Hub : Traits :

Fractured/broken bones in last 5 years

16 significantly associated models · 8 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 4 305291 2058475 2 2 2.1e-07 7.1e-07 3.4e-05 30 CRIPAK FGFRL1
2 6 126752798 128214882 1 1 3.0e-12 2.6e-13 2.6e-02 91 RSPO3
3 12 14337924 15812575 3 1 9.8e-08 1.1e-07 1.0e+00 100 ARHGDIB

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 3.64 1 1 3.0 0.00 1.00 RSPO3
Irritable Bowel Disease (IBD) 1.60 1 0 0.0 0.00 1.00 RSPO3
Breast Cancer 2.34 1 0 0.0 0.00 1.00 RSPO3
Crohns Disease (2012) 3.28 1 0 0.0 0.00 1.00 RSPO3
HDL Cholesterol 2.95 1 0 0.0 0.00 1.00 RSPO3
Triglycerides 2.60 1 0 0.0 0.00 1.00 RSPO3
Blood Platelet Count 0.39 1 0 0.0 0.00 1.00 RSPO3
Blood Red Count 2.90 1 1 3.0 0.00 1.00 RSPO3
Heel T-Score 78.91 4 4 12.1 0.86 0.14 ARHGDIB CRIPAK FGFRL1 RSPO3
Height 1.07 3 2 6.1 0.00 1.00 ARHGDIB CRIPAK RSPO3
Waist Hip Ratio (WHR) 22.16 2 1 3.0 0.00 1.00 FGFRL1 RSPO3
Smoking Status 1.76 1 0 0.0 0.00 1.00 FGFRL1
Lung FVC 1.55 2 0 0.0 0.00 1.00 CRIPAK RSPO3
Hand grip strength (left) 11.55 3 1 3.0 0.00 1.00 ARHGDIB CRIPAK RSPO3
Ever had hysterectomy (womb removed) 3.40 1 0 0.0 0.00 1.00 RSPO3
Systolic blood pressure, automated reading 0.97 1 0 0.0 0.00 1.00 CRIPAK
Impedance of leg (right) 1.04 1 0 0.0 0.00 1.00 CRIPAK
Leg fat-free mass (left) 1.40 2 0 0.0 0.00 1.00 ARHGDIB CRIPAK
Hand grip strength (right) 10.69 2 1 3.0 0.00 1.00 ARHGDIB CRIPAK
Heel bone mineral density (BMD) T-score, automated (left) 53.89 4 3 9.1 -0.86 0.14 ARHGDIB CRIPAK FGFRL1 RSPO3
Supplements: Glucosamine 4.48 1 0 0.0 0.00 1.00 ARHGDIB
Sitting height 2.21 3 0 0.0 0.00 1.00 ARHGDIB CRIPAK RSPO3
Leg predicted mass (left) 1.46 2 0 0.0 0.00 1.00 ARHGDIB CRIPAK
Waist circumference 1.86 1 0 0.0 0.00 1.00 RSPO3
Forced vital capacity (FVC) 3.40 3 0 0.0 0.00 1.00 CRIPAK FGFRL1 RSPO3
Heel bone mineral density (BMD) T-score, automated (right) 52.53 3 3 9.1 0.00 1.00 CRIPAK FGFRL1 RSPO3
Heart attack 3.19 1 0 0.0 0.00 1.00 FGFRL1
Weight 0.98 1 0 0.0 0.00 1.00 CRIPAK
Impedance of arm (right) 2.69 2 1 3.0 0.00 1.00 ARHGDIB CRIPAK
Trunk fat-free mass 3.04 2 1 3.0 0.00 1.00 ARHGDIB CRIPAK
Hip circumference 2.18 1 1 3.0 0.00 1.00 RSPO3
Forced expiratory volume in 1-second (FEV1) 3.75 2 0 0.0 0.00 1.00 CRIPAK RSPO3
Pulse rate 2.92 1 0 0.0 0.00 1.00 CRIPAK
Forced expiratory volume in 1-second (FEV1), Best measure 2.56 2 0 0.0 0.00 1.00 CRIPAK RSPO3
Impedance of arm (left) 2.46 2 1 3.0 0.00 1.00 ARHGDIB CRIPAK
Trunk predicted mass 2.96 2 1 3.0 0.00 1.00 ARHGDIB CRIPAK
Standing height 1.28 2 1 3.0 0.00 1.00 CRIPAK RSPO3
Birth weight 2.08 1 0 0.0 0.00 1.00 RSPO3
Forced vital capacity (FVC), Best measure 2.32 2 0 0.0 0.00 1.00 CRIPAK RSPO3
Arm fat-free mass (right) 3.19 2 2 6.1 0.00 1.00 ARHGDIB CRIPAK
Wheeze or whistling in the chest in last year 1.96 1 0 0.0 0.00 1.00 RSPO3
Arm predicted mass (right) 3.31 2 2 6.1 0.00 1.00 ARHGDIB CRIPAK
Pulse rate, automated reading 3.64 3 0 0.0 0.00 1.00 CRIPAK FGFRL1 RSPO3
Comparative height size at age 10 1.93 1 1 3.0 0.00 1.00 CRIPAK
Forced expiratory volume in 1-second (FEV1), predicted 1.73 1 0 0.0 0.00 1.00 CRIPAK
Whole body fat-free mass 2.50 2 1 3.0 0.00 1.00 ARHGDIB CRIPAK
Leg fat-free mass (right) 1.72 2 0 0.0 0.00 1.00 ARHGDIB CRIPAK
Osteoporosis (self-reported) 5.02 1 0 0.0 0.00 1.00 RSPO3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.63 1 0 0.0 0.00 1.00 RSPO3
Whole body water mass 2.58 2 1 3.0 0.00 1.00 ARHGDIB CRIPAK
Leg predicted mass (right) 1.69 2 0 0.0 0.00 1.00 ARHGDIB CRIPAK
Basal metabolic rate 2.21 2 1 3.0 0.00 1.00 ARHGDIB CRIPAK
Arm fat-free mass (left) 3.08 2 2 6.1 0.00 1.00 ARHGDIB CRIPAK
Myopia 3.30 1 0 0.0 0.00 1.00 RSPO3
Supplements: Calcium 4.62 1 0 0.0 0.00 1.00 ARHGDIB
Heart attack/myocardial infarction (self-reported) 2.70 1 0 0.0 0.00 1.00 FGFRL1
Impedance of whole body 1.76 2 0 0.0 0.00 1.00 ARHGDIB CRIPAK
Arm predicted mass (left) 2.90 2 1 3.0 0.00 1.00 ARHGDIB CRIPAK

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.28
GTEx Adipose Visceral Omentum 0 0.0000 1.34
GTEx Adrenal Gland 0 0.0000 1.34
GTEx Artery Aorta 1 0.0336 1.38
GTEx Artery Coronary 0 0.0000 1.37
GTEx Artery Tibial 2 0.0532 1.36
GTEx Brain Caudate basal ganglia 0 0.0000 1.26
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.25
GTEx Brain Cerebellum 0 0.0000 1.33
GTEx Brain Cortex 0 0.0000 1.42
GTEx Brain Frontal Cortex BA9 0 0.0000 1.35
GTEx Brain Hippocampus 0 0.0000 1.39
GTEx Brain Hypothalamus 1 0.1695 1.34
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.34
GTEx Brain Putamen basal ganglia 0 0.0000 1.32
GTEx Breast Mammary Tissue 0 0.0000 1.30
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.25
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.29
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.30
GTEx Cells Transformed fibroblasts 1 0.0238 1.32
GTEx Colon Sigmoid 0 0.0000 1.26
GTEx Colon Transverse 0 0.0000 1.27
GTEx Esophagus Gastroesophageal Junction 1 0.0692 1.37
GTEx Esophagus Mucosa 0 0.0000 1.31
GTEx Esophagus Muscularis 0 0.0000 1.35
GTEx Heart Atrial Appendage 0 0.0000 1.30
GTEx Heart Left Ventricle 0 0.0000 1.34
GTEx Liver 0 0.0000 1.30
GTEx Lung 0 0.0000 1.30
GTEx Muscle Skeletal 0 0.0000 1.29
GTEx Nerve Tibial 0 0.0000 1.34
GTEx Ovary 0 0.0000 1.42
GTEx Pancreas 0 0.0000 1.28
GTEx Pituitary 0 0.0000 1.30
GTEx Prostate 0 0.0000 1.29
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.30
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.33
GTEx Small Intestine Terminal Ileum 0 0.0000 1.36
GTEx Spleen 0 0.0000 1.29
GTEx Stomach 0 0.0000 1.30
GTEx Testis 0 0.0000 1.34
GTEx Thyroid 1 0.0250 1.33
GTEx Uterus 0 0.0000 1.46
GTEx Vagina 0 0.0000 1.44
GTEx Whole Blood 0 0.0000 1.31
METSIM Adipose 2 0.0434 1.25
NTR Blood 0 0.0000 1.32
ROSMAP Brain Pre-frontal Cortex 1 0.0228 1.24
YFS Blood 0 0.0000 1.27
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.28
TCGA Breast Tumor 0 0.0000 1.40
TCGA Breast Normal 2 0.0475 1.26
TCGA Ovarian Tumor 0 0.0000 1.19
TCGA Prostate Tumor 2 0.0578 1.32