Hub : Traits :

Neck or shoulder pain in last month

4 significantly associated models · 3 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	57622089	59105913	1	1	1.5e-07	1.5e-07	1.00	100	PXK
2	16	71206836	72569466	1	1	2.0e-08	2.4e-06	0.65	99	ATXN1L
3	18	30921425	31568499	1	1	2.1e-08	7.6e-08	0.15	93	ASXL3

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Pain experienced in last month	10.07	2	1	2.2	1	ASXL3 ATXN1L
Neuroticism	7.71	2	1	2.2	1	ASXL3 ATXN1L
Overall health rating	7.01	3	1	2.2	1	ASXL3 ATXN1L PXK
Neuroticism (Nagel 2018)	6.66	2	1	2.2	1	ASXL3 ATXN1L
Stomach or abdominal pain in last month	6.31	2	0	0.0	1	ATXN1L PXK
Depression (Nagel 2018)	5.93	2	0	0.0	1	ASXL3 ATXN1L
Worry (Nagel 2018)	5.89	1	1	2.2	1	ASXL3
Neuroticism score	5.73	2	1	2.2	1	ASXL3 ATXN1L
Mean Putamen Volume	5.36	1	0	0.0	1	PXK
Seen doctor (GP) for nerves, anxiety, tension or depression	5.24	1	0	0.0	1	ASXL3
Lupus	5.23	1	0	0.0	1	PXK
Fluid intelligence score	5.20	1	0	0.0	1	ATXN1L
Intelligence (Savage-Jansen 2018)	5.06	2	1	2.2	1	ASXL3 ATXN1L
Emphysema/chronic bronchitis	4.95	1	0	0.0	1	PXK
Frequency of tiredness / lethargy in last 2 weeks	4.91	2	0	0.0	1	ASXL3 ATXN1L
Back pain experienced in last month	4.88	1	0	0.0	1	ATXN1L
Frequency of depressed mood in last 2 weeks	4.78	1	0	0.0	1	ASXL3
Nervous feelings	4.78	1	0	0.0	1	ASXL3
Chest pain or discomfort	4.64	1	0	0.0	1	ASXL3
Mood swings	4.58	2	0	0.0	1	ASXL3 ATXN1L
Supplements: Glucosamine	4.51	1	0	0.0	1	ASXL3
Major Depression (MDD)	4.42	1	0	0.0	1	ASXL3
Depressed Affect (Nagel 2018)	4.29	2	0	0.0	1	ASXL3 ATXN1L
Loneliness, isolation	4.28	1	0	0.0	1	ASXL3
Bilateral oophorectomy (both ovaries removed)	4.15	1	0	0.0	1	ATXN1L
Mineral and other dietary supplements	4.10	2	0	0.0	1	ASXL3 PXK
Verbal and Numeric Reasoning (VNR)	4.08	1	0	0.0	1	ATXN1L
Tense / 'highly strung'	3.98	1	0	0.0	1	ASXL3
Hearing difficulty/problems with background noise	3.95	2	0	0.0	1	ASXL3 ATXN1L
Frequency of unenthusiasm / disinterest in last 2 weeks	3.90	1	0	0.0	1	ATXN1L
Supplements: Fish oil (including cod liver oil)	3.88	2	0	0.0	1	ASXL3 PXK
Seen a psychiatrist for nerves, anxiety, tension or depression	3.81	1	0	0.0	1	ASXL3
Schizophrenia vs Biploar Disorder	3.75	1	0	0.0	1	ATXN1L
Irritability	3.75	2	0	0.0	1	ASXL3 ATXN1L
Qualifications: O levels/GCSEs or equivalent	3.69	1	0	0.0	1	ATXN1L
Fed-up feelings	3.68	1	0	0.0	1	ATXN1L
Qualifications: College or University degree	3.63	2	0	0.0	1	ATXN1L PXK
Hearing difficulty/problems: Yes	3.60	1	0	0.0	1	ATXN1L
Age at first live birth	3.57	2	0	0.0	1	ATXN1L PXK
Commuting to job workplace: Public transport	3.57	1	0	0.0	1	ATXN1L
Wheeze or whistling in the chest in last year	3.54	2	0	0.0	1	ASXL3 PXK
Number of live births	3.52	1	0	0.0	1	ATXN1L
Qualifications: None of the above	3.42	1	0	0.0	1	ATXN1L
Commuting to job workplace: Car/motor vehicle	3.37	1	0	0.0	1	ATXN1L
Eye problems/disorders: None of the above	3.30	1	0	0.0	1	PXK
Loud music exposure frequency	3.29	1	0	0.0	1	ATXN1L
Medication: Cholesterol lowering	3.26	1	0	0.0	1	ATXN1L
Pulse rate	3.25	1	0	0.0	1	PXK
Ovarian Cancer	3.21	1	0	0.0	1	ATXN1L
Systolic Blood Pressure	3.21	1	1	2.2	1	ATXN1L
Worry too long after embarrassment	3.17	1	0	0.0	1	ASXL3
Family relationship satisfaction	3.17	1	0	0.0	1	ASXL3
LDL Cholesterol	3.13	1	0	0.0	1	ATXN1L
Chronic bronchitis/emphysema (mother)	3.10	1	0	0.0	1	ASXL3
Depression (self-reported)	3.09	1	0	0.0	1	ASXL3
Medication: Atorvastatin	3.07	1	0	0.0	1	ATXN1L
Suffer from 'nerves'	2.86	1	0	0.0	1	ASXL3
Pulse rate, automated reading	2.84	3	0	0.0	1	ASXL3 ATXN1L PXK
Prospective memory result	2.82	1	0	0.0	1	ATXN1L
High cholesterol (Self-reported)	2.81	1	0	0.0	1	ATXN1L
Hypothyroidism/myxoedema (self-reported)	2.79	1	0	0.0	1	PXK
Age at last live birth	2.78	1	0	0.0	1	PXK
Unable to work because of sickness or disability	2.78	1	0	0.0	1	ASXL3
Medication: Levothyroxine sodium	2.77	1	0	0.0	1	PXK
Average weekly champagne plus white wine intake	2.76	1	0	0.0	1	PXK
Arm fat-free mass (left)	2.76	2	1	2.2	1	ASXL3 ATXN1L
Arm fat-free mass (right)	2.72	2	1	2.2	1	ASXL3 ATXN1L
Bipolar Disorder (2018)	2.64	1	0	0.0	1	ASXL3
Arm predicted mass (right)	2.62	2	1	2.2	1	ASXL3 ATXN1L
Ever highly irritable/argumentative for 2 days	2.56	1	0	0.0	1	ATXN1L
Medication: Paracetamol	2.56	1	0	0.0	1	ASXL3
Arm predicted mass (left)	2.52	2	1	2.2	1	ASXL3 ATXN1L
Schizophrenia (2014)	2.50	1	0	0.0	1	ASXL3
Breast Cancer	2.46	1	0	0.0	1	ATXN1L
Qualifications: A levels/AS levels or equivalent	2.44	2	0	0.0	1	ATXN1L PXK
Shortness of breath walking on level ground	2.44	1	0	0.0	1	ATXN1L
Diverticular disease/diverticulitis (self-reported)	2.43	1	0	0.0	1	PXK
Worrier / anxious feelings	2.40	1	0	0.0	1	ASXL3
HDL Cholesterol	2.38	1	0	0.0	1	ATXN1L
Qualifications: nursing, teaching	2.29	1	0	0.0	1	ATXN1L
Blood Red Count	2.25	2	1	2.2	1	ATXN1L PXK
Age when periods started (menarche)	2.25	1	0	0.0	1	PXK
Trunk predicted mass	2.25	2	1	2.2	1	ASXL3 ATXN1L
Systolic blood pressure, automated reading	2.24	1	0	0.0	1	ATXN1L
Knee pain experienced in last month	2.22	1	0	0.0	1	ATXN1L
Forced expiratory volume in 1-second (FEV1)	2.19	2	0	0.0	1	ASXL3 ATXN1L
Trunk fat-free mass	2.18	2	1	2.2	1	ASXL3 ATXN1L
Comparative height size at age 10	2.12	1	1	2.2	1	ATXN1L
Basal metabolic rate	2.08	2	1	2.2	1	ASXL3 ATXN1L
Whole body water mass	2.07	2	1	2.2	1	ASXL3 ATXN1L
Cardiovascular Disease	2.05	1	0	0.0	1	ATXN1L
Whole body fat-free mass	2.03	2	1	2.2	1	ASXL3 ATXN1L
Medication: Blood pressure	2.02	1	0	0.0	1	ATXN1L
Financial difficulties in last 2 years	1.99	1	0	0.0	1	ASXL3
Schizophrenia (2018)	1.98	1	0	0.0	1	ASXL3
Bipolar Disorder or Schizophrenia	1.94	1	0	0.0	1	ASXL3
Age at First Birth	1.94	1	0	0.0	1	ATXN1L
Hypothyroidism (self reported)	1.91	1	0	0.0	1	PXK
Sensitivity / hurt feelings	1.91	1	0	0.0	1	ASXL3
Medication: Simvastatin	1.89	1	0	0.0	1	ATXN1L
Forced expiratory volume in 1-second (FEV1), Best measure	1.83	1	0	0.0	1	ATXN1L
Chronotype (morning person)	1.81	1	0	0.0	1	ASXL3
Hand grip strength (left)	1.80	1	0	0.0	1	ATXN1L
Weight	1.79	1	0	0.0	1	ATXN1L
Forced vital capacity (FVC), Best measure	1.79	1	0	0.0	1	ATXN1L
Impedance of arm (right)	1.76	2	0	0.0	1	ASXL3 ATXN1L
Alcohol intake frequency.	1.73	1	0	0.0	1	PXK
Miserableness	1.68	1	0	0.0	1	ASXL3
Leg fat-free mass (right)	1.65	2	0	0.0	1	ASXL3 ATXN1L
Leg predicted mass (right)	1.65	2	0	0.0	1	ASXL3 ATXN1L
Forced vital capacity (FVC)	1.62	2	0	0.0	1	ASXL3 ATXN1L
Impedance of arm (left)	1.60	2	0	0.0	1	ASXL3 ATXN1L
Leg predicted mass (left)	1.58	2	0	0.0	1	ASXL3 ATXN1L
Leg fat-free mass (left)	1.57	2	0	0.0	1	ASXL3 ATXN1L
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.52	1	0	0.0	1	ATXN1L
Vascular/heart problems diagnosed by doctor	1.51	1	0	0.0	1	ATXN1L
Waist circumference	1.47	1	0	0.0	1	ATXN1L
Leg fat mass (left)	1.43	1	0	0.0	1	ATXN1L
High blood pressure	1.38	1	0	0.0	1	ATXN1L
Hand grip strength (right)	1.36	1	0	0.0	1	ATXN1L
Diastolic blood pressure, automated reading	1.33	1	0	0.0	1	ATXN1L
Leg fat mass (right)	1.24	1	0	0.0	1	ATXN1L
Arm fat mass (left)	1.21	1	0	0.0	1	ATXN1L
Hypertension (Self-reported)	1.20	1	0	0.0	1	ATXN1L
Whole body fat mass	1.15	1	0	0.0	1	ATXN1L
Arm fat mass (right)	1.14	1	0	0.0	1	ATXN1L
Blood Platelet Count	1.13	2	0	0.0	1	ATXN1L PXK
Body mass index (BMI)	1.08	1	0	0.0	1	ATXN1L
Trunk fat mass	1.05	1	0	0.0	1	ATXN1L
Lung FEV1/FVC ratio	1.03	1	0	0.0	1	PXK
BMI	1.01	1	0	0.0	1	ATXN1L
Impedance of whole body	0.90	1	0	0.0	1	ASXL3
Height	0.88	1	1	2.2	1	ATXN1L
Sitting height	0.86	1	0	0.0	1	ATXN1L
Standing height	0.82	1	0	0.0	1	ATXN1L
Lung FVC	0.73	1	0	0.0	1	ASXL3
Tanning	0.51	1	0	0.0	1	ATXN1L
Hair Pigment	0.17	1	0	0.0	1	ATXN1L

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Liver	0	0.000	1.6
GTEx	Adipose Subcutaneous	0	0.000	1.5
GTEx	Adipose Visceral Omentum	1	0.049	1.5
GTEx	Artery Aorta	0	0.000	1.5
GTEx	Brain Caudate basal ganglia	0	0.000	1.5
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.5
GTEx	Brain Frontal Cortex BA9	0	0.000	1.5
GTEx	Breast Mammary Tissue	0	0.000	1.5
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.5
GTEx	Cells Transformed fibroblasts	0	0.000	1.5
GTEx	Colon Transverse	0	0.000	1.5
GTEx	Esophagus Mucosa	0	0.000	1.5
GTEx	Esophagus Muscularis	0	0.000	1.5
GTEx	Heart Left Ventricle	0	0.000	1.5
GTEx	Lung	0	0.000	1.5
GTEx	Muscle Skeletal	0	0.000	1.5
GTEx	Ovary	0	0.000	1.5
GTEx	Pituitary	0	0.000	1.5
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.5
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.5
GTEx	Small Intestine Terminal Ileum	0	0.000	1.5
GTEx	Spleen	0	0.000	1.5
GTEx	Stomach	0	0.000	1.5
GTEx	Thyroid	0	0.000	1.5
GTEx	Uterus	0	0.000	1.5
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.5
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
GTEx	Adrenal Gland	0	0.000	1.4
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Artery Tibial	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Cortex	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Nerve Tibial	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Testis	0	0.000	1.4
GTEx	Whole Blood	0	0.000	1.4
METSIM	Adipose	0	0.000	1.4
NTR	Blood	0	0.000	1.4
YFS	Blood	1	0.022	1.4
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.4
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3