Hub : Traits :

Schizophrenia vs Biploar Disorder

5 significantly associated models · 4 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	173437024	175663031	3	1	1.3e-08	8.1e-09	1	100	GAS5

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Alcohol usually taken with meals	22.79	1	1	2.2	1	GAS5
Frequency of tiredness / lethargy in last 2 weeks	10.50	1	0	0.0	1	GAS5
Headache pain in last month	9.08	1	0	0.0	1	GAS5
Wheeze or whistling in the chest in last year	7.06	1	0	0.0	1	GAS5
Emphysema/chronic bronchitis	6.96	1	0	0.0	1	GAS5
Respiratory disease	6.66	1	0	0.0	1	GAS5
Schizophrenia (2014)	6.63	1	0	0.0	1	GAS5
Commuting to job workplace: Car/motor vehicle	6.43	1	0	0.0	1	GAS5
Age when periods started (menarche)	6.30	1	0	0.0	1	GAS5
Pack years of smoking	5.82	1	0	0.0	1	GAS5
Pack years adult smoking proportion	5.63	1	0	0.0	1	GAS5
Financial situation satisfaction	5.45	1	0	0.0	1	GAS5
Pain experienced in last month	5.23	1	0	0.0	1	GAS5
Worry (Nagel 2018)	5.19	1	0	0.0	1	GAS5
Schizophrenia (2018)	4.54	1	0	0.0	1	GAS5
Neuroticism score	4.52	1	0	0.0	1	GAS5
Pulse rate, automated reading	4.40	1	0	0.0	1	GAS5
Taking other prescription medications	4.35	1	0	0.0	1	GAS5
Asthma	4.35	1	0	0.0	1	GAS5
Long-standing illness, disability or infirmity	4.35	1	0	0.0	1	GAS5
Smoking Status	4.28	1	0	0.0	1	GAS5
Tense / 'highly strung'	4.28	1	0	0.0	1	GAS5
Asthma (self-reported)	4.18	1	0	0.0	1	GAS5
Miserableness	4.15	1	0	0.0	1	GAS5
Number of treatments/medications taken	4.08	1	0	0.0	1	GAS5
Overall health rating	3.93	1	0	0.0	1	GAS5
Qualifications: None of the above	3.90	1	0	0.0	1	GAS5
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.83	1	0	0.0	1	GAS5
Neuroticism	3.71	1	0	0.0	1	GAS5
Depressed Affect (Nagel 2018)	3.62	1	0	0.0	1	GAS5
Hypothyroidism (self reported)	3.22	1	0	0.0	1	GAS5
Blood White Count	2.98	1	0	0.0	1	GAS5
Qualifications: College or University degree	2.89	1	0	0.0	1	GAS5
Forced expiratory volume in 1-second (FEV1), Best measure	2.45	1	0	0.0	1	GAS5
Blood Red Count	2.29	1	0	0.0	1	GAS5
Forced expiratory volume in 1-second (FEV1)	2.06	1	0	0.0	1	GAS5
Arm predicted mass (left)	2.03	1	0	0.0	1	GAS5
Heel T-Score	1.99	1	0	0.0	1	GAS5
Arm fat-free mass (left)	1.92	1	0	0.0	1	GAS5
Waist Hip Ratio (WHR)	1.84	1	0	0.0	1	GAS5
Trunk predicted mass	1.83	1	0	0.0	1	GAS5
Trunk fat-free mass	1.81	1	0	0.0	1	GAS5
Impedance of arm (left)	1.77	1	0	0.0	1	GAS5
Lung FVC	1.76	1	0	0.0	1	GAS5
Hip circumference	1.76	1	0	0.0	1	GAS5
Arm predicted mass (right)	1.35	1	0	0.0	1	GAS5
Arm fat-free mass (right)	1.32	1	0	0.0	1	GAS5
Whole body water mass	1.28	1	0	0.0	1	GAS5
Whole body fat-free mass	1.23	1	0	0.0	1	GAS5
Basal metabolic rate	1.22	1	0	0.0	1	GAS5
Height	0.64	1	0	0.0	1	GAS5
Hair Pigment	0.32	1	0	0.0	1	GAS5

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Putamen basal ganglia	0	0.000	1.6
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.6
GTEx	Ovary	0	0.000	1.6
GTEx	Small Intestine Terminal Ileum	0	0.000	1.6
GTEx	Vagina	0	0.000	1.6
GTEx	Adipose Visceral Omentum	0	0.000	1.5
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Coronary	0	0.000	1.5
GTEx	Brain Caudate basal ganglia	0	0.000	1.5
GTEx	Brain Cerebellum	0	0.000	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.5
GTEx	Brain Hippocampus	0	0.000	1.5
GTEx	Brain Hypothalamus	0	0.000	1.5
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.5
GTEx	Cells Transformed fibroblasts	0	0.000	1.5
GTEx	Colon Sigmoid	0	0.000	1.5
GTEx	Colon Transverse	0	0.000	1.5
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.5
GTEx	Esophagus Mucosa	0	0.000	1.5
GTEx	Esophagus Muscularis	0	0.000	1.5
GTEx	Heart Atrial Appendage	1	0.068	1.5
GTEx	Lung	1	0.038	1.5
GTEx	Muscle Skeletal	0	0.000	1.5
GTEx	Pancreas	0	0.000	1.5
GTEx	Pituitary	0	0.000	1.5
GTEx	Prostate	0	0.000	1.5
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.5
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.5
GTEx	Spleen	0	0.000	1.5
GTEx	Testis	0	0.000	1.5
GTEx	Whole Blood	0	0.000	1.5
NTR	Blood	0	0.000	1.5
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.044	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.5
GTEx	Adipose Subcutaneous	0	0.000	1.4
GTEx	Artery Aorta	0	0.000	1.4
GTEx	Artery Tibial	0	0.000	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Heart Left Ventricle	0	0.000	1.4
GTEx	Liver	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Stomach	0	0.000	1.4
GTEx	Thyroid	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
METSIM	Adipose	0	0.000	1.4
YFS	Blood	0	0.000	1.4
CommonMind	Brain Pre-frontal Cortex	1	0.020	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.037	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3