Hub : Genes

TOX

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1579 0.0524 1.3e-03 0.001 NA -0.001 NA 0.000 2.3e-01 NA 3.9e-01 NA 3.0e-01
2 GTEx Brain Hypothalamus 0.4790 0.1390 5.5e-03 0.067 NA -0.011 NA 0.093 1.2e-02 NA 7.2e-01 NA 3.4e-03
3 GTEx Heart Left Ventricle 0.3578 0.0644 1.3e-07 0.203 NA 0.270 NA 0.201 4.4e-11 NA 1.1e-14 NA 5.7e-11
4 GTEx Thyroid 0.1170 0.0420 2.4e-03 0.031 NA 0.030 NA 0.053 1.8e-03 NA 2.2e-03 NA 6.8e-05
5 YFS Blood 0.0296 0.0100 2.1e-04 0.021 0.015 0.016 0.017 0.018 1.2e-07 6.9e-06 3.3e-06 1.5e-06 1.2e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 1.6 2.6 8.0 0.1 -0.7 -0.7 -2.0 -2.8
Bipolar Disorder or Schizophrenia 0.6 1.5 2.9 0.1 -1.5 -0.3 -1.7 -1.5
Depressed Affect (Nagel 2018) 0.1 0.2 0.7 -0.2 -0.4 -0.1 0.9 0.4
Depression (Nagel 2018) 0.9 1.3 5.3 0.3 -2.3 -1.0 0.0 -0.6
Intelligence (Savage-Jansen 2018) 1.4 4.3 10.5 3.2 1.8 -0.1 1.7 2.2
Neuroticism (Nagel 2018) 0.6 1.4 2.8 1.3 -1.5 1.7 0.4 0.4
Schizophrenia (2018) 0.2 0.5 1.8 0.0 -1.3 0.2 -0.6 0.4
Schizophrenia vs Biploar Disorder 0.8 1.0 2.3 -1.3 -0.3 -0.3 1.5 0.9
Worry (Nagel 2018) 1.6 3.4 6.2 2.5 -2.0 2.4 -0.3 1.0
Alzheimer’s Disease (in mother) 1.7 2.0 5.4 -2.0 -0.5 0.4 0.2 -2.3
Alzheimer’s Disease (in father) 1.3 1.4 4.3 0.4 -1.4 -0.2 -2.1 -0.9
Alzheimer’s Disease (including proxy) 0.9 1.3 4.1 -0.8 -1.1 0.3 -0.7 -2.0
Crohns Disease (2017) 0.7 1.5 2.9 -1.7 -0.7 1.3 0.9 -1.2
Irritable Bowel Disease (IBD) 0.4 0.9 2.2 -1.5 -0.4 0.5 0.4 -1.4
Ulcerative Colitis (UC) 0.2 0.3 0.7 -0.4 -0.3 -0.7 -0.1 -0.8
Major Depression (MDD) 0.9 1.1 3.2 0.3 -1.3 0.0 -1.8 -0.7
Reaction Time 0.3 0.6 2.1 -0.5 -1.5 0.8 -0.2 0.5
Verbal and Numeric Reasoning (VNR) 1.4 3.3 7.4 2.7 0.2 1.4 1.5 2.1
Breast Cancer 0.2 0.4 1.0 0.8 -0.5 0.2 -0.5 1.0
Ovarian Cancer 0.7 1.0 4.1 -0.4 0.4 2.0 0.3 0.5
Prostate Cancer 0.8 1.1 2.6 -0.8 0.6 -0.6 1.6 -1.4
Age at First Birth 0.7 1.1 3.6 0.9 -0.3 0.6 -1.9 -0.8
Bipolar Disorder (2011) 1.1 1.0 3.0 -0.4 -0.9 -0.2 -1.7 -1.1
Body Mass Index (BMI) (2010) 1.0 1.3 4.3 0.7 -1.4 2.1 -0.3 0.0
Coronary Artery Disease (CAD) 0.5 0.5 1.1 -0.3 -0.6 -1.1 -0.6 -0.9
Crohns Disease (2012) 0.7 1.1 3.3 -1.8 0.3 0.3 1.3 -0.8
Mean Putamen Volume 1.2 1.4 4.0 0.4 -1.1 1.0 2.0 0.5
Fasting Glucose 2.1 2.6 6.9 -1.3 -2.6 0.6 -0.1 -2.0
HbA1C 0.1 0.1 0.4 0.1 -0.0 0.1 -0.2 -0.6
HDL Cholesterol 0.1 0.2 0.3 -0.2 0.2 -0.6 -0.6 0.1
LDL Cholesterol 0.5 0.7 2.5 0.7 0.4 0.3 0.6 1.6
Lupus 1.3 1.9 5.1 -1.2 -2.3 1.5 0.6 -0.8
Neuroticism (2016) 0.4 0.6 1.1 0.8 0.5 1.1 0.3 0.9
Primary Biliary Cirrhosis 0.3 0.5 1.1 0.5 -0.7 -0.3 -1.1 -0.5
Rheumatoid Arthritis 0.6 0.8 2.4 -0.7 -1.5 0.9 0.7 -0.1
Schizophrenia (2014) 0.2 0.3 1.0 -0.3 -1.0 -0.2 -0.7 -0.2
Triglycerides 0.2 0.4 1.4 -0.0 1.2 -0.5 0.1 -0.5
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.4 0.3 -1.6 1.1 -0.9 0.2
Ulcerative Colitis 0.2 0.3 0.7 -0.7 -0.4 0.5 -0.3 0.9
Blood Eosinophil Count 0.2 1.3 2.2 1.4 -1.1 1.5 -0.8 0.7
Blood Platelet Count 0.3 2.9 10.0 -1.9 -0.3 1.0 -0.1 -3.2
Blood Red Count 0.2 1.6 5.4 2.3 -0.9 0.2 -1.2 0.4
Blood White Count 0.5 3.9 8.6 0.5 -2.3 2.9 0.2 2.3
Heel T-Score 0.2 1.8 6.3 0.8 -0.8 0.2 1.1 -2.5
BMI 0.4 2.1 4.9 -2.2 -0.9 1.4 0.4 -1.6
Height 0.3 6.3 15.8 -1.2 -4.0 3.3 -1.4 -1.1
Waist Hip Ratio (WHR) 0.5 2.3 5.1 -2.3 -1.2 1.6 -1.4 0.5
Systolic Blood Pressure 0.5 2.4 11.7 0.3 0.4 -3.4 0.3 0.1
Smoking Status 0.4 1.0 2.7 -0.8 -1.0 0.1 1.7 0.8
Allergy or Eczema 0.4 1.0 2.2 1.5 -0.8 -0.5 -1.3 -0.6
Cardiovascular Disease 0.2 0.7 1.2 0.7 0.8 0.9 1.1 0.6
Hypothyroidism (self reported) 0.3 0.7 1.5 1.2 -0.3 0.3 0.8 -1.0
Respiratory disease 1.9 4.2 11.6 -1.4 -1.5 -0.2 -2.3 -3.4
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.9 -0.1 -1.7 0.7 -1.4 -0.6
Lung FEV1/FVC ratio 0.3 1.3 2.5 -1.3 -0.5 1.5 -0.5 -1.6
Lung FVC 0.2 1.0 2.5 0.2 1.6 1.2 -0.8 -0.8
Neuroticism 0.5 1.1 4.4 2.1 -0.7 0.5 -0.2 0.5
Chronotype (morning person) 0.6 1.4 2.6 1.6 -0.1 -0.9 -1.2 1.5
Hair Pigment 0.1 3.5 12.4 -0.9 0.2 0.6 1.9 3.5
Tanning 0.1 1.1 5.1 -0.4 2.3 0.7 -0.0 -0.1
Hand grip strength (left) 0.9 2.5 7.6 -0.1 1.9 -0.6 0.8 -2.7
Number of treatments/medications taken 0.6 1.1 4.5 -0.8 -0.3 2.1 0.5 -0.5
Average weekly spirits intake 1.2 1.4 4.1 -2.0 -0.6 1.5 -0.6 0.3
Sensitivity / hurt feelings 0.3 0.5 1.6 0.0 -0.0 1.2 -0.9 0.2
Frequency of depressed mood in last 2 weeks 2.0 2.8 10.0 1.9 -3.2 -0.2 -0.4 0.1
Hearing difficulty/problems: Yes 0.2 0.3 0.9 -0.9 -0.8 -0.1 -0.1 -0.3
Relative age of first facial hair 0.4 0.8 2.2 -0.0 1.2 0.2 0.5 1.5
Other serious medical condition/disability diagnosed by doctor 0.6 0.8 2.5 -0.6 -1.6 -1.0 -0.3 -0.4
Ever used hormone-replacement therapy (HRT) 1.0 1.2 3.1 -0.8 0.8 1.2 0.6 1.8
Ever had hysterectomy (womb removed) 0.9 1.0 2.2 -1.1 -0.2 1.5 1.1 0.3
Systolic blood pressure, automated reading 0.4 1.1 2.4 -1.5 -0.4 -1.4 -0.9 0.4
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 4.0 -0.4 0.3 0.2 0.2 -2.0
Angina 0.3 0.4 1.3 0.6 0.5 0.5 1.1 0.1
Medication for hormone replacement therapy 0.3 0.3 0.7 -0.5 -0.1 -0.8 -0.3 0.8
Vitamin and mineral supplements 0.3 0.5 0.8 -0.7 0.9 -0.8 0.5 -0.1
Supplements: Zinc 1.4 1.5 3.6 0.6 -1.9 1.8 -0.7 -0.0
Medication: Co-codamol 2.2 2.5 11.4 -3.4 -0.0 -0.2 -0.4 -0.9
Medication: Metformin 0.6 0.8 2.8 -1.7 0.0 0.6 -0.8 -0.5
Diabetes (father) 0.4 0.5 1.4 -0.7 -0.2 0.1 1.2 -0.8
Diabetes (mother) 0.3 0.4 0.8 0.3 0.2 -0.5 -0.8 -0.9
Severe depression (siblings) 0.4 0.5 1.2 0.0 -0.9 0.5 1.1 -0.1
Pack years adult smoking proportion 0.2 0.3 1.1 -0.1 -0.4 -0.5 1.0 0.3
Impedance of leg (right) 0.7 3.5 10.6 3.3 -0.3 -2.6 -0.5 0.3
Leg fat-free mass (left) 0.6 3.3 5.4 -2.2 -2.3 2.2 0.0 -1.1
Trunk fat percentage 0.4 1.7 5.7 -0.9 -2.4 0.1 -0.4 -1.3
Hand grip strength (right) 1.2 3.4 10.0 -0.3 3.2 -1.2 0.5 -2.2
Townsend deprivation index at recruitment 0.4 0.6 1.7 -0.0 -1.3 0.2 0.5 1.0
Current tobacco smoking 1.1 1.8 6.1 0.5 -2.5 0.3 1.2 1.2
Average weekly fortified wine intake 0.6 0.7 1.7 -1.3 -0.3 -1.2 -0.1 -0.5
Maternal smoking around birth 1.0 1.5 3.7 0.1 0.4 -1.8 -1.9 -0.6
Fed-up feelings 0.5 0.9 3.6 -0.9 -0.2 0.3 -0.3 1.9
Frequency of unenthusiasm / disinterest in last 2 weeks 1.6 2.1 7.2 1.4 -2.7 -0.5 1.1 -0.1
Relative age voice broke 1.8 2.7 11.1 -0.8 3.3 -0.3 1.3 0.3
Taking other prescription medications 1.8 2.8 9.6 -0.9 -1.6 3.1 -0.9 -0.1
Age when periods started (menarche) 0.9 2.2 4.8 1.5 1.0 -1.2 -1.1 -2.2
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.9 -0.2 0.5 1.4 0.7 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.0 2.1 -1.2 -1.4 -0.0 1.0 -0.8
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.6 -0.2 0.3 0.4 -0.8 0.1
Qualifications: CSEs or equivalent 1.1 1.4 4.3 -2.1 -0.2 1.4 0.7 0.4
Serious illness, injury or assault to yourself 0.1 0.2 0.4 0.6 -0.5 0.2 -0.2 0.3
High blood pressure 0.2 0.6 1.1 -1.0 0.0 0.7 0.6 1.1
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.4 1.6 0.0 0.0 -0.5 -0.3
Multivitamins +/- minerals 0.2 0.3 0.7 0.5 -0.2 -0.1 -0.8 -0.8
Stomach or abdominal pain in last month 0.3 0.3 0.9 0.4 -0.4 -0.9 0.5 -0.4
Supplements: Glucosamine 0.7 0.9 2.1 -0.7 1.0 1.4 -0.8 0.5
Diverticular disease/diverticulitis (self-reported) 0.2 0.2 1.0 -0.1 0.3 -1.0 0.2 -0.1
Medication: Atenolol 0.2 0.3 0.5 0.4 -0.6 -0.7 0.5 -0.1
Medication: Levothyroxine sodium 1.0 1.8 4.3 2.1 -1.3 0.3 0.6 -1.6
Sitting height 0.1 0.7 1.4 -0.2 -1.0 1.2 -0.2 1.0
Chronic bronchitis/emphysema (father) 1.1 1.3 5.7 -0.1 -1.0 -2.4 -0.2 -0.0
High blood pressure (mother) 1.1 1.6 3.1 1.6 1.2 -1.8 0.9 0.4
Body mass index (BMI) 0.6 2.8 7.1 -2.7 -1.6 1.7 0.4 -1.1
Impedance of leg (left) 0.6 2.8 6.7 2.6 -0.2 -2.6 -0.6 0.6
Leg predicted mass (left) 0.6 3.4 5.3 -2.2 -2.3 2.3 -0.0 -1.1
Trunk fat mass 0.7 2.9 8.7 -1.7 -3.0 0.8 -0.5 -1.5
Waist circumference 1.4 5.1 11.5 -3.4 -2.7 2.4 -0.6 -0.7
Number of incorrect matches in round 0.2 0.4 1.6 0.0 -1.3 0.4 0.5 -0.1
Past tobacco smoking 0.2 0.3 0.6 0.8 -0.5 -0.4 -0.2 -0.8
Alcohol usually taken with meals 1.9 3.1 5.6 2.4 1.0 -2.3 1.5 -1.0
Nervous feelings 1.6 3.0 6.1 2.3 -1.2 1.5 0.2 2.5
Frequency of tenseness / restlessness in last 2 weeks 0.6 1.0 1.8 0.1 -1.3 1.3 1.1 0.6
Hearing difficulty/problems with background noise 1.5 2.4 6.0 2.0 -2.4 1.4 0.3 -0.1
Hair/balding pattern: Pattern 2 0.7 0.8 2.4 -0.5 0.6 1.5 -0.5 1.0
Had menopause 1.2 1.5 2.7 -1.5 1.5 1.6 0.4 0.2
Had other major operations 1.3 1.6 3.5 0.2 1.8 1.0 0.2 1.9
Forced vital capacity (FVC) 0.3 1.2 2.5 0.7 0.3 1.3 -1.6 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.2 -1.0 -1.1 -0.4 0.7 -0.6
Ever unenthusiastic/disinterested for a whole week 1.2 1.5 4.1 0.2 -2.0 -0.1 -0.8 1.6
Qualifications: None of the above 0.9 2.0 8.3 -2.9 0.1 -0.5 -1.1 -0.5
Financial difficulties in last 2 years 1.7 2.3 4.9 -2.2 0.9 -0.4 1.0 2.1
Mouth/teeth dental problems 1.7 2.6 8.3 -0.9 0.6 -1.8 0.1 -2.9
Heart attack 0.6 0.8 3.1 1.8 0.2 -0.5 0.7 -0.1
Allergy 0.7 1.5 4.6 0.5 1.3 0.0 2.2 1.0
Pain all over the body in last month 1.8 1.9 3.4 0.7 -1.4 1.9 -0.4 1.8
Diabetes (self-reported) 0.6 0.9 3.1 -0.7 -1.0 0.2 -1.7 -0.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.8 -0.1 -0.1 0.9 0.6 0.1
Medication: Ramipril 0.1 0.1 0.2 -0.1 -0.3 -0.3 -0.5 -0.1
Medication: Simvastatin 0.3 0.4 1.1 0.6 -1.1 0.0 -0.4 0.7
Fluid intelligence score 0.9 1.9 6.0 2.5 0.5 -1.4 0.9 0.8
Illnesses of siblings 0.7 1.0 3.1 1.8 0.0 0.5 -0.1 -1.3
Neuroticism score 0.5 1.0 2.4 1.6 -0.9 0.8 -0.1 1.1
Weight 1.0 4.7 8.9 -2.8 -3.0 2.1 -0.0 -1.5
Impedance of arm (right) 0.9 4.0 12.0 3.5 -0.5 -2.5 0.0 1.2
Arm fat percentage (right) 0.5 1.9 6.8 -1.5 -2.6 0.3 -0.1 -0.7
Trunk fat-free mass 1.0 5.5 9.5 -2.8 -2.8 3.1 -0.6 -1.4
Hip circumference 0.8 3.6 9.2 -3.0 -2.1 1.1 -0.0 -1.7
Time employed in main current job 0.1 0.1 0.2 0.1 0.2 -0.4 -0.1 -0.5
Alcohol intake versus 10 years previously 0.9 1.3 3.7 -0.8 -0.8 1.2 -1.9 0.2
Father’s age at death 2.0 2.7 8.8 1.9 0.9 -0.3 3.0 -0.4
Worrier / anxious feelings 1.2 2.3 5.3 1.4 -1.0 2.3 0.1 1.8
Frequency of tiredness / lethargy in last 2 weeks 1.9 3.1 6.4 -0.3 -2.5 2.5 -0.0 1.8
Falls in the last year 0.8 1.1 3.6 -0.5 -1.9 1.1 0.0 -0.5
Hair/balding pattern: Pattern 3 1.8 2.6 6.9 -0.6 -2.4 0.0 0.1 -2.6
Number of live births 1.8 2.5 7.0 -2.7 2.3 -0.3 0.2 -0.5
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 5.7 -0.4 0.1 1.2 -2.0 -2.4
Pulse rate 1.8 3.1 9.0 1.8 -0.4 1.1 -1.2 3.0
Happiness 0.4 0.5 1.0 0.7 -0.9 0.4 -1.0 -0.2
Noisy workplace 0.1 0.1 0.2 -0.5 0.3 0.1 0.0 -0.4
Qualifications: A levels/AS levels or equivalent 1.2 2.6 4.8 2.2 0.5 -1.9 -0.1 2.2
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.1 -0.4 -1.0 0.8 1.0 -0.8
Mouth/teeth dental problems: Dentures 1.1 1.8 6.7 -0.3 1.1 1.1 0.1 2.6
Asthma 2.3 4.6 8.8 -2.0 -2.2 -0.1 -2.3 -3.0
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.8 -0.1 0.1 -0.7 0.9 0.3
Medication: Cholesterol lowering 0.2 0.4 0.7 0.6 -0.4 0.6 0.9 0.4
Depression (self-reported) 0.9 1.1 3.1 -0.6 -0.9 -1.8 -0.3 -1.0
Medication: Lansoprazole 0.6 0.7 2.5 0.3 -0.1 1.6 -0.5 0.7
Prospective memory result 0.9 1.1 2.9 -1.1 -0.4 1.7 0.6 0.9
Lung cancer (father) 1.1 1.3 2.3 -1.5 -1.3 -0.5 -1.4 0.6
Illnesses of mother 0.2 0.3 0.9 -0.6 -0.2 0.1 -0.3 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 5.6 -0.3 -0.1 1.2 -2.1 -2.4
Pulse wave Arterial Stiffness index 0.3 0.3 0.9 0.4 0.3 1.0 0.6 0.1
Impedance of arm (left) 1.3 6.0 17.2 4.2 0.8 -3.4 0.3 0.8
Arm fat mass (right) 0.6 2.6 6.0 -1.9 -2.4 1.3 -0.2 -1.2
Trunk predicted mass 1.0 5.4 10.1 -2.7 -2.8 3.2 -0.6 -1.3
Standing height 0.3 3.1 11.3 -0.1 -3.4 1.2 -1.0 -1.4
Length of working week for main job 0.3 0.3 0.6 0.7 0.8 0.5 0.4 0.3
Exposure to tobacco smoke at home 0.2 0.2 0.5 -0.7 0.6 -0.2 -0.6 -0.0
Breastfed as a baby 0.8 1.0 2.7 0.5 1.6 1.2 0.1 -0.9
Tense / ‘highly strung’ 1.8 2.9 8.2 0.3 -2.9 1.9 -1.7 0.5
Seen doctor (GP) for nerves, anxiety, tension or depression 1.0 1.5 3.8 -0.9 -1.9 0.5 0.0 1.6
Hair/balding pattern: Pattern 4 0.3 0.6 1.7 -0.7 -1.3 0.1 -0.9 0.4
Birth weight of first child 1.3 2.4 8.2 1.4 1.2 0.6 2.9 -0.0
Peak expiratory flow (PEF) 0.8 2.0 4.3 -1.2 0.1 1.1 -1.7 -2.1
Pulse wave reflection index 1.6 2.0 4.0 -0.7 1.3 2.0 1.9 -0.8
Ever highly irritable/argumentative for 2 days 1.9 2.2 7.4 -2.7 -0.4 1.2 0.0 -1.5
Loud music exposure frequency 2.8 3.1 8.5 -0.7 -1.6 0.1 -1.9 -2.9
Qualifications: O levels/GCSEs or equivalent 0.5 0.8 3.7 0.4 1.9 0.4 0.2 -0.2
Mouth/teeth dental problems: Bleeding gums 1.5 2.0 4.5 1.2 -0.0 1.9 -0.6 2.1
Blood clot in the leg (DVT) 1.8 2.3 4.5 -1.5 -2.1 -0.9 -2.0 -0.3
Medication: Paracetamol 1.0 1.7 5.0 0.6 -0.7 2.2 0.3 1.6
Headache pain in last month 0.2 0.4 0.7 0.8 -0.8 -0.8 -0.2 0.1
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.7 0.3 0.5 0.1 -0.8 -0.8
Glaucoma (self-reported) 0.6 0.7 1.2 0.9 0.6 -1.1 1.0 -0.5
Gout (self-reported) 1.1 1.5 2.7 0.9 -1.2 1.6 -0.9 1.4
Hypothyroidism/myxoedema (self-reported) 0.7 1.4 3.2 1.1 -0.4 0.9 1.8 -1.2
Medication: Amlodipine 1.3 1.8 4.0 -1.7 -1.2 0.8 -0.2 2.0
Medication: Ventolin 100micrograms inhaler 1.4 1.7 4.0 -1.5 -1.3 0.9 -0.3 -2.0
Birth weight 0.4 0.9 2.0 -0.7 -1.1 -1.4 0.8 -0.2
Chronic bronchitis/emphysema (mother) 0.7 0.9 2.5 0.7 -0.5 -0.5 -1.6 -0.9
High blood pressure (siblings) 0.7 1.0 1.9 -1.3 -0.0 -1.2 0.2 1.4
Forced vital capacity (FVC), Best measure 0.5 1.7 3.7 0.5 -0.7 1.6 -1.9 -1.2
Body fat percentage 0.4 1.6 5.1 -1.2 -2.3 0.2 -0.1 -1.2
Leg fat percentage (right) 0.5 1.8 4.8 -1.7 -2.2 0.4 0.0 -1.1
Arm fat-free mass (right) 0.9 4.8 8.6 -2.9 -2.1 2.8 -0.4 -1.8
Exposure to tobacco smoke outside home 0.4 0.5 1.3 -0.6 -0.7 0.4 -0.2 -1.1
Comparative body size at age 10 0.5 1.4 5.1 0.6 -2.3 0.7 -0.7 0.6
Number of full brothers 1.2 1.5 3.7 -1.6 -1.0 0.0 -0.5 -1.9
Worry too long after embarrassment 1.5 2.5 6.4 2.5 -2.2 1.2 0.4 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.3 1.7 3.9 -2.0 -1.9 -0.8 0.2 -0.5
Wheeze or whistling in the chest in last year 1.4 2.5 5.3 -1.7 -2.3 1.0 -1.1 -1.4
Number of children fathered 0.3 0.3 0.6 -0.4 0.4 -0.7 0.2 -0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 1.9 1.4 0.1 0.1 0.1 -0.7
Age at first live birth 1.3 2.4 8.6 0.8 -0.8 -2.9 -0.5 -1.3
Pulse wave peak to peak time 0.3 0.3 0.6 -0.4 -0.6 -0.8 -0.7 -0.1
Health satisfaction 1.1 1.4 5.0 0.3 -2.2 0.4 -0.5 -1.3
Shortness of breath walking on level ground 0.8 1.0 2.4 -0.0 -0.6 1.0 1.5 1.1
Qualifications: College or University degree 2.5 7.7 18.4 4.3 -2.1 -3.1 -1.9 1.6
Eye problems/disorders: None of the above 3.3 3.8 11.1 0.2 -0.3 3.3 0.3 2.8
Mouth/teeth dental problems: Loose teeth 1.9 2.2 7.2 1.1 -2.7 1.4 0.0 0.8
Emphysema/chronic bronchitis 0.8 0.8 3.2 -1.8 0.0 0.2 -0.4 0.9
Medication for pain relief, constipation, heartburn 0.8 1.3 3.8 -0.4 0.6 -1.9 -1.3 0.5
Neck or shoulder pain in last month 0.7 1.0 2.6 -0.4 -1.6 0.8 -0.8 0.9
Medication: Blood pressure 0.4 0.6 1.1 -1.0 -0.2 -0.7 1.0 0.8
Angina (self-reported) 0.1 0.2 0.3 0.6 0.4 0.3 0.6 0.2
Migraine (self-reported) 2.5 3.0 7.9 1.9 2.8 -1.7 -0.0 -0.9
Medication: Ibuprofen 0.7 0.9 1.6 -1.1 0.8 -1.3 0.8 -0.4
Medication: Allopurinol 0.7 0.9 2.3 0.4 -0.3 1.2 -0.6 1.5
Medication: Omeprazole 0.8 0.9 2.8 1.7 -0.4 -0.2 0.8 -1.0
Medication: Seretide 50 evohaler 0.5 0.6 1.8 0.2 0.1 0.3 -1.1 -1.3
Mean time to correctly identify matches 0.8 1.5 2.6 -1.5 -1.6 1.4 0.4 0.7
Heart disease (mother) 0.4 0.5 1.6 -0.4 -1.3 0.6 0.1 0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 2.4 -1.5 0.4 -0.9 -0.5 -0.3
Whole body fat mass 0.6 2.6 7.8 -1.6 -2.8 1.0 -0.1 -1.3
Leg fat mass (right) 0.7 2.7 7.4 -1.9 -2.7 1.1 -0.1 -1.2
Arm predicted mass (right) 1.0 5.2 9.2 -3.0 -2.1 3.0 -0.3 -1.8
Pulse rate, automated reading 1.9 6.2 23.2 1.5 0.2 2.2 -0.7 4.8
Alcohol intake frequency. 0.8 1.9 3.8 0.2 -1.9 1.2 -1.9 -0.8
Comparative height size at age 10 0.5 2.9 5.7 0.0 -2.4 2.0 -0.9 -2.0
Number of full sisters 0.9 1.1 3.5 0.6 -1.9 0.1 -1.2 0.4
Suffer from ‘nerves’ 0.4 0.6 1.4 0.8 -1.2 0.8 -0.6 -0.4
Overall health rating 1.8 3.8 9.1 -0.2 -3.0 2.1 -0.3 2.3
Chest pain or discomfort 0.4 0.6 2.0 -1.4 -1.0 -0.0 0.2 0.3
Had major operations 0.6 0.7 1.7 0.0 0.3 -1.2 -0.5 -1.3
Age at last live birth 1.5 2.2 8.5 0.0 -0.8 -2.9 -0.6 -1.2
Family relationship satisfaction 0.3 0.4 1.6 0.1 -0.6 -0.1 -1.3 -0.1
Leg pain on walking 1.1 1.3 3.3 0.2 0.5 1.7 1.8 0.6
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.3 3.4 -1.1 0.8 1.8 -0.7 -0.8
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.8 -2.0 0.0 0.1 0.0 0.1
Illness, injury, bereavement, stress in last 2 years 0.6 0.8 1.2 1.0 1.0 -1.1 -0.8 0.2
Medication: Aspirin 0.9 1.2 3.2 0.3 -1.8 1.5 0.2 -0.3
Supplements: Vitamin C 2.8 3.3 10.5 1.3 -3.2 1.0 -1.7 -0.7
Knee pain experienced in last month 0.3 0.5 1.1 0.9 0.5 1.0 -0.7 -0.2
Hypertension (Self-reported) 0.2 0.6 1.3 -0.7 0.3 1.1 0.8 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.0 0.2 0.0 1.0 0.6 -0.8
Illnesses of father: Heart disease 2.0 2.8 5.5 0.1 -1.9 -0.3 -2.1 -2.3
Illnesses of siblings: Diabetes 0.8 1.0 4.5 -2.1 0.2 0.0 0.6 0.4
Smoking status: Previous 0.5 0.7 2.1 -1.0 1.4 0.5 0.0 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.6 4.2 1.1 -2.0 0.5 -1.1 -1.0
Whole body fat-free mass 0.9 5.0 8.9 -2.7 -2.6 3.0 -0.4 -1.3
Leg fat-free mass (right) 0.7 3.8 7.2 -2.7 -2.2 2.5 -0.1 -1.0
Arm fat percentage (left) 0.3 1.2 3.8 -1.2 -2.0 -0.2 -0.0 -0.9
Average weekly red wine intake 3.1 4.6 8.4 2.5 0.8 -2.9 2.6 -0.8
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.0 -0.6 0.3 -0.1 -1.0 0.2
Mood swings 0.6 1.1 2.7 0.1 -0.5 1.4 0.6 1.7
Loneliness, isolation 0.6 0.9 2.5 -0.3 0.2 -1.6 -0.3 -1.3
Long-standing illness, disability or infirmity 1.2 1.8 5.2 -1.4 -2.3 1.2 -0.2 -0.5
Ever had bowel cancer screening 0.9 1.0 2.3 -0.3 -1.5 -0.8 -1.4 -0.1
Diabetes diagnosed by doctor 0.6 1.1 2.6 -0.6 -1.6 1.0 -1.1 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.9 0.0 -0.1 -0.2 -0.7 0.9
Friendships satisfaction 0.5 0.6 2.1 1.0 0.1 -0.2 1.4 -0.1
Qualifications: nursing, teaching 0.2 0.4 0.8 0.6 0.1 -0.4 0.7 0.9
Commuting to job workplace: Walk 0.8 0.9 2.5 1.6 0.4 -0.7 -0.1 1.1
Eye problems/disorders: Cataract 2.5 2.9 12.2 -0.3 1.1 -3.5 0.5 -1.0
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.5 0.2 -0.5 -0.7 0.0 0.2
Medication for cholesterol 0.2 0.3 1.0 -0.1 -0.6 -1.0 0.1 -0.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.7 2.0 4.6 -0.6 -1.2 1.3 -1.3 2.1
Back pain experienced in last month 0.7 1.1 2.3 -1.0 -1.0 1.5 0.7 -0.8
Mineral and other dietary supplements 2.0 2.6 9.5 -1.2 -0.7 -3.1 0.9 -1.0
Breast cancer (self-reported) 1.2 1.4 2.8 -0.7 -0.9 1.7 -0.6 1.5
Asthma (self-reported) 2.4 4.9 9.3 -1.8 -2.4 -0.0 -2.4 -3.0
Osteoporosis (self-reported) 0.2 0.2 0.5 -0.1 -0.7 0.3 -0.6 0.0
Osteoarthritis (self-reported) 0.7 0.9 2.4 0.3 -0.9 1.6 1.0 0.0
Medication: Aspirin 1.2 1.6 4.4 0.6 -2.1 1.7 0.6 0.1
Medication: Gliclazide 0.1 0.2 0.5 0.1 0.2 -0.0 0.7 0.5
Illnesses of father: None of the above (group 1) 1.3 1.6 4.4 0.1 1.5 0.6 2.1 1.0
Smoking status: Current 1.2 1.8 6.7 0.5 -2.6 -0.1 1.1 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.8 6.2 -1.2 2.5 0.4 0.2 -1.1
Whole body water mass 0.9 5.1 8.7 -2.8 -2.6 3.0 -0.3 -1.4
Leg predicted mass (right) 0.7 3.7 6.6 -2.6 -2.2 2.4 -0.1 -1.1
Arm fat mass (left) 0.5 2.2 5.3 -1.7 -2.3 1.2 -0.1 -1.2
Number of self-reported non-cancer illnesses 0.4 0.7 1.6 1.0 -1.3 0.3 -0.3 -0.7
Average weekly champagne plus white wine intake 0.3 0.5 0.8 0.7 0.9 -0.2 0.9 0.5
Miserableness 0.5 0.9 1.9 1.0 -0.5 0.7 0.8 1.4
Guilty feelings 0.1 0.1 0.3 0.1 -0.3 -0.3 0.0 0.6
Wears glasses or contact lenses 0.8 1.0 1.8 1.0 -1.1 -0.8 -0.4 -1.3
Ever taken oral contraceptive pill 0.6 0.7 1.6 -0.1 1.1 0.3 0.6 1.3
Hearing aid user 0.5 0.5 1.3 -0.8 0.1 0.7 0.4 -1.1
Mother’s age at death 2.6 3.2 7.9 2.1 1.7 0.2 2.8 0.9
Financial situation satisfaction 0.5 0.6 1.7 -0.1 -1.3 -0.4 -1.2 0.3
Tinnitus: Yes, now most or all of the time 1.3 1.5 3.7 -1.9 -1.6 -0.3 -0.5 -0.8
Commuting to job workplace: Public transport 1.0 1.2 3.6 1.2 0.6 -1.9 -0.6 -0.0
Eye problems/disorders: Glaucoma 0.7 0.8 1.3 0.6 0.4 -1.0 1.2 -1.0
Medication: Blood pressure 0.2 0.3 0.7 0.1 0.5 0.8 -0.4 0.8
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.2 0.9 1.1 0.7 0.6 0.7
Supplements: Fish oil (including cod liver oil) 2.0 2.7 12.0 -0.4 0.5 3.5 -0.9 -0.1
High cholesterol (Self-reported) 0.4 0.7 1.9 0.6 1.4 0.7 0.6 0.4
Medication: Bendroflumethiazide 0.2 0.2 0.6 -0.4 -0.6 -0.8 0.2 0.3
Medication: Paracetamol 1.0 1.5 5.5 0.4 0.0 2.4 0.9 1.1
Medication: Lisinopril 0.5 0.7 1.6 1.3 0.2 -0.3 -0.6 -1.2
Medication: Atorvastatin 0.8 1.0 2.5 0.6 -1.3 1.6 -0.8 0.2
Illnesses of father: High blood pressure 0.8 1.0 2.6 0.4 1.6 -1.0 0.6 -0.9
Alcohol drinker status: Never 0.6 0.8 1.7 1.3 -1.0 0.1 -1.0 -0.2
Ever smoked 0.1 0.1 0.3 -0.5 0.0 -0.1 -0.3 0.5
Basal metabolic rate 0.9 5.2 8.0 -2.8 -2.8 2.8 -0.2 -1.5
Leg fat percentage (left) 0.6 2.2 5.0 -2.2 -2.2 0.7 0.1 -0.9
Arm fat-free mass (left) 1.3 6.6 12.3 -3.1 -2.8 3.5 -0.4 -1.7
Number of operations (self-reported) 0.8 1.1 3.2 0.9 1.8 -1.2 0.1 0.2
Average weekly beer plus cider intake 1.8 2.5 5.4 -2.2 0.9 1.2 -2.3 -0.4
Irritability 0.5 0.8 1.9 1.0 -1.4 0.8 0.5 -0.4
Risk taking 1.3 1.9 6.5 -0.3 1.1 -0.1 -1.2 -2.5
Ever had prostate specific antigen (PSA) test 1.3 1.5 3.2 -1.2 1.2 -1.8 -0.4 -1.0
Fractured/broken bones in last 5 years 1.0 1.2 5.9 -0.1 2.4 -0.3 0.5 -0.1
Age started oral contraceptive pill 0.5 0.6 2.1 -0.1 -0.8 0.6 -1.4 0.0
Diastolic blood pressure, automated reading 0.2 0.7 2.3 -1.5 1.1 0.1 0.1 0.3
Ever depressed for a whole week 1.4 1.8 2.9 -1.7 -1.5 0.8 -1.5 0.9
Unable to work because of sickness or disability 1.2 1.6 3.8 -1.4 -1.9 1.4 -0.3 0.6
Commuting to job workplace: Cycle 1.1 1.3 4.5 0.2 -0.5 -0.8 1.0 -2.1
Myopia 8.8 12.8 39.4 -0.7 -0.3 -6.3 -1.4 -4.7
Vascular/heart problems diagnosed by doctor 0.1 0.4 0.9 0.6 0.2 -0.7 -0.9 -0.5
Cholesterol lowering medication 0.5 0.8 2.1 -0.1 -0.2 0.9 -1.4 -0.9
Medication: Omeprazole (e.g. Zanprol) 0.7 0.9 1.6 1.0 -0.2 -0.3 1.2 -1.3
Pain experienced in last month 1.4 2.3 7.2 -0.8 1.8 -2.7 -0.5 -0.1
Supplements: Calcium 2.1 2.3 6.6 1.0 -1.5 2.6 -0.9 1.0
Basal cell carcinoma (self-reported) 0.4 0.4 1.6 1.3 0.1 -0.6 -0.4 0.2
Heart attack/myocardial infarction (self-reported) 0.7 0.9 4.0 2.0 0.5 -0.5 0.5 0.1
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 4.1 -1.3 -2.0 -1.0 -1.9 -0.4
Heart disease (siblings) 0.4 0.5 1.0 -1.0 0.0 0.4 -0.6 -1.0
Alcohol drinker status: Previous 0.8 0.9 2.5 1.3 -0.3 1.6 0.4 0.3
Pack years of smoking 0.2 0.3 1.0 -0.1 -0.4 -0.7 1.0 0.3
Impedance of whole body 1.1 5.4 15.3 3.9 0.5 -3.3 -0.2 0.6
Leg fat mass (left) 0.8 3.0 7.1 -2.3 -2.7 1.3 0.0 -1.1
Arm predicted mass (left) 1.3 6.5 11.6 -3.3 -2.7 3.4 -0.4 -1.5