Hub : Traits :

Medication: Ibuprofen

5 significantly associated models · 4 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	6	12020241	13990267	2	1	1.1e-07	2.7e-08	1	100	RP1-257A7.5
2	12	56805309	58303535	2	1	7.6e-11	6.9e-11	1	100	LRP1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Headache pain in last month	67.80	2	2	4.4	1	LRP1 RP1-257A7.5
Migraine (self-reported)	62.79	2	2	4.4	1	LRP1 RP1-257A7.5
Medication: Ibuprofen (e.g. Nurofen)	36.02	2	2	4.4	1	LRP1 RP1-257A7.5
Medication: Paracetamol	32.66	2	2	4.4	1	LRP1 RP1-257A7.5
Medication for pain relief, constipation, heartburn	27.73	2	1	2.2	1	LRP1 RP1-257A7.5
Medication: Paracetamol	25.92	2	1	2.2	1	LRP1 RP1-257A7.5
Heart attack/myocardial infarction (self-reported)	24.75	1	1	2.2	1	RP1-257A7.5
Heart attack	23.85	1	1	2.2	1	RP1-257A7.5
Coronary Artery Disease (CAD)	19.32	1	1	2.2	1	RP1-257A7.5
Illnesses of father: Heart disease	15.87	1	1	2.2	1	RP1-257A7.5
Pain experienced in last month	15.81	2	1	2.2	1	LRP1 RP1-257A7.5
Lung FEV1/FVC ratio	12.90	1	1	2.2	1	LRP1
Angina (self-reported)	12.38	1	1	2.2	1	RP1-257A7.5
Angina	12.31	1	1	2.2	1	RP1-257A7.5
Heart disease (siblings)	10.91	1	1	2.2	1	RP1-257A7.5
Vitamin and mineral supplements	10.72	1	1	2.2	1	LRP1
Alcohol intake frequency.	9.65	2	0	0.0	1	LRP1 RP1-257A7.5
Pulse wave Arterial Stiffness index	9.58	1	0	0.0	1	RP1-257A7.5
Pulse wave peak to peak time	8.40	1	0	0.0	1	RP1-257A7.5
Number of treatments/medications taken	8.16	2	0	0.0	1	LRP1 RP1-257A7.5
Heart disease (mother)	8.06	1	0	0.0	1	RP1-257A7.5
Respiratory disease	7.27	1	1	2.2	1	LRP1
Myopia	7.13	1	0	0.0	1	LRP1
Mineral and other dietary supplements	7.06	1	0	0.0	1	LRP1
Hayfever/allergic rhinitis (self-reported)	6.97	1	0	0.0	1	LRP1
Supplements: Fish oil (including cod liver oil)	6.17	1	0	0.0	1	LRP1
Multivitamins +/- minerals	6.08	1	0	0.0	1	LRP1
Asthma	5.99	1	0	0.0	1	LRP1
Asthma (self-reported)	5.94	1	0	0.0	1	LRP1
Had major operations	5.81	1	0	0.0	1	RP1-257A7.5
Primary Biliary Cirrhosis	5.80	1	0	0.0	1	LRP1
Hand grip strength (left)	5.77	1	1	2.2	1	RP1-257A7.5
Hand grip strength (right)	5.69	2	0	0.0	1	LRP1 RP1-257A7.5
Number of operations (self-reported)	4.96	1	0	0.0	1	LRP1
High blood pressure (mother)	4.89	1	0	0.0	1	RP1-257A7.5
Systolic blood pressure, automated reading	4.80	2	0	0.0	1	LRP1 RP1-257A7.5
Allergy	4.74	1	0	0.0	1	LRP1
Supplements: Calcium	4.60	1	0	0.0	1	LRP1
Birth weight	4.42	2	0	0.0	1	LRP1 RP1-257A7.5
Leg fat percentage (right)	4.23	2	0	0.0	1	LRP1 RP1-257A7.5
Neck or shoulder pain in last month	4.11	1	0	0.0	1	LRP1
Back pain experienced in last month	4.10	1	0	0.0	1	LRP1
Leg fat percentage (left)	4.06	2	0	0.0	1	LRP1 RP1-257A7.5
Sensitivity / hurt feelings	3.98	1	0	0.0	1	LRP1
High blood pressure (siblings)	3.75	1	0	0.0	1	LRP1
Allergy or Eczema	3.64	1	0	0.0	1	LRP1
Hayfever, allergic rhinitis or eczema	3.64	1	0	0.0	1	LRP1
Hair/balding pattern: Pattern 2	3.57	1	0	0.0	1	LRP1
Knee pain experienced in last month	3.56	1	0	0.0	1	RP1-257A7.5
Medication: Aspirin	3.50	1	0	0.0	1	RP1-257A7.5
Systolic Blood Pressure	3.49	1	1	2.2	1	RP1-257A7.5
Gout (self-reported)	3.49	1	0	0.0	1	LRP1
Illnesses of father: None of the above (group 1)	3.47	1	0	0.0	1	RP1-257A7.5
Medication: Bendroflumethiazide	3.47	1	0	0.0	1	RP1-257A7.5
Medication: Seretide 50 evohaler	3.38	1	0	0.0	1	LRP1
Medication: Aspirin	3.27	1	0	0.0	1	RP1-257A7.5
Miserableness	3.26	1	0	0.0	1	LRP1
Sitting height	3.22	1	1	2.2	1	LRP1
Prospective memory result	3.22	1	0	0.0	1	LRP1
Medication: Ventolin 100micrograms inhaler	3.11	1	0	0.0	1	LRP1
Neuroticism	3.08	1	0	0.0	1	LRP1
Body fat percentage	3.08	2	0	0.0	1	LRP1 RP1-257A7.5
Pulse wave reflection index	3.07	1	0	0.0	1	LRP1
Average weekly beer plus cider intake	3.04	1	0	0.0	1	LRP1
Depressed Affect (Nagel 2018)	3.00	1	0	0.0	1	LRP1
Arm fat percentage (left)	2.74	2	0	0.0	1	LRP1 RP1-257A7.5
Arm fat percentage (right)	2.59	2	0	0.0	1	LRP1 RP1-257A7.5
Mood swings	2.59	1	0	0.0	1	LRP1
Pack years adult smoking proportion	2.52	1	0	0.0	1	LRP1
Pulse rate, automated reading	2.45	1	0	0.0	1	RP1-257A7.5
Trunk fat percentage	2.42	2	0	0.0	1	LRP1 RP1-257A7.5
Fluid intelligence score	2.35	1	0	0.0	1	LRP1
BMI	2.34	1	0	0.0	1	LRP1
Schizophrenia (2018)	2.31	1	0	0.0	1	LRP1
Blood Eosinophil Count	2.20	1	1	2.2	1	LRP1
Bipolar Disorder or Schizophrenia	1.99	1	0	0.0	1	LRP1
Qualifications: None of the above	1.91	1	0	0.0	1	LRP1
Body mass index (BMI)	1.86	1	0	0.0	1	LRP1
Leg fat mass (right)	1.83	1	0	0.0	1	LRP1
Hypertension (Self-reported)	1.83	1	0	0.0	1	RP1-257A7.5
Standing height	1.76	1	1	2.2	1	LRP1
Leg fat mass (left)	1.73	1	0	0.0	1	LRP1
High blood pressure	1.59	1	0	0.0	1	RP1-257A7.5
Chronotype (morning person)	1.49	1	0	0.0	1	RP1-257A7.5
Trunk predicted mass	1.30	1	0	0.0	1	LRP1
Trunk fat-free mass	1.29	1	0	0.0	1	LRP1
Forced vital capacity (FVC)	1.27	1	0	0.0	1	LRP1
Diastolic blood pressure, automated reading	1.27	1	0	0.0	1	RP1-257A7.5
Height	1.19	1	1	2.2	1	LRP1
Blood Red Count	0.90	1	0	0.0	1	RP1-257A7.5
Whole body fat-free mass	0.87	1	0	0.0	1	LRP1
Whole body water mass	0.87	1	0	0.0	1	LRP1
Arm fat-free mass (right)	0.68	1	0	0.0	1	LRP1
Blood Platelet Count	0.66	1	0	0.0	1	LRP1
Blood White Count	0.64	1	0	0.0	1	RP1-257A7.5
Hair Pigment	0.33	1	0	0.0	1	LRP1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	2	0.053	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Prostate	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Artery Aorta	2	0.067	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
METSIM	Adipose	0	0.000	1.1
YFS	Blood	0	0.000	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.1
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.0