Hub : Traits :

Handedness (chirality/laterality): Left-handed

300 significantly associated models · 19 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 209599808 211264173 1 1 1.5e-07 2.8e-09 0.005 78 MAP2
2 17 42774693 45796313 18 1 1.8e-12 2.5e-08 0.202 95 ARL17B

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 16.4 1 1 2.2 0 1 ARL17B
Depression (Nagel 2018) 10.5 1 1 2.2 0 1 ARL17B
Intelligence (Savage-Jansen 2018) 6.1 1 1 2.2 0 1 ARL17B
Neuroticism (Nagel 2018) 23.4 1 1 2.2 0 1 ARL17B
Worry (Nagel 2018) 14.2 1 1 2.2 0 1 ARL17B
Reaction Time 10.9 1 1 2.2 0 1 ARL17B
Verbal and Numeric Reasoning (VNR) 3.8 1 0 0.0 0 1 ARL17B
Breast Cancer 4.0 1 0 0.0 0 1 ARL17B
Neuroticism (2016) 8.1 1 0 0.0 0 1 ARL17B
Blood Eosinophil Count 5.5 1 1 2.2 0 1 ARL17B
Blood Red Count 6.4 1 1 2.2 0 1 ARL17B
Heel T-Score 3.9 1 1 2.2 0 1 ARL17B
Height 3.1 1 1 2.2 0 1 ARL17B
Waist Hip Ratio (WHR) 2.6 1 0 0.0 0 1 ARL17B
Systolic Blood Pressure 3.4 1 1 2.2 0 1 ARL17B
Lung FVC 28.3 2 2 4.4 0 1 ARL17B MAP2
Neuroticism 20.5 1 1 2.2 0 1 ARL17B
Hand grip strength (left) 8.5 1 1 2.2 0 1 ARL17B
Sensitivity / hurt feelings 19.1 1 1 2.2 0 1 ARL17B
Frequency of depressed mood in last 2 weeks 9.1 1 0 0.0 0 1 ARL17B
Relative age of first facial hair 13.2 1 1 2.2 0 1 ARL17B
Systolic blood pressure, automated reading 4.6 1 0 0.0 0 1 ARL17B
Trunk fat percentage 5.4 1 1 2.2 0 1 ARL17B
Hand grip strength (right) 9.1 1 1 2.2 0 1 ARL17B
Fed-up feelings 5.3 1 0 0.0 0 1 ARL17B
Relative age voice broke 7.0 1 0 0.0 0 1 ARL17B
Age when periods started (menarche) 3.3 1 0 0.0 0 1 ARL17B
Sitting height 6.5 1 1 2.2 0 1 ARL17B
Trunk fat mass 4.0 1 1 2.2 0 1 ARL17B
Nervous feelings 10.4 1 1 2.2 0 1 ARL17B
Frequency of tenseness / restlessness in last 2 weeks 16.1 1 1 2.2 0 1 ARL17B
Hearing difficulty/problems with background noise 6.4 1 0 0.0 0 1 ARL17B
Hair/balding pattern: Pattern 2 13.1 1 1 2.2 0 1 ARL17B
Forced vital capacity (FVC) 25.3 2 1 2.2 0 1 ARL17B MAP2
Mouth/teeth dental problems 6.5 1 0 0.0 0 1 ARL17B
Fluid intelligence score 4.4 1 0 0.0 0 1 ARL17B
Neuroticism score 18.0 1 1 2.2 0 1 ARL17B
Impedance of arm (right) 9.0 2 1 2.2 0 1 ARL17B MAP2
Time employed in main current job 8.9 1 0 0.0 0 1 ARL17B
Worrier / anxious feelings 9.9 1 1 2.2 0 1 ARL17B
Hair/balding pattern: Pattern 3 21.5 1 1 2.2 0 1 ARL17B
Forced expiratory volume in 1-second (FEV1) 24.5 2 1 2.2 0 1 ARL17B MAP2
Forced expiratory volume in 1-second (FEV1), Best measure 21.9 1 1 2.2 0 1 ARL17B
Impedance of arm (left) 7.8 1 1 2.2 0 1 ARL17B
Standing height 3.3 1 1 2.2 0 1 ARL17B
Tense / 'highly strung' 6.2 1 0 0.0 0 1 ARL17B
Hair/balding pattern: Pattern 4 25.6 1 1 2.2 0 1 ARL17B
Peak expiratory flow (PEF) 11.0 1 1 2.2 0 1 ARL17B
Medication: Paracetamol 6.8 1 0 0.0 0 1 ARL17B
Headache pain in last month 16.7 1 1 2.2 0 1 ARL17B
Forced vital capacity (FVC), Best measure 23.7 2 1 2.2 0 1 ARL17B MAP2
Body fat percentage 3.1 1 0 0.0 0 1 ARL17B
Number of full brothers 8.9 1 0 0.0 0 1 ARL17B
Worry too long after embarrassment 9.7 1 1 2.2 0 1 ARL17B
Qualifications: College or University degree 3.2 1 0 0.0 0 1 ARL17B
Emphysema/chronic bronchitis 8.4 1 0 0.0 0 1 ARL17B
Mean time to correctly identify matches 8.7 1 1 2.2 0 1 ARL17B
Reproduciblity of spirometry measurement using ERS/ATS criteria 7.4 1 0 0.0 0 1 ARL17B
Whole body fat mass 2.2 1 0 0.0 0 1 ARL17B
Alcohol intake frequency. 4.7 1 0 0.0 0 1 ARL17B
Comparative height size at age 10 3.7 1 1 2.2 0 1 ARL17B
Suffer from 'nerves' 8.0 1 0 0.0 0 1 ARL17B
Mood swings 14.4 1 1 2.2 0 1 ARL17B
Mouth/teeth dental problems: Mouth ulcers 6.6 1 0 0.0 0 1 ARL17B
Forced expiratory volume in 1-second (FEV1), predicted percentage 19.4 2 1 2.2 0 1 ARL17B MAP2
Miserableness 5.2 1 0 0.0 0 1 ARL17B
Guilty feelings 5.9 1 0 0.0 0 1 ARL17B
Medication: Paracetamol 6.6 1 0 0.0 0 1 ARL17B
Irritability 8.3 1 1 2.2 0 1 ARL17B
Fractured/broken bones in last 5 years 5.8 1 0 0.0 0 1 ARL17B
Pain experienced in last month 5.9 1 0 0.0 0 1 ARL17B
Impedance of whole body 6.0 1 1 2.2 0 1 ARL17B

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 6 0.172 1.2
GTEx Adipose Visceral Omentum 6 0.295 1.3
GTEx Adrenal Gland 5 0.343 1.3
GTEx Artery Aorta 9 0.302 1.3
GTEx Artery Coronary 8 0.676 1.5
GTEx Artery Tibial 5 0.133 1.2
GTEx Brain Caudate basal ganglia 4 0.435 1.3
GTEx Brain Cerebellar Hemisphere 5 0.336 1.3
GTEx Brain Cerebellum 4 0.202 1.3
GTEx Brain Cortex 2 0.193 1.3
GTEx Brain Frontal Cortex BA9 4 0.433 1.3
GTEx Brain Hippocampus 3 0.573 1.6
GTEx Brain Hypothalamus 2 0.339 1.4
GTEx Brain Nucleus accumbens basal ganglia 5 0.578 1.4
GTEx Brain Putamen basal ganglia 3 0.481 1.4
GTEx Breast Mammary Tissue 8 0.405 1.3
GTEx Breast Mammary Tissue (Male) 6 0.503 1.4
GTEx Breast Mammary Tissue (Female) 7 0.426 1.3
GTEx Cells EBV-transformed lymphocytes 9 0.632 1.4
GTEx Cells Transformed fibroblasts 6 0.143 1.1
GTEx Colon Sigmoid 8 0.547 1.3
GTEx Colon Transverse 6 0.291 1.2
GTEx Esophagus Gastroesophageal Junction 8 0.554 1.3
GTEx Esophagus Mucosa 7 0.211 1.2
GTEx Esophagus Muscularis 10 0.309 1.2
GTEx Heart Atrial Appendage 6 0.380 1.3
GTEx Heart Left Ventricle 7 0.458 1.2
GTEx Liver 3 0.418 1.3
GTEx Lung 6 0.209 1.3
GTEx Muscle Skeletal 5 0.173 1.2
GTEx Nerve Tibial 5 0.116 1.2
GTEx Ovary 6 0.661 1.4
GTEx Pancreas 5 0.306 1.2
GTEx Pituitary 4 0.359 1.3
GTEx Prostate 4 0.479 1.4
GTEx Skin Not Sun Exposed Suprapubic 7 0.285 1.3
GTEx Skin Sun Exposed Lower leg 6 0.165 1.2
GTEx Small Intestine Terminal Ileum 3 0.651 1.4
GTEx Spleen 5 0.354 1.2
GTEx Stomach 6 0.413 1.3
GTEx Testis 10 0.317 1.2
GTEx Thyroid 8 0.200 1.2
GTEx Uterus 6 1.058 1.4
GTEx Vagina 3 0.472 1.4
GTEx Whole Blood 4 0.201 1.2
METSIM Adipose 2 0.043 1.1
NTR Blood 1 0.042 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.1
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 1 0.019 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.060 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 2 0.045 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 3 0.273 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.1
The Cancer Genome Atlas Esophageal Carcinoma 2 0.292 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 2 0.196 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.098 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.046 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 1 0.090 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 2 0.068 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.080 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 2 0.126 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 2 0.120 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 1 0.075 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 3 0.065 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 1 0.145 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 2 0.187 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.1
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.197 1.2