Hub : Traits :

Medication: Ibuprofen

5 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 12020241 13990267 2 1 1.1e-07 2.7e-08 1 100 RP1-257A7.5
2 12 56805309 58303535 2 1 7.6e-11 6.9e-11 1 100 LRP1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 1.99 1 0 0.0 0 1 LRP1
Depressed Affect (Nagel 2018) 3.00 1 0 0.0 0 1 LRP1
Schizophrenia (2018) 2.31 1 0 0.0 0 1 LRP1
Coronary Artery Disease (CAD) 19.32 1 1 2.2 0 1 RP1-257A7.5
Primary Biliary Cirrhosis 5.80 1 0 0.0 0 1 LRP1
Blood Eosinophil Count 2.20 1 1 2.2 0 1 LRP1
Blood Platelet Count 0.66 1 0 0.0 0 1 LRP1
Blood Red Count 0.90 1 0 0.0 0 1 RP1-257A7.5
Blood White Count 0.64 1 0 0.0 0 1 RP1-257A7.5
BMI 2.34 1 0 0.0 0 1 LRP1
Height 1.19 1 1 2.2 0 1 LRP1
Systolic Blood Pressure 3.49 1 1 2.2 0 1 RP1-257A7.5
Allergy or Eczema 3.64 1 0 0.0 0 1 LRP1
Respiratory disease 7.27 1 1 2.2 0 1 LRP1
Lung FEV1/FVC ratio 12.90 1 1 2.2 0 1 LRP1
Neuroticism 3.08 1 0 0.0 0 1 LRP1
Chronotype (morning person) 1.49 1 0 0.0 0 1 RP1-257A7.5
Hair Pigment 0.33 1 0 0.0 0 1 LRP1
Hand grip strength (left) 5.77 1 1 2.2 0 1 RP1-257A7.5
Number of treatments/medications taken 8.16 2 0 0.0 0 1 LRP1 RP1-257A7.5
Sensitivity / hurt feelings 3.98 1 0 0.0 0 1 LRP1
Systolic blood pressure, automated reading 4.80 2 0 0.0 0 1 LRP1 RP1-257A7.5
Angina 12.31 1 1 2.2 0 1 RP1-257A7.5
Vitamin and mineral supplements 10.72 1 1 2.2 0 1 LRP1
Pack years adult smoking proportion 2.52 1 0 0.0 0 1 LRP1
Trunk fat percentage 2.42 2 0 0.0 0 1 LRP1 RP1-257A7.5
Hand grip strength (right) 5.69 2 0 0.0 0 1 LRP1 RP1-257A7.5
High blood pressure 1.59 1 0 0.0 0 1 RP1-257A7.5
Hayfever, allergic rhinitis or eczema 3.64 1 0 0.0 0 1 LRP1
Multivitamins +/- minerals 6.08 1 0 0.0 0 1 LRP1
Sitting height 3.22 1 1 2.2 0 1 LRP1
High blood pressure (mother) 4.89 1 0 0.0 0 1 RP1-257A7.5
Body mass index (BMI) 1.86 1 0 0.0 0 1 LRP1
Hair/balding pattern: Pattern 2 3.57 1 0 0.0 0 1 LRP1
Forced vital capacity (FVC) 1.27 1 0 0.0 0 1 LRP1
Qualifications: None of the above 1.91 1 0 0.0 0 1 LRP1
Heart attack 23.85 1 1 2.2 0 1 RP1-257A7.5
Allergy 4.74 1 0 0.0 0 1 LRP1
Hayfever/allergic rhinitis (self-reported) 6.97 1 0 0.0 0 1 LRP1
Fluid intelligence score 2.35 1 0 0.0 0 1 LRP1
Arm fat percentage (right) 2.59 2 0 0.0 0 1 LRP1 RP1-257A7.5
Trunk fat-free mass 1.29 1 0 0.0 0 1 LRP1
Asthma 5.99 1 0 0.0 0 1 LRP1
Medication: Ibuprofen (e.g. Nurofen) 36.02 2 2 4.4 0 1 LRP1 RP1-257A7.5
Prospective memory result 3.22 1 0 0.0 0 1 LRP1
Pulse wave Arterial Stiffness index 9.58 1 0 0.0 0 1 RP1-257A7.5
Trunk predicted mass 1.30 1 0 0.0 0 1 LRP1
Standing height 1.76 1 1 2.2 0 1 LRP1
Pulse wave reflection index 3.07 1 0 0.0 0 1 LRP1
Medication: Paracetamol 32.66 2 2 4.4 0 1 LRP1 RP1-257A7.5
Headache pain in last month 67.80 2 2 4.4 0 1 LRP1 RP1-257A7.5
Gout (self-reported) 3.49 1 0 0.0 0 1 LRP1
Medication: Ventolin 100micrograms inhaler 3.11 1 0 0.0 0 1 LRP1
Birth weight 4.42 2 0 0.0 0 1 LRP1 RP1-257A7.5
High blood pressure (siblings) 3.75 1 0 0.0 0 1 LRP1
Body fat percentage 3.08 2 0 0.0 0 1 LRP1 RP1-257A7.5
Leg fat percentage (right) 4.23 2 0 0.0 0 1 LRP1 RP1-257A7.5
Arm fat-free mass (right) 0.68 1 0 0.0 0 1 LRP1
Pulse wave peak to peak time 8.40 1 0 0.0 0 1 RP1-257A7.5
Medication for pain relief, constipation, heartburn 27.73 2 1 2.2 0 1 LRP1 RP1-257A7.5
Neck or shoulder pain in last month 4.11 1 0 0.0 0 1 LRP1
Angina (self-reported) 12.38 1 1 2.2 0 1 RP1-257A7.5
Migraine (self-reported) 62.79 2 2 4.4 0 1 LRP1 RP1-257A7.5
Medication: Seretide 50 evohaler 3.38 1 0 0.0 0 1 LRP1
Heart disease (mother) 8.06 1 0 0.0 0 1 RP1-257A7.5
Leg fat mass (right) 1.83 1 0 0.0 0 1 LRP1
Pulse rate, automated reading 2.45 1 0 0.0 0 1 RP1-257A7.5
Alcohol intake frequency. 9.65 2 0 0.0 0 1 LRP1 RP1-257A7.5
Had major operations 5.81 1 0 0.0 0 1 RP1-257A7.5
Medication: Aspirin 3.27 1 0 0.0 0 1 RP1-257A7.5
Knee pain experienced in last month 3.56 1 0 0.0 0 1 RP1-257A7.5
Hypertension (Self-reported) 1.83 1 0 0.0 0 1 RP1-257A7.5
Illnesses of father: Heart disease 15.87 1 1 2.2 0 1 RP1-257A7.5
Whole body fat-free mass 0.87 1 0 0.0 0 1 LRP1
Arm fat percentage (left) 2.74 2 0 0.0 0 1 LRP1 RP1-257A7.5
Mood swings 2.59 1 0 0.0 0 1 LRP1
Back pain experienced in last month 4.10 1 0 0.0 0 1 LRP1
Mineral and other dietary supplements 7.06 1 0 0.0 0 1 LRP1
Asthma (self-reported) 5.94 1 0 0.0 0 1 LRP1
Medication: Aspirin 3.50 1 0 0.0 0 1 RP1-257A7.5
Illnesses of father: None of the above (group 1) 3.47 1 0 0.0 0 1 RP1-257A7.5
Whole body water mass 0.87 1 0 0.0 0 1 LRP1
Miserableness 3.26 1 0 0.0 0 1 LRP1
Supplements: Fish oil (including cod liver oil) 6.17 1 0 0.0 0 1 LRP1
Medication: Bendroflumethiazide 3.47 1 0 0.0 0 1 RP1-257A7.5
Medication: Paracetamol 25.92 2 1 2.2 0 1 LRP1 RP1-257A7.5
Leg fat percentage (left) 4.06 2 0 0.0 0 1 LRP1 RP1-257A7.5
Number of operations (self-reported) 4.96 1 0 0.0 0 1 LRP1
Average weekly beer plus cider intake 3.04 1 0 0.0 0 1 LRP1
Diastolic blood pressure, automated reading 1.27 1 0 0.0 0 1 RP1-257A7.5
Myopia 7.13 1 0 0.0 0 1 LRP1
Pain experienced in last month 15.81 2 1 2.2 0 1 LRP1 RP1-257A7.5
Supplements: Calcium 4.60 1 0 0.0 0 1 LRP1
Heart attack/myocardial infarction (self-reported) 24.75 1 1 2.2 0 1 RP1-257A7.5
Heart disease (siblings) 10.91 1 1 2.2 0 1 RP1-257A7.5
Leg fat mass (left) 1.73 1 0 0.0 0 1 LRP1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 2 0.067 1.2
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 2 0.053 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.3
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.3
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.0
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2