Hub : Traits :

Schizophrenia vs Biploar Disorder

5 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 173437024 175663031 3 1 1.3e-08 8.1e-09 1 100 GAS5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 3.62 1 0 0.0 0 1 GAS5
Schizophrenia (2018) 4.54 1 0 0.0 0 1 GAS5
Worry (Nagel 2018) 5.19 1 0 0.0 0 1 GAS5
Schizophrenia (2014) 6.63 1 0 0.0 0 1 GAS5
Blood Red Count 2.29 1 0 0.0 0 1 GAS5
Blood White Count 2.98 1 0 0.0 0 1 GAS5
Heel T-Score 1.99 1 0 0.0 0 1 GAS5
Height 0.64 1 0 0.0 0 1 GAS5
Waist Hip Ratio (WHR) 1.84 1 0 0.0 0 1 GAS5
Smoking Status 4.28 1 0 0.0 0 1 GAS5
Hypothyroidism (self reported) 3.22 1 0 0.0 0 1 GAS5
Respiratory disease 6.66 1 0 0.0 0 1 GAS5
Lung FVC 1.76 1 0 0.0 0 1 GAS5
Neuroticism 3.71 1 0 0.0 0 1 GAS5
Hair Pigment 0.32 1 0 0.0 0 1 GAS5
Number of treatments/medications taken 4.08 1 0 0.0 0 1 GAS5
Pack years adult smoking proportion 5.63 1 0 0.0 0 1 GAS5
Taking other prescription medications 4.35 1 0 0.0 0 1 GAS5
Age when periods started (menarche) 6.30 1 0 0.0 0 1 GAS5
Alcohol usually taken with meals 22.79 1 1 2.2 0 1 GAS5
Qualifications: None of the above 3.90 1 0 0.0 0 1 GAS5
Neuroticism score 4.52 1 0 0.0 0 1 GAS5
Trunk fat-free mass 1.81 1 0 0.0 0 1 GAS5
Hip circumference 1.76 1 0 0.0 0 1 GAS5
Frequency of tiredness / lethargy in last 2 weeks 10.50 1 0 0.0 0 1 GAS5
Forced expiratory volume in 1-second (FEV1) 2.06 1 0 0.0 0 1 GAS5
Asthma 4.35 1 0 0.0 0 1 GAS5
Forced expiratory volume in 1-second (FEV1), Best measure 2.45 1 0 0.0 0 1 GAS5
Impedance of arm (left) 1.77 1 0 0.0 0 1 GAS5
Trunk predicted mass 1.83 1 0 0.0 0 1 GAS5
Tense / 'highly strung' 4.28 1 0 0.0 0 1 GAS5
Headache pain in last month 9.08 1 0 0.0 0 1 GAS5
Arm fat-free mass (right) 1.32 1 0 0.0 0 1 GAS5
Wheeze or whistling in the chest in last year 7.06 1 0 0.0 0 1 GAS5
Qualifications: College or University degree 2.89 1 0 0.0 0 1 GAS5
Emphysema/chronic bronchitis 6.96 1 0 0.0 0 1 GAS5
Arm predicted mass (right) 1.35 1 0 0.0 0 1 GAS5
Pulse rate, automated reading 4.40 1 0 0.0 0 1 GAS5
Overall health rating 3.93 1 0 0.0 0 1 GAS5
Commuting to job workplace: Car/motor vehicle 6.43 1 0 0.0 0 1 GAS5
Whole body fat-free mass 1.23 1 0 0.0 0 1 GAS5
Long-standing illness, disability or infirmity 4.35 1 0 0.0 0 1 GAS5
Asthma (self-reported) 4.18 1 0 0.0 0 1 GAS5
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.83 1 0 0.0 0 1 GAS5
Whole body water mass 1.28 1 0 0.0 0 1 GAS5
Miserableness 4.15 1 0 0.0 0 1 GAS5
Financial situation satisfaction 5.45 1 0 0.0 0 1 GAS5
Basal metabolic rate 1.22 1 0 0.0 0 1 GAS5
Arm fat-free mass (left) 1.92 1 0 0.0 0 1 GAS5
Pain experienced in last month 5.23 1 0 0.0 0 1 GAS5
Pack years of smoking 5.82 1 0 0.0 0 1 GAS5
Arm predicted mass (left) 2.03 1 0 0.0 0 1 GAS5

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.4
GTEx Adipose Visceral Omentum 0 0.000 1.5
GTEx Adrenal Gland 0 0.000 1.5
GTEx Artery Aorta 0 0.000 1.4
GTEx Artery Coronary 0 0.000 1.5
GTEx Artery Tibial 0 0.000 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.5
GTEx Brain Cerebellar Hemisphere 0 0.000 1.4
GTEx Brain Cerebellum 0 0.000 1.5
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.5
GTEx Brain Hippocampus 0 0.000 1.5
GTEx Brain Hypothalamus 0 0.000 1.5
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.5
GTEx Brain Putamen basal ganglia 0 0.000 1.6
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.4
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.6
GTEx Cells Transformed fibroblasts 0 0.000 1.5
GTEx Colon Sigmoid 0 0.000 1.5
GTEx Colon Transverse 0 0.000 1.5
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.5
GTEx Esophagus Mucosa 0 0.000 1.5
GTEx Esophagus Muscularis 0 0.000 1.5
GTEx Heart Atrial Appendage 1 0.068 1.5
GTEx Heart Left Ventricle 0 0.000 1.4
GTEx Liver 0 0.000 1.4
GTEx Lung 1 0.038 1.5
GTEx Muscle Skeletal 0 0.000 1.5
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.6
GTEx Pancreas 0 0.000 1.5
GTEx Pituitary 0 0.000 1.5
GTEx Prostate 0 0.000 1.5
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.5
GTEx Skin Sun Exposed Lower leg 0 0.000 1.5
GTEx Small Intestine Terminal Ileum 0 0.000 1.6
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.4
GTEx Testis 0 0.000 1.5
GTEx Thyroid 0 0.000 1.4
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.6
GTEx Whole Blood 0 0.000 1.5
METSIM Adipose 0 0.000 1.4
NTR Blood 0 0.000 1.5
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.5
YFS Blood 0 0.000 1.4
CommonMind Brain Pre-frontal Cortex 1 0.020 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.037 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.044 1.5
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4