Hub : Traits :

Osteoarthritis (self-reported)

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 69978290 71471456 1 1 1.1e-08 1.6e-10 0.004 80 TGFA

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Prostate Cancer 3.54 1 0 0 0 1 TGFA
Age at First Birth 6.87 1 0 0 0 1 TGFA
Blood Platelet Count 0.55 1 0 0 0 1 TGFA
Heel T-Score 2.05 1 0 0 0 1 TGFA
BMI 1.96 1 0 0 0 1 TGFA
Allergy or Eczema 2.09 1 0 0 0 1 TGFA
Hand grip strength (left) 22.85 1 1 3 0 1 TGFA
Angina 5.73 1 0 0 0 1 TGFA
Diabetes (father) 6.15 1 0 0 0 1 TGFA
Impedance of leg (right) 1.25 1 0 0 0 1 TGFA
Trunk fat percentage 1.18 1 0 0 0 1 TGFA
Hand grip strength (right) 26.05 1 1 3 0 1 TGFA
Fed-up feelings 2.64 1 0 0 0 1 TGFA
Heel bone mineral density (BMD) T-score, automated (left) 4.40 1 0 0 0 1 TGFA
Multivitamins +/- minerals 3.49 1 0 0 0 1 TGFA
Supplements: Glucosamine 6.03 1 0 0 0 1 TGFA
High blood pressure (mother) 2.83 1 0 0 0 1 TGFA
Body mass index (BMI) 2.18 1 0 0 0 1 TGFA
Impedance of leg (left) 1.31 1 0 0 0 1 TGFA
Trunk fat mass 1.06 1 0 0 0 1 TGFA
Waist circumference 1.05 1 0 0 0 1 TGFA
Heel bone mineral density (BMD) T-score, automated (right) 2.34 1 0 0 0 1 TGFA
Allergy 2.36 1 0 0 0 1 TGFA
Weight 1.12 1 0 0 0 1 TGFA
Arm fat percentage (right) 1.60 1 0 0 0 1 TGFA
Hip circumference 1.82 1 0 0 0 1 TGFA
Frequency of tiredness / lethargy in last 2 weeks 2.39 1 0 0 0 1 TGFA
Asthma 2.90 1 0 0 0 1 TGFA
Medication: Ibuprofen (e.g. Nurofen) 6.75 1 0 0 0 1 TGFA
Pulse wave Arterial Stiffness index 4.28 1 0 0 0 1 TGFA
Arm fat mass (right) 1.31 1 0 0 0 1 TGFA
Exposure to tobacco smoke at home 3.60 1 0 0 0 1 TGFA
Loud music exposure frequency 9.04 1 0 0 0 1 TGFA
Medication: Paracetamol 4.67 1 0 0 0 1 TGFA
Body fat percentage 1.12 1 0 0 0 1 TGFA
Pulse wave peak to peak time 4.82 1 0 0 0 1 TGFA
Medication for pain relief, constipation, heartburn 7.22 1 0 0 0 1 TGFA
Angina (self-reported) 6.08 1 0 0 0 1 TGFA
Medication: Ibuprofen 7.97 1 0 0 0 1 TGFA
Whole body fat mass 1.34 1 0 0 0 1 TGFA
Leg fat mass (right) 1.30 1 0 0 0 1 TGFA
Overall health rating 3.60 1 0 0 0 1 TGFA
Knee pain experienced in last month 5.59 1 0 0 0 1 TGFA
Arm fat percentage (left) 1.78 1 0 0 0 1 TGFA
Long-standing illness, disability or infirmity 4.34 1 0 0 0 1 TGFA
Asthma (self-reported) 2.41 1 0 0 0 1 TGFA
Arm fat mass (left) 1.44 1 0 0 0 1 TGFA
Number of self-reported non-cancer illnesses 2.58 1 0 0 0 1 TGFA
Pain type(s) experienced in last month: Hip pain 3.48 1 0 0 0 1 TGFA
Medication: Paracetamol 4.76 1 0 0 0 1 TGFA
Medication: Omeprazole (e.g. Zanprol) 3.51 1 0 0 0 1 TGFA
Basal cell carcinoma (self-reported) 4.05 1 0 0 0 1 TGFA
Leg fat mass (left) 1.19 1 0 0 0 1 TGFA

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.36
GTEx Adipose Visceral Omentum 0 0.0000 1.35
GTEx Adrenal Gland 0 0.0000 1.24
GTEx Artery Aorta 0 0.0000 1.30
GTEx Artery Coronary 0 0.0000 1.25
GTEx Artery Tibial 0 0.0000 1.34
GTEx Brain Caudate basal ganglia 0 0.0000 1.26
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.27
GTEx Brain Cerebellum 0 0.0000 1.36
GTEx Brain Cortex 0 0.0000 1.29
GTEx Brain Frontal Cortex BA9 0 0.0000 1.34
GTEx Brain Hippocampus 0 0.0000 1.34
GTEx Brain Hypothalamus 0 0.0000 1.29
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.33
GTEx Brain Putamen basal ganglia 0 0.0000 1.27
GTEx Breast Mammary Tissue 0 0.0000 1.39
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.36
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.30
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.26
GTEx Cells Transformed fibroblasts 0 0.0000 1.32
GTEx Colon Sigmoid 0 0.0000 1.36
GTEx Colon Transverse 0 0.0000 1.30
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.37
GTEx Esophagus Mucosa 0 0.0000 1.32
GTEx Esophagus Muscularis 0 0.0000 1.31
GTEx Heart Atrial Appendage 0 0.0000 1.28
GTEx Heart Left Ventricle 0 0.0000 1.31
GTEx Liver 0 0.0000 1.28
GTEx Lung 0 0.0000 1.30
GTEx Muscle Skeletal 0 0.0000 1.33
GTEx Nerve Tibial 0 0.0000 1.35
GTEx Ovary 0 0.0000 1.33
GTEx Pancreas 0 0.0000 1.37
GTEx Pituitary 0 0.0000 1.24
GTEx Prostate 0 0.0000 1.38
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.38
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.37
GTEx Small Intestine Terminal Ileum 0 0.0000 1.16
GTEx Spleen 0 0.0000 1.34
GTEx Stomach 0 0.0000 1.32
GTEx Testis 0 0.0000 1.30
GTEx Thyroid 0 0.0000 1.36
GTEx Uterus 0 0.0000 1.26
GTEx Vagina 0 0.0000 1.30
GTEx Whole Blood 0 0.0000 1.30
METSIM Adipose 0 0.0000 1.33
NTR Blood 0 0.0000 1.27
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.28
YFS Blood 0 0.0000 1.24
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.26
TCGA Breast Tumor 0 0.0000 1.40
TCGA Breast Normal 0 0.0000 1.22
TCGA Ovarian Tumor 0 0.0000 1.21
TCGA Prostate Tumor 0 0.0000 1.21