Hub : Traits :

Diabetes (mother)

17 significantly associated models · 12 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	185112300	185786406	1	1	2.0e-10	4.3e-11	6.5e-02	92	IGF2BP2
2	4	6024426	6552201	1	1	1.5e-08	6.6e-08	2.9e-02	84	WFS1
3	10	11515875	13569805	3	1	1.1e-09	4.4e-10	1.0e+00	100	CAMK1D
4	10	93730592	95128815	1	1	3.2e-08	1.6e-07	7.7e-01	100	EIF2S2P3
5	10	113511441	115622375	2	1	2.4e-20	9.7e-69	2.9e-53	23	TCF7L2
6	11	71769936	73198494	1	1	1.1e-07	2.9e-08	1.0e-03	65	STARD10
7	16	67423939	68988905	2	1	1.2e-08	2.4e-07	1.5e-01	92	PLA2G15

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Type 2 Diabetes (T2D) (2018)	47.86	6	6	13.3	1.00	1.7e-05	CAMK1D EIF2S2P3 IGF2BP2 STARD10 TCF7L2 WFS1
Diabetes diagnosed by doctor	39.91	6	5	11.1	1.00	3.4e-05	CAMK1D EIF2S2P3 IGF2BP2 STARD10 TCF7L2 WFS1
Diabetes (self-reported)	35.91	6	4	8.9	0.99	6.9e-05	CAMK1D EIF2S2P3 IGF2BP2 STARD10 TCF7L2 WFS1
Medication: Metformin	31.16	6	4	8.9	1.00	3.9e-06	CAMK1D EIF2S2P3 IGF2BP2 STARD10 TCF7L2 WFS1
Diabetes (father)	27.16	4	3	6.7	1.00	1.1e-03	EIF2S2P3 IGF2BP2 TCF7L2 WFS1
Type 2 Diabetes (T2D) (2012)	20.79	5	3	6.7	0.96	1.0e-02	EIF2S2P3 IGF2BP2 STARD10 TCF7L2 WFS1
Illnesses of siblings: Diabetes	18.42	5	3	6.7	1.00	1.1e-04	CAMK1D EIF2S2P3 IGF2BP2 TCF7L2 WFS1
Medication: Gliclazide	17.74	5	2	4.4	0.99	1.5e-03	CAMK1D EIF2S2P3 IGF2BP2 TCF7L2 WFS1
Eye problems/disorders: Diabetes related eye disease	9.07	3	0	0.0	0.00	1.0e+00	IGF2BP2 TCF7L2 WFS1
Lung FEV1/FVC ratio	8.12	3	3	6.7	0.00	1.0e+00	CAMK1D IGF2BP2 STARD10
Fasting Glucose	7.08	4	0	0.0	0.98	2.1e-02	CAMK1D IGF2BP2 STARD10 TCF7L2
Medication: Cholesterol lowering	5.42	3	0	0.0	0.00	1.0e+00	CAMK1D IGF2BP2 TCF7L2
HDL Cholesterol	5.30	1	1	2.2	0.00	1.0e+00	PLA2G15
Waist Hip Ratio (WHR)	5.23	3	3	6.7	0.00	1.0e+00	EIF2S2P3 IGF2BP2 TCF7L2
Medication: Aspirin	5.08	2	0	0.0	0.00	1.0e+00	IGF2BP2 TCF7L2
Medication: Atorvastatin	4.79	2	0	0.0	0.00	1.0e+00	IGF2BP2 TCF7L2
Medication for cholesterol, blood pressure or diabetes	4.72	2	0	0.0	0.00	1.0e+00	CAMK1D IGF2BP2
Illnesses of father: None of the above (group 1)	4.54	1	0	0.0	0.00	1.0e+00	CAMK1D
Medication: Aspirin	4.45	1	0	0.0	0.00	1.0e+00	IGF2BP2
Medication: Simvastatin	4.41	2	0	0.0	0.00	1.0e+00	CAMK1D TCF7L2
Breast Cancer	4.37	1	1	2.2	0.00	1.0e+00	TCF7L2
Cholesterol lowering medication	4.27	1	0	0.0	0.00	1.0e+00	TCF7L2
Peak expiratory flow (PEF)	4.04	2	1	2.2	0.00	1.0e+00	CAMK1D IGF2BP2
Forced expiratory volume in 1-second (FEV1)	3.94	2	1	2.2	0.00	1.0e+00	CAMK1D IGF2BP2
Forced expiratory volume in 1-second (FEV1), Best measure	3.85	2	1	2.2	0.00	1.0e+00	CAMK1D IGF2BP2
Birth weight	3.71	2	1	2.2	0.00	1.0e+00	EIF2S2P3 TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.70	2	1	2.2	0.00	1.0e+00	CAMK1D IGF2BP2
Blood Eosinophil Count	3.47	3	2	4.4	0.00	1.0e+00	EIF2S2P3 PLA2G15 STARD10
Illnesses of mother	3.42	1	0	0.0	0.00	1.0e+00	IGF2BP2
Lung FVC	3.37	4	2	4.4	-0.57	4.3e-01	CAMK1D IGF2BP2 PLA2G15 STARD10
Bipolar Disorder (2011)	3.31	1	0	0.0	0.00	1.0e+00	PLA2G15
Long-standing illness, disability or infirmity	3.19	1	0	0.0	0.00	1.0e+00	IGF2BP2
Body Mass Index (BMI) (2010)	2.98	1	0	0.0	0.00	1.0e+00	TCF7L2
Number of treatments/medications taken	2.93	2	0	0.0	0.00	1.0e+00	IGF2BP2 WFS1
Hip circumference	2.77	1	1	2.2	0.00	1.0e+00	TCF7L2
Illnesses of siblings	2.65	1	0	0.0	0.00	1.0e+00	IGF2BP2
Heart attack/myocardial infarction (self-reported)	2.64	1	0	0.0	0.00	1.0e+00	PLA2G15
Pulse rate, automated reading	2.60	4	0	0.0	0.59	4.1e-01	EIF2S2P3 STARD10 TCF7L2 WFS1
Frequency of unenthusiasm / disinterest in last 2 weeks	2.58	1	0	0.0	0.00	1.0e+00	PLA2G15
Crohns Disease (2017)	2.57	1	0	0.0	0.00	1.0e+00	STARD10
Ever highly irritable/argumentative for 2 days	2.52	1	0	0.0	0.00	1.0e+00	PLA2G15
Medication: Blood pressure	2.51	1	0	0.0	0.00	1.0e+00	CAMK1D
Age at First Birth	2.47	1	0	0.0	0.00	1.0e+00	PLA2G15
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.45	1	0	0.0	0.00	1.0e+00	TCF7L2
Heart attack	2.21	1	0	0.0	0.00	1.0e+00	PLA2G15
Systolic blood pressure, automated reading	2.16	1	1	2.2	0.00	1.0e+00	CAMK1D
Qualifications: nursing, teaching	2.13	1	0	0.0	0.00	1.0e+00	TCF7L2
Age at first live birth	2.11	1	0	0.0	0.00	1.0e+00	PLA2G15
High cholesterol (Self-reported)	2.09	1	0	0.0	0.00	1.0e+00	TCF7L2
Medication for pain relief, constipation, heartburn	2.07	1	0	0.0	0.00	1.0e+00	IGF2BP2
Age at last live birth	2.07	1	0	0.0	0.00	1.0e+00	EIF2S2P3
Overall health rating	2.06	1	0	0.0	0.00	1.0e+00	IGF2BP2
Birth weight of first child	2.05	1	0	0.0	0.00	1.0e+00	IGF2BP2
Forced vital capacity (FVC)	2.01	3	0	0.0	0.00	1.0e+00	CAMK1D IGF2BP2 PLA2G15
Irritable Bowel Disease (IBD)	1.98	2	0	0.0	0.00	1.0e+00	EIF2S2P3 STARD10
Respiratory disease	1.98	1	0	0.0	0.00	1.0e+00	EIF2S2P3
Frequency of tenseness / restlessness in last 2 weeks	1.97	1	0	0.0	0.00	1.0e+00	PLA2G15
Intelligence (Savage-Jansen 2018)	1.96	1	1	2.2	0.00	1.0e+00	PLA2G15
Systolic Blood Pressure	1.92	2	1	2.2	0.00	1.0e+00	CAMK1D TCF7L2
Impedance of whole body	1.92	3	1	2.2	0.00	1.0e+00	PLA2G15 TCF7L2 WFS1
Number of self-reported non-cancer illnesses	1.90	1	0	0.0	0.00	1.0e+00	IGF2BP2
Asthma	1.89	1	0	0.0	0.00	1.0e+00	EIF2S2P3
Impedance of arm (left)	1.89	3	0	0.0	0.00	1.0e+00	PLA2G15 TCF7L2 WFS1
Leg fat mass (right)	1.89	2	1	2.2	0.00	1.0e+00	TCF7L2 WFS1
Leg fat mass (left)	1.87	2	1	2.2	0.00	1.0e+00	TCF7L2 WFS1
Body mass index (BMI)	1.84	2	1	2.2	0.00	1.0e+00	TCF7L2 WFS1
Asthma (self-reported)	1.84	1	0	0.0	0.00	1.0e+00	EIF2S2P3
Ever had stillbirth, spontaneous miscarriage or termination	1.83	1	0	0.0	0.00	1.0e+00	TCF7L2
Breast cancer (self-reported)	1.82	1	0	0.0	0.00	1.0e+00	TCF7L2
Depression (Nagel 2018)	1.81	1	0	0.0	0.00	1.0e+00	PLA2G15
Verbal and Numeric Reasoning (VNR)	1.81	1	0	0.0	0.00	1.0e+00	PLA2G15
BMI	1.80	3	1	2.2	0.00	1.0e+00	PLA2G15 TCF7L2 WFS1
Impedance of arm (right)	1.80	3	0	0.0	0.00	1.0e+00	PLA2G15 TCF7L2 WFS1
Forced vital capacity (FVC), Best measure	1.80	2	0	0.0	0.00	1.0e+00	CAMK1D PLA2G15
Waist circumference	1.79	2	0	0.0	0.00	1.0e+00	TCF7L2 WFS1
Worrier / anxious feelings	1.78	1	0	0.0	0.00	1.0e+00	TCF7L2
Loneliness, isolation	1.78	1	0	0.0	0.00	1.0e+00	PLA2G15
Leg fat percentage (left)	1.78	1	1	2.2	0.00	1.0e+00	TCF7L2
Leg fat percentage (right)	1.76	1	1	2.2	0.00	1.0e+00	TCF7L2
Mouth/teeth dental problems: Dentures	1.72	1	0	0.0	0.00	1.0e+00	STARD10
Fed-up feelings	1.68	1	0	0.0	0.00	1.0e+00	PLA2G15
Hypothyroidism (self reported)	1.67	1	0	0.0	0.00	1.0e+00	IGF2BP2
Vascular/heart problems diagnosed by doctor	1.67	2	0	0.0	0.00	1.0e+00	CAMK1D IGF2BP2
Impedance of leg (left)	1.66	2	1	2.2	0.00	1.0e+00	PLA2G15 WFS1
Neuroticism (Nagel 2018)	1.63	1	0	0.0	0.00	1.0e+00	PLA2G15
Blood Platelet Count	1.59	2	1	2.2	0.00	1.0e+00	EIF2S2P3 IGF2BP2
Impedance of leg (right)	1.57	3	0	0.0	0.00	1.0e+00	PLA2G15 TCF7L2 WFS1
Headache pain in last month	1.55	1	0	0.0	0.00	1.0e+00	STARD10
Heart disease (siblings)	1.48	1	0	0.0	0.00	1.0e+00	IGF2BP2
Wheeze or whistling in the chest in last year	1.45	1	0	0.0	0.00	1.0e+00	IGF2BP2
Hypertension (Self-reported)	1.44	2	0	0.0	0.00	1.0e+00	CAMK1D IGF2BP2
Cardiovascular Disease	1.43	2	0	0.0	0.00	1.0e+00	CAMK1D IGF2BP2
High blood pressure	1.43	2	0	0.0	0.00	1.0e+00	CAMK1D IGF2BP2
Neuroticism score	1.42	1	0	0.0	0.00	1.0e+00	PLA2G15
Gout (self-reported)	1.42	1	0	0.0	0.00	1.0e+00	WFS1
Arm fat mass (right)	1.38	1	0	0.0	0.00	1.0e+00	TCF7L2
Leg fat-free mass (left)	1.37	4	0	0.0	-0.52	4.8e-01	PLA2G15 STARD10 TCF7L2 WFS1
Leg predicted mass (left)	1.36	4	0	0.0	-0.51	4.9e-01	PLA2G15 STARD10 TCF7L2 WFS1
Neuroticism	1.35	1	0	0.0	0.00	1.0e+00	PLA2G15
Weight	1.34	2	0	0.0	0.00	1.0e+00	TCF7L2 WFS1
Arm fat mass (left)	1.32	1	0	0.0	0.00	1.0e+00	TCF7L2
Heel T-Score	1.31	3	1	2.2	0.00	1.0e+00	IGF2BP2 STARD10 TCF7L2
Whole body fat mass	1.31	1	0	0.0	0.00	1.0e+00	TCF7L2
Smoking Status	1.30	1	0	0.0	0.00	1.0e+00	WFS1
Hypothyroidism/myxoedema (self-reported)	1.29	1	0	0.0	0.00	1.0e+00	IGF2BP2
Arm predicted mass (left)	1.28	3	0	0.0	0.00	1.0e+00	PLA2G15 TCF7L2 WFS1
Allergy or Eczema	1.27	1	0	0.0	0.00	1.0e+00	WFS1
Arm fat-free mass (left)	1.27	3	0	0.0	0.00	1.0e+00	PLA2G15 TCF7L2 WFS1
Fluid intelligence score	1.26	1	0	0.0	0.00	1.0e+00	PLA2G15
Basal metabolic rate	1.25	3	0	0.0	0.00	1.0e+00	PLA2G15 TCF7L2 WFS1
Leg fat-free mass (right)	1.23	4	0	0.0	-0.50	5.0e-01	PLA2G15 STARD10 TCF7L2 WFS1
Leg predicted mass (right)	1.22	4	0	0.0	-0.51	4.9e-01	PLA2G15 STARD10 TCF7L2 WFS1
Arm fat-free mass (right)	1.20	3	0	0.0	0.00	1.0e+00	PLA2G15 TCF7L2 WFS1
Depressed Affect (Nagel 2018)	1.18	1	0	0.0	0.00	1.0e+00	PLA2G15
Arm predicted mass (right)	1.18	2	0	0.0	0.00	1.0e+00	PLA2G15 WFS1
Whole body fat-free mass	1.18	2	0	0.0	0.00	1.0e+00	PLA2G15 WFS1
Tense / 'highly strung'	1.17	1	0	0.0	0.00	1.0e+00	PLA2G15
Whole body water mass	1.17	2	0	0.0	0.00	1.0e+00	PLA2G15 WFS1
Qualifications: College or University degree	1.16	1	0	0.0	0.00	1.0e+00	PLA2G15
Pack years of smoking	1.14	1	0	0.0	0.00	1.0e+00	STARD10
Body fat percentage	1.11	1	0	0.0	0.00	1.0e+00	TCF7L2
Worry (Nagel 2018)	1.10	1	0	0.0	0.00	1.0e+00	PLA2G15
Arm fat percentage (left)	1.07	1	0	0.0	0.00	1.0e+00	TCF7L2
Arm fat percentage (right)	1.06	1	0	0.0	0.00	1.0e+00	TCF7L2
Diastolic blood pressure, automated reading	1.05	1	0	0.0	0.00	1.0e+00	TCF7L2
Trunk predicted mass	1.04	2	0	0.0	0.00	1.0e+00	PLA2G15 WFS1
Trunk fat-free mass	1.03	2	0	0.0	0.00	1.0e+00	PLA2G15 WFS1
Trunk fat mass	0.97	1	0	0.0	0.00	1.0e+00	TCF7L2
Trunk fat percentage	0.77	1	0	0.0	0.00	1.0e+00	TCF7L2
Blood Red Count	0.74	2	0	0.0	0.00	1.0e+00	EIF2S2P3 IGF2BP2
Comparative height size at age 10	0.47	1	0	0.0	0.00	1.0e+00	EIF2S2P3
Blood White Count	0.43	1	0	0.0	0.00	1.0e+00	IGF2BP2
Height	0.17	1	0	0.0	0.00	1.0e+00	TCF7L2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Spleen	1	0.071	1.4
GTEx	Thyroid	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	1	0.034	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	1	0.031	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	2	0.070	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Prostate	1	0.120	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Whole Blood	1	0.050	1.3
METSIM	Adipose	1	0.022	1.3
NTR	Blood	2	0.083	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
YFS	Blood	3	0.065	1.3
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	2	0.049	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2