Hub : Traits :

Diabetes (father)

7 significantly associated models · 6 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	42767044	44157441	1	1	1.0e-07	1.0e-08	1.4e-02	82	AC010883.5
2	3	185112300	185786406	1	1	4.1e-13	2.2e-16	6.2e-05	76	IGF2BP2
3	10	92987510	95128815	2	1	1.3e-11	1.8e-11	1.8e-01	96	EIF2S2P3
4	10	113511441	115622375	2	1	1.6e-26	2.8e-62	1.6e-37	41	TCF7L2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Type 2 Diabetes (T2D) (2018)	73.53	4	4	8.9	0.98	0.01785	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Diabetes diagnosed by doctor	62.29	4	4	8.9	1.00	0.00079	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Diabetes (self-reported)	53.21	4	3	6.7	0.98	0.01769	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Medication: Metformin	46.63	4	4	8.9	0.99	0.01179	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Diabetes (mother)	33.83	4	3	6.7	0.99	0.00509	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Type 2 Diabetes (T2D) (2012)	30.40	4	3	6.7	0.40	0.59810	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Medication: Gliclazide	26.79	4	2	4.4	0.96	0.04105	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Illnesses of siblings: Diabetes	22.66	4	2	4.4	0.96	0.04118	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Eye problems/disorders: Diabetes related eye disease	12.94	3	0	0.0	0.00	1.00000	EIF2S2P3 IGF2BP2 TCF7L2
Waist Hip Ratio (WHR)	9.37	4	3	6.7	0.79	0.21259	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Blood Platelet Count	8.32	4	2	4.4	-0.27	0.73399	AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Birth weight	7.59	3	1	2.2	0.00	1.00000	AC010883.5 EIF2S2P3 TCF7L2
Breast Cancer	7.09	1	1	2.2	0.00	1.00000	TCF7L2
Medication: Cholesterol lowering	6.69	2	0	0.0	0.00	1.00000	IGF2BP2 TCF7L2
Fasting Glucose	6.63	2	0	0.0	0.00	1.00000	IGF2BP2 TCF7L2
Medication: Atorvastatin	6.57	2	0	0.0	0.00	1.00000	IGF2BP2 TCF7L2
Peak expiratory flow (PEF)	5.89	2	1	2.2	0.00	1.00000	AC010883.5 IGF2BP2
Cholesterol lowering medication	5.81	1	0	0.0	0.00	1.00000	TCF7L2
Medication: Aspirin	5.73	2	0	0.0	0.00	1.00000	IGF2BP2 TCF7L2
Crohns Disease (2017)	5.34	1	1	2.2	0.00	1.00000	AC010883.5
Irritable Bowel Disease (IBD)	5.15	2	1	2.2	0.00	1.00000	AC010883.5 EIF2S2P3
Medication: Aspirin	5.06	1	0	0.0	0.00	1.00000	IGF2BP2
Illnesses of mother	4.66	1	0	0.0	0.00	1.00000	IGF2BP2
Medication: Simvastatin	4.58	2	0	0.0	0.00	1.00000	IGF2BP2 TCF7L2
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.28	1	0	0.0	0.00	1.00000	TCF7L2
Lung FEV1/FVC ratio	4.27	2	2	4.4	0.00	1.00000	AC010883.5 IGF2BP2
HbA1C	4.16	1	0	0.0	0.00	1.00000	EIF2S2P3
Medication for cholesterol, blood pressure or diabetes	4.16	2	0	0.0	0.00	1.00000	IGF2BP2 TCF7L2
Illnesses of father: None of the above (group 1)	4.16	2	0	0.0	0.00	1.00000	EIF2S2P3 TCF7L2
Heel T-Score	4.09	3	2	4.4	0.00	1.00000	AC010883.5 IGF2BP2 TCF7L2
Long-standing illness, disability or infirmity	4.04	1	0	0.0	0.00	1.00000	IGF2BP2
Blood Eosinophil Count	4.03	2	2	4.4	0.00	1.00000	AC010883.5 EIF2S2P3
Heart attack/myocardial infarction (self-reported)	3.96	1	0	0.0	0.00	1.00000	AC010883.5
Heart attack	3.88	1	0	0.0	0.00	1.00000	AC010883.5
Hip circumference	3.83	1	1	2.2	0.00	1.00000	TCF7L2
Illnesses of siblings	3.80	1	0	0.0	0.00	1.00000	IGF2BP2
Hypothyroidism (self reported)	3.70	2	0	0.0	0.00	1.00000	AC010883.5 IGF2BP2
Birth weight of first child	3.53	1	0	0.0	0.00	1.00000	IGF2BP2
Asthma	3.47	2	0	0.0	0.00	1.00000	AC010883.5 EIF2S2P3
Ever had hysterectomy (womb removed)	3.46	1	0	0.0	0.00	1.00000	AC010883.5
Fed-up feelings	3.44	1	0	0.0	0.00	1.00000	AC010883.5
Worrier / anxious feelings	3.26	1	0	0.0	0.00	1.00000	TCF7L2
Average weekly champagne plus white wine intake	3.23	1	0	0.0	0.00	1.00000	TCF7L2
Asthma (self-reported)	3.19	1	0	0.0	0.00	1.00000	EIF2S2P3
Age at last live birth	3.17	1	0	0.0	0.00	1.00000	EIF2S2P3
Hypothyroidism/myxoedema (self-reported)	3.13	2	0	0.0	0.00	1.00000	AC010883.5 IGF2BP2
Irritability	3.12	1	0	0.0	0.00	1.00000	AC010883.5
Leg fat percentage (left)	2.99	2	1	2.2	0.00	1.00000	AC010883.5 TCF7L2
Heel bone mineral density (BMD) T-score, automated (left)	2.96	2	0	0.0	0.00	1.00000	AC010883.5 TCF7L2
Ulcerative Colitis	2.93	1	0	0.0	0.00	1.00000	AC010883.5
Impedance of leg (left)	2.88	1	1	2.2	0.00	1.00000	AC010883.5
Neuroticism score	2.88	1	0	0.0	0.00	1.00000	AC010883.5
Body Mass Index (BMI) (2010)	2.83	1	0	0.0	0.00	1.00000	TCF7L2
Respiratory disease	2.83	1	0	0.0	0.00	1.00000	EIF2S2P3
Leg fat percentage (right)	2.78	1	1	2.2	0.00	1.00000	TCF7L2
Breast cancer (self-reported)	2.76	1	0	0.0	0.00	1.00000	TCF7L2
Medication for pain relief, constipation, heartburn	2.75	1	0	0.0	0.00	1.00000	IGF2BP2
Wheeze or whistling in the chest in last year	2.74	1	0	0.0	0.00	1.00000	IGF2BP2
Pulse rate, automated reading	2.74	3	0	0.0	0.00	1.00000	AC010883.5 EIF2S2P3 TCF7L2
Mood swings	2.73	1	0	0.0	0.00	1.00000	AC010883.5
Hair/balding pattern: Pattern 4	2.69	1	0	0.0	0.00	1.00000	AC010883.5
Crohns Disease (2012)	2.68	1	0	0.0	0.00	1.00000	AC010883.5
Ever had stillbirth, spontaneous miscarriage or termination	2.67	1	0	0.0	0.00	1.00000	TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.60	1	0	0.0	0.00	1.00000	IGF2BP2
Verbal and Numeric Reasoning (VNR)	2.58	1	0	0.0	0.00	1.00000	EIF2S2P3
Impedance of leg (right)	2.57	2	1	2.2	0.00	1.00000	AC010883.5 TCF7L2
Heel bone mineral density (BMD) T-score, automated (right)	2.57	2	0	0.0	0.00	1.00000	AC010883.5 TCF7L2
Qualifications: nursing, teaching	2.51	1	0	0.0	0.00	1.00000	TCF7L2
Impedance of whole body	2.51	2	1	2.2	0.00	1.00000	AC010883.5 TCF7L2
Leg fat mass (left)	2.48	1	1	2.2	0.00	1.00000	TCF7L2
Neuroticism (Nagel 2018)	2.45	1	0	0.0	0.00	1.00000	AC010883.5
Ulcerative Colitis (UC)	2.45	1	0	0.0	0.00	1.00000	AC010883.5
High blood pressure (siblings)	2.44	1	0	0.0	0.00	1.00000	IGF2BP2
High cholesterol (Self-reported)	2.44	1	0	0.0	0.00	1.00000	TCF7L2
Number of treatments/medications taken	2.42	1	0	0.0	0.00	1.00000	IGF2BP2
Allergy or Eczema	2.37	1	0	0.0	0.00	1.00000	AC010883.5
Hayfever, allergic rhinitis or eczema	2.36	1	0	0.0	0.00	1.00000	AC010883.5
Leg fat mass (right)	2.36	1	1	2.2	0.00	1.00000	TCF7L2
Number of self-reported non-cancer illnesses	2.32	1	0	0.0	0.00	1.00000	IGF2BP2
Forced expiratory volume in 1-second (FEV1)	2.29	1	0	0.0	0.00	1.00000	IGF2BP2
Depressed Affect (Nagel 2018)	2.26	1	0	0.0	0.00	1.00000	AC010883.5
Allergy	2.24	1	0	0.0	0.00	1.00000	AC010883.5
Comparative height size at age 10	2.21	2	1	2.2	0.00	1.00000	AC010883.5 EIF2S2P3
Vitamin and mineral supplements	2.08	1	0	0.0	0.00	1.00000	AC010883.5
Hand grip strength (right)	2.07	1	0	0.0	0.00	1.00000	AC010883.5
Maternal smoking around birth	2.06	1	0	0.0	0.00	1.00000	AC010883.5
Body fat percentage	2.06	2	0	0.0	0.00	1.00000	AC010883.5 TCF7L2
Forced expiratory volume in 1-second (FEV1), Best measure	2.05	1	0	0.0	0.00	1.00000	IGF2BP2
Body mass index (BMI)	2.04	1	1	2.2	0.00	1.00000	TCF7L2
Impedance of arm (left)	2.01	2	0	0.0	0.00	1.00000	AC010883.5 TCF7L2
Medication: Paracetamol	1.98	1	0	0.0	0.00	1.00000	AC010883.5
BMI	1.92	1	1	2.2	0.00	1.00000	TCF7L2
Triglycerides	1.88	1	0	0.0	0.00	1.00000	EIF2S2P3
Myopia	1.88	1	0	0.0	0.00	1.00000	TCF7L2
Heart disease (siblings)	1.88	1	0	0.0	0.00	1.00000	IGF2BP2
Neck or shoulder pain in last month	1.87	1	0	0.0	0.00	1.00000	AC010883.5
Whole body fat mass	1.87	1	0	0.0	0.00	1.00000	TCF7L2
Illnesses of father: Heart disease	1.83	1	0	0.0	0.00	1.00000	AC010883.5
Hand grip strength (left)	1.75	1	0	0.0	0.00	1.00000	AC010883.5
Neuroticism	1.69	1	0	0.0	0.00	1.00000	AC010883.5
Overall health rating	1.68	1	0	0.0	0.00	1.00000	IGF2BP2
Arm fat percentage (left)	1.68	1	0	0.0	0.00	1.00000	TCF7L2
Systolic Blood Pressure	1.66	1	1	2.2	0.00	1.00000	TCF7L2
Impedance of arm (right)	1.66	2	0	0.0	0.00	1.00000	AC010883.5 TCF7L2
Vascular/heart problems diagnosed by doctor	1.66	1	0	0.0	0.00	1.00000	IGF2BP2
Arm fat mass (right)	1.64	1	0	0.0	0.00	1.00000	TCF7L2
Waist circumference	1.63	1	0	0.0	0.00	1.00000	TCF7L2
Arm fat mass (left)	1.61	1	0	0.0	0.00	1.00000	TCF7L2
Age at first live birth	1.59	1	0	0.0	0.00	1.00000	EIF2S2P3
Medication: Paracetamol	1.57	1	0	0.0	0.00	1.00000	AC010883.5
Chronotype (morning person)	1.55	1	0	0.0	0.00	1.00000	IGF2BP2
Multivitamins +/- minerals	1.54	1	0	0.0	0.00	1.00000	AC010883.5
Arm fat percentage (right)	1.50	1	0	0.0	0.00	1.00000	TCF7L2
Trunk fat percentage	1.48	2	0	0.0	0.00	1.00000	AC010883.5 TCF7L2
Trunk fat mass	1.46	2	0	0.0	0.00	1.00000	AC010883.5 TCF7L2
Worry (Nagel 2018)	1.45	1	0	0.0	0.00	1.00000	AC010883.5
Lung FVC	1.37	1	0	0.0	0.00	1.00000	IGF2BP2
Alcohol usually taken with meals	1.33	1	0	0.0	0.00	1.00000	TCF7L2
High blood pressure	1.30	1	0	0.0	0.00	1.00000	IGF2BP2
Cardiovascular Disease	1.28	1	0	0.0	0.00	1.00000	IGF2BP2
Hypertension (Self-reported)	1.28	1	0	0.0	0.00	1.00000	IGF2BP2
Weight	1.21	1	0	0.0	0.00	1.00000	TCF7L2
Blood Red Count	1.20	2	0	0.0	0.00	1.00000	EIF2S2P3 IGF2BP2
Diastolic blood pressure, automated reading	1.19	1	0	0.0	0.00	1.00000	TCF7L2
Age when periods started (menarche)	1.17	1	0	0.0	0.00	1.00000	AC010883.5
Forced vital capacity (FVC)	1.03	1	0	0.0	0.00	1.00000	IGF2BP2
Leg predicted mass (left)	0.70	1	0	0.0	0.00	1.00000	TCF7L2
Leg fat-free mass (left)	0.68	1	0	0.0	0.00	1.00000	TCF7L2
Leg predicted mass (right)	0.65	1	0	0.0	0.00	1.00000	TCF7L2
Basal metabolic rate	0.64	1	0	0.0	0.00	1.00000	TCF7L2
Arm fat-free mass (left)	0.64	1	0	0.0	0.00	1.00000	TCF7L2
Leg fat-free mass (right)	0.62	1	0	0.0	0.00	1.00000	TCF7L2
Height	0.61	2	1	2.2	0.00	1.00000	AC010883.5 TCF7L2
Arm predicted mass (left)	0.60	1	0	0.0	0.00	1.00000	TCF7L2
Arm fat-free mass (right)	0.53	1	0	0.0	0.00	1.00000	TCF7L2
Whole body fat-free mass	0.50	1	0	0.0	0.00	1.00000	TCF7L2
Arm predicted mass (right)	0.49	1	0	0.0	0.00	1.00000	TCF7L2
Whole body water mass	0.49	1	0	0.0	0.00	1.00000	TCF7L2
Standing height	0.44	1	0	0.0	0.00	1.00000	AC010883.5
Blood White Count	0.39	1	0	0.0	0.00	1.00000	IGF2BP2
Hair Pigment	0.24	1	0	0.0	0.00	1.00000	AC010883.5

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Prostate	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.4
GTEx	Adipose Visceral Omentum	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	1	0.034	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	1	0.024	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	1	0.031	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Lung	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Thyroid	2	0.050	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
NTR	Blood	1	0.042	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.1