	-0.3
Peak expiratory flow (PEF)	2.0	4.6	11.2	1.7	-0.2	3.0	0.4	-3.3
Pulse wave reflection index	1.3	1.6	3.2	0.2	1.3	1.8	-0.8	-1.6
Ever highly irritable/argumentative for 2 days	1.0	1.2	3.0	-1.7	0.4	-1.4	0.4	0.9
Loud music exposure frequency	0.6	0.7	1.4	-0.8	0.1	-0.2	1.2	-1.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.9	0.4	1.0	0.1	0.2	0.9
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.6	-2.1	-0.5	-0.6	0.6	1.2
Blood clot in the leg (DVT)	0.5	0.7	1.7	0.9	0.7	0.6	0.3	-1.3
Medication: Paracetamol	1.8	3.0	11.9	-3.5	1.4	0.4	-0.9	-0.3
Headache pain in last month	3.0	5.2	20.9	-4.6	1.7	0.9	-1.0	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.2	-0.3	1.1	0.0	0.0	0.2
Glaucoma (self-reported)	1.1	1.2	2.3	-1.3	-1.5	0.9	-0.0	-1.2
Gout (self-reported)	1.1	1.5	4.4	-1.0	0.3	2.1	0.1	-1.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	1.1	0.2	-0.1	-1.0	0.5	0.1
Medication: Amlodipine	1.6	2.2	4.0	-0.2	-2.0	1.6	-1.0	-1.8
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.7	-0.2	-0.2	1.3	0.3	-1.0
Birth weight	0.5	1.2	4.7	-0.5	0.3	0.7	-2.2	-0.5
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.4	-0.6	0.4	0.5	1.2	0.8
High blood pressure (siblings)	0.7	1.0	3.8	-2.0	0.7	0.4	-0.7	0.0
Forced vital capacity (FVC), Best measure	0.2	0.9	1.8	-1.0	0.4	1.0	-0.7	-1.4
Body fat percentage	0.7	2.6	5.4	-2.3	1.2	-1.8	-0.1	1.7
Leg fat percentage (right)	0.9	3.1	7.1	-2.0	0.6	-2.7	-0.4	1.9
Arm fat-free mass (right)	0.2	1.0	3.1	0.6	1.8	-0.1	1.2	-0.4
Exposure to tobacco smoke outside home	0.6	0.7	2.6	0.3	0.3	-0.9	0.2	1.6
Comparative body size at age 10	1.8	5.0	9.9	-2.0	1.3	1.7	-3.2	-2.6
Number of full brothers	3.0	3.8	9.1	-3.0	-0.5	1.0	-2.7	1.1
Worry too long after embarrassment	0.5	0.8	1.7	-1.3	0.6	-1.3	-0.4	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.3	6.9	0.0	-0.4	-2.1	0.3	2.6
Wheeze or whistling in the chest in last year	0.6	1.0	2.3	-1.5	-0.0	1.2	-1.1	-0.3
Number of children fathered	1.0	1.1	1.7	-1.0	-1.3	0.0	-1.1	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	2.6	-0.1	-0.9	-0.6	1.6	-0.6
Age at first live birth	1.3	2.2	8.6	0.8	-2.9	-1.1	0.7	-0.3
Pulse wave peak to peak time	1.3	1.5	2.7	-0.1	-1.5	-0.9	1.6	1.3
Health satisfaction	1.0	1.3	3.0	0.4	1.3	-1.2	-0.6	1.7
Shortness of breath walking on level ground	1.3	1.5	6.6	0.6	2.6	0.1	-0.1	0.9
Qualifications: College or University degree	0.9	2.7	9.0	1.2	-1.1	1.4	0.2	-3.0
Eye problems/disorders: None of the above	2.0	2.3	10.3	3.2	0.8	0.2	0.5	0.4
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.6	-0.9	0.3	-0.5	0.6	1.3
Emphysema/chronic bronchitis	0.8	0.9	3.2	-0.5	0.9	-0.3	0.6	1.8
Medication for pain relief, constipation, heartburn	2.0	3.5	7.6	2.8	-2.6	-0.8	1.5	0.5
Neck or shoulder pain in last month	0.2	0.3	0.6	-0.1	0.5	-0.7	0.3	0.7
Medication: Blood pressure	0.5	0.9	3.0	0.5	-1.7	0.0	-0.6	-0.9
Angina (self-reported)	0.5	0.7	1.6	-1.1	-0.5	0.6	-0.0	-1.3
Migraine (self-reported)	5.8	7.2	22.9	-4.8	2.2	1.2	-2.6	0.2
Medication: Ibuprofen	3.8	4.6	13.1	-3.6	2.1	-0.5	-2.3	0.1
Medication: Allopurinol	2.2	3.0	7.4	-0.9	-0.5	2.7	0.1	-2.5
Medication: Omeprazole	0.5	0.6	1.3	1.1	0.7	-0.1	-0.6	-0.8
Medication: Seretide 50 evohaler	0.3	0.4	1.2	-0.2	-1.1	-0.6	0.6	-0.0
Mean time to correctly identify matches	0.8	1.6	4.2	0.5	-1.5	-2.1	0.1	1.1
Heart disease (mother)	0.8	0.9	2.5	-1.6	-1.4	-0.1	-0.0	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.1	3.7	6.9	1.7	-1.6	2.6	1.6	-2.0
Whole body fat mass	0.3	1.4	2.5	-1.6	1.6	-1.1	0.3	0.9
Leg fat mass (right)	0.4	1.5	3.7	-1.9	1.6	-1.1	-0.1	0.6
Arm predicted mass (right)	0.2	1.0	3.9	0.6	2.0	-0.2	0.9	-0.2
Pulse rate, automated reading	0.3	1.0	2.0	1.1	-0.4	-1.4	-0.7	1.2
Alcohol intake frequency.	1.2	2.9	7.4	-0.8	1.5	-2.0	0.4	2.7
Comparative height size at age 10	0.1	0.7	3.0	-0.3	1.7	0.3	0.4	0.1
Number of full sisters	0.6	0.7	2.1	-1.4	-0.2	0.9	-0.8	0.4
Suffer from ‘nerves’	0.8	1.3	3.9	0.2	-2.0	-1.5	0.4	-0.3
Overall health rating	0.3	0.6	1.7	0.3	0.4	-0.7	-0.6	1.3
Chest pain or discomfort	0.3	0.4	1.5	-0.6	1.2	0.5	-0.0	-0.3
Had major operations	0.5	0.6	1.2	0.9	-1.1	0.6	-0.3	-0.8
Age at last live birth	0.8	1.2	3.7	-0.1	-1.9	-0.1	0.6	-1.4
Family relationship satisfaction	0.4	0.5	1.9	0.1	0.9	1.4	-0.1	-0.1
Leg pain on walking	2.0	2.5	6.8	-1.5	1.8	-0.0	-2.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.2	0.3	2.1	0.7	-1.7	-0.1
Commuting to job workplace: Car/motor vehicle	1.7	2.0	3.5	-1.6	0.3	-1.9	0.9	1.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	1.8	-1.2	-1.4	-0.3	-1.0	0.4
Medication: Aspirin	0.1	0.1	0.5	0.1	0.7	-0.3	0.1	0.2
Supplements: Vitamin C	0.9	1.1	2.7	-0.6	-1.1	1.1	-0.4	-1.6
Knee pain experienced in last month	1.3	2.0	4.9	0.9	1.0	-2.2	1.4	1.1
Hypertension (Self-reported)	0.3	0.7	1.9	0.1	-1.4	0.8	-0.5	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.0	0.4	-1.0	0.1	-0.6	-0.5
Illnesses of father: Heart disease	0.6	0.8	2.0	1.4	0.5	1.0	0.6	-0.1
Illnesses of siblings: Diabetes	0.3	0.4	1.4	-0.5	-1.2	-0.0	-0.3	-0.1
Smoking status: Previous	1.3	1.9	8.6	-0.2	0.8	0.5	2.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	5.0	-1.4	-0.3	2.2	0.1	-2.2
Whole body fat-free mass	0.3	1.7	3.9	0.7	2.0	1.0	1.4	-1.2
Leg fat-free mass (right)	0.4	2.4	5.9	0.2	2.4	1.7	1.1	-1.3
Arm fat percentage (left)	0.5	2.1	6.2	-2.5	1.5	-0.9	-0.6	1.1
Average weekly red wine intake	0.8	1.1	3.1	1.8	0.3	1.0	0.6	-1.0
Handedness (chirality/laterality): Left-handed	2.5	3.0	5.2	0.6	-1.9	2.0	-1.3	-2.3
Mood swings	1.1	2.0	7.8	-2.8	1.0	-0.5	-0.3	0.8
Loneliness, isolation	1.1	1.5	3.7	-1.0	0.4	-1.7	0.1	1.9
Long-standing illness, disability or infirmity	0.3	0.4	1.2	-0.3	0.7	-1.1	-0.0	0.4
Ever had bowel cancer screening	1.1	1.3	3.7	-1.2	-0.4	-1.9	-0.6	0.9
Diabetes diagnosed by doctor	0.9	1.6	4.1	1.6	0.1	-0.3	2.0	0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.2	1.2	-0.2	-0.0	0.8	1.8
Friendships satisfaction	0.4	0.5	1.1	-1.1	0.8	0.3	-0.3	0.6
Qualifications: nursing, teaching	0.7	1.1	3.8	-0.1	-0.3	1.0	0.9	-1.9
Commuting to job workplace: Walk	0.3	0.3	0.8	0.1	0.0	0.9	-0.7	-0.5
Eye problems/disorders: Cataract	6.0	6.9	29.6	-5.4	0.1	-0.0	-2.2	0.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	7.1	-0.9	-0.1	1.5	-0.9	-2.7
Medication for cholesterol	0.3	0.4	1.1	-0.6	0.4	-1.0	0.2	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	4.5	2.1	-0.9	-0.6	1.1	0.1
Back pain experienced in last month	1.8	2.6	6.0	-0.7	1.0	-2.4	0.4	2.4
Mineral and other dietary supplements	0.3	0.4	0.9	0.4	-1.0	-0.1	-0.8	0.7
Breast cancer (self-reported)	0.7	0.8	1.6	1.0	1.3	-0.5	0.7	0.7
Asthma (self-reported)	1.1	2.1	6.5	-2.5	-0.2	0.9	-1.7	-0.6
Osteoporosis (self-reported)	0.2	0.3	0.9	0.7	-0.3	-0.3	-0.0	-0.9
Osteoarthritis (self-reported)	0.5	0.7	1.6	-0.6	0.0	-1.2	0.2	1.3
Medication: Aspirin	0.0	0.0	0.2	0.0	0.1	-0.1	-0.0	-0.4
Medication: Gliclazide	0.3	0.4	1.1	-1.0	0.2	-0.0	0.7	-0.5
Illnesses of father: None of the above (group 1)	1.2	1.4	4.2	-2.0	-0.8	-0.6	-1.4	-0.5
Smoking status: Current	0.7	1.2	3.7	-1.1	0.7	0.7	-1.9	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.0	-0.0	0.5	-0.9	-1.0	-0.7
Whole body water mass	0.3	1.8	4.1	0.7	2.0	1.1	1.4	-1.2
Leg predicted mass (right)	0.5	2.4	5.8	0.3	2.4	1.8	1.1	-1.4
Arm fat mass (left)	0.3	1.2	3.0	-1.6	1.7	-0.4	-0.1	0.5
Number of self-reported non-cancer illnesses	0.6	1.0	3.2	-1.8	-0.6	-0.2	-1.1	0.4
Average weekly champagne plus white wine intake	2.0	2.8	7.9	1.6	-2.8	0.2	1.4	-1.1
Miserableness	0.6	1.0	2.2	-1.5	1.1	0.5	-1.1	-0.2
Guilty feelings	0.2	0.3	0.7	-0.8	0.4	-0.3	0.8	0.2
Wears glasses or contact lenses	0.9	1.1	1.7	-1.2	-0.5	-1.3	-1.3	0.2
Ever taken oral contraceptive pill	0.8	0.9	2.2	0.1	-0.1	-1.4	0.5	1.5
Hearing aid user	0.8	0.9	3.0	-0.2	1.7	0.6	1.0	0.2
Mother’s age at death	0.3	0.4	0.7	0.7	0.8	0.6	0.3	-0.5
Financial situation satisfaction	0.2	0.3	0.8	-0.1	0.3	-0.1	-0.7	-0.9
Tinnitus: Yes, now most or all of the time	0.9	1.1	4.6	-0.1	0.1	2.1	-0.2	-0.9
Commuting to job workplace: Public transport	0.3	0.4	1.0	0.4	1.0	0.7	0.2	-0.5
Eye problems/disorders: Glaucoma	1.0	1.2	2.4	-0.7	-1.6	1.2	0.0	-1.3
Medication: Blood pressure	0.2	0.3	0.8	-0.2	-0.9	0.7	-0.4	-0.4
Pain type(s) experienced in last month: Hip pain	1.5	1.9	5.8	2.4	0.1	-0.6	1.8	0.4
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.7	-0.1	0.3	-0.1	0.3	-0.8
High cholesterol (Self-reported)	0.5	1.0	2.1	-1.5	-1.2	0.0	-0.2	1.2
Medication: Bendroflumethiazide	0.3	0.4	0.9	-0.7	-0.9	-0.8	0.1	0.2
Medication: Paracetamol	1.5	2.4	10.5	-3.2	0.0	-0.7	-0.9	-0.3
Medication: Lisinopril	0.3	0.4	1.4	-0.3	0.5	0.6	-1.2	-0.1
Medication: Atorvastatin	1.2	1.5	3.1	1.1	-0.8	1.5	0.7	-1.8
Illnesses of father: High blood pressure	0.5	0.6	1.4	0.2	0.9	-0.1	0.8	1.2
Alcohol drinker status: Never	0.8	0.9	2.7	1.7	0.6	0.8	0.0	-0.9
Ever smoked	1.2	2.1	5.1	-0.4	1.0	2.3	1.8	-0.9
Basal metabolic rate	0.3	1.5	4.6	0.2	2.1	0.8	1.2	-1.0
Leg fat percentage (left)	1.1	3.9	10.4	-1.7	0.6	-3.2	-0.3	2.4
Arm fat-free mass (left)	0.2	0.9	1.9	0.2	1.3	0.3	1.4	-0.8
Number of operations (self-reported)	0.2	0.2	0.5	-0.4	-0.1	-0.0	0.7	0.7
Average weekly beer plus cider intake	0.4	0.6	1.8	-0.2	1.0	-0.6	0.3	1.4
Irritability	1.0	1.7	3.6	-1.5	1.2	-1.9	0.5	0.8
Risk taking	1.6	2.4	6.2	-0.0	-0.2	2.5	0.8	-2.2
Ever had prostate specific antigen (PSA) test	1.0	1.1	3.5	1.9	0.4	-0.3	1.3	-0.5
Fractured/broken bones in last 5 years	0.5	0.6	2.5	-0.3	0.6	-0.3	-1.6	-0.3
Age started oral contraceptive pill	2.7	3.4	12.0	1.8	-3.5	-0.8	0.9	-0.7
Diastolic blood pressure, automated reading	2.6	8.0	34.6	5.9	-0.4	1.0	1.9	-0.7
Ever depressed for a whole week	0.8	1.0	2.9	-1.7	0.7	-0.6	-0.9	0.5
Unable to work because of sickness or disability	0.7	0.9	1.5	-1.2	-1.0	0.6	-0.5	-1.1
Commuting to job workplace: Cycle	1.3	1.6	5.9	-0.2	2.4	0.5	0.5	-1.2
Myopia	1.1	1.6	5.2	-0.9	1.2	0.8	-2.3	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.8	3.0	0.3	1.7	-0.7	0.2	0.8
Cholesterol lowering medication	0.0	0.0	0.1	0.3	0.2	0.1	-0.0	0.2
Medication: Omeprazole (e.g. Zanprol)	1.3	1.6	5.2	2.3	0.8	0.4	-0.9	-1.1
Pain experienced in last month	1.0	1.6	4.4	2.1	-0.9	0.9	0.2	-1.3
Supplements: Calcium	0.2	0.3	0.6	0.8	-0.2	-0.1	0.8	-0.2
Basal cell carcinoma (self-reported)	1.3	1.6	5.3	-0.2	-2.3	0.6	-0.4	-1.4
Heart attack/myocardial infarction (self-reported)	0.9	1.1	2.3	1.5	0.5	0.9	1.0	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.3	0.9	0.6	0.5	0.3	0.1	-1.0
Heart disease (siblings)	0.4	0.5	1.5	0.6	-0.7	0.1	1.2	0.1
Alcohol drinker status: Previous	2.0	2.3	5.0	1.0	2.2	-1.3	0.7	1.8
Pack years of smoking	1.1	1.6	4.5	-2.1	0.3	0.9	-1.6	0.3
Impedance of whole body	0.2	0.9	2.7	-1.6	-0.5	-0.7	-0.5	0.9
Leg fat mass (left)	0.4	1.4	2.4	-1.6	1.4	-1.3	0.1	0.9
Arm predicted mass (left)	0.2	0.9	2.3	0.1	1.5	0.4	1.3	-0.7