Hub : Traits :

Neck or shoulder pain in last month

4 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 57622089 59105913 1 1 1.5e-07 1.5e-07 1.00 100 PXK
2 16 71206836 72569466 1 1 2.0e-08 2.4e-06 0.65 99 ATXN1L
3 18 30921425 31568499 1 1 2.1e-08 7.6e-08 0.15 93 ASXL3

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 2.64 1 0 0.0 0 1 ASXL3
Bipolar Disorder or Schizophrenia 1.94 1 0 0.0 0 1 ASXL3
Depressed Affect (Nagel 2018) 4.29 2 0 0.0 0 1 ASXL3 ATXN1L
Depression (Nagel 2018) 5.93 2 0 0.0 0 1 ASXL3 ATXN1L
Intelligence (Savage-Jansen 2018) 5.06 2 1 2.2 0 1 ASXL3 ATXN1L
Neuroticism (Nagel 2018) 6.66 2 1 2.2 0 1 ASXL3 ATXN1L
Schizophrenia (2018) 1.98 1 0 0.0 0 1 ASXL3
Schizophrenia vs Biploar Disorder 3.75 1 0 0.0 0 1 ATXN1L
Worry (Nagel 2018) 5.89 1 1 2.2 0 1 ASXL3
Major Depression (MDD) 4.42 1 0 0.0 0 1 ASXL3
Verbal and Numeric Reasoning (VNR) 4.08 1 0 0.0 0 1 ATXN1L
Breast Cancer 2.46 1 0 0.0 0 1 ATXN1L
Ovarian Cancer 3.21 1 0 0.0 0 1 ATXN1L
Age at First Birth 1.94 1 0 0.0 0 1 ATXN1L
Mean Putamen Volume 5.36 1 0 0.0 0 1 PXK
HDL Cholesterol 2.38 1 0 0.0 0 1 ATXN1L
LDL Cholesterol 3.13 1 0 0.0 0 1 ATXN1L
Lupus 5.23 1 0 0.0 0 1 PXK
Schizophrenia (2014) 2.50 1 0 0.0 0 1 ASXL3
Blood Platelet Count 1.13 2 0 0.0 0 1 ATXN1L PXK
Blood Red Count 2.25 2 1 2.2 0 1 ATXN1L PXK
BMI 1.01 1 0 0.0 0 1 ATXN1L
Height 0.88 1 1 2.2 0 1 ATXN1L
Systolic Blood Pressure 3.21 1 1 2.2 0 1 ATXN1L
Cardiovascular Disease 2.05 1 0 0.0 0 1 ATXN1L
Hypothyroidism (self reported) 1.91 1 0 0.0 0 1 PXK
Lung FEV1/FVC ratio 1.03 1 0 0.0 0 1 PXK
Lung FVC 0.73 1 0 0.0 0 1 ASXL3
Neuroticism 7.71 2 1 2.2 0 1 ASXL3 ATXN1L
Chronotype (morning person) 1.81 1 0 0.0 0 1 ASXL3
Hair Pigment 0.17 1 0 0.0 0 1 ATXN1L
Tanning 0.51 1 0 0.0 0 1 ATXN1L
Hand grip strength (left) 1.80 1 0 0.0 0 1 ATXN1L
Sensitivity / hurt feelings 1.91 1 0 0.0 0 1 ASXL3
Frequency of depressed mood in last 2 weeks 4.78 1 0 0.0 0 1 ASXL3
Hearing difficulty/problems: Yes 3.60 1 0 0.0 0 1 ATXN1L
Systolic blood pressure, automated reading 2.24 1 0 0.0 0 1 ATXN1L
Leg fat-free mass (left) 1.57 2 0 0.0 0 1 ASXL3 ATXN1L
Hand grip strength (right) 1.36 1 0 0.0 0 1 ATXN1L
Fed-up feelings 3.68 1 0 0.0 0 1 ATXN1L
Frequency of unenthusiasm / disinterest in last 2 weeks 3.90 1 0 0.0 0 1 ATXN1L
Age when periods started (menarche) 2.25 1 0 0.0 0 1 PXK
Bilateral oophorectomy (both ovaries removed) 4.15 1 0 0.0 0 1 ATXN1L
High blood pressure 1.38 1 0 0.0 0 1 ATXN1L
Stomach or abdominal pain in last month 6.31 2 0 0.0 0 1 ATXN1L PXK
Supplements: Glucosamine 4.51 1 0 0.0 0 1 ASXL3
Diverticular disease/diverticulitis (self-reported) 2.43 1 0 0.0 0 1 PXK
Medication: Levothyroxine sodium 2.77 1 0 0.0 0 1 PXK
Sitting height 0.86 1 0 0.0 0 1 ATXN1L
Body mass index (BMI) 1.08 1 0 0.0 0 1 ATXN1L
Leg predicted mass (left) 1.58 2 0 0.0 0 1 ASXL3 ATXN1L
Trunk fat mass 1.05 1 0 0.0 0 1 ATXN1L
Waist circumference 1.47 1 0 0.0 0 1 ATXN1L
Nervous feelings 4.78 1 0 0.0 0 1 ASXL3
Hearing difficulty/problems with background noise 3.95 2 0 0.0 0 1 ASXL3 ATXN1L
Forced vital capacity (FVC) 1.62 2 0 0.0 0 1 ASXL3 ATXN1L
Qualifications: None of the above 3.42 1 0 0.0 0 1 ATXN1L
Financial difficulties in last 2 years 1.99 1 0 0.0 0 1 ASXL3
Medication: Simvastatin 1.89 1 0 0.0 0 1 ATXN1L
Fluid intelligence score 5.20 1 0 0.0 0 1 ATXN1L
Neuroticism score 5.73 2 1 2.2 0 1 ASXL3 ATXN1L
Weight 1.79 1 0 0.0 0 1 ATXN1L
Impedance of arm (right) 1.76 2 0 0.0 0 1 ASXL3 ATXN1L
Trunk fat-free mass 2.18 2 1 2.2 0 1 ASXL3 ATXN1L
Worrier / anxious feelings 2.40 1 0 0.0 0 1 ASXL3
Frequency of tiredness / lethargy in last 2 weeks 4.91 2 0 0.0 0 1 ASXL3 ATXN1L
Number of live births 3.52 1 0 0.0 0 1 ATXN1L
Forced expiratory volume in 1-second (FEV1) 2.19 2 0 0.0 0 1 ASXL3 ATXN1L
Pulse rate 3.25 1 0 0.0 0 1 PXK
Qualifications: A levels/AS levels or equivalent 2.44 2 0 0.0 0 1 ATXN1L PXK
Medication: Cholesterol lowering 3.26 1 0 0.0 0 1 ATXN1L
Depression (self-reported) 3.09 1 0 0.0 0 1 ASXL3
Prospective memory result 2.82 1 0 0.0 0 1 ATXN1L
Forced expiratory volume in 1-second (FEV1), Best measure 1.83 1 0 0.0 0 1 ATXN1L
Impedance of arm (left) 1.60 2 0 0.0 0 1 ASXL3 ATXN1L
Arm fat mass (right) 1.14 1 0 0.0 0 1 ATXN1L
Trunk predicted mass 2.25 2 1 2.2 0 1 ASXL3 ATXN1L
Standing height 0.82 1 0 0.0 0 1 ATXN1L
Tense / 'highly strung' 3.98 1 0 0.0 0 1 ASXL3
Seen doctor (GP) for nerves, anxiety, tension or depression 5.24 1 0 0.0 0 1 ASXL3
Ever highly irritable/argumentative for 2 days 2.56 1 0 0.0 0 1 ATXN1L
Loud music exposure frequency 3.29 1 0 0.0 0 1 ATXN1L
Qualifications: O levels/GCSEs or equivalent 3.69 1 0 0.0 0 1 ATXN1L
Medication: Paracetamol 2.56 1 0 0.0 0 1 ASXL3
Hypothyroidism/myxoedema (self-reported) 2.79 1 0 0.0 0 1 PXK
Chronic bronchitis/emphysema (mother) 3.10 1 0 0.0 0 1 ASXL3
Forced vital capacity (FVC), Best measure 1.79 1 0 0.0 0 1 ATXN1L
Arm fat-free mass (right) 2.72 2 1 2.2 0 1 ASXL3 ATXN1L
Worry too long after embarrassment 3.17 1 0 0.0 0 1 ASXL3
Seen a psychiatrist for nerves, anxiety, tension or depression 3.81 1 0 0.0 0 1 ASXL3
Wheeze or whistling in the chest in last year 3.54 2 0 0.0 0 1 ASXL3 PXK
Age at first live birth 3.57 2 0 0.0 0 1 ATXN1L PXK
Shortness of breath walking on level ground 2.44 1 0 0.0 0 1 ATXN1L
Qualifications: College or University degree 3.63 2 0 0.0 0 1 ATXN1L PXK
Eye problems/disorders: None of the above 3.30 1 0 0.0 0 1 PXK
Emphysema/chronic bronchitis 4.95 1 0 0.0 0 1 PXK
Whole body fat mass 1.15 1 0 0.0 0 1 ATXN1L
Leg fat mass (right) 1.24 1 0 0.0 0 1 ATXN1L
Arm predicted mass (right) 2.62 2 1 2.2 0 1 ASXL3 ATXN1L
Pulse rate, automated reading 2.84 3 0 0.0 0 1 ASXL3 ATXN1L PXK
Alcohol intake frequency. 1.73 1 0 0.0 0 1 PXK
Comparative height size at age 10 2.12 1 1 2.2 0 1 ATXN1L
Suffer from 'nerves' 2.86 1 0 0.0 0 1 ASXL3
Overall health rating 7.01 3 1 2.2 0 1 ASXL3 ATXN1L PXK
Chest pain or discomfort 4.64 1 0 0.0 0 1 ASXL3
Age at last live birth 2.78 1 0 0.0 0 1 PXK
Family relationship satisfaction 3.17 1 0 0.0 0 1 ASXL3
Commuting to job workplace: Car/motor vehicle 3.37 1 0 0.0 0 1 ATXN1L
Knee pain experienced in last month 2.22 1 0 0.0 0 1 ATXN1L
Hypertension (Self-reported) 1.20 1 0 0.0 0 1 ATXN1L
Whole body fat-free mass 2.03 2 1 2.2 0 1 ASXL3 ATXN1L
Leg fat-free mass (right) 1.65 2 0 0.0 0 1 ASXL3 ATXN1L
Mood swings 4.58 2 0 0.0 0 1 ASXL3 ATXN1L
Loneliness, isolation 4.28 1 0 0.0 0 1 ASXL3
Qualifications: nursing, teaching 2.29 1 0 0.0 0 1 ATXN1L
Back pain experienced in last month 4.88 1 0 0.0 0 1 ATXN1L
Mineral and other dietary supplements 4.10 2 0 0.0 0 1 ASXL3 PXK
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.52 1 0 0.0 0 1 ATXN1L
Whole body water mass 2.07 2 1 2.2 0 1 ASXL3 ATXN1L
Leg predicted mass (right) 1.65 2 0 0.0 0 1 ASXL3 ATXN1L
Arm fat mass (left) 1.21 1 0 0.0 0 1 ATXN1L
Average weekly champagne plus white wine intake 2.76 1 0 0.0 0 1 PXK
Miserableness 1.68 1 0 0.0 0 1 ASXL3
Commuting to job workplace: Public transport 3.57 1 0 0.0 0 1 ATXN1L
Medication: Blood pressure 2.02 1 0 0.0 0 1 ATXN1L
Supplements: Fish oil (including cod liver oil) 3.88 2 0 0.0 0 1 ASXL3 PXK
High cholesterol (Self-reported) 2.81 1 0 0.0 0 1 ATXN1L
Medication: Atorvastatin 3.07 1 0 0.0 0 1 ATXN1L
Basal metabolic rate 2.08 2 1 2.2 0 1 ASXL3 ATXN1L
Arm fat-free mass (left) 2.76 2 1 2.2 0 1 ASXL3 ATXN1L
Irritability 3.75 2 0 0.0 0 1 ASXL3 ATXN1L
Diastolic blood pressure, automated reading 1.33 1 0 0.0 0 1 ATXN1L
Unable to work because of sickness or disability 2.78 1 0 0.0 0 1 ASXL3
Vascular/heart problems diagnosed by doctor 1.51 1 0 0.0 0 1 ATXN1L
Pain experienced in last month 10.07 2 1 2.2 0 1 ASXL3 ATXN1L
Impedance of whole body 0.90 1 0 0.0 0 1 ASXL3
Leg fat mass (left) 1.43 1 0 0.0 0 1 ATXN1L
Arm predicted mass (left) 2.52 2 1 2.2 0 1 ASXL3 ATXN1L

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.5
GTEx Adipose Visceral Omentum 1 0.049 1.5
GTEx Adrenal Gland 0 0.000 1.4
GTEx Artery Aorta 0 0.000 1.5
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 0 0.000 1.4
GTEx Brain Caudate basal ganglia 0 0.000 1.5
GTEx Brain Cerebellar Hemisphere 0 0.000 1.5
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.4
GTEx Brain Frontal Cortex BA9 0 0.000 1.5
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.5
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 1 0.070 1.5
GTEx Cells Transformed fibroblasts 0 0.000 1.5
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.5
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.5
GTEx Esophagus Muscularis 0 0.000 1.5
GTEx Heart Atrial Appendage 0 0.000 1.4
GTEx Heart Left Ventricle 0 0.000 1.5
GTEx Liver 0 0.000 1.6
GTEx Lung 0 0.000 1.5
GTEx Muscle Skeletal 0 0.000 1.5
GTEx Nerve Tibial 0 0.000 1.4
GTEx Ovary 0 0.000 1.5
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.5
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.5
GTEx Skin Sun Exposed Lower leg 0 0.000 1.5
GTEx Small Intestine Terminal Ileum 0 0.000 1.5
GTEx Spleen 0 0.000 1.5
GTEx Stomach 0 0.000 1.5
GTEx Testis 0 0.000 1.4
GTEx Thyroid 0 0.000 1.5
GTEx Uterus 0 0.000 1.5
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.4
METSIM Adipose 0 0.000 1.4
NTR Blood 0 0.000 1.4
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.5
YFS Blood 1 0.022 1.4
CommonMind Brain Pre-frontal Cortex 0 0.000 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.5
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.5
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.4
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.3
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.4
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.4