Hub : Traits :

Myopia

16 significantly associated models · 11 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 52134325 53518049 1 1 1.9e-07 3.4e-06 5.5e-01 98 RP11-155O18.6
2 1 112517914 113941737 1 1 3.9e-07 6.6e-07 4.9e-02 84 MOV10
3 2 177791737 179672547 1 1 1.3e-08 3.4e-10 6.7e-06 49 PDE11A
4 2 232714559 234168951 3 1 6.6e-11 3.7e-15 5.4e-06 67 PRSS56
5 7 1580921 2977732 1 1 3.0e-07 2.4e-07 2.0e-01 94 FTSJ2
6 8 59021648 60728159 2 1 3.5e-10 4.3e-12 2.1e-04 71 TOX
7 9 138403706 139836362 1 1 9.7e-09 7.2e-08 9.4e-01 100 QSOX2
8 10 85312966 86715813 1 1 1.2e-07 8.7e-07 1.7e-01 92 RGR

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Reaction Time 1.63 1 0 0.0 0.00 1.000 RP11-155O18.6
Neuroticism 1.05 1 0 0.0 0.00 1.000 FTSJ2
Schizophrenia 2.24 2 0 0.0 0.00 1.000 FTSJ2 MOV10
Heel T-Score 3.26 1 1 3.0 0.00 1.000 MOV10
BMI 0.40 1 0 0.0 0.00 1.000 QSOX2
Height 3.43 5 3 9.1 -0.74 0.153 MOV10 PDE11A QSOX2 RP11-155O18.6 TOX
Waist Hip Ratio (WHR) 0.42 1 0 0.0 0.00 1.000 MOV10
Systolic Blood Pressure 2.23 3 1 3.0 0.00 1.000 FTSJ2 MOV10 TOX
Allergy or Eczema 0.58 1 0 0.0 0.00 1.000 MOV10
Cardiovascular Disease 1.04 1 0 0.0 0.00 1.000 MOV10
Lung FVC 3.39 2 1 3.0 0.00 1.000 MOV10 QSOX2
Neuroticism 1.35 1 0 0.0 0.00 1.000 FTSJ2
Hand grip strength (left) 1.58 1 0 0.0 0.00 1.000 MOV10
Number of treatments/medications taken 2.02 2 0 0.0 0.00 1.000 FTSJ2 MOV10
Systolic blood pressure, automated reading 1.36 1 0 0.0 0.00 1.000 MOV10
Impedance of leg (right) 1.12 1 1 3.0 0.00 1.000 MOV10
Leg fat-free mass (left) 1.07 1 0 0.0 0.00 1.000 QSOX2
Trunk fat percentage 1.33 1 1 3.0 0.00 1.000 MOV10
Hand grip strength (right) 1.50 1 0 0.0 0.00 1.000 MOV10
Taking other prescription medications 1.67 1 0 0.0 0.00 1.000 TOX
Age when periods started (menarche) 1.04 1 0 0.0 0.00 1.000 RP11-155O18.6
Heel bone mineral density (BMD) T-score, automated (left) 3.17 1 1 3.0 0.00 1.000 MOV10
High blood pressure 1.40 1 0 0.0 0.00 1.000 MOV10
Hayfever, allergic rhinitis or eczema 0.67 1 0 0.0 0.00 1.000 MOV10
Medication: Atenolol 1.47 1 0 0.0 0.00 1.000 MOV10
Sitting height 2.14 1 1 3.0 0.00 1.000 QSOX2
Impedance of leg (left) 1.25 1 1 3.0 0.00 1.000 MOV10
Leg predicted mass (left) 1.07 2 0 0.0 0.00 1.000 PDE11A QSOX2
Trunk fat mass 1.51 1 1 3.0 0.00 1.000 MOV10
Waist circumference 0.91 1 0 0.0 0.00 1.000 MOV10
Number of incorrect matches in round 1.31 1 0 0.0 0.00 1.000 QSOX2
Had other major operations 1.57 1 0 0.0 0.00 1.000 PRSS56
Forced vital capacity (FVC) 3.47 1 1 3.0 0.00 1.000 QSOX2
Heel bone mineral density (BMD) T-score, automated (right) 2.93 1 1 3.0 0.00 1.000 MOV10
Mouth/teeth dental problems 1.68 1 0 0.0 0.00 1.000 PDE11A
Weight 1.37 2 0 0.0 0.00 1.000 MOV10 QSOX2
Impedance of arm (right) 1.36 3 0 0.0 0.00 1.000 FTSJ2 MOV10 QSOX2
Arm fat percentage (right) 0.64 1 0 0.0 0.00 1.000 MOV10
Trunk fat-free mass 1.22 3 0 0.0 0.00 1.000 PDE11A QSOX2 TOX
Hip circumference 0.98 1 0 0.0 0.00 1.000 MOV10
Forced expiratory volume in 1-second (FEV1) 2.98 2 1 3.0 0.00 1.000 QSOX2 RP11-155O18.6
Qualifications: A levels/AS levels or equivalent 1.47 1 0 0.0 0.00 1.000 FTSJ2
Forced expiratory volume in 1-second (FEV1), Best measure 3.19 1 1 3.0 0.00 1.000 QSOX2
Impedance of arm (left) 1.41 4 0 0.0 0.99 0.011 FTSJ2 MOV10 QSOX2 TOX
Arm fat mass (right) 0.91 1 0 0.0 0.00 1.000 MOV10
Trunk predicted mass 1.22 3 0 0.0 0.00 1.000 PDE11A QSOX2 TOX
Standing height 2.65 3 2 6.1 0.00 1.000 MOV10 PDE11A QSOX2
Peak expiratory flow (PEF) 1.48 1 0 0.0 0.00 1.000 QSOX2
Ever highly irritable/argumentative for 2 days 3.61 1 0 0.0 0.00 1.000 MOV10
Medication: Paracetamol 1.92 1 0 0.0 0.00 1.000 MOV10
Forced vital capacity (FVC), Best measure 4.00 1 1 3.0 0.00 1.000 QSOX2
Body fat percentage 1.19 1 1 3.0 0.00 1.000 MOV10
Leg fat percentage (right) 1.27 2 0 0.0 0.00 1.000 MOV10 QSOX2
Arm fat-free mass (right) 0.96 1 0 0.0 0.00 1.000 MOV10
Comparative body size at age 10 0.99 1 0 0.0 0.00 1.000 MOV10
Wheeze or whistling in the chest in last year 1.27 1 0 0.0 0.00 1.000 QSOX2
Qualifications: College or University degree 1.70 3 0 0.0 0.00 1.000 FTSJ2 RP11-155O18.6 TOX
Eye problems/disorders: None of the above 2.48 1 0 0.0 0.00 1.000 TOX
Whole body fat mass 1.30 1 1 3.0 0.00 1.000 MOV10
Leg fat mass (right) 1.18 1 0 0.0 0.00 1.000 MOV10
Arm predicted mass (right) 0.92 2 0 0.0 0.00 1.000 MOV10 TOX
Pulse rate, automated reading 1.42 1 0 0.0 0.00 1.000 PRSS56
Comparative height size at age 10 2.94 3 2 6.1 0.00 1.000 MOV10 PDE11A QSOX2
Medication: Aspirin 1.64 1 0 0.0 0.00 1.000 FTSJ2
Hypertension (Self-reported) 1.35 1 0 0.0 0.00 1.000 MOV10
Forced expiratory volume in 1-second (FEV1), predicted 2.58 2 0 0.0 0.00 1.000 PDE11A QSOX2
Whole body fat-free mass 1.17 3 0 0.0 0.00 1.000 PDE11A QSOX2 TOX
Leg fat-free mass (right) 1.08 1 0 0.0 0.00 1.000 QSOX2
Arm fat percentage (left) 0.60 1 0 0.0 0.00 1.000 MOV10
Handedness (chirality/laterality): Left-handed 1.32 1 0 0.0 0.00 1.000 RGR
Loneliness, isolation 1.57 1 0 0.0 0.00 1.000 MOV10
Eye problems/disorders: Cataract 2.15 1 0 0.0 0.00 1.000 TOX
Medication for cholesterol 1.83 1 0 0.0 0.00 1.000 MOV10
Mineral and other dietary supplements 1.81 1 0 0.0 0.00 1.000 TOX
Medication: Aspirin 1.63 1 0 0.0 0.00 1.000 FTSJ2
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.86 1 0 0.0 0.00 1.000 QSOX2
Whole body water mass 1.14 1 0 0.0 0.00 1.000 QSOX2
Leg predicted mass (right) 1.06 1 0 0.0 0.00 1.000 QSOX2
Arm fat mass (left) 0.80 1 0 0.0 0.00 1.000 MOV10
Number of self-reported non-cancer illnesses 1.26 1 0 0.0 0.00 1.000 FTSJ2
Miserableness 1.78 1 0 0.0 0.00 1.000 FTSJ2
Ever taken oral contraceptive pill 1.72 1 0 0.0 0.00 1.000 QSOX2
Medication: Blood pressure 2.34 1 1 3.0 0.00 1.000 MOV10
Supplements: Fish oil (including cod liver oil) 1.89 1 0 0.0 0.00 1.000 TOX
Medication: Bendroflumethiazide 1.31 1 0 0.0 0.00 1.000 MOV10
Basal metabolic rate 1.32 3 0 0.0 0.00 1.000 MOV10 PDE11A QSOX2
Leg fat percentage (left) 1.27 1 0 0.0 0.00 1.000 MOV10
Arm fat-free mass (left) 1.20 2 0 0.0 0.00 1.000 MOV10 TOX
Irritability 1.22 1 0 0.0 0.00 1.000 FTSJ2
Ever had prostate specific antigen (PSA) test 3.10 1 0 0.0 0.00 1.000 RGR
Diastolic blood pressure, automated reading 2.73 2 1 3.0 0.00 1.000 MOV10 QSOX2
Vascular/heart problems diagnosed by doctor 1.23 1 0 0.0 0.00 1.000 MOV10
Impedance of whole body 1.33 3 0 0.0 0.00 1.000 FTSJ2 MOV10 TOX
Leg fat mass (left) 1.19 1 0 0.0 0.00 1.000 MOV10
Arm predicted mass (left) 1.18 3 0 0.0 0.00 1.000 MOV10 QSOX2 TOX

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.41
GTEx Adipose Visceral Omentum 1 0.0491 1.48
GTEx Adrenal Gland 0 0.0000 1.46
GTEx Artery Aorta 0 0.0000 1.51
GTEx Artery Coronary 0 0.0000 1.45
GTEx Artery Tibial 0 0.0000 1.41
GTEx Brain Caudate basal ganglia 0 0.0000 1.31
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.48
GTEx Brain Cerebellum 0 0.0000 1.58
GTEx Brain Cortex 0 0.0000 1.48
GTEx Brain Frontal Cortex BA9 0 0.0000 1.52
GTEx Brain Hippocampus 0 0.0000 1.41
GTEx Brain Hypothalamus 0 0.0000 1.41
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.40
GTEx Brain Putamen basal ganglia 0 0.0000 1.38
GTEx Breast Mammary Tissue 0 0.0000 1.48
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.52
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.50
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.47
GTEx Cells Transformed fibroblasts 2 0.0476 1.49
GTEx Colon Sigmoid 0 0.0000 1.57
GTEx Colon Transverse 2 0.0969 1.55
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.45
GTEx Esophagus Mucosa 0 0.0000 1.48
GTEx Esophagus Muscularis 0 0.0000 1.49
GTEx Heart Atrial Appendage 1 0.0633 1.53
GTEx Heart Left Ventricle 3 0.1961 1.57
GTEx Liver 0 0.0000 1.63
GTEx Lung 0 0.0000 1.50
GTEx Muscle Skeletal 0 0.0000 1.58
GTEx Nerve Tibial 0 0.0000 1.44
GTEx Ovary 0 0.0000 1.50
GTEx Pancreas 0 0.0000 1.52
GTEx Pituitary 0 0.0000 1.54
GTEx Prostate 0 0.0000 1.46
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.43
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.48
GTEx Small Intestine Terminal Ileum 0 0.0000 1.48
GTEx Spleen 0 0.0000 1.51
GTEx Stomach 0 0.0000 1.49
GTEx Testis 0 0.0000 1.50
GTEx Thyroid 0 0.0000 1.49
GTEx Uterus 0 0.0000 1.44
GTEx Vagina 0 0.0000 1.46
GTEx Whole Blood 0 0.0000 1.56
METSIM Adipose 0 0.0000 1.36
NTR Blood 0 0.0000 1.47
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.46
YFS Blood 0 0.0000 1.40
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.42
TCGA Breast Tumor 0 0.0000 1.40
TCGA Breast Normal 1 0.0238 1.43
TCGA Ovarian Tumor 0 0.0000 1.33
TCGA Prostate Tumor 2 0.0578 1.43