TWAS hub - TOX

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1579	0.0524	1.3e-03	0.001	NA	-0.001	NA	0.000	2.3e-01	NA	3.9e-01	NA	3.0e-01
2	GTEx	Brain Hypothalamus	0.4790	0.1390	5.5e-03	0.067	NA	-0.011	NA	0.093	1.2e-02	NA	7.2e-01	NA	3.4e-03
3	GTEx	Heart Left Ventricle	0.3578	0.0644	1.3e-07	0.203	NA	0.270	NA	0.201	4.4e-11	NA	1.1e-14	NA	5.7e-11
4	GTEx	Thyroid	0.1170	0.0420	2.4e-03	0.031	NA	0.030	NA	0.053	1.8e-03	NA	2.2e-03	NA	6.8e-05
5	YFS	Blood	0.0296	0.0100	2.1e-04	0.021	0.015	0.016	0.017	0.018	1.2e-07	6.9e-06	3.3e-06	1.5e-06	1.2e-06

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Myopia	8.8	12.8	39.4	-0.7	-0.3	-6.3	-1.4	-4.7
Eye problems/disorders: None of the above	3.3	3.8	11.1	0.2	-0.3	3.3	0.3	2.8
Average weekly red wine intake	3.1	4.6	8.4	2.5	0.8	-2.9	2.6	-0.8
Loud music exposure frequency	2.8	3.1	8.5	-0.7	-1.6	0.1	-1.9	-2.9
Supplements: Vitamin C	2.8	3.3	10.5	1.3	-3.2	1.0	-1.7	-0.7
Mother’s age at death	2.6	3.2	7.9	2.1	1.7	0.2	2.8	0.9
Qualifications: College or University degree	2.5	7.7	18.4	4.3	-2.1	-3.1	-1.9	1.6
Migraine (self-reported)	2.5	3.0	7.9	1.9	2.8	-1.7	-0.0	-0.9
Eye problems/disorders: Cataract	2.5	2.9	12.2	-0.3	1.1	-3.5	0.5	-1.0
Asthma (self-reported)	2.4	4.9	9.3	-1.8	-2.4	-0.0	-2.4	-3.0
Asthma	2.3	4.6	8.8	-2.0	-2.2	-0.1	-2.3	-3.0
Medication: Co-codamol	2.2	2.5	11.4	-3.4	-0.0	-0.2	-0.4	-0.9
Fasting Glucose	2.1	2.6	6.9	-1.3	-2.6	0.6	-0.1	-2.0
Supplements: Calcium	2.1	2.3	6.6	1.0	-1.5	2.6	-0.9	1.0
Frequency of depressed mood in last 2 weeks	2.0	2.8	10.0	1.9	-3.2	-0.2	-0.4	0.1
Father’s age at death	2.0	2.7	8.8	1.9	0.9	-0.3	3.0	-0.4
Illnesses of father: Heart disease	2.0	2.8	5.5	0.1	-1.9	-0.3	-2.1	-2.3
Mineral and other dietary supplements	2.0	2.6	9.5	-1.2	-0.7	-3.1	0.9	-1.0
Supplements: Fish oil (including cod liver oil)	2.0	2.7	12.0	-0.4	0.5	3.5	-0.9	-0.1
Respiratory disease	1.9	4.2	11.6	-1.4	-1.5	-0.2	-2.3	-3.4
Alcohol usually taken with meals	1.9	3.1	5.6	2.4	1.0	-2.3	1.5	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.9	3.1	6.4	-0.3	-2.5	2.5	-0.0	1.8
Ever highly irritable/argumentative for 2 days	1.9	2.2	7.4	-2.7	-0.4	1.2	0.0	-1.5
Mouth/teeth dental problems: Loose teeth	1.9	2.2	7.2	1.1	-2.7	1.4	0.0	0.8
Pulse rate, automated reading	1.9	6.2	23.2	1.5	0.2	2.2	-0.7	4.8
Relative age voice broke	1.8	2.7	11.1	-0.8	3.3	-0.3	1.3	0.3
Taking other prescription medications	1.8	2.8	9.6	-0.9	-1.6	3.1	-0.9	-0.1
Pain all over the body in last month	1.8	1.9	3.4	0.7	-1.4	1.9	-0.4	1.8
Hair/balding pattern: Pattern 3	1.8	2.6	6.9	-0.6	-2.4	0.0	0.1	-2.6
Number of live births	1.8	2.5	7.0	-2.7	2.3	-0.3	0.2	-0.5
Pulse rate	1.8	3.1	9.0	1.8	-0.4	1.1	-1.2	3.0
Tense / ‘highly strung’	1.8	2.9	8.2	0.3	-2.9	1.9	-1.7	0.5
Blood clot in the leg (DVT)	1.8	2.3	4.5	-1.5	-2.1	-0.9	-2.0	-0.3
Overall health rating	1.8	3.8	9.1	-0.2	-3.0	2.1	-0.3	2.3
Average weekly beer plus cider intake	1.8	2.5	5.4	-2.2	0.9	1.2	-2.3	-0.4
Alzheimer’s Disease (in mother)	1.7	2.0	5.4	-2.0	-0.5	0.4	0.2	-2.3
Financial difficulties in last 2 years	1.7	2.3	4.9	-2.2	0.9	-0.4	1.0	2.1
Mouth/teeth dental problems	1.7	2.6	8.3	-0.9	0.6	-1.8	0.1	-2.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.7	2.0	4.6	-0.6	-1.2	1.3	-1.3	2.1
Deep venous thrombosis (DVT) (self-reported)	1.7	2.2	4.1	-1.3	-2.0	-1.0	-1.9	-0.4
Bipolar Disorder (2018)	1.6	2.6	8.0	0.1	-0.7	-0.7	-2.0	-2.8
Worry (Nagel 2018)	1.6	3.4	6.2	2.5	-2.0	2.4	-0.3	1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.1	7.2	1.4	-2.7	-0.5	1.1	-0.1
Nervous feelings	1.6	3.0	6.1	2.3	-1.2	1.5	0.2	2.5
Pulse wave reflection index	1.6	2.0	4.0	-0.7	1.3	2.0	1.9	-0.8
Hearing difficulty/problems with background noise	1.5	2.4	6.0	2.0	-2.4	1.4	0.3	-0.1
Mouth/teeth dental problems: Bleeding gums	1.5	2.0	4.5	1.2	-0.0	1.9	-0.6	2.1
Worry too long after embarrassment	1.5	2.5	6.4	2.5	-2.2	1.2	0.4	-0.1
Age at last live birth	1.5	2.2	8.5	0.0	-0.8	-2.9	-0.6	-1.2
Intelligence (Savage-Jansen 2018)	1.4	4.3	10.5	3.2	1.8	-0.1	1.7	2.2
Verbal and Numeric Reasoning (VNR)	1.4	3.3	7.4	2.7	0.2	1.4	1.5	2.1
Supplements: Zinc	1.4	1.5	3.6	0.6	-1.9	1.8	-0.7	-0.0
Waist circumference	1.4	5.1	11.5	-3.4	-2.7	2.4	-0.6	-0.7
Medication: Ventolin 100micrograms inhaler	1.4	1.7	4.0	-1.5	-1.3	0.9	-0.3	-2.0
Wheeze or whistling in the chest in last year	1.4	2.5	5.3	-1.7	-2.3	1.0	-1.1	-1.4
Ever depressed for a whole week	1.4	1.8	2.9	-1.7	-1.5	0.8	-1.5	0.9
Pain experienced in last month	1.4	2.3	7.2	-0.8	1.8	-2.7	-0.5	-0.1
Alzheimer’s Disease (in father)	1.3	1.4	4.3	0.4	-1.4	-0.2	-2.1	-0.9
Lupus	1.3	1.9	5.1	-1.2	-2.3	1.5	0.6	-0.8
Had other major operations	1.3	1.6	3.5	0.2	1.8	1.0	0.2	1.9
Impedance of arm (left)	1.3	6.0	17.2	4.2	0.8	-3.4	0.3	0.8
Birth weight of first child	1.3	2.4	8.2	1.4	1.2	0.6	2.9	-0.0
Medication: Amlodipine	1.3	1.8	4.0	-1.7	-1.2	0.8	-0.2	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	3.9	-2.0	-1.9	-0.8	0.2	-0.5
Age at first live birth	1.3	2.4	8.6	0.8	-0.8	-2.9	-0.5	-1.3
Illnesses of father: None of the above (group 1)	1.3	1.6	4.4	0.1	1.5	0.6	2.1	1.0
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.7	-1.9	-1.6	-0.3	-0.5	-0.8
Arm fat-free mass (left)	1.3	6.6	12.3	-3.1	-2.8	3.5	-0.4	-1.7
Risk taking	1.3	1.9	6.5	-0.3	1.1	-0.1	-1.2	-2.5
Ever had prostate specific antigen (PSA) test	1.3	1.5	3.2	-1.2	1.2	-1.8	-0.4	-1.0
Arm predicted mass (left)	1.3	6.5	11.6	-3.3	-2.7	3.4	-0.4	-1.5
Mean Putamen Volume	1.2	1.4	4.0	0.4	-1.1	1.0	2.0	0.5
Average weekly spirits intake	1.2	1.4	4.1	-2.0	-0.6	1.5	-0.6	0.3
Hand grip strength (right)	1.2	3.4	10.0	-0.3	3.2	-1.2	0.5	-2.2
Had menopause	1.2	1.5	2.7	-1.5	1.5	1.6	0.4	0.2
Ever unenthusiastic/disinterested for a whole week	1.2	1.5	4.1	0.2	-2.0	-0.1	-0.8	1.6
Worrier / anxious feelings	1.2	2.3	5.3	1.4	-1.0	2.3	0.1	1.8
Qualifications: A levels/AS levels or equivalent	1.2	2.6	4.8	2.2	0.5	-1.9	-0.1	2.2
Number of full brothers	1.2	1.5	3.7	-1.6	-1.0	0.0	-0.5	-1.9
Long-standing illness, disability or infirmity	1.2	1.8	5.2	-1.4	-2.3	1.2	-0.2	-0.5
Breast cancer (self-reported)	1.2	1.4	2.8	-0.7	-0.9	1.7	-0.6	1.5
Medication: Aspirin	1.2	1.6	4.4	0.6	-2.1	1.7	0.6	0.1
Smoking status: Current	1.2	1.8	6.7	0.5	-2.6	-0.1	1.1	1.0
Unable to work because of sickness or disability	1.2	1.6	3.8	-1.4	-1.9	1.4	-0.3	0.6
Bipolar Disorder (2011)	1.1	1.0	3.0	-0.4	-0.9	-0.2	-1.7	-1.1
Current tobacco smoking	1.1	1.8	6.1	0.5	-2.5	0.3	1.2	1.2
Qualifications: CSEs or equivalent	1.1	1.4	4.3	-2.1	-0.2	1.4	0.7	0.4
Chronic bronchitis/emphysema (father)	1.1	1.3	5.7	-0.1	-1.0	-2.4	-0.2	-0.0
High blood pressure (mother)	1.1	1.6	3.1	1.6	1.2	-1.8	0.9	0.4
Mouth/teeth dental problems: Dentures	1.1	1.8	6.7	-0.3	1.1	1.1	0.1	2.6
Lung cancer (father)	1.1	1.3	2.3	-1.5	-1.3	-0.5	-1.4	0.6
Gout (self-reported)	1.1	1.5	2.7	0.9	-1.2	1.6	-0.9	1.4
Health satisfaction	1.1	1.4	5.0	0.3	-2.2	0.4	-0.5	-1.3
Leg pain on walking	1.1	1.3	3.3	0.2	0.5	1.7	1.8	0.6
Commuting to job workplace: Cycle	1.1	1.3	4.5	0.2	-0.5	-0.8	1.0	-2.1
Impedance of whole body	1.1	5.4	15.3	3.9	0.5	-3.3	-0.2	0.6
Body Mass Index (BMI) (2010)	1.0	1.3	4.3	0.7	-1.4	2.1	-0.3	0.0
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.1	-0.8	0.8	1.2	0.6	1.8
Maternal smoking around birth	1.0	1.5	3.7	0.1	0.4	-1.8	-1.9	-0.6
Medication: Levothyroxine sodium	1.0	1.8	4.3	2.1	-1.3	0.3	0.6	-1.6
Weight	1.0	4.7	8.9	-2.8	-3.0	2.1	-0.0	-1.5
Trunk fat-free mass	1.0	5.5	9.5	-2.8	-2.8	3.1	-0.6	-1.4
Trunk predicted mass	1.0	5.4	10.1	-2.7	-2.8	3.2	-0.6	-1.3
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.5	3.8	-0.9	-1.9	0.5	0.0	1.6
Medication: Paracetamol	1.0	1.7	5.0	0.6	-0.7	2.2	0.3	1.6
Arm predicted mass (right)	1.0	5.2	9.2	-3.0	-2.1	3.0	-0.3	-1.8
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.3	3.4	-1.1	0.8	1.8	-0.7	-0.8
Commuting to job workplace: Public transport	1.0	1.2	3.6	1.2	0.6	-1.9	-0.6	-0.0
Medication: Paracetamol	1.0	1.5	5.5	0.4	0.0	2.4	0.9	1.1
Fractured/broken bones in last 5 years	1.0	1.2	5.9	-0.1	2.4	-0.3	0.5	-0.1
Depression (Nagel 2018)	0.9	1.3	5.3	0.3	-2.3	-1.0	0.0	-0.6
Alzheimer’s Disease (including proxy)	0.9	1.3	4.1	-0.8	-1.1	0.3	-0.7	-2.0
Major Depression (MDD)	0.9	1.1	3.2	0.3	-1.3	0.0	-1.8	-0.7
Hand grip strength (left)	0.9	2.5	7.6	-0.1	1.9	-0.6	0.8	-2.7
Ever had hysterectomy (womb removed)	0.9	1.0	2.2	-1.1	-0.2	1.5	1.1	0.3
Age when periods started (menarche)	0.9	2.2	4.8	1.5	1.0	-1.2	-1.1	-2.2
Qualifications: None of the above	0.9	2.0	8.3	-2.9	0.1	-0.5	-1.1	-0.5
Fluid intelligence score	0.9	1.9	6.0	2.5	0.5	-1.4	0.9	0.8
Impedance of arm (right)	0.9	4.0	12.0	3.5	-0.5	-2.5	0.0	1.2
Alcohol intake versus 10 years previously	0.9	1.3	3.7	-0.8	-0.8	1.2	-1.9	0.2
Depression (self-reported)	0.9	1.1	3.1	-0.6	-0.9	-1.8	-0.3	-1.0
Prospective memory result	0.9	1.1	2.9	-1.1	-0.4	1.7	0.6	0.9
Arm fat-free mass (right)	0.9	4.8	8.6	-2.9	-2.1	2.8	-0.4	-1.8
Number of full sisters	0.9	1.1	3.5	0.6	-1.9	0.1	-1.2	0.4
Medication: Aspirin	0.9	1.2	3.2	0.3	-1.8	1.5	0.2	-0.3
Whole body fat-free mass	0.9	5.0	8.9	-2.7	-2.6	3.0	-0.4	-1.3
Ever had bowel cancer screening	0.9	1.0	2.3	-0.3	-1.5	-0.8	-1.4	-0.1
Whole body water mass	0.9	5.1	8.7	-2.8	-2.6	3.0	-0.3	-1.4
Basal metabolic rate	0.9	5.2	8.0	-2.8	-2.8	2.8	-0.2	-1.5
Schizophrenia vs Biploar Disorder	0.8	1.0	2.3	-1.3	-0.3	-0.3	1.5	0.9
Prostate Cancer	0.8	1.1	2.6	-0.8	0.6	-0.6	1.6	-1.4
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.4	0.3	-1.6	1.1	-0.9	0.2
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	4.0	-0.4	0.3	0.2	0.2	-2.0
Hip circumference	0.8	3.6	9.2	-3.0	-2.1	1.1	-0.0	-1.7
Falls in the last year	0.8	1.1	3.6	-0.5	-1.9	1.1	0.0	-0.5
Breastfed as a baby	0.8	1.0	2.7	0.5	1.6	1.2	0.1	-0.9
Peak expiratory flow (PEF)	0.8	2.0	4.3	-1.2	0.1	1.1	-1.7	-2.1
Shortness of breath walking on level ground	0.8	1.0	2.4	-0.0	-0.6	1.0	1.5	1.1
Emphysema/chronic bronchitis	0.8	0.8	3.2	-1.8	0.0	0.2	-0.4	0.9
Medication for pain relief, constipation, heartburn	0.8	1.3	3.8	-0.4	0.6	-1.9	-1.3	0.5
Medication: Omeprazole	0.8	0.9	2.8	1.7	-0.4	-0.2	0.8	-1.0
Mean time to correctly identify matches	0.8	1.5	2.6	-1.5	-1.6	1.4	0.4	0.7
Alcohol intake frequency.	0.8	1.9	3.8	0.2	-1.9	1.2	-1.9	-0.8
Illnesses of siblings: Diabetes	0.8	1.0	4.5	-2.1	0.2	0.0	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.6	4.2	1.1	-2.0	0.5	-1.1	-1.0
Commuting to job workplace: Walk	0.8	0.9	2.5	1.6	0.4	-0.7	-0.1	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.8	6.2	-1.2	2.5	0.4	0.2	-1.1
Wears glasses or contact lenses	0.8	1.0	1.8	1.0	-1.1	-0.8	-0.4	-1.3
Medication: Atorvastatin	0.8	1.0	2.5	0.6	-1.3	1.6	-0.8	0.2
Illnesses of father: High blood pressure	0.8	1.0	2.6	0.4	1.6	-1.0	0.6	-0.9
Number of operations (self-reported)	0.8	1.1	3.2	0.9	1.8	-1.2	0.1	0.2
Alcohol drinker status: Previous	0.8	0.9	2.5	1.3	-0.3	1.6	0.4	0.3
Leg fat mass (left)	0.8	3.0	7.1	-2.3	-2.7	1.3	0.0	-1.1
Crohns Disease (2017)	0.7	1.5	2.9	-1.7	-0.7	1.3	0.9	-1.2
Ovarian Cancer	0.7	1.0	4.1	-0.4	0.4	2.0	0.3	0.5
Age at First Birth	0.7	1.1	3.6	0.9	-0.3	0.6	-1.9	-0.8
Crohns Disease (2012)	0.7	1.1	3.3	-1.8	0.3	0.3	1.3	-0.8
Impedance of leg (right)	0.7	3.5	10.6	3.3	-0.3	-2.6	-0.5	0.3
Supplements: Glucosamine	0.7	0.9	2.1	-0.7	1.0	1.4	-0.8	0.5
Trunk fat mass	0.7	2.9	8.7	-1.7	-3.0	0.8	-0.5	-1.5
Hair/balding pattern: Pattern 2	0.7	0.8	2.4	-0.5	0.6	1.5	-0.5	1.0
Allergy	0.7	1.5	4.6	0.5	1.3	0.0	2.2	1.0
Illnesses of siblings	0.7	1.0	3.1	1.8	0.0	0.5	-0.1	-1.3
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.7	-0.4	0.1	1.2	-2.0	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	5.6	-0.3	-0.1	1.2	-2.1	-2.4
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	3.2	1.1	-0.4	0.9	1.8	-1.2
Chronic bronchitis/emphysema (mother)	0.7	0.9	2.5	0.7	-0.5	-0.5	-1.6	-0.9
High blood pressure (siblings)	0.7	1.0	1.9	-1.3	-0.0	-1.2	0.2	1.4
Neck or shoulder pain in last month	0.7	1.0	2.6	-0.4	-1.6	0.8	-0.8	0.9
Medication: Ibuprofen	0.7	0.9	1.6	-1.1	0.8	-1.3	0.8	-0.4
Medication: Allopurinol	0.7	0.9	2.3	0.4	-0.3	1.2	-0.6	1.5
Leg fat mass (right)	0.7	2.7	7.4	-1.9	-2.7	1.1	-0.1	-1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.8	-2.0	0.0	0.1	0.0	0.1
Leg fat-free mass (right)	0.7	3.8	7.2	-2.7	-2.2	2.5	-0.1	-1.0
Back pain experienced in last month	0.7	1.1	2.3	-1.0	-1.0	1.5	0.7	-0.8
Osteoarthritis (self-reported)	0.7	0.9	2.4	0.3	-0.9	1.6	1.0	0.0
Leg predicted mass (right)	0.7	3.7	6.6	-2.6	-2.2	2.4	-0.1	-1.1
Eye problems/disorders: Glaucoma	0.7	0.8	1.3	0.6	0.4	-1.0	1.2	-1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.6	1.0	-0.2	-0.3	1.2	-1.3
Heart attack/myocardial infarction (self-reported)	0.7	0.9	4.0	2.0	0.5	-0.5	0.5	0.1
Bipolar Disorder or Schizophrenia	0.6	1.5	2.9	0.1	-1.5	-0.3	-1.7	-1.5
Neuroticism (Nagel 2018)	0.6	1.4	2.8	1.3	-1.5	1.7	0.4	0.4
Rheumatoid Arthritis	0.6	0.8	2.4	-0.7	-1.5	0.9	0.7	-0.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.9	-0.1	-1.7	0.7	-1.4	-0.6
Chronotype (morning person)	0.6	1.4	2.6	1.6	-0.1	-0.9	-1.2	1.5
Number of treatments/medications taken	0.6	1.1	4.5	-0.8	-0.3	2.1	0.5	-0.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	2.5	-0.6	-1.6	-1.0	-0.3	-0.4
Medication: Metformin	0.6	0.8	2.8	-1.7	0.0	0.6	-0.8	-0.5
Leg fat-free mass (left)	0.6	3.3	5.4	-2.2	-2.3	2.2	0.0	-1.1
Average weekly fortified wine intake	0.6	0.7	1.7	-1.3	-0.3	-1.2	-0.1	-0.5
Body mass index (BMI)	0.6	2.8	7.1	-2.7	-1.6	1.7	0.4	-1.1
Impedance of leg (left)	0.6	2.8	6.7	2.6	-0.2	-2.6	-0.6	0.6
Leg predicted mass (left)	0.6	3.4	5.3	-2.2	-2.3	2.3	-0.0	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.8	0.1	-1.3	1.3	1.1	0.6
Heart attack	0.6	0.8	3.1	1.8	0.2	-0.5	0.7	-0.1
Diabetes (self-reported)	0.6	0.9	3.1	-0.7	-1.0	0.2	-1.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	1.1	-0.4	-1.0	0.8	1.0	-0.8
Medication: Lansoprazole	0.6	0.7	2.5	0.3	-0.1	1.6	-0.5	0.7
Arm fat mass (right)	0.6	2.6	6.0	-1.9	-2.4	1.3	-0.2	-1.2
Glaucoma (self-reported)	0.6	0.7	1.2	0.9	0.6	-1.1	1.0	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	2.4	-1.5	0.4	-0.9	-0.5	-0.3
Whole body fat mass	0.6	2.6	7.8	-1.6	-2.8	1.0	-0.1	-1.3
Had major operations	0.6	0.7	1.7	0.0	0.3	-1.2	-0.5	-1.3
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.2	1.0	1.0	-1.1	-0.8	0.2
Mood swings	0.6	1.1	2.7	0.1	-0.5	1.4	0.6	1.7
Loneliness, isolation	0.6	0.9	2.5	-0.3	0.2	-1.6	-0.3	-1.3
Diabetes diagnosed by doctor	0.6	1.1	2.6	-0.6	-1.6	1.0	-1.1	-0.3
Ever taken oral contraceptive pill	0.6	0.7	1.6	-0.1	1.1	0.3	0.6	1.3
Alcohol drinker status: Never	0.6	0.8	1.7	1.3	-1.0	0.1	-1.0	-0.2
Leg fat percentage (left)	0.6	2.2	5.0	-2.2	-2.2	0.7	0.1	-0.9
Coronary Artery Disease (CAD)	0.5	0.5	1.1	-0.3	-0.6	-1.1	-0.6	-0.9
LDL Cholesterol	0.5	0.7	2.5	0.7	0.4	0.3	0.6	1.6
Blood White Count	0.5	3.9	8.6	0.5	-2.3	2.9	0.2	2.3
Waist Hip Ratio (WHR)	0.5	2.3	5.1	-2.3	-1.2	1.6	-1.4	0.5
Systolic Blood Pressure	0.5	2.4	11.7	0.3	0.4	-3.4	0.3	0.1
Neuroticism	0.5	1.1	4.4	2.1	-0.7	0.5	-0.2	0.5
Fed-up feelings	0.5	0.9	3.6	-0.9	-0.2	0.3	-0.3	1.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.5	1.9	-0.2	0.5	1.4	0.7	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.0	2.1	-1.2	-1.4	-0.0	1.0	-0.8
Neuroticism score	0.5	1.0	2.4	1.6	-0.9	0.8	-0.1	1.1
Arm fat percentage (right)	0.5	1.9	6.8	-1.5	-2.6	0.3	-0.1	-0.7
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	3.7	0.4	1.9	0.4	0.2	-0.2
Forced vital capacity (FVC), Best measure	0.5	1.7	3.7	0.5	-0.7	1.6	-1.9	-1.2
Leg fat percentage (right)	0.5	1.8	4.8	-1.7	-2.2	0.4	0.0	-1.1
Comparative body size at age 10	0.5	1.4	5.1	0.6	-2.3	0.7	-0.7	0.6
Medication: Seretide 50 evohaler	0.5	0.6	1.8	0.2	0.1	0.3	-1.1	-1.3
Comparative height size at age 10	0.5	2.9	5.7	0.0	-2.4	2.0	-0.9	-2.0
Smoking status: Previous	0.5	0.7	2.1	-1.0	1.4	0.5	0.0	0.2
Friendships satisfaction	0.5	0.6	2.1	1.0	0.1	-0.2	1.4	-0.1
Arm fat mass (left)	0.5	2.2	5.3	-1.7	-2.3	1.2	-0.1	-1.2
Miserableness	0.5	0.9	1.9	1.0	-0.5	0.7	0.8	1.4
Hearing aid user	0.5	0.5	1.3	-0.8	0.1	0.7	0.4	-1.1
Financial situation satisfaction	0.5	0.6	1.7	-0.1	-1.3	-0.4	-1.2	0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.2	0.9	1.1	0.7	0.6	0.7
Medication: Lisinopril	0.5	0.7	1.6	1.3	0.2	-0.3	-0.6	-1.2
Irritability	0.5	0.8	1.9	1.0	-1.4	0.8	0.5	-0.4
Age started oral contraceptive pill	0.5	0.6	2.1	-0.1	-0.8	0.6	-1.4	0.0
Cholesterol lowering medication	0.5	0.8	2.1	-0.1	-0.2	0.9	-1.4	-0.9
Irritable Bowel Disease (IBD)	0.4	0.9	2.2	-1.5	-0.4	0.5	0.4	-1.4
Neuroticism (2016)	0.4	0.6	1.1	0.8	0.5	1.1	0.3	0.9
BMI	0.4	2.1	4.9	-2.2	-0.9	1.4	0.4	-1.6
Smoking Status	0.4	1.0	2.7	-0.8	-1.0	0.1	1.7	0.8
Allergy or Eczema	0.4	1.0	2.2	1.5	-0.8	-0.5	-1.3	-0.6
Relative age of first facial hair	0.4	0.8	2.2	-0.0	1.2	0.2	0.5	1.5
Systolic blood pressure, automated reading	0.4	1.1	2.4	-1.5	-0.4	-1.4	-0.9	0.4
Diabetes (father)	0.4	0.5	1.4	-0.7	-0.2	0.1	1.2	-0.8
Severe depression (siblings)	0.4	0.5	1.2	0.0	-0.9	0.5	1.1	-0.1
Trunk fat percentage	0.4	1.7	5.7	-0.9	-2.4	0.1	-0.4	-1.3
Townsend deprivation index at recruitment	0.4	0.6	1.7	-0.0	-1.3	0.2	0.5	1.0
Happiness	0.4	0.5	1.0	0.7	-0.9	0.4	-1.0	-0.2
Birth weight	0.4	0.9	2.0	-0.7	-1.1	-1.4	0.8	-0.2
Body fat percentage	0.4	1.6	5.1	-1.2	-2.3	0.2	-0.1	-1.2
Exposure to tobacco smoke outside home	0.4	0.5	1.3	-0.6	-0.7	0.4	-0.2	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.9	1.4	0.1	0.1	0.1	-0.7
Medication: Blood pressure	0.4	0.6	1.1	-1.0	-0.2	-0.7	1.0	0.8
Heart disease (mother)	0.4	0.5	1.6	-0.4	-1.3	0.6	0.1	0.4
Suffer from ‘nerves’	0.4	0.6	1.4	0.8	-1.2	0.8	-0.6	-0.4
Chest pain or discomfort	0.4	0.6	2.0	-1.4	-1.0	-0.0	0.2	0.3
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	1.0	-1.3	0.3	-0.3	-0.7
High cholesterol (Self-reported)	0.4	0.7	1.9	0.6	1.4	0.7	0.6	0.4
Basal cell carcinoma (self-reported)	0.4	0.4	1.6	1.3	0.1	-0.6	-0.4	0.2
Heart disease (siblings)	0.4	0.5	1.0	-1.0	0.0	0.4	-0.6	-1.0
Reaction Time	0.3	0.6	2.1	-0.5	-1.5	0.8	-0.2	0.5
Primary Biliary Cirrhosis	0.3	0.5	1.1	0.5	-0.7	-0.3	-1.1	-0.5
Blood Platelet Count	0.3	2.9	10.0	-1.9	-0.3	1.0	-0.1	-3.2
Height	0.3	6.3	15.8	-1.2	-4.0	3.3	-1.4	-1.1
Hypothyroidism (self reported)	0.3	0.7	1.5	1.2	-0.3	0.3	0.8	-1.0
Lung FEV1/FVC ratio	0.3	1.3	2.5	-1.3	-0.5	1.5	-0.5	-1.6
Sensitivity / hurt feelings	0.3	0.5	1.6	0.0	-0.0	1.2	-0.9	0.2
Angina	0.3	0.4	1.3	0.6	0.5	0.5	1.1	0.1
Medication for hormone replacement therapy	0.3	0.3	0.7	-0.5	-0.1	-0.8	-0.3	0.8
Vitamin and mineral supplements	0.3	0.5	0.8	-0.7	0.9	-0.8	0.5	-0.1
Diabetes (mother)	0.3	0.4	0.8	0.3	0.2	-0.5	-0.8	-0.9
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.4	1.6	0.0	0.0	-0.5	-0.3
Stomach or abdominal pain in last month	0.3	0.3	0.9	0.4	-0.4	-0.9	0.5	-0.4
Forced vital capacity (FVC)	0.3	1.2	2.5	0.7	0.3	1.3	-1.6	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.2	-1.0	-1.1	-0.4	0.7	-0.6
Medication: Simvastatin	0.3	0.4	1.1	0.6	-1.1	0.0	-0.4	0.7
Pulse wave Arterial Stiffness index	0.3	0.3	0.9	0.4	0.3	1.0	0.6	0.1
Standing height	0.3	3.1	11.3	-0.1	-3.4	1.2	-1.0	-1.4
Length of working week for main job	0.3	0.3	0.6	0.7	0.8	0.5	0.4	0.3
Hair/balding pattern: Pattern 4	0.3	0.6	1.7	-0.7	-1.3	0.1	-0.9	0.4
Number of children fathered	0.3	0.3	0.6	-0.4	0.4	-0.7	0.2	-0.8
Pulse wave peak to peak time	0.3	0.3	0.6	-0.4	-0.6	-0.8	-0.7	-0.1
Family relationship satisfaction	0.3	0.4	1.6	0.1	-0.6	-0.1	-1.3	-0.1
Knee pain experienced in last month	0.3	0.5	1.1	0.9	0.5	1.0	-0.7	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.0	0.2	0.0	1.0	0.6	-0.8
Arm fat percentage (left)	0.3	1.2	3.8	-1.2	-2.0	-0.2	-0.0	-0.9
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.0	-0.6	0.3	-0.1	-1.0	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.9	0.0	-0.1	-0.2	-0.7	0.9
Average weekly champagne plus white wine intake	0.3	0.5	0.8	0.7	0.9	-0.2	0.9	0.5
Schizophrenia (2018)	0.2	0.5	1.8	0.0	-1.3	0.2	-0.6	0.4
Ulcerative Colitis (UC)	0.2	0.3	0.7	-0.4	-0.3	-0.7	-0.1	-0.8
Breast Cancer	0.2	0.4	1.0	0.8	-0.5	0.2	-0.5	1.0
Schizophrenia (2014)	0.2	0.3	1.0	-0.3	-1.0	-0.2	-0.7	-0.2
Triglycerides	0.2	0.4	1.4	-0.0	1.2	-0.5	0.1	-0.5
Ulcerative Colitis	0.2	0.3	0.7	-0.7	-0.4	0.5	-0.3	0.9
Blood Eosinophil Count	0.2	1.3	2.2	1.4	-1.1	1.5	-0.8	0.7
Blood Red Count	0.2	1.6	5.4	2.3	-0.9	0.2	-1.2	0.4
Heel T-Score	0.2	1.8	6.3	0.8	-0.8	0.2	1.1	-2.5
Cardiovascular Disease	0.2	0.7	1.2	0.7	0.8	0.9	1.1	0.6
Lung FVC	0.2	1.0	2.5	0.2	1.6	1.2	-0.8	-0.8
Hearing difficulty/problems: Yes	0.2	0.3	0.9	-0.9	-0.8	-0.1	-0.1	-0.3
Pack years adult smoking proportion	0.2	0.3	1.1	-0.1	-0.4	-0.5	1.0	0.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	-0.2	0.3	0.4	-0.8	0.1
High blood pressure	0.2	0.6	1.1	-1.0	0.0	0.7	0.6	1.1
Multivitamins +/- minerals	0.2	0.3	0.7	0.5	-0.2	-0.1	-0.8	-0.8
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	1.0	-0.1	0.3	-1.0	0.2	-0.1
Medication: Atenolol	0.2	0.3	0.5	0.4	-0.6	-0.7	0.5	-0.1
Number of incorrect matches in round	0.2	0.4	1.6	0.0	-1.3	0.4	0.5	-0.1
Past tobacco smoking	0.2	0.3	0.6	0.8	-0.5	-0.4	-0.2	-0.8
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.8	-0.1	-0.1	0.9	0.6	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.8	-0.1	0.1	-0.7	0.9	0.3
Medication: Cholesterol lowering	0.2	0.4	0.7	0.6	-0.4	0.6	0.9	0.4
Illnesses of mother	0.2	0.3	0.9	-0.6	-0.2	0.1	-0.3	0.9
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.7	0.6	-0.2	-0.6	-0.0
Headache pain in last month	0.2	0.4	0.7	0.8	-0.8	-0.8	-0.2	0.1
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.7	0.3	0.5	0.1	-0.8	-0.8
Hypertension (Self-reported)	0.2	0.6	1.3	-0.7	0.3	1.1	0.8	0.7
Qualifications: nursing, teaching	0.2	0.4	0.8	0.6	0.1	-0.4	0.7	0.9
Medication for cholesterol	0.2	0.3	1.0	-0.1	-0.6	-1.0	0.1	-0.6
Osteoporosis (self-reported)	0.2	0.2	0.5	-0.1	-0.7	0.3	-0.6	0.0
Medication: Blood pressure	0.2	0.3	0.7	0.1	0.5	0.8	-0.4	0.8
Medication: Bendroflumethiazide	0.2	0.2	0.6	-0.4	-0.6	-0.8	0.2	0.3
Diastolic blood pressure, automated reading	0.2	0.7	2.3	-1.5	1.1	0.1	0.1	0.3
Pack years of smoking	0.2	0.3	1.0	-0.1	-0.4	-0.7	1.0	0.3
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	-0.2	-0.4	-0.1	0.9	0.4
HbA1C	0.1	0.1	0.4	0.1	-0.0	0.1	-0.2	-0.6
HDL Cholesterol	0.1	0.2	0.3	-0.2	0.2	-0.6	-0.6	0.1
Hair Pigment	0.1	3.5	12.4	-0.9	0.2	0.6	1.9	3.5
Tanning	0.1	1.1	5.1	-0.4	2.3	0.7	-0.0	-0.1
Serious illness, injury or assault to yourself	0.1	0.2	0.4	0.6	-0.5	0.2	-0.2	0.3
Sitting height	0.1	0.7	1.4	-0.2	-1.0	1.2	-0.2	1.0
Medication: Ramipril	0.1	0.1	0.2	-0.1	-0.3	-0.3	-0.5	-0.1
Time employed in main current job	0.1	0.1	0.2	0.1	0.2	-0.4	-0.1	-0.5
Noisy workplace	0.1	0.1	0.2	-0.5	0.3	0.1	0.0	-0.4
Angina (self-reported)	0.1	0.2	0.3	0.6	0.4	0.3	0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.5	0.2	-0.5	-0.7	0.0	0.2
Medication: Gliclazide	0.1	0.2	0.5	0.1	0.2	-0.0	0.7	0.5
Guilty feelings	0.1	0.1	0.3	0.1	-0.3	-0.3	0.0	0.6
Ever smoked	0.1	0.1	0.3	-0.5	0.0	-0.1	-0.3	0.5
Vascular/heart problems diagnosed by doctor	0.1	0.4	0.9	0.6	0.2	-0.7	-0.9	-0.5

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