Hub : Traits :

Diabetes (father)

7 significantly associated models · 6 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 42767044 44157441 1 1 1.0e-07 1.0e-08 1.4e-02 82 AC010883.5
2 3 185112300 185786406 1 1 4.1e-13 2.2e-16 6.2e-05 76 IGF2BP2
3 10 92987510 95128815 2 1 1.3e-11 1.8e-11 1.8e-01 96 EIF2S2P3
4 10 113511441 115622375 2 1 1.6e-26 2.8e-62 1.6e-37 41 TCF7L2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 2.26 1 0 0.0 0.00 1.00000 AC010883.5
Neuroticism (Nagel 2018) 2.45 1 0 0.0 0.00 1.00000 AC010883.5
Worry (Nagel 2018) 1.45 1 0 0.0 0.00 1.00000 AC010883.5
Crohns Disease (2017) 5.34 1 1 2.2 0.00 1.00000 AC010883.5
Irritable Bowel Disease (IBD) 5.15 2 1 2.2 0.00 1.00000 AC010883.5 EIF2S2P3
Ulcerative Colitis (UC) 2.45 1 0 0.0 0.00 1.00000 AC010883.5
Verbal and Numeric Reasoning (VNR) 2.58 1 0 0.0 0.00 1.00000 EIF2S2P3
Breast Cancer 7.09 1 1 2.2 0.00 1.00000 TCF7L2
Body Mass Index (BMI) (2010) 2.83 1 0 0.0 0.00 1.00000 TCF7L2
Crohns Disease (2012) 2.68 1 0 0.0 0.00 1.00000 AC010883.5
Fasting Glucose 6.63 2 0 0.0 0.00 1.00000 IGF2BP2 TCF7L2
HbA1C 4.16 1 0 0.0 0.00 1.00000 EIF2S2P3
Triglycerides 1.88 1 0 0.0 0.00 1.00000 EIF2S2P3
Type 2 Diabetes (T2D) (2012) 30.40 4 3 6.7 0.40 0.59810 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Ulcerative Colitis 2.93 1 0 0.0 0.00 1.00000 AC010883.5
Blood Eosinophil Count 4.03 2 2 4.4 0.00 1.00000 AC010883.5 EIF2S2P3
Blood Platelet Count 8.32 4 2 4.4 -0.27 0.73399 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Blood Red Count 1.20 2 0 0.0 0.00 1.00000 EIF2S2P3 IGF2BP2
Blood White Count 0.39 1 0 0.0 0.00 1.00000 IGF2BP2
Heel T-Score 4.09 3 2 4.4 0.00 1.00000 AC010883.5 IGF2BP2 TCF7L2
BMI 1.92 1 1 2.2 0.00 1.00000 TCF7L2
Height 0.61 2 1 2.2 0.00 1.00000 AC010883.5 TCF7L2
Waist Hip Ratio (WHR) 9.37 4 3 6.7 0.79 0.21259 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Systolic Blood Pressure 1.66 1 1 2.2 0.00 1.00000 TCF7L2
Allergy or Eczema 2.37 1 0 0.0 0.00 1.00000 AC010883.5
Cardiovascular Disease 1.28 1 0 0.0 0.00 1.00000 IGF2BP2
Hypothyroidism (self reported) 3.70 2 0 0.0 0.00 1.00000 AC010883.5 IGF2BP2
Respiratory disease 2.83 1 0 0.0 0.00 1.00000 EIF2S2P3
Type 2 Diabetes (T2D) (2018) 73.53 4 4 8.9 0.98 0.01785 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Lung FEV1/FVC ratio 4.27 2 2 4.4 0.00 1.00000 AC010883.5 IGF2BP2
Lung FVC 1.37 1 0 0.0 0.00 1.00000 IGF2BP2
Neuroticism 1.69 1 0 0.0 0.00 1.00000 AC010883.5
Chronotype (morning person) 1.55 1 0 0.0 0.00 1.00000 IGF2BP2
Hair Pigment 0.24 1 0 0.0 0.00 1.00000 AC010883.5
Hand grip strength (left) 1.75 1 0 0.0 0.00 1.00000 AC010883.5
Number of treatments/medications taken 2.42 1 0 0.0 0.00 1.00000 IGF2BP2
Ever had hysterectomy (womb removed) 3.46 1 0 0.0 0.00 1.00000 AC010883.5
Eye problems/disorders: Diabetes related eye disease 12.94 3 0 0.0 0.00 1.00000 EIF2S2P3 IGF2BP2 TCF7L2
Vitamin and mineral supplements 2.08 1 0 0.0 0.00 1.00000 AC010883.5
Medication: Metformin 46.63 4 4 8.9 0.99 0.01179 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Diabetes (mother) 33.83 4 3 6.7 0.99 0.00509 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Impedance of leg (right) 2.57 2 1 2.2 0.00 1.00000 AC010883.5 TCF7L2
Leg fat-free mass (left) 0.68 1 0 0.0 0.00 1.00000 TCF7L2
Trunk fat percentage 1.48 2 0 0.0 0.00 1.00000 AC010883.5 TCF7L2
Hand grip strength (right) 2.07 1 0 0.0 0.00 1.00000 AC010883.5
Maternal smoking around birth 2.06 1 0 0.0 0.00 1.00000 AC010883.5
Fed-up feelings 3.44 1 0 0.0 0.00 1.00000 AC010883.5
Age when periods started (menarche) 1.17 1 0 0.0 0.00 1.00000 AC010883.5
Heel bone mineral density (BMD) T-score, automated (left) 2.96 2 0 0.0 0.00 1.00000 AC010883.5 TCF7L2
High blood pressure 1.30 1 0 0.0 0.00 1.00000 IGF2BP2
Hayfever, allergic rhinitis or eczema 2.36 1 0 0.0 0.00 1.00000 AC010883.5
Multivitamins +/- minerals 1.54 1 0 0.0 0.00 1.00000 AC010883.5
Body mass index (BMI) 2.04 1 1 2.2 0.00 1.00000 TCF7L2
Impedance of leg (left) 2.88 1 1 2.2 0.00 1.00000 AC010883.5
Leg predicted mass (left) 0.70 1 0 0.0 0.00 1.00000 TCF7L2
Trunk fat mass 1.46 2 0 0.0 0.00 1.00000 AC010883.5 TCF7L2
Waist circumference 1.63 1 0 0.0 0.00 1.00000 TCF7L2
Alcohol usually taken with meals 1.33 1 0 0.0 0.00 1.00000 TCF7L2
Forced vital capacity (FVC) 1.03 1 0 0.0 0.00 1.00000 IGF2BP2
Heel bone mineral density (BMD) T-score, automated (right) 2.57 2 0 0.0 0.00 1.00000 AC010883.5 TCF7L2
Heart attack 3.88 1 0 0.0 0.00 1.00000 AC010883.5
Allergy 2.24 1 0 0.0 0.00 1.00000 AC010883.5
Diabetes (self-reported) 53.21 4 3 6.7 0.98 0.01769 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Medication: Simvastatin 4.58 2 0 0.0 0.00 1.00000 IGF2BP2 TCF7L2
Illnesses of siblings 3.80 1 0 0.0 0.00 1.00000 IGF2BP2
Neuroticism score 2.88 1 0 0.0 0.00 1.00000 AC010883.5
Weight 1.21 1 0 0.0 0.00 1.00000 TCF7L2
Impedance of arm (right) 1.66 2 0 0.0 0.00 1.00000 AC010883.5 TCF7L2
Arm fat percentage (right) 1.50 1 0 0.0 0.00 1.00000 TCF7L2
Hip circumference 3.83 1 1 2.2 0.00 1.00000 TCF7L2
Worrier / anxious feelings 3.26 1 0 0.0 0.00 1.00000 TCF7L2
Forced expiratory volume in 1-second (FEV1) 2.29 1 0 0.0 0.00 1.00000 IGF2BP2
Asthma 3.47 2 0 0.0 0.00 1.00000 AC010883.5 EIF2S2P3
Medication: Cholesterol lowering 6.69 2 0 0.0 0.00 1.00000 IGF2BP2 TCF7L2
Illnesses of mother 4.66 1 0 0.0 0.00 1.00000 IGF2BP2
Forced expiratory volume in 1-second (FEV1), Best measure 2.05 1 0 0.0 0.00 1.00000 IGF2BP2
Impedance of arm (left) 2.01 2 0 0.0 0.00 1.00000 AC010883.5 TCF7L2
Arm fat mass (right) 1.64 1 0 0.0 0.00 1.00000 TCF7L2
Standing height 0.44 1 0 0.0 0.00 1.00000 AC010883.5
Hair/balding pattern: Pattern 4 2.69 1 0 0.0 0.00 1.00000 AC010883.5
Birth weight of first child 3.53 1 0 0.0 0.00 1.00000 IGF2BP2
Peak expiratory flow (PEF) 5.89 2 1 2.2 0.00 1.00000 AC010883.5 IGF2BP2
Medication: Paracetamol 1.98 1 0 0.0 0.00 1.00000 AC010883.5
Medication for cholesterol, blood pressure or diabetes 4.16 2 0 0.0 0.00 1.00000 IGF2BP2 TCF7L2
Hypothyroidism/myxoedema (self-reported) 3.13 2 0 0.0 0.00 1.00000 AC010883.5 IGF2BP2
Birth weight 7.59 3 1 2.2 0.00 1.00000 AC010883.5 EIF2S2P3 TCF7L2
High blood pressure (siblings) 2.44 1 0 0.0 0.00 1.00000 IGF2BP2
Body fat percentage 2.06 2 0 0.0 0.00 1.00000 AC010883.5 TCF7L2
Leg fat percentage (right) 2.78 1 1 2.2 0.00 1.00000 TCF7L2
Arm fat-free mass (right) 0.53 1 0 0.0 0.00 1.00000 TCF7L2
Wheeze or whistling in the chest in last year 2.74 1 0 0.0 0.00 1.00000 IGF2BP2
Age at first live birth 1.59 1 0 0.0 0.00 1.00000 EIF2S2P3
Medication for pain relief, constipation, heartburn 2.75 1 0 0.0 0.00 1.00000 IGF2BP2
Neck or shoulder pain in last month 1.87 1 0 0.0 0.00 1.00000 AC010883.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.28 1 0 0.0 0.00 1.00000 TCF7L2
Whole body fat mass 1.87 1 0 0.0 0.00 1.00000 TCF7L2
Leg fat mass (right) 2.36 1 1 2.2 0.00 1.00000 TCF7L2
Arm predicted mass (right) 0.49 1 0 0.0 0.00 1.00000 TCF7L2
Pulse rate, automated reading 2.74 3 0 0.0 0.00 1.00000 AC010883.5 EIF2S2P3 TCF7L2
Comparative height size at age 10 2.21 2 1 2.2 0.00 1.00000 AC010883.5 EIF2S2P3
Overall health rating 1.68 1 0 0.0 0.00 1.00000 IGF2BP2
Age at last live birth 3.17 1 0 0.0 0.00 1.00000 EIF2S2P3
Medication: Aspirin 5.06 1 0 0.0 0.00 1.00000 IGF2BP2
Hypertension (Self-reported) 1.28 1 0 0.0 0.00 1.00000 IGF2BP2
Illnesses of father: Heart disease 1.83 1 0 0.0 0.00 1.00000 AC010883.5
Illnesses of siblings: Diabetes 22.66 4 2 4.4 0.96 0.04118 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Whole body fat-free mass 0.50 1 0 0.0 0.00 1.00000 TCF7L2
Leg fat-free mass (right) 0.62 1 0 0.0 0.00 1.00000 TCF7L2
Arm fat percentage (left) 1.68 1 0 0.0 0.00 1.00000 TCF7L2
Mood swings 2.73 1 0 0.0 0.00 1.00000 AC010883.5
Long-standing illness, disability or infirmity 4.04 1 0 0.0 0.00 1.00000 IGF2BP2
Diabetes diagnosed by doctor 62.29 4 4 8.9 1.00 0.00079 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination 2.67 1 0 0.0 0.00 1.00000 TCF7L2
Qualifications: nursing, teaching 2.51 1 0 0.0 0.00 1.00000 TCF7L2
Breast cancer (self-reported) 2.76 1 0 0.0 0.00 1.00000 TCF7L2
Asthma (self-reported) 3.19 1 0 0.0 0.00 1.00000 EIF2S2P3
Medication: Aspirin 5.73 2 0 0.0 0.00 1.00000 IGF2BP2 TCF7L2
Medication: Gliclazide 26.79 4 2 4.4 0.96 0.04105 AC010883.5 EIF2S2P3 IGF2BP2 TCF7L2
Illnesses of father: None of the above (group 1) 4.16 2 0 0.0 0.00 1.00000 EIF2S2P3 TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.60 1 0 0.0 0.00 1.00000 IGF2BP2
Whole body water mass 0.49 1 0 0.0 0.00 1.00000 TCF7L2
Leg predicted mass (right) 0.65 1 0 0.0 0.00 1.00000 TCF7L2
Arm fat mass (left) 1.61 1 0 0.0 0.00 1.00000 TCF7L2
Number of self-reported non-cancer illnesses 2.32 1 0 0.0 0.00 1.00000 IGF2BP2
Average weekly champagne plus white wine intake 3.23 1 0 0.0 0.00 1.00000 TCF7L2
High cholesterol (Self-reported) 2.44 1 0 0.0 0.00 1.00000 TCF7L2
Medication: Paracetamol 1.57 1 0 0.0 0.00 1.00000 AC010883.5
Medication: Atorvastatin 6.57 2 0 0.0 0.00 1.00000 IGF2BP2 TCF7L2
Basal metabolic rate 0.64 1 0 0.0 0.00 1.00000 TCF7L2
Leg fat percentage (left) 2.99 2 1 2.2 0.00 1.00000 AC010883.5 TCF7L2
Arm fat-free mass (left) 0.64 1 0 0.0 0.00 1.00000 TCF7L2
Irritability 3.12 1 0 0.0 0.00 1.00000 AC010883.5
Diastolic blood pressure, automated reading 1.19 1 0 0.0 0.00 1.00000 TCF7L2
Myopia 1.88 1 0 0.0 0.00 1.00000 TCF7L2
Vascular/heart problems diagnosed by doctor 1.66 1 0 0.0 0.00 1.00000 IGF2BP2
Cholesterol lowering medication 5.81 1 0 0.0 0.00 1.00000 TCF7L2
Heart attack/myocardial infarction (self-reported) 3.96 1 0 0.0 0.00 1.00000 AC010883.5
Heart disease (siblings) 1.88 1 0 0.0 0.00 1.00000 IGF2BP2
Impedance of whole body 2.51 2 1 2.2 0.00 1.00000 AC010883.5 TCF7L2
Leg fat mass (left) 2.48 1 1 2.2 0.00 1.00000 TCF7L2
Arm predicted mass (left) 0.60 1 0 0.0 0.00 1.00000 TCF7L2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.3
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 1 0.034 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.1
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 1 0.031 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.3
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 2 0.050 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 1 0.042 1.3
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.4
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2