Hub : Traits :

Number of incorrect matches in round

189 significantly associated models · 44 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	201158976	202552839	1	1	2.1e-07	5.2e-07	1.00000	100	SHISA4
2	5	92267794	94144549	1	1	2.6e-08	6.5e-09	0.00975	80	FAM172A
3	7	5925156	7318723	1	1	2.8e-07	1.5e-04	0.00337	40	ZDHHC4
4	8	135770324	137364619	1	1	4.8e-08	1.7e-06	0.52700	98	KHDRBS3
5	10	102853189	104242886	2	1	3.7e-09	8.3e-10	0.00097	71	NPM3
6	15	90718541	92120170	1	1	7.6e-08	7.2e-08	1.00000	100	FURIN
7	16	28825605	31833122	36	2	1.7e-12	1.1e-10	0.04950	91	KAT8 TBX6
8	17	28010628	28676527	1	1	1.7e-07	3.6e-06	0.44000	97	EFCAB5

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder or Schizophrenia	4.02	1	1	2.2	0.00	1.00	FURIN
Intelligence (Savage-Jansen 2018)	3.68	3	1	2.2	0.00	1.00	EFCAB5 KHDRBS3 NPM3
Neuroticism (Nagel 2018)	3.48	3	0	0.0	0.00	1.00	FURIN KAT8 KHDRBS3
Schizophrenia (2018)	4.03	1	1	2.2	0.00	1.00	FURIN
Worry (Nagel 2018)	3.55	2	0	0.0	0.00	1.00	KAT8 TBX6
Alzheimer’s Disease (in mother)	3.49	1	0	0.0	0.00	1.00	KAT8
Alzheimer’s Disease (including proxy)	3.38	1	0	0.0	0.00	1.00	KAT8
Verbal and Numeric Reasoning (VNR)	3.80	2	1	2.2	0.00	1.00	KHDRBS3 NPM3
Breast Cancer	1.86	1	0	0.0	0.00	1.00	FURIN
Schizophrenia (2014)	3.28	1	1	2.2	0.00	1.00	FURIN
Triglycerides	2.55	1	0	0.0	0.00	1.00	KAT8
Blood Eosinophil Count	1.85	2	1	2.2	0.00	1.00	KAT8 TBX6
Blood Platelet Count	0.89	2	2	4.4	0.00	1.00	EFCAB5 TBX6
Blood Red Count	3.74	4	4	8.9	0.10	0.90	EFCAB5 KAT8 KHDRBS3 TBX6
Blood White Count	1.77	3	2	4.4	0.00	1.00	EFCAB5 FURIN NPM3
Heel T-Score	1.78	4	2	4.4	0.64	0.36	EFCAB5 KAT8 SHISA4 TBX6
BMI	4.57	3	2	4.4	0.00	1.00	EFCAB5 KAT8 TBX6
Height	1.73	3	3	6.7	0.00	1.00	EFCAB5 FURIN TBX6
Systolic Blood Pressure	4.15	2	1	2.2	0.00	1.00	FURIN NPM3
Smoking Status	2.30	1	0	0.0	0.00	1.00	KAT8
Cardiovascular Disease	4.76	3	3	6.7	0.00	1.00	EFCAB5 FURIN KAT8
Respiratory disease	1.48	1	0	0.0	0.00	1.00	FURIN
Lung FEV1/FVC ratio	4.43	2	1	2.2	0.00	1.00	EFCAB5 TBX6
Lung FVC	1.84	2	1	2.2	0.00	1.00	KAT8 KHDRBS3
Neuroticism	3.22	2	0	0.0	0.00	1.00	FURIN KHDRBS3
Hair Pigment	0.18	2	0	0.0	0.00	1.00	FURIN NPM3
Hand grip strength (left)	4.09	2	1	2.2	0.00	1.00	NPM3 TBX6
Sensitivity / hurt feelings	4.10	2	1	2.2	0.00	1.00	FURIN KHDRBS3
Hearing difficulty/problems: Yes	2.25	1	0	0.0	0.00	1.00	FAM172A
Systolic blood pressure, automated reading	3.09	1	1	2.2	0.00	1.00	FURIN
Angina	3.88	1	1	2.2	0.00	1.00	FURIN
Diabetes (father)	1.81	1	0	0.0	0.00	1.00	TBX6
Impedance of leg (right)	3.80	3	2	4.4	0.00	1.00	FURIN KAT8 TBX6
Leg fat-free mass (left)	5.18	3	2	4.4	0.00	1.00	FURIN KAT8 TBX6
Trunk fat percentage	2.75	2	1	2.2	0.00	1.00	KAT8 KHDRBS3
Hand grip strength (right)	3.13	2	0	0.0	0.00	1.00	NPM3 TBX6
Current tobacco smoking	1.94	1	0	0.0	0.00	1.00	FAM172A
Age when periods started (menarche)	1.84	1	0	0.0	0.00	1.00	FAM172A
High blood pressure	4.62	3	2	4.4	0.00	1.00	EFCAB5 FURIN KAT8
Medication: Atenolol	2.31	1	0	0.0	0.00	1.00	FURIN
Sitting height	0.73	2	0	0.0	0.00	1.00	FAM172A TBX6
High blood pressure (mother)	3.63	1	1	2.2	0.00	1.00	FURIN
Body mass index (BMI)	4.85	2	2	4.4	0.00	1.00	KAT8 TBX6
Impedance of leg (left)	3.53	3	3	6.7	0.00	1.00	FURIN KAT8 TBX6
Leg predicted mass (left)	5.17	3	2	4.4	0.00	1.00	FURIN KAT8 TBX6
Trunk fat mass	3.77	2	2	4.4	0.00	1.00	KAT8 TBX6
Waist circumference	5.78	2	2	4.4	0.00	1.00	KAT8 TBX6
Nervous feelings	3.26	2	0	0.0	0.00	1.00	KAT8 TBX6
Forced vital capacity (FVC)	3.25	4	2	4.4	0.39	0.61	EFCAB5 KAT8 KHDRBS3 TBX6
Qualifications: None of the above	2.13	1	1	2.2	0.00	1.00	NPM3
Financial difficulties in last 2 years	2.18	1	0	0.0	0.00	1.00	KAT8
Heart attack	2.98	1	0	0.0	0.00	1.00	FURIN
Allergy	1.22	1	0	0.0	0.00	1.00	FURIN
Fluid intelligence score	3.02	1	1	2.2	0.00	1.00	NPM3
Illnesses of siblings	5.07	2	1	2.2	0.00	1.00	EFCAB5 KAT8
Neuroticism score	2.29	1	0	0.0	0.00	1.00	KHDRBS3
Weight	5.60	2	2	4.4	0.00	1.00	KAT8 TBX6
Impedance of arm (right)	2.68	2	2	4.4	0.00	1.00	KAT8 TBX6
Arm fat percentage (right)	3.76	2	2	4.4	0.00	1.00	KAT8 TBX6
Trunk fat-free mass	4.80	2	2	4.4	0.00	1.00	KAT8 TBX6
Hip circumference	5.56	2	2	4.4	0.00	1.00	KAT8 TBX6
Number of live births	3.30	1	0	0.0	0.00	1.00	TBX6
Forced expiratory volume in 1-second (FEV1)	2.46	3	0	0.0	0.00	1.00	KAT8 KHDRBS3 TBX6
Pulse rate	1.47	1	0	0.0	0.00	1.00	SHISA4
Qualifications: A levels/AS levels or equivalent	2.00	1	0	0.0	0.00	1.00	NPM3
Forced expiratory volume in 1-second (FEV1), Best measure	2.19	2	1	2.2	0.00	1.00	KAT8 KHDRBS3
Impedance of arm (left)	2.89	2	2	4.4	0.00	1.00	KAT8 TBX6
Arm fat mass (right)	5.05	2	2	4.4	0.00	1.00	KAT8 TBX6
Trunk predicted mass	4.85	2	2	4.4	0.00	1.00	KAT8 TBX6
Standing height	1.59	2	2	4.4	0.00	1.00	EFCAB5 TBX6
Tense / 'highly strung'	4.28	3	0	0.0	0.00	1.00	FURIN KAT8 TBX6
Birth weight of first child	3.16	1	1	2.2	0.00	1.00	FURIN
Peak expiratory flow (PEF)	2.52	1	0	0.0	0.00	1.00	FAM172A
Medication for cholesterol, blood pressure or diabetes	3.15	2	0	0.0	0.00	1.00	EFCAB5 FURIN
Birth weight	2.36	1	1	2.2	0.00	1.00	FURIN
High blood pressure (siblings)	5.82	2	1	2.2	0.00	1.00	EFCAB5 KAT8
Forced vital capacity (FVC), Best measure	2.88	4	1	2.2	0.44	0.56	EFCAB5 KAT8 KHDRBS3 TBX6
Body fat percentage	3.04	1	1	2.2	0.00	1.00	KAT8
Leg fat percentage (right)	2.80	2	1	2.2	0.00	1.00	EFCAB5 KAT8
Arm fat-free mass (right)	4.96	2	2	4.4	0.00	1.00	KAT8 TBX6
Comparative body size at age 10	1.59	1	0	0.0	0.00	1.00	KAT8
Qualifications: College or University degree	2.81	2	1	2.2	0.00	1.00	KAT8 NPM3
Medication: Blood pressure	3.30	1	0	0.0	0.00	1.00	FURIN
Angina (self-reported)	3.63	1	0	0.0	0.00	1.00	FURIN
Mean time to correctly identify matches	2.74	1	0	0.0	0.00	1.00	FAM172A
Whole body fat mass	4.19	2	2	4.4	0.00	1.00	KAT8 TBX6
Leg fat mass (right)	4.31	2	2	4.4	0.00	1.00	KAT8 TBX6
Arm predicted mass (right)	5.12	2	2	4.4	0.00	1.00	KAT8 TBX6
Pulse rate, automated reading	1.77	1	1	2.2	0.00	1.00	SHISA4
Alcohol intake frequency.	2.98	2	1	2.2	0.00	1.00	KAT8 TBX6
Comparative height size at age 10	2.42	2	1	2.2	0.00	1.00	EFCAB5 TBX6
Suffer from 'nerves'	1.95	1	0	0.0	0.00	1.00	TBX6
Overall health rating	2.22	1	1	2.2	0.00	1.00	KAT8
Medication: Aspirin	3.23	1	0	0.0	0.00	1.00	FURIN
Knee pain experienced in last month	1.69	1	0	0.0	0.00	1.00	KAT8
Hypertension (Self-reported)	4.53	3	2	4.4	0.00	1.00	EFCAB5 FURIN KAT8
Forced expiratory volume in 1-second (FEV1), predicted	1.34	1	0	0.0	0.00	1.00	TBX6
Whole body fat-free mass	5.19	3	2	4.4	0.00	1.00	FURIN KAT8 TBX6
Leg fat-free mass (right)	5.35	3	2	4.4	0.00	1.00	FURIN KAT8 TBX6
Arm fat percentage (left)	3.70	2	2	4.4	0.00	1.00	KAT8 TBX6
Handedness (chirality/laterality): Left-handed	2.69	1	0	0.0	0.00	1.00	FURIN
Medication for cholesterol	2.56	1	0	0.0	0.00	1.00	KAT8
Medication: Aspirin	3.22	1	0	0.0	0.00	1.00	FURIN
Illnesses of father: None of the above (group 1)	3.72	1	0	0.0	0.00	1.00	FURIN
Smoking status: Current	1.89	1	0	0.0	0.00	1.00	FAM172A
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.64	2	1	2.2	0.00	1.00	KAT8 KHDRBS3
Whole body water mass	5.20	3	2	4.4	0.00	1.00	FURIN KAT8 TBX6
Leg predicted mass (right)	5.36	3	2	4.4	0.00	1.00	FURIN KAT8 TBX6
Arm fat mass (left)	5.08	2	2	4.4	0.00	1.00	KAT8 TBX6
Medication: Blood pressure	4.14	2	1	2.2	0.00	1.00	FURIN KAT8
High cholesterol (Self-reported)	2.57	1	0	0.0	0.00	1.00	KAT8
Medication: Bendroflumethiazide	4.03	2	0	0.0	0.00	1.00	FURIN TBX6
Basal metabolic rate	5.48	2	2	4.4	0.00	1.00	KAT8 TBX6
Leg fat percentage (left)	2.82	1	1	2.2	0.00	1.00	KAT8
Arm fat-free mass (left)	5.19	2	2	4.4	0.00	1.00	KAT8 TBX6
Number of operations (self-reported)	2.27	1	0	0.0	0.00	1.00	FURIN
Fractured/broken bones in last 5 years	1.70	1	0	0.0	0.00	1.00	KAT8
Diastolic blood pressure, automated reading	2.60	2	2	4.4	0.00	1.00	FURIN KAT8
Vascular/heart problems diagnosed by doctor	5.37	3	2	4.4	0.00	1.00	EFCAB5 FURIN KAT8
Cholesterol lowering medication	4.00	2	0	0.0	0.00	1.00	EFCAB5 KAT8
Heart attack/myocardial infarction (self-reported)	2.68	1	0	0.0	0.00	1.00	FURIN
Impedance of whole body	3.54	2	2	4.4	0.00	1.00	KAT8 TBX6
Leg fat mass (left)	4.27	2	2	4.4	0.00	1.00	KAT8 TBX6
Arm predicted mass (left)	5.25	2	2	4.4	0.00	1.00	KAT8 TBX6

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	5	0.143	1.7
GTEx	Adipose Visceral Omentum	6	0.295	1.7
GTEx	Adrenal Gland	3	0.206	1.7
GTEx	Artery Aorta	7	0.235	1.7
GTEx	Artery Coronary	2	0.169	1.7
GTEx	Artery Tibial	7	0.186	1.6
GTEx	Brain Caudate basal ganglia	1	0.109	1.7
GTEx	Brain Cerebellar Hemisphere	2	0.134	1.7
GTEx	Brain Cerebellum	1	0.050	1.6
GTEx	Brain Cortex	1	0.097	1.6
GTEx	Brain Frontal Cortex BA9	1	0.108	1.8
GTEx	Brain Hippocampus	0	0.000	1.9
GTEx	Brain Hypothalamus	0	0.000	1.7
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.7
GTEx	Brain Putamen basal ganglia	0	0.000	1.5
GTEx	Breast Mammary Tissue	2	0.101	1.7
GTEx	Breast Mammary Tissue (Male)	1	0.084	1.7
GTEx	Breast Mammary Tissue (Female)	2	0.122	1.6
GTEx	Cells EBV-transformed lymphocytes	2	0.141	1.8
GTEx	Cells Transformed fibroblasts	6	0.143	1.7
GTEx	Colon Sigmoid	0	0.000	1.6
GTEx	Colon Transverse	3	0.145	1.7
GTEx	Esophagus Gastroesophageal Junction	1	0.069	1.7
GTEx	Esophagus Mucosa	4	0.120	1.7
GTEx	Esophagus Muscularis	4	0.124	1.7
GTEx	Heart Atrial Appendage	3	0.190	1.7
GTEx	Heart Left Ventricle	4	0.261	1.7
GTEx	Liver	2	0.279	1.8
GTEx	Lung	5	0.174	1.7
GTEx	Muscle Skeletal	2	0.069	1.7
GTEx	Nerve Tibial	4	0.093	1.7
GTEx	Ovary	5	0.551	2.0
GTEx	Pancreas	1	0.061	1.7
GTEx	Pituitary	3	0.269	1.9
GTEx	Prostate	4	0.479	1.8
GTEx	Skin Not Sun Exposed Suprapubic	2	0.081	1.7
GTEx	Skin Sun Exposed Lower leg	4	0.110	1.7
GTEx	Small Intestine Terminal Ileum	2	0.434	1.9
GTEx	Spleen	2	0.142	1.7
GTEx	Stomach	3	0.206	1.8
GTEx	Testis	4	0.127	1.7
GTEx	Thyroid	6	0.150	1.7
GTEx	Uterus	2	0.353	1.8
GTEx	Vagina	1	0.157	1.7
GTEx	Whole Blood	3	0.151	1.7
METSIM	Adipose	2	0.043	1.6
NTR	Blood	1	0.042	1.6
ROSMAP	Brain Pre-frontal Cortex	13	0.296	1.7
YFS	Blood	4	0.087	1.6
CommonMind	Brain Pre-frontal Cortex	6	0.112	1.6
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.7
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.6
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.6
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.7
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.7
The Cancer Genome Atlas	Glioblastoma Multiforme	2	0.196	1.8
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.6
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	3	0.073	1.6
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	3	0.146	1.7
The Cancer Genome Atlas	Brain Lower Grade Glioma	4	0.093	1.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.6
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.6
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.6
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.6
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.6
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.7
The Cancer Genome Atlas	Prostate Adenocarcinoma	6	0.130	1.6
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.7
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.094	1.7
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.6
The Cancer Genome Atlas	Testicular Germ Cell Tumors	3	0.235	1.7
The Cancer Genome Atlas	Thyroid Carcinoma	2	0.039	1.6
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.5