Hub : Traits :

Handedness (chirality/laterality): Left-handed

300 significantly associated models · 19 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	209599808	211264173	1	1	1.5e-07	2.8e-09	0.005	78	MAP2
2	17	42774693	45796313	18	1	1.8e-12	2.5e-08	0.202	95	ARL17B

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Lung FVC	28.3	2	2	4.4	1	ARL17B MAP2
Hair/balding pattern: Pattern 4	25.6	1	1	2.2	1	ARL17B
Forced vital capacity (FVC)	25.3	2	1	2.2	1	ARL17B MAP2
Forced expiratory volume in 1-second (FEV1)	24.5	2	1	2.2	1	ARL17B MAP2
Forced vital capacity (FVC), Best measure	23.7	2	1	2.2	1	ARL17B MAP2
Neuroticism (Nagel 2018)	23.4	1	1	2.2	1	ARL17B
Forced expiratory volume in 1-second (FEV1), Best measure	21.9	1	1	2.2	1	ARL17B
Hair/balding pattern: Pattern 3	21.5	1	1	2.2	1	ARL17B
Neuroticism	20.5	1	1	2.2	1	ARL17B
Forced expiratory volume in 1-second (FEV1), predicted percentage	19.4	2	1	2.2	1	ARL17B MAP2
Sensitivity / hurt feelings	19.1	1	1	2.2	1	ARL17B
Neuroticism score	18.0	1	1	2.2	1	ARL17B
Headache pain in last month	16.7	1	1	2.2	1	ARL17B
Depressed Affect (Nagel 2018)	16.4	1	1	2.2	1	ARL17B
Frequency of tenseness / restlessness in last 2 weeks	16.1	1	1	2.2	1	ARL17B
Mood swings	14.4	1	1	2.2	1	ARL17B
Worry (Nagel 2018)	14.2	1	1	2.2	1	ARL17B
Relative age of first facial hair	13.2	1	1	2.2	1	ARL17B
Hair/balding pattern: Pattern 2	13.1	1	1	2.2	1	ARL17B
Peak expiratory flow (PEF)	11.0	1	1	2.2	1	ARL17B
Reaction Time	10.9	1	1	2.2	1	ARL17B
Depression (Nagel 2018)	10.5	1	1	2.2	1	ARL17B
Nervous feelings	10.4	1	1	2.2	1	ARL17B
Worrier / anxious feelings	9.9	1	1	2.2	1	ARL17B
Worry too long after embarrassment	9.7	1	1	2.2	1	ARL17B
Frequency of depressed mood in last 2 weeks	9.1	1	0	0.0	1	ARL17B
Hand grip strength (right)	9.1	1	1	2.2	1	ARL17B
Impedance of arm (right)	9.0	2	1	2.2	1	ARL17B MAP2
Time employed in main current job	8.9	1	0	0.0	1	ARL17B
Number of full brothers	8.9	1	0	0.0	1	ARL17B
Mean time to correctly identify matches	8.7	1	1	2.2	1	ARL17B
Hand grip strength (left)	8.5	1	1	2.2	1	ARL17B
Emphysema/chronic bronchitis	8.4	1	0	0.0	1	ARL17B
Irritability	8.3	1	1	2.2	1	ARL17B
Neuroticism (2016)	8.1	1	0	0.0	1	ARL17B
Suffer from 'nerves'	8.0	1	0	0.0	1	ARL17B
Impedance of arm (left)	7.8	1	1	2.2	1	ARL17B
Reproduciblity of spirometry measurement using ERS/ATS criteria	7.4	1	0	0.0	1	ARL17B
Relative age voice broke	7.0	1	0	0.0	1	ARL17B
Medication: Paracetamol	6.8	1	0	0.0	1	ARL17B
Mouth/teeth dental problems: Mouth ulcers	6.6	1	0	0.0	1	ARL17B
Medication: Paracetamol	6.6	1	0	0.0	1	ARL17B
Sitting height	6.5	1	1	2.2	1	ARL17B
Mouth/teeth dental problems	6.5	1	0	0.0	1	ARL17B
Blood Red Count	6.4	1	1	2.2	1	ARL17B
Hearing difficulty/problems with background noise	6.4	1	0	0.0	1	ARL17B
Tense / 'highly strung'	6.2	1	0	0.0	1	ARL17B
Intelligence (Savage-Jansen 2018)	6.1	1	1	2.2	1	ARL17B
Impedance of whole body	6.0	1	1	2.2	1	ARL17B
Guilty feelings	5.9	1	0	0.0	1	ARL17B
Pain experienced in last month	5.9	1	0	0.0	1	ARL17B
Fractured/broken bones in last 5 years	5.8	1	0	0.0	1	ARL17B
Blood Eosinophil Count	5.5	1	1	2.2	1	ARL17B
Trunk fat percentage	5.4	1	1	2.2	1	ARL17B
Fed-up feelings	5.3	1	0	0.0	1	ARL17B
Miserableness	5.2	1	0	0.0	1	ARL17B
Alcohol intake frequency.	4.7	1	0	0.0	1	ARL17B
Systolic blood pressure, automated reading	4.6	1	0	0.0	1	ARL17B
Fluid intelligence score	4.4	1	0	0.0	1	ARL17B
Breast Cancer	4.0	1	0	0.0	1	ARL17B
Trunk fat mass	4.0	1	1	2.2	1	ARL17B
Heel T-Score	3.9	1	1	2.2	1	ARL17B
Verbal and Numeric Reasoning (VNR)	3.8	1	0	0.0	1	ARL17B
Comparative height size at age 10	3.7	1	1	2.2	1	ARL17B
Systolic Blood Pressure	3.4	1	1	2.2	1	ARL17B
Age when periods started (menarche)	3.3	1	0	0.0	1	ARL17B
Standing height	3.3	1	1	2.2	1	ARL17B
Qualifications: College or University degree	3.2	1	0	0.0	1	ARL17B
Height	3.1	1	1	2.2	1	ARL17B
Body fat percentage	3.1	1	0	0.0	1	ARL17B
Waist Hip Ratio (WHR)	2.6	1	0	0.0	1	ARL17B
Whole body fat mass	2.2	1	0	0.0	1	ARL17B

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Hippocampus	3	0.573	1.6
GTEx	Artery Coronary	8	0.676	1.5
GTEx	Brain Hypothalamus	2	0.339	1.4
GTEx	Brain Nucleus accumbens basal ganglia	5	0.578	1.4
GTEx	Brain Putamen basal ganglia	3	0.481	1.4
GTEx	Breast Mammary Tissue (Male)	6	0.503	1.4
GTEx	Cells EBV-transformed lymphocytes	9	0.632	1.4
GTEx	Ovary	6	0.661	1.4
GTEx	Prostate	4	0.479	1.4
GTEx	Small Intestine Terminal Ileum	3	0.651	1.4
GTEx	Uterus	6	1.058	1.4
GTEx	Vagina	3	0.472	1.4
GTEx	Adipose Visceral Omentum	6	0.295	1.3
GTEx	Adrenal Gland	5	0.343	1.3
GTEx	Artery Aorta	9	0.302	1.3
GTEx	Brain Caudate basal ganglia	4	0.435	1.3
GTEx	Brain Cerebellar Hemisphere	5	0.336	1.3
GTEx	Brain Cerebellum	4	0.202	1.3
GTEx	Brain Cortex	2	0.193	1.3
GTEx	Brain Frontal Cortex BA9	4	0.433	1.3
GTEx	Breast Mammary Tissue	8	0.405	1.3
GTEx	Breast Mammary Tissue (Female)	7	0.426	1.3
GTEx	Colon Sigmoid	8	0.547	1.3
GTEx	Esophagus Gastroesophageal Junction	8	0.554	1.3
GTEx	Heart Atrial Appendage	6	0.380	1.3
GTEx	Liver	3	0.418	1.3
GTEx	Lung	6	0.209	1.3
GTEx	Pituitary	4	0.359	1.3
GTEx	Skin Not Sun Exposed Suprapubic	7	0.285	1.3
GTEx	Stomach	6	0.413	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	3	0.273	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	2	0.292	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	2	0.126	1.3
GTEx	Adipose Subcutaneous	6	0.172	1.2
GTEx	Artery Tibial	5	0.133	1.2
GTEx	Colon Transverse	6	0.291	1.2
GTEx	Esophagus Mucosa	7	0.211	1.2
GTEx	Esophagus Muscularis	10	0.309	1.2
GTEx	Heart Left Ventricle	7	0.458	1.2
GTEx	Muscle Skeletal	5	0.173	1.2
GTEx	Nerve Tibial	5	0.116	1.2
GTEx	Pancreas	5	0.306	1.2
GTEx	Skin Sun Exposed Lower leg	6	0.165	1.2
GTEx	Spleen	5	0.354	1.2
GTEx	Testis	10	0.317	1.2
GTEx	Thyroid	8	0.200	1.2
GTEx	Whole Blood	4	0.201	1.2
NTR	Blood	1	0.042	1.2
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	2	0.196	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.098	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.046	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	2	0.120	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	1	0.075	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	1	0.145	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	2	0.187	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.197	1.2
GTEx	Cells Transformed fibroblasts	6	0.143	1.1
METSIM	Adipose	2	0.043	1.1
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.1
YFS	Blood	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.060	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.1
The Cancer Genome Atlas	Lung Adenocarcinoma	2	0.068	1.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	3	0.065	1.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.1