Hub : Traits :

Illnesses of siblings: Diabetes

4 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 185112300 185786406 1 1 2.5e-08 4.7e-10 4.7e-03 79 IGF2BP2
2 10 11693166 13569805 1 1 2.2e-07 7.2e-06 1.0e+00 100 CAMK1D
3 10 114018656 115622375 1 1 4.8e-12 7.2e-34 3.0e-24 30 TCF7L2
4 19 18333894 19729194 1 1 1.1e-07 5.6e-07 1.0e+00 100 DDX49

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 2.21 1 0 0.0 0.00 1.000 DDX49
Bipolar Disorder or Schizophrenia 0.87 1 0 0.0 0.00 1.000 CAMK1D
Depressed Affect (Nagel 2018) 1.73 1 0 0.0 0.00 1.000 DDX49
Neuroticism (Nagel 2018) 1.58 1 0 0.0 0.00 1.000 DDX49
Schizophrenia (2018) 1.51 1 0 0.0 0.00 1.000 DDX49
Schizophrenia vs Biploar Disorder 2.34 1 0 0.0 0.00 1.000 DDX49
Breast Cancer 8.66 2 1 2.2 0.00 1.000 DDX49 TCF7L2
Age at First Birth 2.77 1 0 0.0 0.00 1.000 DDX49
Body Mass Index (BMI) (2010) 3.50 1 0 0.0 0.00 1.000 TCF7L2
Coronary Artery Disease (CAD) 3.30 2 0 0.0 0.00 1.000 CAMK1D DDX49
Fasting Glucose 8.83 4 0 0.0 0.98 0.016 CAMK1D DDX49 IGF2BP2 TCF7L2
LDL Cholesterol 5.04 1 1 2.2 0.00 1.000 DDX49
Schizophrenia (2014) 2.00 2 0 0.0 0.00 1.000 CAMK1D DDX49
Triglycerides 6.82 1 1 2.2 0.00 1.000 DDX49
Type 2 Diabetes (T2D) (2012) 17.07 3 2 4.4 0.00 1.000 CAMK1D IGF2BP2 TCF7L2
Blood Eosinophil Count 0.24 1 0 0.0 0.00 1.000 DDX49
Blood Platelet Count 3.33 3 2 4.4 0.00 1.000 DDX49 IGF2BP2 TCF7L2
Blood Red Count 0.95 3 0 0.0 0.00 1.000 DDX49 IGF2BP2 TCF7L2
Blood White Count 0.41 1 0 0.0 0.00 1.000 IGF2BP2
Heel T-Score 2.93 3 2 4.4 0.00 1.000 DDX49 IGF2BP2 TCF7L2
BMI 2.60 2 1 2.2 0.00 1.000 DDX49 TCF7L2
Height 2.41 2 1 2.2 0.00 1.000 DDX49 TCF7L2
Waist Hip Ratio (WHR) 6.18 2 2 4.4 0.00 1.000 IGF2BP2 TCF7L2
Systolic Blood Pressure 2.87 2 1 2.2 0.00 1.000 CAMK1D TCF7L2
Cardiovascular Disease 2.13 2 0 0.0 0.00 1.000 CAMK1D IGF2BP2
Hypothyroidism (self reported) 2.17 1 0 0.0 0.00 1.000 IGF2BP2
Type 2 Diabetes (T2D) (2018) 59.52 4 3 6.7 0.93 0.066 CAMK1D DDX49 IGF2BP2 TCF7L2
Lung FEV1/FVC ratio 10.42 3 2 4.4 0.00 1.000 CAMK1D DDX49 IGF2BP2
Lung FVC 3.55 2 1 2.2 0.00 1.000 CAMK1D IGF2BP2
Chronotype (morning person) 2.93 3 0 0.0 0.00 1.000 CAMK1D IGF2BP2 TCF7L2
Hair Pigment 0.11 1 0 0.0 0.00 1.000 DDX49
Number of treatments/medications taken 4.45 2 0 0.0 0.00 1.000 DDX49 IGF2BP2
Average weekly spirits intake 2.77 1 0 0.0 0.00 1.000 DDX49
Sensitivity / hurt feelings 2.02 1 0 0.0 0.00 1.000 DDX49
Systolic blood pressure, automated reading 2.94 1 1 2.2 0.00 1.000 CAMK1D
Eye problems/disorders: Diabetes related eye disease 11.91 3 0 0.0 0.00 1.000 DDX49 IGF2BP2 TCF7L2
Medication: Metformin 41.26 4 3 6.7 0.94 0.064 CAMK1D DDX49 IGF2BP2 TCF7L2
Diabetes (father) 34.90 2 2 4.4 0.00 1.000 IGF2BP2 TCF7L2
Diabetes (mother) 34.03 4 3 6.7 0.97 0.035 CAMK1D DDX49 IGF2BP2 TCF7L2
Impedance of leg (right) 1.35 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Leg fat-free mass (left) 1.88 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Trunk fat percentage 0.86 1 0 0.0 0.00 1.000 TCF7L2
Hand grip strength (right) 1.04 1 0 0.0 0.00 1.000 TCF7L2
Townsend deprivation index at recruitment 1.53 1 0 0.0 0.00 1.000 IGF2BP2
Maternal smoking around birth 3.12 1 0 0.0 0.00 1.000 DDX49
Fed-up feelings 2.58 1 0 0.0 0.00 1.000 DDX49
Taking other prescription medications 4.45 1 0 0.0 0.00 1.000 DDX49
Bilateral oophorectomy (both ovaries removed) 1.87 1 0 0.0 0.00 1.000 IGF2BP2
Heel bone mineral density (BMD) T-score, automated (left) 2.04 1 0 0.0 0.00 1.000 TCF7L2
High blood pressure 2.28 2 0 0.0 0.00 1.000 CAMK1D IGF2BP2
Stomach or abdominal pain in last month 3.71 1 0 0.0 0.00 1.000 DDX49
Supplements: Glucosamine 1.66 1 0 0.0 0.00 1.000 DDX49
Sitting height 1.28 1 1 2.2 0.00 1.000 DDX49
Body mass index (BMI) 2.99 2 1 2.2 0.00 1.000 DDX49 TCF7L2
Impedance of leg (left) 1.40 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Leg predicted mass (left) 1.87 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Trunk fat mass 1.09 1 0 0.0 0.00 1.000 TCF7L2
Waist circumference 1.74 1 0 0.0 0.00 1.000 TCF7L2
Alcohol usually taken with meals 1.69 1 0 0.0 0.00 1.000 TCF7L2
Hair/balding pattern: Pattern 2 1.84 1 0 0.0 0.00 1.000 DDX49
Forced vital capacity (FVC) 3.23 3 0 0.0 0.00 1.000 CAMK1D DDX49 IGF2BP2
Heel bone mineral density (BMD) T-score, automated (right) 1.79 1 0 0.0 0.00 1.000 TCF7L2
Qualifications: None of the above 2.56 1 0 0.0 0.00 1.000 DDX49
Mouth/teeth dental problems 2.33 1 0 0.0 0.00 1.000 DDX49
Pain all over the body in last month 2.50 1 0 0.0 0.00 1.000 DDX49
Diabetes (self-reported) 43.96 4 2 4.4 0.90 0.096 CAMK1D DDX49 IGF2BP2 TCF7L2
Medication: Ramipril 3.64 1 0 0.0 0.00 1.000 CAMK1D
Medication: Simvastatin 7.72 4 0 0.0 0.64 0.358 CAMK1D DDX49 IGF2BP2 TCF7L2
Illnesses of siblings 4.18 1 0 0.0 0.00 1.000 IGF2BP2
Weight 1.37 1 0 0.0 0.00 1.000 TCF7L2
Impedance of arm (right) 2.69 2 1 2.2 0.00 1.000 DDX49 TCF7L2
Arm fat percentage (right) 1.58 1 0 0.0 0.00 1.000 TCF7L2
Trunk fat-free mass 1.26 1 0 0.0 0.00 1.000 DDX49
Hip circumference 3.86 1 1 2.2 0.00 1.000 TCF7L2
Worrier / anxious feelings 2.99 2 0 0.0 0.00 1.000 IGF2BP2 TCF7L2
Frequency of tiredness / lethargy in last 2 weeks 2.23 1 0 0.0 0.00 1.000 DDX49
Number of live births 2.20 1 0 0.0 0.00 1.000 DDX49
Forced expiratory volume in 1-second (FEV1) 6.48 2 1 2.2 0.00 1.000 CAMK1D IGF2BP2
Pulse rate 1.94 1 0 0.0 0.00 1.000 CAMK1D
Qualifications: A levels/AS levels or equivalent 2.63 1 0 0.0 0.00 1.000 DDX49
Serious illness, injury or assault of a close relative in last 2 years 2.63 1 0 0.0 0.00 1.000 DDX49
Medication: Cholesterol lowering 9.35 4 0 0.0 0.60 0.396 CAMK1D DDX49 IGF2BP2 TCF7L2
Medication: Lansoprazole 2.07 1 0 0.0 0.00 1.000 DDX49
Illnesses of mother 5.16 1 0 0.0 0.00 1.000 IGF2BP2
Forced expiratory volume in 1-second (FEV1), Best measure 6.41 3 1 2.2 0.00 1.000 CAMK1D DDX49 IGF2BP2
Impedance of arm (left) 2.69 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Arm fat mass (right) 1.74 1 0 0.0 0.00 1.000 TCF7L2
Trunk predicted mass 1.27 1 0 0.0 0.00 1.000 DDX49
Standing height 3.16 1 1 2.2 0.00 1.000 DDX49
Birth weight of first child 4.46 3 0 0.0 0.00 1.000 DDX49 IGF2BP2 TCF7L2
Peak expiratory flow (PEF) 6.21 2 1 2.2 0.00 1.000 CAMK1D IGF2BP2
Medication: Paracetamol 3.11 1 0 0.0 0.00 1.000 DDX49
Medication for cholesterol, blood pressure or diabetes 6.77 3 0 0.0 0.00 1.000 CAMK1D IGF2BP2 TCF7L2
Hypothyroidism/myxoedema (self-reported) 2.00 1 0 0.0 0.00 1.000 IGF2BP2
Birth weight 3.12 2 0 0.0 0.00 1.000 DDX49 TCF7L2
High blood pressure (siblings) 1.60 1 0 0.0 0.00 1.000 IGF2BP2
Forced vital capacity (FVC), Best measure 3.30 2 0 0.0 0.00 1.000 CAMK1D DDX49
Body fat percentage 1.97 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Leg fat percentage (right) 5.30 2 2 4.4 0.00 1.000 DDX49 TCF7L2
Arm fat-free mass (right) 0.79 1 0 0.0 0.00 1.000 TCF7L2
Wheeze or whistling in the chest in last year 2.31 1 0 0.0 0.00 1.000 IGF2BP2
Age at first live birth 4.26 1 1 2.2 0.00 1.000 DDX49
Qualifications: College or University degree 1.91 1 0 0.0 0.00 1.000 DDX49
Medication for pain relief, constipation, heartburn 3.54 2 0 0.0 0.00 1.000 DDX49 IGF2BP2
Medication: Blood pressure 3.61 2 0 0.0 0.00 1.000 CAMK1D IGF2BP2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.89 1 0 0.0 0.00 1.000 TCF7L2
Whole body fat mass 1.70 1 0 0.0 0.00 1.000 TCF7L2
Leg fat mass (right) 3.14 2 1 2.2 0.00 1.000 DDX49 TCF7L2
Arm predicted mass (right) 0.69 1 0 0.0 0.00 1.000 TCF7L2
Pulse rate, automated reading 0.93 1 0 0.0 0.00 1.000 TCF7L2
Comparative height size at age 10 2.51 1 1 2.2 0.00 1.000 DDX49
Overall health rating 4.00 2 0 0.0 0.00 1.000 DDX49 IGF2BP2
Age at last live birth 2.06 1 0 0.0 0.00 1.000 DDX49
Qualifications: NVQ or HND or HNC or equivalent 2.36 1 0 0.0 0.00 1.000 DDX49
Medication: Aspirin 5.78 1 0 0.0 0.00 1.000 IGF2BP2
Hypertension (Self-reported) 2.32 2 0 0.0 0.00 1.000 CAMK1D IGF2BP2
Illnesses of father: Heart disease 2.84 1 0 0.0 0.00 1.000 DDX49
Forced expiratory volume in 1-second (FEV1), predicted 2.14 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Whole body fat-free mass 1.47 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Leg fat-free mass (right) 1.97 2 1 2.2 0.00 1.000 DDX49 TCF7L2
Arm fat percentage (left) 1.64 1 0 0.0 0.00 1.000 TCF7L2
Handedness (chirality/laterality): Left-handed 1.82 1 0 0.0 0.00 1.000 DDX49
Loneliness, isolation 2.13 1 0 0.0 0.00 1.000 DDX49
Long-standing illness, disability or infirmity 5.82 2 0 0.0 0.00 1.000 CAMK1D IGF2BP2
Diabetes diagnosed by doctor 50.58 4 3 6.7 0.92 0.079 CAMK1D DDX49 IGF2BP2 TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination 3.20 1 0 0.0 0.00 1.000 TCF7L2
Qualifications: nursing, teaching 4.03 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Breast cancer (self-reported) 2.69 1 0 0.0 0.00 1.000 TCF7L2
Osteoarthritis (self-reported) 1.38 1 0 0.0 0.00 1.000 DDX49
Medication: Aspirin 6.79 2 0 0.0 0.00 1.000 IGF2BP2 TCF7L2
Medication: Gliclazide 25.83 4 2 4.4 0.93 0.067 CAMK1D DDX49 IGF2BP2 TCF7L2
Illnesses of father: None of the above (group 1) 6.20 2 0 0.0 0.00 1.000 CAMK1D TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.15 2 1 2.2 0.00 1.000 CAMK1D IGF2BP2
Whole body water mass 1.45 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Leg predicted mass (right) 1.99 2 1 2.2 0.00 1.000 DDX49 TCF7L2
Arm fat mass (left) 1.61 1 0 0.0 0.00 1.000 TCF7L2
Number of self-reported non-cancer illnesses 3.50 1 0 0.0 0.00 1.000 IGF2BP2
Average weekly champagne plus white wine intake 3.21 1 0 0.0 0.00 1.000 TCF7L2
High cholesterol (Self-reported) 6.18 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Medication: Paracetamol 1.99 1 0 0.0 0.00 1.000 DDX49
Medication: Atorvastatin 7.47 2 0 0.0 0.00 1.000 IGF2BP2 TCF7L2
Illnesses of father: High blood pressure 1.83 1 0 0.0 0.00 1.000 CAMK1D
Basal metabolic rate 1.39 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Leg fat percentage (left) 5.54 2 2 4.4 0.00 1.000 DDX49 TCF7L2
Arm fat-free mass (left) 0.89 1 0 0.0 0.00 1.000 TCF7L2
Diastolic blood pressure, automated reading 1.77 2 0 0.0 0.00 1.000 DDX49 TCF7L2
Unable to work because of sickness or disability 2.60 1 0 0.0 0.00 1.000 DDX49
Myopia 1.48 1 0 0.0 0.00 1.000 TCF7L2
Vascular/heart problems diagnosed by doctor 2.53 2 0 0.0 0.00 1.000 CAMK1D IGF2BP2
Cholesterol lowering medication 6.20 2 0 0.0 0.00 1.000 IGF2BP2 TCF7L2
Heart disease (siblings) 2.07 1 0 0.0 0.00 1.000 IGF2BP2
Impedance of whole body 1.02 1 0 0.0 0.00 1.000 TCF7L2
Leg fat mass (left) 3.17 2 1 2.2 0.00 1.000 DDX49 TCF7L2
Arm predicted mass (left) 0.83 1 0 0.0 0.00 1.000 TCF7L2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 0 0.000 1.4
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 1 0.034 1.3
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.3
GTEx Brain Hippocampus 1 0.191 1.3
GTEx Brain Hypothalamus 0 0.000 1.3
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.3
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.3
GTEx Lung 1 0.035 1.2
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.3
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.3
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.4
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.1
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2