Hub : Traits :

Number of incorrect matches in round

189 significantly associated models · 44 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 201158976 202552839 1 1 2.1e-07 5.2e-07 1.00000 100 SHISA4
2 5 92267794 94144549 1 1 2.6e-08 6.5e-09 0.00975 80 FAM172A
3 7 5925156 7318723 1 1 2.8e-07 1.5e-04 0.00337 40 ZDHHC4
4 8 135770324 137364619 1 1 4.8e-08 1.7e-06 0.52700 98 KHDRBS3
5 10 102853189 104242886 2 1 3.7e-09 8.3e-10 0.00097 71 NPM3
6 15 90718541 92120170 1 1 7.6e-08 7.2e-08 1.00000 100 FURIN
7 16 28825605 31833122 36 2 1.7e-12 1.1e-10 0.04950 91 KAT8 TBX6
8 17 28010628 28676527 1 1 1.7e-07 3.6e-06 0.44000 97 EFCAB5

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 4.02 1 1 2.2 0.00 1.00 FURIN
Intelligence (Savage-Jansen 2018) 3.68 3 1 2.2 0.00 1.00 EFCAB5 KHDRBS3 NPM3
Neuroticism (Nagel 2018) 3.48 3 0 0.0 0.00 1.00 FURIN KAT8 KHDRBS3
Schizophrenia (2018) 4.03 1 1 2.2 0.00 1.00 FURIN
Worry (Nagel 2018) 3.55 2 0 0.0 0.00 1.00 KAT8 TBX6
Alzheimer’s Disease (in mother) 3.49 1 0 0.0 0.00 1.00 KAT8
Alzheimer’s Disease (including proxy) 3.38 1 0 0.0 0.00 1.00 KAT8
Verbal and Numeric Reasoning (VNR) 3.80 2 1 2.2 0.00 1.00 KHDRBS3 NPM3
Breast Cancer 1.86 1 0 0.0 0.00 1.00 FURIN
Schizophrenia (2014) 3.28 1 1 2.2 0.00 1.00 FURIN
Triglycerides 2.55 1 0 0.0 0.00 1.00 KAT8
Blood Eosinophil Count 1.85 2 1 2.2 0.00 1.00 KAT8 TBX6
Blood Platelet Count 0.89 2 2 4.4 0.00 1.00 EFCAB5 TBX6
Blood Red Count 3.74 4 4 8.9 0.10 0.90 EFCAB5 KAT8 KHDRBS3 TBX6
Blood White Count 1.77 3 2 4.4 0.00 1.00 EFCAB5 FURIN NPM3
Heel T-Score 1.78 4 2 4.4 0.64 0.36 EFCAB5 KAT8 SHISA4 TBX6
BMI 4.57 3 2 4.4 0.00 1.00 EFCAB5 KAT8 TBX6
Height 1.73 3 3 6.7 0.00 1.00 EFCAB5 FURIN TBX6
Systolic Blood Pressure 4.15 2 1 2.2 0.00 1.00 FURIN NPM3
Smoking Status 2.30 1 0 0.0 0.00 1.00 KAT8
Cardiovascular Disease 4.76 3 3 6.7 0.00 1.00 EFCAB5 FURIN KAT8
Respiratory disease 1.48 1 0 0.0 0.00 1.00 FURIN
Lung FEV1/FVC ratio 4.43 2 1 2.2 0.00 1.00 EFCAB5 TBX6
Lung FVC 1.84 2 1 2.2 0.00 1.00 KAT8 KHDRBS3
Neuroticism 3.22 2 0 0.0 0.00 1.00 FURIN KHDRBS3
Hair Pigment 0.18 2 0 0.0 0.00 1.00 FURIN NPM3
Hand grip strength (left) 4.09 2 1 2.2 0.00 1.00 NPM3 TBX6
Sensitivity / hurt feelings 4.10 2 1 2.2 0.00 1.00 FURIN KHDRBS3
Hearing difficulty/problems: Yes 2.25 1 0 0.0 0.00 1.00 FAM172A
Systolic blood pressure, automated reading 3.09 1 1 2.2 0.00 1.00 FURIN
Angina 3.88 1 1 2.2 0.00 1.00 FURIN
Diabetes (father) 1.81 1 0 0.0 0.00 1.00 TBX6
Impedance of leg (right) 3.80 3 2 4.4 0.00 1.00 FURIN KAT8 TBX6
Leg fat-free mass (left) 5.18 3 2 4.4 0.00 1.00 FURIN KAT8 TBX6
Trunk fat percentage 2.75 2 1 2.2 0.00 1.00 KAT8 KHDRBS3
Hand grip strength (right) 3.13 2 0 0.0 0.00 1.00 NPM3 TBX6
Current tobacco smoking 1.94 1 0 0.0 0.00 1.00 FAM172A
Age when periods started (menarche) 1.84 1 0 0.0 0.00 1.00 FAM172A
High blood pressure 4.62 3 2 4.4 0.00 1.00 EFCAB5 FURIN KAT8
Medication: Atenolol 2.31 1 0 0.0 0.00 1.00 FURIN
Sitting height 0.73 2 0 0.0 0.00 1.00 FAM172A TBX6
High blood pressure (mother) 3.63 1 1 2.2 0.00 1.00 FURIN
Body mass index (BMI) 4.85 2 2 4.4 0.00 1.00 KAT8 TBX6
Impedance of leg (left) 3.53 3 3 6.7 0.00 1.00 FURIN KAT8 TBX6
Leg predicted mass (left) 5.17 3 2 4.4 0.00 1.00 FURIN KAT8 TBX6
Trunk fat mass 3.77 2 2 4.4 0.00 1.00 KAT8 TBX6
Waist circumference 5.78 2 2 4.4 0.00 1.00 KAT8 TBX6
Nervous feelings 3.26 2 0 0.0 0.00 1.00 KAT8 TBX6
Forced vital capacity (FVC) 3.25 4 2 4.4 0.39 0.61 EFCAB5 KAT8 KHDRBS3 TBX6
Qualifications: None of the above 2.13 1 1 2.2 0.00 1.00 NPM3
Financial difficulties in last 2 years 2.18 1 0 0.0 0.00 1.00 KAT8
Heart attack 2.98 1 0 0.0 0.00 1.00 FURIN
Allergy 1.22 1 0 0.0 0.00 1.00 FURIN
Fluid intelligence score 3.02 1 1 2.2 0.00 1.00 NPM3
Illnesses of siblings 5.07 2 1 2.2 0.00 1.00 EFCAB5 KAT8
Neuroticism score 2.29 1 0 0.0 0.00 1.00 KHDRBS3
Weight 5.60 2 2 4.4 0.00 1.00 KAT8 TBX6
Impedance of arm (right) 2.68 2 2 4.4 0.00 1.00 KAT8 TBX6
Arm fat percentage (right) 3.76 2 2 4.4 0.00 1.00 KAT8 TBX6
Trunk fat-free mass 4.80 2 2 4.4 0.00 1.00 KAT8 TBX6
Hip circumference 5.56 2 2 4.4 0.00 1.00 KAT8 TBX6
Number of live births 3.30 1 0 0.0 0.00 1.00 TBX6
Forced expiratory volume in 1-second (FEV1) 2.46 3 0 0.0 0.00 1.00 KAT8 KHDRBS3 TBX6
Pulse rate 1.47 1 0 0.0 0.00 1.00 SHISA4
Qualifications: A levels/AS levels or equivalent 2.00 1 0 0.0 0.00 1.00 NPM3
Forced expiratory volume in 1-second (FEV1), Best measure 2.19 2 1 2.2 0.00 1.00 KAT8 KHDRBS3
Impedance of arm (left) 2.89 2 2 4.4 0.00 1.00 KAT8 TBX6
Arm fat mass (right) 5.05 2 2 4.4 0.00 1.00 KAT8 TBX6
Trunk predicted mass 4.85 2 2 4.4 0.00 1.00 KAT8 TBX6
Standing height 1.59 2 2 4.4 0.00 1.00 EFCAB5 TBX6
Tense / 'highly strung' 4.28 3 0 0.0 0.00 1.00 FURIN KAT8 TBX6
Birth weight of first child 3.16 1 1 2.2 0.00 1.00 FURIN
Peak expiratory flow (PEF) 2.52 1 0 0.0 0.00 1.00 FAM172A
Medication for cholesterol, blood pressure or diabetes 3.15 2 0 0.0 0.00 1.00 EFCAB5 FURIN
Birth weight 2.36 1 1 2.2 0.00 1.00 FURIN
High blood pressure (siblings) 5.82 2 1 2.2 0.00 1.00 EFCAB5 KAT8
Forced vital capacity (FVC), Best measure 2.88 4 1 2.2 0.44 0.56 EFCAB5 KAT8 KHDRBS3 TBX6
Body fat percentage 3.04 1 1 2.2 0.00 1.00 KAT8
Leg fat percentage (right) 2.80 2 1 2.2 0.00 1.00 EFCAB5 KAT8
Arm fat-free mass (right) 4.96 2 2 4.4 0.00 1.00 KAT8 TBX6
Comparative body size at age 10 1.59 1 0 0.0 0.00 1.00 KAT8
Qualifications: College or University degree 2.81 2 1 2.2 0.00 1.00 KAT8 NPM3
Medication: Blood pressure 3.30 1 0 0.0 0.00 1.00 FURIN
Angina (self-reported) 3.63 1 0 0.0 0.00 1.00 FURIN
Mean time to correctly identify matches 2.74 1 0 0.0 0.00 1.00 FAM172A
Whole body fat mass 4.19 2 2 4.4 0.00 1.00 KAT8 TBX6
Leg fat mass (right) 4.31 2 2 4.4 0.00 1.00 KAT8 TBX6
Arm predicted mass (right) 5.12 2 2 4.4 0.00 1.00 KAT8 TBX6
Pulse rate, automated reading 1.77 1 1 2.2 0.00 1.00 SHISA4
Alcohol intake frequency. 2.98 2 1 2.2 0.00 1.00 KAT8 TBX6
Comparative height size at age 10 2.42 2 1 2.2 0.00 1.00 EFCAB5 TBX6
Suffer from 'nerves' 1.95 1 0 0.0 0.00 1.00 TBX6
Overall health rating 2.22 1 1 2.2 0.00 1.00 KAT8
Medication: Aspirin 3.23 1 0 0.0 0.00 1.00 FURIN
Knee pain experienced in last month 1.69 1 0 0.0 0.00 1.00 KAT8
Hypertension (Self-reported) 4.53 3 2 4.4 0.00 1.00 EFCAB5 FURIN KAT8
Forced expiratory volume in 1-second (FEV1), predicted 1.34 1 0 0.0 0.00 1.00 TBX6
Whole body fat-free mass 5.19 3 2 4.4 0.00 1.00 FURIN KAT8 TBX6
Leg fat-free mass (right) 5.35 3 2 4.4 0.00 1.00 FURIN KAT8 TBX6
Arm fat percentage (left) 3.70 2 2 4.4 0.00 1.00 KAT8 TBX6
Handedness (chirality/laterality): Left-handed 2.69 1 0 0.0 0.00 1.00 FURIN
Medication for cholesterol 2.56 1 0 0.0 0.00 1.00 KAT8
Medication: Aspirin 3.22 1 0 0.0 0.00 1.00 FURIN
Illnesses of father: None of the above (group 1) 3.72 1 0 0.0 0.00 1.00 FURIN
Smoking status: Current 1.89 1 0 0.0 0.00 1.00 FAM172A
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.64 2 1 2.2 0.00 1.00 KAT8 KHDRBS3
Whole body water mass 5.20 3 2 4.4 0.00 1.00 FURIN KAT8 TBX6
Leg predicted mass (right) 5.36 3 2 4.4 0.00 1.00 FURIN KAT8 TBX6
Arm fat mass (left) 5.08 2 2 4.4 0.00 1.00 KAT8 TBX6
Medication: Blood pressure 4.14 2 1 2.2 0.00 1.00 FURIN KAT8
High cholesterol (Self-reported) 2.57 1 0 0.0 0.00 1.00 KAT8
Medication: Bendroflumethiazide 4.03 2 0 0.0 0.00 1.00 FURIN TBX6
Basal metabolic rate 5.48 2 2 4.4 0.00 1.00 KAT8 TBX6
Leg fat percentage (left) 2.82 1 1 2.2 0.00 1.00 KAT8
Arm fat-free mass (left) 5.19 2 2 4.4 0.00 1.00 KAT8 TBX6
Number of operations (self-reported) 2.27 1 0 0.0 0.00 1.00 FURIN
Fractured/broken bones in last 5 years 1.70 1 0 0.0 0.00 1.00 KAT8
Diastolic blood pressure, automated reading 2.60 2 2 4.4 0.00 1.00 FURIN KAT8
Vascular/heart problems diagnosed by doctor 5.37 3 2 4.4 0.00 1.00 EFCAB5 FURIN KAT8
Cholesterol lowering medication 4.00 2 0 0.0 0.00 1.00 EFCAB5 KAT8
Heart attack/myocardial infarction (self-reported) 2.68 1 0 0.0 0.00 1.00 FURIN
Impedance of whole body 3.54 2 2 4.4 0.00 1.00 KAT8 TBX6
Leg fat mass (left) 4.27 2 2 4.4 0.00 1.00 KAT8 TBX6
Arm predicted mass (left) 5.25 2 2 4.4 0.00 1.00 KAT8 TBX6

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 5 0.143 1.7
GTEx Adipose Visceral Omentum 6 0.295 1.7
GTEx Adrenal Gland 3 0.206 1.7
GTEx Artery Aorta 7 0.235 1.7
GTEx Artery Coronary 2 0.169 1.7
GTEx Artery Tibial 7 0.186 1.6
GTEx Brain Caudate basal ganglia 1 0.109 1.7
GTEx Brain Cerebellar Hemisphere 2 0.134 1.7
GTEx Brain Cerebellum 1 0.050 1.6
GTEx Brain Cortex 1 0.097 1.6
GTEx Brain Frontal Cortex BA9 1 0.108 1.8
GTEx Brain Hippocampus 0 0.000 1.9
GTEx Brain Hypothalamus 0 0.000 1.7
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.7
GTEx Brain Putamen basal ganglia 0 0.000 1.5
GTEx Breast Mammary Tissue 2 0.101 1.7
GTEx Breast Mammary Tissue (Male) 1 0.084 1.7
GTEx Breast Mammary Tissue (Female) 2 0.122 1.6
GTEx Cells EBV-transformed lymphocytes 2 0.141 1.8
GTEx Cells Transformed fibroblasts 6 0.143 1.7
GTEx Colon Sigmoid 0 0.000 1.6
GTEx Colon Transverse 3 0.145 1.7
GTEx Esophagus Gastroesophageal Junction 1 0.069 1.7
GTEx Esophagus Mucosa 4 0.120 1.7
GTEx Esophagus Muscularis 4 0.124 1.7
GTEx Heart Atrial Appendage 3 0.190 1.7
GTEx Heart Left Ventricle 4 0.261 1.7
GTEx Liver 2 0.279 1.8
GTEx Lung 5 0.174 1.7
GTEx Muscle Skeletal 2 0.069 1.7
GTEx Nerve Tibial 4 0.093 1.7
GTEx Ovary 5 0.551 2.0
GTEx Pancreas 1 0.061 1.7
GTEx Pituitary 3 0.269 1.9
GTEx Prostate 4 0.479 1.8
GTEx Skin Not Sun Exposed Suprapubic 2 0.081 1.7
GTEx Skin Sun Exposed Lower leg 4 0.110 1.7
GTEx Small Intestine Terminal Ileum 2 0.434 1.9
GTEx Spleen 2 0.142 1.7
GTEx Stomach 3 0.206 1.8
GTEx Testis 4 0.127 1.7
GTEx Thyroid 6 0.150 1.7
GTEx Uterus 2 0.353 1.8
GTEx Vagina 1 0.157 1.7
GTEx Whole Blood 3 0.151 1.7
METSIM Adipose 2 0.043 1.6
NTR Blood 1 0.042 1.6
ROSMAP Brain Pre-frontal Cortex 13 0.296 1.7
YFS Blood 4 0.087 1.6
CommonMind Brain Pre-frontal Cortex 6 0.112 1.6
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.7
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.6
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.6
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.7
The Cancer Genome Atlas Esophageal Carcinoma 1 0.146 1.7
The Cancer Genome Atlas Glioblastoma Multiforme 2 0.196 1.8
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 2 0.073 1.6
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 3 0.073 1.6
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 3 0.146 1.7
The Cancer Genome Atlas Brain Lower Grade Glioma 4 0.093 1.6
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.6
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.068 1.6
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.080 1.6
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.6
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.6
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.7
The Cancer Genome Atlas Prostate Adenocarcinoma 6 0.130 1.6
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.7
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.094 1.7
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.5
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.6
The Cancer Genome Atlas Testicular Germ Cell Tumors 3 0.235 1.7
The Cancer Genome Atlas Thyroid Carcinoma 2 0.039 1.6
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.5