Hub : Traits :

Illnesses of siblings: Diabetes

4 significantly associated models · 4 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	185112300	185786406	1	1	2.5e-08	4.7e-10	4.7e-03	79	IGF2BP2
2	10	11693166	13569805	1	1	2.2e-07	7.2e-06	1.0e+00	100	CAMK1D
3	10	114018656	115622375	1	1	4.8e-12	7.2e-34	3.0e-24	30	TCF7L2
4	19	18333894	19729194	1	1	1.1e-07	5.6e-07	1.0e+00	100	DDX49

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Type 2 Diabetes (T2D) (2018)	59.52	4	3	6.7	0.93	0.066	CAMK1D DDX49 IGF2BP2 TCF7L2
Diabetes diagnosed by doctor	50.58	4	3	6.7	0.92	0.079	CAMK1D DDX49 IGF2BP2 TCF7L2
Diabetes (self-reported)	43.96	4	2	4.4	0.90	0.096	CAMK1D DDX49 IGF2BP2 TCF7L2
Medication: Metformin	41.26	4	3	6.7	0.94	0.064	CAMK1D DDX49 IGF2BP2 TCF7L2
Diabetes (father)	34.90	2	2	4.4	0.00	1.000	IGF2BP2 TCF7L2
Diabetes (mother)	34.03	4	3	6.7	0.97	0.035	CAMK1D DDX49 IGF2BP2 TCF7L2
Medication: Gliclazide	25.83	4	2	4.4	0.93	0.067	CAMK1D DDX49 IGF2BP2 TCF7L2
Type 2 Diabetes (T2D) (2012)	17.07	3	2	4.4	0.00	1.000	CAMK1D IGF2BP2 TCF7L2
Eye problems/disorders: Diabetes related eye disease	11.91	3	0	0.0	0.00	1.000	DDX49 IGF2BP2 TCF7L2
Lung FEV1/FVC ratio	10.42	3	2	4.4	0.00	1.000	CAMK1D DDX49 IGF2BP2
Medication: Cholesterol lowering	9.35	4	0	0.0	0.60	0.396	CAMK1D DDX49 IGF2BP2 TCF7L2
Fasting Glucose	8.83	4	0	0.0	0.98	0.016	CAMK1D DDX49 IGF2BP2 TCF7L2
Breast Cancer	8.66	2	1	2.2	0.00	1.000	DDX49 TCF7L2
Medication: Simvastatin	7.72	4	0	0.0	0.64	0.358	CAMK1D DDX49 IGF2BP2 TCF7L2
Medication: Atorvastatin	7.47	2	0	0.0	0.00	1.000	IGF2BP2 TCF7L2
Triglycerides	6.82	1	1	2.2	0.00	1.000	DDX49
Medication: Aspirin	6.79	2	0	0.0	0.00	1.000	IGF2BP2 TCF7L2
Medication for cholesterol, blood pressure or diabetes	6.77	3	0	0.0	0.00	1.000	CAMK1D IGF2BP2 TCF7L2
Forced expiratory volume in 1-second (FEV1)	6.48	2	1	2.2	0.00	1.000	CAMK1D IGF2BP2
Forced expiratory volume in 1-second (FEV1), Best measure	6.41	3	1	2.2	0.00	1.000	CAMK1D DDX49 IGF2BP2
Peak expiratory flow (PEF)	6.21	2	1	2.2	0.00	1.000	CAMK1D IGF2BP2
Illnesses of father: None of the above (group 1)	6.20	2	0	0.0	0.00	1.000	CAMK1D TCF7L2
Cholesterol lowering medication	6.20	2	0	0.0	0.00	1.000	IGF2BP2 TCF7L2
Waist Hip Ratio (WHR)	6.18	2	2	4.4	0.00	1.000	IGF2BP2 TCF7L2
High cholesterol (Self-reported)	6.18	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.15	2	1	2.2	0.00	1.000	CAMK1D IGF2BP2
Long-standing illness, disability or infirmity	5.82	2	0	0.0	0.00	1.000	CAMK1D IGF2BP2
Medication: Aspirin	5.78	1	0	0.0	0.00	1.000	IGF2BP2
Leg fat percentage (left)	5.54	2	2	4.4	0.00	1.000	DDX49 TCF7L2
Leg fat percentage (right)	5.30	2	2	4.4	0.00	1.000	DDX49 TCF7L2
Illnesses of mother	5.16	1	0	0.0	0.00	1.000	IGF2BP2
LDL Cholesterol	5.04	1	1	2.2	0.00	1.000	DDX49
Birth weight of first child	4.46	3	0	0.0	0.00	1.000	DDX49 IGF2BP2 TCF7L2
Number of treatments/medications taken	4.45	2	0	0.0	0.00	1.000	DDX49 IGF2BP2
Taking other prescription medications	4.45	1	0	0.0	0.00	1.000	DDX49
Age at first live birth	4.26	1	1	2.2	0.00	1.000	DDX49
Illnesses of siblings	4.18	1	0	0.0	0.00	1.000	IGF2BP2
Qualifications: nursing, teaching	4.03	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Overall health rating	4.00	2	0	0.0	0.00	1.000	DDX49 IGF2BP2
Hip circumference	3.86	1	1	2.2	0.00	1.000	TCF7L2
Stomach or abdominal pain in last month	3.71	1	0	0.0	0.00	1.000	DDX49
Medication: Ramipril	3.64	1	0	0.0	0.00	1.000	CAMK1D
Medication: Blood pressure	3.61	2	0	0.0	0.00	1.000	CAMK1D IGF2BP2
Lung FVC	3.55	2	1	2.2	0.00	1.000	CAMK1D IGF2BP2
Medication for pain relief, constipation, heartburn	3.54	2	0	0.0	0.00	1.000	DDX49 IGF2BP2
Body Mass Index (BMI) (2010)	3.50	1	0	0.0	0.00	1.000	TCF7L2
Number of self-reported non-cancer illnesses	3.50	1	0	0.0	0.00	1.000	IGF2BP2
Blood Platelet Count	3.33	3	2	4.4	0.00	1.000	DDX49 IGF2BP2 TCF7L2
Coronary Artery Disease (CAD)	3.30	2	0	0.0	0.00	1.000	CAMK1D DDX49
Forced vital capacity (FVC), Best measure	3.30	2	0	0.0	0.00	1.000	CAMK1D DDX49
Forced vital capacity (FVC)	3.23	3	0	0.0	0.00	1.000	CAMK1D DDX49 IGF2BP2
Average weekly champagne plus white wine intake	3.21	1	0	0.0	0.00	1.000	TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination	3.20	1	0	0.0	0.00	1.000	TCF7L2
Leg fat mass (left)	3.17	2	1	2.2	0.00	1.000	DDX49 TCF7L2
Standing height	3.16	1	1	2.2	0.00	1.000	DDX49
Leg fat mass (right)	3.14	2	1	2.2	0.00	1.000	DDX49 TCF7L2
Maternal smoking around birth	3.12	1	0	0.0	0.00	1.000	DDX49
Birth weight	3.12	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Medication: Paracetamol	3.11	1	0	0.0	0.00	1.000	DDX49
Body mass index (BMI)	2.99	2	1	2.2	0.00	1.000	DDX49 TCF7L2
Worrier / anxious feelings	2.99	2	0	0.0	0.00	1.000	IGF2BP2 TCF7L2
Systolic blood pressure, automated reading	2.94	1	1	2.2	0.00	1.000	CAMK1D
Heel T-Score	2.93	3	2	4.4	0.00	1.000	DDX49 IGF2BP2 TCF7L2
Chronotype (morning person)	2.93	3	0	0.0	0.00	1.000	CAMK1D IGF2BP2 TCF7L2
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.89	1	0	0.0	0.00	1.000	TCF7L2
Systolic Blood Pressure	2.87	2	1	2.2	0.00	1.000	CAMK1D TCF7L2
Illnesses of father: Heart disease	2.84	1	0	0.0	0.00	1.000	DDX49
Age at First Birth	2.77	1	0	0.0	0.00	1.000	DDX49
Average weekly spirits intake	2.77	1	0	0.0	0.00	1.000	DDX49
Impedance of arm (right)	2.69	2	1	2.2	0.00	1.000	DDX49 TCF7L2
Impedance of arm (left)	2.69	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Breast cancer (self-reported)	2.69	1	0	0.0	0.00	1.000	TCF7L2
Qualifications: A levels/AS levels or equivalent	2.63	1	0	0.0	0.00	1.000	DDX49
Serious illness, injury or assault of a close relative in last 2 years	2.63	1	0	0.0	0.00	1.000	DDX49
BMI	2.60	2	1	2.2	0.00	1.000	DDX49 TCF7L2
Unable to work because of sickness or disability	2.60	1	0	0.0	0.00	1.000	DDX49
Fed-up feelings	2.58	1	0	0.0	0.00	1.000	DDX49
Qualifications: None of the above	2.56	1	0	0.0	0.00	1.000	DDX49
Vascular/heart problems diagnosed by doctor	2.53	2	0	0.0	0.00	1.000	CAMK1D IGF2BP2
Comparative height size at age 10	2.51	1	1	2.2	0.00	1.000	DDX49
Pain all over the body in last month	2.50	1	0	0.0	0.00	1.000	DDX49
Height	2.41	2	1	2.2	0.00	1.000	DDX49 TCF7L2
Qualifications: NVQ or HND or HNC or equivalent	2.36	1	0	0.0	0.00	1.000	DDX49
Schizophrenia vs Biploar Disorder	2.34	1	0	0.0	0.00	1.000	DDX49
Mouth/teeth dental problems	2.33	1	0	0.0	0.00	1.000	DDX49
Hypertension (Self-reported)	2.32	2	0	0.0	0.00	1.000	CAMK1D IGF2BP2
Wheeze or whistling in the chest in last year	2.31	1	0	0.0	0.00	1.000	IGF2BP2
High blood pressure	2.28	2	0	0.0	0.00	1.000	CAMK1D IGF2BP2
Frequency of tiredness / lethargy in last 2 weeks	2.23	1	0	0.0	0.00	1.000	DDX49
Bipolar Disorder (2018)	2.21	1	0	0.0	0.00	1.000	DDX49
Number of live births	2.20	1	0	0.0	0.00	1.000	DDX49
Hypothyroidism (self reported)	2.17	1	0	0.0	0.00	1.000	IGF2BP2
Forced expiratory volume in 1-second (FEV1), predicted	2.14	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Cardiovascular Disease	2.13	2	0	0.0	0.00	1.000	CAMK1D IGF2BP2
Loneliness, isolation	2.13	1	0	0.0	0.00	1.000	DDX49
Medication: Lansoprazole	2.07	1	0	0.0	0.00	1.000	DDX49
Heart disease (siblings)	2.07	1	0	0.0	0.00	1.000	IGF2BP2
Age at last live birth	2.06	1	0	0.0	0.00	1.000	DDX49
Heel bone mineral density (BMD) T-score, automated (left)	2.04	1	0	0.0	0.00	1.000	TCF7L2
Sensitivity / hurt feelings	2.02	1	0	0.0	0.00	1.000	DDX49
Schizophrenia (2014)	2.00	2	0	0.0	0.00	1.000	CAMK1D DDX49
Hypothyroidism/myxoedema (self-reported)	2.00	1	0	0.0	0.00	1.000	IGF2BP2
Leg predicted mass (right)	1.99	2	1	2.2	0.00	1.000	DDX49 TCF7L2
Medication: Paracetamol	1.99	1	0	0.0	0.00	1.000	DDX49
Body fat percentage	1.97	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Leg fat-free mass (right)	1.97	2	1	2.2	0.00	1.000	DDX49 TCF7L2
Pulse rate	1.94	1	0	0.0	0.00	1.000	CAMK1D
Qualifications: College or University degree	1.91	1	0	0.0	0.00	1.000	DDX49
Leg fat-free mass (left)	1.88	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Bilateral oophorectomy (both ovaries removed)	1.87	1	0	0.0	0.00	1.000	IGF2BP2
Leg predicted mass (left)	1.87	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Hair/balding pattern: Pattern 2	1.84	1	0	0.0	0.00	1.000	DDX49
Illnesses of father: High blood pressure	1.83	1	0	0.0	0.00	1.000	CAMK1D
Handedness (chirality/laterality): Left-handed	1.82	1	0	0.0	0.00	1.000	DDX49
Heel bone mineral density (BMD) T-score, automated (right)	1.79	1	0	0.0	0.00	1.000	TCF7L2
Diastolic blood pressure, automated reading	1.77	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Waist circumference	1.74	1	0	0.0	0.00	1.000	TCF7L2
Arm fat mass (right)	1.74	1	0	0.0	0.00	1.000	TCF7L2
Depressed Affect (Nagel 2018)	1.73	1	0	0.0	0.00	1.000	DDX49
Whole body fat mass	1.70	1	0	0.0	0.00	1.000	TCF7L2
Alcohol usually taken with meals	1.69	1	0	0.0	0.00	1.000	TCF7L2
Supplements: Glucosamine	1.66	1	0	0.0	0.00	1.000	DDX49
Arm fat percentage (left)	1.64	1	0	0.0	0.00	1.000	TCF7L2
Arm fat mass (left)	1.61	1	0	0.0	0.00	1.000	TCF7L2
High blood pressure (siblings)	1.60	1	0	0.0	0.00	1.000	IGF2BP2
Neuroticism (Nagel 2018)	1.58	1	0	0.0	0.00	1.000	DDX49
Arm fat percentage (right)	1.58	1	0	0.0	0.00	1.000	TCF7L2
Townsend deprivation index at recruitment	1.53	1	0	0.0	0.00	1.000	IGF2BP2
Schizophrenia (2018)	1.51	1	0	0.0	0.00	1.000	DDX49
Myopia	1.48	1	0	0.0	0.00	1.000	TCF7L2
Whole body fat-free mass	1.47	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Whole body water mass	1.45	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Impedance of leg (left)	1.40	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Basal metabolic rate	1.39	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Osteoarthritis (self-reported)	1.38	1	0	0.0	0.00	1.000	DDX49
Weight	1.37	1	0	0.0	0.00	1.000	TCF7L2
Impedance of leg (right)	1.35	2	0	0.0	0.00	1.000	DDX49 TCF7L2
Sitting height	1.28	1	1	2.2	0.00	1.000	DDX49
Trunk predicted mass	1.27	1	0	0.0	0.00	1.000	DDX49
Trunk fat-free mass	1.26	1	0	0.0	0.00	1.000	DDX49
Trunk fat mass	1.09	1	0	0.0	0.00	1.000	TCF7L2
Hand grip strength (right)	1.04	1	0	0.0	0.00	1.000	TCF7L2
Impedance of whole body	1.02	1	0	0.0	0.00	1.000	TCF7L2
Blood Red Count	0.95	3	0	0.0	0.00	1.000	DDX49 IGF2BP2 TCF7L2
Pulse rate, automated reading	0.93	1	0	0.0	0.00	1.000	TCF7L2
Arm fat-free mass (left)	0.89	1	0	0.0	0.00	1.000	TCF7L2
Bipolar Disorder or Schizophrenia	0.87	1	0	0.0	0.00	1.000	CAMK1D
Trunk fat percentage	0.86	1	0	0.0	0.00	1.000	TCF7L2
Arm predicted mass (left)	0.83	1	0	0.0	0.00	1.000	TCF7L2
Arm fat-free mass (right)	0.79	1	0	0.0	0.00	1.000	TCF7L2
Arm predicted mass (right)	0.69	1	0	0.0	0.00	1.000	TCF7L2
Blood White Count	0.41	1	0	0.0	0.00	1.000	IGF2BP2
Blood Eosinophil Count	0.24	1	0	0.0	0.00	1.000	DDX49
Hair Pigment	0.11	1	0	0.0	0.00	1.000	DDX49

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Artery Aorta	1	0.034	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	1	0.191	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Pancreas	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Lung	1	0.035	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Vagina	0	0.000	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.1