Hub : Genes

ITM2C

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0800	0.0340	1.3e-02	-0.002	0.022	0.022	0.024	-0.002	6.7e-01	8.5e-04	1.0e-03	5.5e-04	5.7e-01
2	GTEx	Nerve Tibial	0.1621	0.0587	5.8e-03	0.022	NA	0.038	NA	0.024	1.1e-02	NA	9.8e-04	NA	8.1e-03
3	GTEx	Testis	0.2900	0.0890	5.3e-03	0.006	NA	0.012	NA	0.023	1.7e-01	NA	8.9e-02	NA	3.2e-02
4	YFS	Blood	0.0845	0.0217	4.1e-07	0.045	0.023	0.045	0.060	0.045	1.7e-14	5.1e-08	1.8e-14	8.7e-19	2.1e-14
5	TCGA	Thyroid Carcinoma	0.0740	0.0390	4.5e-03	0.032	0.003	0.001	NA	0.003	4.4e-04	1.5e-01	2.2e-01	NA	1.6e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.1	3.0	0.0	-1.0	1.3	-1.7	0.1
Bipolar Disorder or Schizophrenia	0.1	0.3	1.1	-0.4	-0.2	0.2	-1.1	-0.2
Depressed Affect (Nagel 2018)	0.5	1.0	2.4	0.4	0.9	-1.5	-0.7	-1.0
Depression (Nagel 2018)	1.1	1.7	5.3	0.5	-0.6	-1.5	-2.3	-0.3
Intelligence (Savage-Jansen 2018)	0.6	1.9	4.0	-1.1	-2.0	0.4	-1.7	0.9
Neuroticism (Nagel 2018)	0.4	0.9	3.0	-0.2	-0.2	-1.7	-1.0	-0.8
Schizophrenia (2018)	0.1	0.2	0.6	-0.7	0.3	-0.5	0.0	-0.5
Schizophrenia vs Biploar Disorder	0.8	1.1	3.3	-0.4	0.1	-1.8	-1.3	0.6
Worry (Nagel 2018)	0.7	1.5	3.4	-0.9	-1.8	-1.8	-0.2	-0.7
Alzheimer’s Disease (in mother)	1.3	1.5	4.9	-0.4	-1.2	-2.2	0.8	0.3
Alzheimer’s Disease (in father)	0.7	0.7	1.5	-0.8	1.2	0.8	0.5	-0.7
Alzheimer’s Disease (including proxy)	0.9	1.3	2.5	-0.2	-1.2	-1.6	1.5	-0.5
Crohns Disease (2017)	0.3	0.6	1.3	-0.9	1.1	-0.1	-0.5	-0.6
Irritable Bowel Disease (IBD)	0.3	0.8	1.4	-0.8	1.0	1.2	0.9	-0.3
Ulcerative Colitis (UC)	0.6	1.1	3.7	0.2	0.8	1.1	1.9	0.1
Major Depression (MDD)	0.4	0.5	1.0	1.0	0.7	0.0	0.6	0.8
Reaction Time	0.6	1.1	3.2	0.9	-1.2	-1.8	0.4	-0.4
Verbal and Numeric Reasoning (VNR)	0.4	0.9	2.2	0.3	-1.0	-0.7	-1.5	0.9
Breast Cancer	0.6	1.5	3.6	0.4	-0.8	1.9	-0.3	1.8
Ovarian Cancer	0.6	0.8	1.8	-0.5	-0.2	1.3	0.2	-1.3
Prostate Cancer	0.3	0.4	1.1	0.4	0.5	-0.3	1.0	-0.5
Age at First Birth	0.8	1.2	3.2	0.9	1.3	-1.8	-0.5	-0.1
Bipolar Disorder (2011)	0.8	0.7	2.5	0.6	1.6	0.0	-0.9	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	2.6	-1.6	0.4	0.2	-0.1	0.1
Coronary Artery Disease (CAD)	0.7	0.9	1.5	-0.8	1.1	-1.2	0.2	-0.9
Crohns Disease (2012)	0.4	0.7	1.8	-0.7	0.5	0.2	-1.3	-1.0
Mean Putamen Volume	0.4	0.5	1.1	0.4	0.5	0.5	1.0	-0.8
Fasting Glucose	0.7	0.8	2.0	-0.3	-0.1	-1.4	0.7	-1.1
HbA1C	1.5	1.6	4.0	-0.4	-0.7	-2.0	1.6	-1.0
HDL Cholesterol	0.6	1.1	2.3	1.5	-0.7	0.2	-1.1	1.1
LDL Cholesterol	0.3	0.5	1.0	-0.8	1.0	-0.5	-0.3	0.8
Lupus	0.4	0.6	1.8	-1.3	-0.5	0.2	1.1	0.2
Neuroticism (2016)	0.2	0.4	0.6	0.7	0.4	0.7	0.8	0.3
Primary Biliary Cirrhosis	0.3	0.4	1.0	-0.1	-0.2	0.7	1.0	-0.5
Rheumatoid Arthritis	0.6	0.8	1.7	-0.7	0.5	0.1	1.3	1.2
Schizophrenia (2014)	0.2	0.3	1.1	0.3	-0.4	-0.3	-1.1	-0.5
Triglycerides	0.3	0.5	1.3	-1.1	0.7	0.4	0.1	0.7
Type 2 Diabetes (T2D) (2012)	2.2	2.5	7.9	-1.1	-2.8	-1.9	-0.1	-0.0
Ulcerative Colitis	1.1	1.7	7.4	-0.1	0.5	0.7	2.7	-0.4
Blood Eosinophil Count	0.6	4.3	18.0	1.2	-0.6	1.4	-4.2	-0.3
Blood Platelet Count	0.0	0.5	0.9	-0.5	-1.0	0.7	-0.4	-0.9
Blood Red Count	0.7	7.0	13.5	2.0	2.3	2.4	3.7	2.6
Blood White Count	0.2	1.5	3.1	0.9	-0.8	-1.0	-1.5	-1.8
Heel T-Score	0.3	2.5	9.9	0.7	-0.5	0.2	1.4	3.1
BMI	0.1	0.6	1.5	-0.2	0.4	1.2	-0.3	1.1
Height	0.1	1.8	3.2	-1.3	-1.4	-0.1	-1.8	1.5
Waist Hip Ratio (WHR)	0.5	2.4	4.2	2.0	-1.3	-0.9	-2.0	-1.1
Systolic Blood Pressure	0.3	1.7	6.3	0.5	0.2	-0.0	1.3	-2.5
Smoking Status	0.6	1.3	2.1	-0.9	1.2	-0.7	-1.4	1.3
Allergy or Eczema	0.3	0.9	2.2	-0.1	1.5	0.9	0.8	1.0
Cardiovascular Disease	0.2	0.6	1.3	1.0	-0.8	0.0	0.0	-1.2
Hypothyroidism (self reported)	0.5	1.0	2.1	0.6	-1.1	-1.1	1.4	-0.7
Respiratory disease	0.3	0.7	1.2	0.9	-1.0	-0.7	-1.1	0.0
Type 2 Diabetes (T2D) (2018)	0.1	0.1	0.4	0.6	0.1	-0.4	-0.1	-0.2
Lung FEV1/FVC ratio	1.0	4.9	15.7	0.9	0.6	2.4	-1.2	4.0
Lung FVC	0.1	0.6	2.2	0.2	0.7	0.0	-0.7	-1.5
Neuroticism	0.2	0.4	1.3	0.2	-0.4	-0.5	-1.1	-0.6
Chronotype (morning person)	0.3	0.7	2.2	0.9	0.1	0.6	0.1	1.5
Hair Pigment	0.0	0.4	1.4	-0.2	-0.2	-0.5	0.6	-1.2
Tanning	0.2	2.3	4.3	-0.8	1.6	1.5	-1.3	2.1
Hand grip strength (left)	0.3	0.7	1.8	-0.6	-0.6	1.0	-0.4	1.4
Number of treatments/medications taken	0.6	1.1	3.7	-0.8	0.6	0.3	0.9	-1.9
Average weekly spirits intake	1.3	1.6	4.6	0.4	0.5	0.5	-2.1	-1.7
Sensitivity / hurt feelings	0.6	1.0	2.3	-1.5	-0.1	-1.3	0.4	-0.8
Frequency of depressed mood in last 2 weeks	0.7	0.9	3.8	0.3	-0.4	-0.4	-1.9	-0.6
Hearing difficulty/problems: Yes	0.6	0.9	3.1	-0.1	-0.1	-1.8	-1.1	0.5
Relative age of first facial hair	0.7	1.5	2.6	0.5	-1.3	-0.7	-1.6	-1.5
Other serious medical condition/disability diagnosed by doctor	1.8	2.3	9.3	0.4	-1.1	-0.7	-0.8	-3.0
Ever used hormone-replacement therapy (HRT)	0.5	0.6	2.5	0.3	0.3	0.7	0.3	1.6
Ever had hysterectomy (womb removed)	1.1	1.3	4.5	-1.1	-2.1	0.4	-0.1	-0.6
Systolic blood pressure, automated reading	0.3	0.9	2.5	0.7	1.0	-0.5	0.7	-1.6
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.3	1.8	-0.6	0.4	-0.6	-1.0
Angina	1.0	1.3	4.3	-0.5	0.4	1.0	-2.1	0.8
Medication for hormone replacement therapy	0.2	0.2	0.5	-0.3	0.7	-0.5	0.5	-0.2
Vitamin and mineral supplements	1.3	1.7	4.5	0.6	-2.1	0.3	1.2	-1.4
Supplements: Zinc	0.7	0.8	2.2	-1.4	-0.0	0.1	-1.5	0.2
Medication: Co-codamol	0.2	0.2	0.4	0.6	0.0	0.5	0.5	-0.3
Medication: Metformin	0.7	1.0	2.8	1.2	-0.2	0.7	-0.6	-1.7
Diabetes (father)	0.9	1.1	1.9	0.8	-0.9	-1.4	-1.0	-1.2
Diabetes (mother)	1.1	1.4	4.7	-2.2	-0.8	-0.0	-1.2	-0.5
Severe depression (siblings)	0.4	0.4	0.7	-0.4	-0.8	0.8	-0.7	-0.5
Pack years adult smoking proportion	0.6	1.0	2.5	-0.7	-1.6	0.3	0.9	-1.0
Impedance of leg (right)	0.2	0.8	1.7	0.5	0.9	-1.1	1.3	-0.3
Leg fat-free mass (left)	0.3	1.6	3.0	-0.1	-0.4	1.7	-1.4	1.7
Trunk fat percentage	0.2	0.8	2.0	0.5	1.4	1.1	-0.7	-0.4
Hand grip strength (right)	0.8	2.1	5.5	-1.1	-0.6	2.4	-0.9	1.7
Townsend deprivation index at recruitment	0.1	0.2	0.4	-0.1	0.5	-0.6	0.2	-0.4
Current tobacco smoking	0.6	1.0	2.0	-0.6	0.7	1.4	1.0	0.9
Average weekly fortified wine intake	1.0	1.1	1.9	1.4	-0.3	-1.3	-1.0	-1.0
Maternal smoking around birth	2.1	3.1	6.3	-1.7	2.5	0.6	-0.5	-2.4
Fed-up feelings	0.8	1.5	3.1	0.6	1.6	-1.1	-0.1	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	1.9	2.5	6.9	-0.7	-2.6	-0.8	-2.1	0.5
Relative age voice broke	1.2	1.9	5.3	-1.4	-0.3	-0.6	-2.3	-1.4
Taking other prescription medications	0.2	0.3	0.7	0.1	0.1	-0.7	0.1	-0.8
Age when periods started (menarche)	0.2	0.6	1.2	0.8	1.1	0.9	-0.3	0.3
Bilateral oophorectomy (both ovaries removed)	0.2	0.3	0.6	0.2	-0.8	0.2	-0.4	-0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.6	3.7	1.1	-1.7	0.2	0.5	1.9
Tinnitus: Yes, but not now, but have in the past	2.6	2.8	6.5	-2.1	-2.6	-0.2	0.9	-1.4
Qualifications: CSEs or equivalent	1.1	1.5	6.2	-0.6	-0.1	0.9	2.5	-0.2
Serious illness, injury or assault to yourself	1.5	1.8	2.9	-1.3	-1.7	-0.9	-1.0	-1.5
High blood pressure	0.4	1.2	3.8	0.8	-0.9	-0.5	0.6	-1.9
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.1	0.0	1.5	1.0	0.6	1.1
Multivitamins +/- minerals	0.9	1.1	3.0	0.3	1.1	-0.2	-1.7	1.0
Stomach or abdominal pain in last month	0.5	0.7	1.6	-1.3	-1.1	-0.3	-0.3	0.6
Supplements: Glucosamine	1.0	1.3	2.6	-1.6	0.7	-0.8	-1.0	1.3
Diverticular disease/diverticulitis (self-reported)	2.2	2.6	6.6	-0.4	-2.4	-2.6	0.0	-0.8
Medication: Atenolol	0.3	0.4	1.4	-0.2	0.1	-0.3	0.6	1.2
Medication: Levothyroxine sodium	0.8	1.3	3.6	0.1	-1.5	-0.9	1.9	-0.2
Sitting height	0.1	0.8	1.4	-0.8	1.1	0.8	-0.1	1.2
Chronic bronchitis/emphysema (father)	1.6	1.9	4.5	1.0	-2.1	0.0	-1.8	-0.6
High blood pressure (mother)	0.7	1.0	2.1	0.6	-1.4	-0.7	-0.3	1.5
Body mass index (BMI)	0.1	0.5	2.0	-0.5	-0.3	1.4	-0.4	0.3
Impedance of leg (left)	0.1	0.7	1.4	0.2	1.1	-0.5	1.2	-0.5
Leg predicted mass (left)	0.3	1.7	3.1	-0.1	-0.6	1.8	-1.3	1.8
Trunk fat mass	0.2	0.8	2.5	0.0	0.8	1.6	-0.9	0.3
Waist circumference	0.1	0.5	1.4	-0.3	-0.8	0.5	-1.2	-0.1
Number of incorrect matches in round	0.7	1.2	4.3	0.7	-2.1	-0.9	-0.1	-0.7
Past tobacco smoking	0.9	1.7	4.6	2.1	1.0	-0.3	1.3	-1.0
Alcohol usually taken with meals	0.3	0.5	1.1	1.0	0.3	0.5	-0.7	0.7
Nervous feelings	1.1	2.1	4.3	-1.1	-2.1	-1.4	1.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	2.3	0.8	-1.5	-0.2	-1.1	1.0
Hearing difficulty/problems with background noise	1.8	2.8	5.6	-2.1	-2.4	-0.9	-1.8	-0.0
Hair/balding pattern: Pattern 2	1.4	1.7	3.3	-1.8	-0.5	1.0	0.8	1.8
Had menopause	1.1	1.4	5.1	-2.2	0.1	-0.6	0.4	1.1
Had other major operations	0.6	0.8	2.3	0.9	0.1	-1.5	-0.3	-0.8
Forced vital capacity (FVC)	0.1	0.4	1.2	0.2	0.4	1.1	-0.6	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	3.5	0.5	-1.9	-0.8	0.9	0.9
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.2	0.0	0.1	-0.9	-1.1	-0.2
Qualifications: None of the above	0.6	1.3	5.5	-0.2	0.1	-0.9	2.4	0.5
Financial difficulties in last 2 years	0.2	0.3	1.4	-1.2	0.2	0.1	-0.4	0.3
Mouth/teeth dental problems	0.2	0.4	1.1	-0.1	-0.5	-0.3	1.0	-0.6
Heart attack	0.2	0.3	1.1	0.1	1.0	-0.5	-0.1	0.2
Allergy	0.1	0.3	1.0	-0.1	-0.6	0.1	0.4	-1.0
Pain all over the body in last month	1.4	1.5	3.8	0.2	-1.4	-1.9	1.1	-0.5
Diabetes (self-reported)	0.5	0.7	1.5	0.8	-1.0	1.2	-0.6	-0.1
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	1.9	0.0	1.4	0.7	0.9	0.0
Medication: Ramipril	0.7	0.9	2.0	-1.1	0.0	-1.4	1.0	-0.2
Medication: Simvastatin	0.6	0.9	1.3	-1.1	1.1	1.1	0.6	0.9
Fluid intelligence score	1.0	2.1	7.0	0.5	-0.2	2.6	-0.9	1.5
Illnesses of siblings	0.6	0.9	2.7	-0.6	0.2	0.3	-1.1	1.6
Neuroticism score	0.5	1.0	2.4	0.8	-0.3	-1.6	-1.2	-0.8
Weight	0.2	1.0	2.1	-0.7	-0.4	1.5	-0.9	1.2
Impedance of arm (right)	0.4	1.9	5.1	0.5	2.3	-1.8	-0.0	-1.1
Arm fat percentage (right)	0.1	0.5	1.1	-0.5	1.0	0.8	-0.3	-0.7
Trunk fat-free mass	0.5	2.9	6.0	-1.0	-1.4	2.2	-0.8	2.5
Hip circumference	0.1	0.5	1.4	-1.2	0.3	0.8	-0.4	0.3
Time employed in main current job	0.6	0.7	1.5	0.4	0.7	1.2	0.8	-0.8
Alcohol intake versus 10 years previously	1.5	2.3	5.4	-1.1	-0.9	-1.8	0.8	-2.3
Father’s age at death	0.5	0.7	1.7	0.3	0.7	-1.0	-1.3	-0.2
Worrier / anxious feelings	0.1	0.3	1.0	0.0	1.0	0.1	-0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	5.8	0.0	-1.3	-1.3	-1.5	-2.4
Falls in the last year	0.9	1.2	2.7	0.9	0.0	-1.6	-1.3	-1.0
Hair/balding pattern: Pattern 3	1.2	1.7	3.6	-0.8	-1.1	-1.3	-1.3	-1.9
Number of live births	0.4	0.6	1.5	1.2	-0.4	0.1	1.0	0.7
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	3.2	0.4	-0.2	1.2	-0.8	1.8
Pulse rate	0.7	1.1	3.6	0.4	-1.1	-0.2	0.8	-1.9
Happiness	0.8	1.0	2.6	-1.6	0.7	-0.6	-1.0	0.8
Noisy workplace	1.2	1.5	3.0	-1.7	-0.8	-0.4	0.8	-1.7
Qualifications: A levels/AS levels or equivalent	1.4	3.1	8.1	1.8	1.0	1.6	-2.9	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	1.0	0.3	-1.0	0.9	-0.3	-0.2
Mouth/teeth dental problems: Dentures	0.2	0.3	0.7	-0.7	0.1	-0.3	0.4	-0.8
Asthma	0.5	1.0	3.5	0.6	-0.1	-1.0	-1.9	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.3	0.3	1.1	0.0	0.7	1.1	-0.0	0.1
Medication: Cholesterol lowering	0.9	1.4	2.3	-1.5	-0.1	1.4	1.1	1.2
Depression (self-reported)	0.4	0.5	0.7	0.7	0.8	0.8	-0.1	0.8
Medication: Lansoprazole	0.9	1.0	3.8	1.9	0.1	1.0	-0.6	-0.1
Prospective memory result	1.1	1.4	3.8	-1.0	-0.7	-2.0	0.5	-1.0
Lung cancer (father)	0.5	0.6	2.2	1.5	0.1	-0.7	0.4	-0.4
Illnesses of mother	1.3	1.6	3.1	-1.1	1.7	1.8	0.2	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.2	4.1	0.2	0.0	1.3	0.3	2.0
Pulse wave Arterial Stiffness index	0.5	0.6	2.1	-1.4	0.3	0.6	-0.5	0.4
Impedance of arm (left)	0.5	2.3	4.5	0.9	2.1	-1.9	-0.5	-1.5
Arm fat mass (right)	0.2	0.7	2.2	-0.6	0.5	1.5	-0.6	0.5
Trunk predicted mass	0.5	2.9	5.8	-1.0	-1.4	2.3	-0.8	2.4
Standing height	0.2	1.9	6.9	-0.6	-0.2	0.5	-1.4	2.6
Length of working week for main job	0.6	0.7	2.1	-1.5	0.4	-0.6	-0.8	-0.1
Exposure to tobacco smoke at home	1.6	1.8	4.5	-0.9	-1.3	-1.2	0.8	2.1
Breastfed as a baby	2.2	2.7	4.4	1.3	2.1	1.5	-1.0	2.0
Tense / ‘highly strung’	2.5	4.1	14.1	-1.2	-3.7	-1.2	0.6	1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	-0.3	-1.2	-1.2	0.2	-0.2
Hair/balding pattern: Pattern 4	0.2	0.4	0.6	0.6	0.6	0.7	0.8	0.7
Birth weight of first child	0.4	0.7	1.7	0.5	-1.3	0.6	0.8	-0.7
Peak expiratory flow (PEF)	0.4	1.0	2.5	0.8	0.2	0.8	-0.9	1.6
Pulse wave reflection index	2.0	2.4	6.0	-2.5	1.0	0.4	-0.3	2.2
Ever highly irritable/argumentative for 2 days	0.8	0.9	3.2	-0.6	-0.2	-0.5	-0.9	1.8
Loud music exposure frequency	1.8	2.0	5.6	-0.9	-2.4	-1.6	0.3	1.0
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.4	0.9	1.3	2.1	-2.0	0.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	2.8	-0.3	1.7	0.4	-0.8	-0.7
Blood clot in the leg (DVT)	1.1	1.4	2.7	0.9	0.6	1.6	1.5	1.1
Medication: Paracetamol	0.4	0.6	2.1	-0.0	-0.3	1.4	0.9	-0.2
Headache pain in last month	1.2	2.0	8.1	-0.3	-2.8	-0.4	-1.1	-0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	2.4	0.7	1.6	-0.4	-0.4	0.1
Glaucoma (self-reported)	2.2	2.6	8.5	0.3	2.9	0.8	-1.6	0.9
Gout (self-reported)	0.6	0.9	2.0	-0.4	-0.6	-0.8	-1.0	-1.4
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	0.2	-1.2	-0.6	1.0	-1.6
Medication: Amlodipine	0.7	0.9	1.9	-1.4	-1.1	-1.2	0.0	-0.1
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.9	-0.4	0.0	0.4	-1.0	0.8
Birth weight	0.4	0.9	2.6	-0.1	-1.2	0.7	-0.3	1.6
Chronic bronchitis/emphysema (mother)	0.6	0.7	2.3	-0.6	1.5	0.6	0.5	-0.5
High blood pressure (siblings)	0.4	0.6	2.1	-1.0	-1.4	-0.1	0.3	-0.1
Forced vital capacity (FVC), Best measure	0.1	0.5	1.2	0.1	1.1	0.8	0.8	0.5
Body fat percentage	0.2	0.7	1.8	0.1	1.3	1.1	-0.4	-0.4
Leg fat percentage (right)	0.1	0.4	1.3	0.3	0.4	1.1	0.5	-0.1
Arm fat-free mass (right)	0.6	2.9	6.7	-0.1	-0.9	2.6	-0.9	2.5
Exposure to tobacco smoke outside home	0.1	0.2	0.5	-0.1	0.7	-0.4	0.4	-0.3
Comparative body size at age 10	0.4	1.2	5.2	0.3	2.3	0.1	-0.6	-0.7
Number of full brothers	0.2	0.3	1.0	-0.2	-0.1	0.5	-1.0	-0.3
Worry too long after embarrassment	0.6	1.0	3.4	1.1	0.5	-0.1	-1.8	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.0	2.6	7.9	0.2	-2.8	-0.5	0.4	2.1
Wheeze or whistling in the chest in last year	0.6	1.0	2.7	0.7	-1.6	-1.1	-0.0	-0.8
Number of children fathered	0.8	0.9	4.2	-0.3	0.2	2.0	0.4	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	1.4	1.7	4.3	0.5	-1.1	-1.4	-2.1	-0.8
Age at first live birth	1.4	2.5	4.9	1.6	-1.8	-0.3	-1.2	2.2
Pulse wave peak to peak time	0.4	0.5	1.9	1.4	-0.4	-0.3	0.4	0.0
Health satisfaction	0.3	0.4	1.1	0.4	-0.4	-0.7	-1.0	0.5
Shortness of breath walking on level ground	1.2	1.4	4.0	-0.9	-2.0	-1.4	-0.8	-0.1
Qualifications: College or University degree	1.2	3.7	12.4	0.9	0.7	0.5	-3.5	2.2
Eye problems/disorders: None of the above	1.9	2.2	3.4	-1.7	-0.8	-1.7	1.9	-1.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.5	1.0	0.9	0.6	-1.2	-0.5
Emphysema/chronic bronchitis	0.3	0.3	1.4	-0.1	0.0	-1.2	-0.5	-0.2
Medication for pain relief, constipation, heartburn	0.9	1.5	6.3	0.0	-0.4	-2.5	-0.9	-0.4
Neck or shoulder pain in last month	0.5	0.7	2.9	0.2	-0.2	0.3	-0.8	1.7
Medication: Blood pressure	0.5	0.9	4.3	0.2	-2.1	0.1	-0.0	-0.5
Angina (self-reported)	1.0	1.4	4.6	-0.3	0.4	1.2	-2.1	0.7
Migraine (self-reported)	0.8	1.0	3.3	-0.1	0.7	1.8	0.1	1.1
Medication: Ibuprofen	0.4	0.5	1.8	0.1	0.4	1.4	0.5	0.5
Medication: Allopurinol	0.5	0.6	2.0	0.1	0.8	-0.4	-0.7	-1.4
Medication: Omeprazole	1.4	1.6	3.9	-2.0	-0.8	-0.8	1.6	-0.7
Medication: Seretide 50 evohaler	1.0	1.1	3.0	1.4	-0.7	0.1	-0.1	1.7
Mean time to correctly identify matches	0.3	0.6	1.5	0.6	-0.6	-1.2	-0.0	-0.9
Heart disease (mother)	1.5	1.8	4.5	0.2	-2.1	-1.4	-0.1	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.0	-0.0	-0.1	-1.4	1.4	-0.3
Whole body fat mass	0.1	0.6	2.1	-0.3	0.6	1.4	-0.6	0.3
Leg fat mass (right)	0.1	0.3	1.3	-0.3	0.1	1.1	0.1	0.5
Arm predicted mass (right)	0.5	2.7	5.7	-0.2	-1.2	2.4	-0.8	2.3
Pulse rate, automated reading	0.3	1.0	1.5	1.1	0.7	1.2	0.4	-1.2
Alcohol intake frequency.	0.3	0.7	1.6	1.1	0.1	-0.9	1.2	-0.5
Comparative height size at age 10	0.4	2.1	4.7	-1.1	-0.5	-2.2	-0.2	2.0
Number of full sisters	1.1	1.3	2.7	0.3	-0.3	-1.5	1.6	-1.2
Suffer from ‘nerves’	0.9	1.5	5.7	-0.5	-2.4	-1.0	0.3	-0.6
Overall health rating	0.6	1.2	3.0	-0.6	-1.7	-1.6	-0.3	-0.2
Chest pain or discomfort	1.1	1.6	4.2	0.4	-0.1	1.6	-2.1	0.9
Had major operations	0.9	1.0	4.3	-2.1	-0.1	0.0	-0.3	0.8
Age at last live birth	0.9	1.3	3.6	1.9	-0.2	-0.1	-1.2	1.2
Family relationship satisfaction	1.6	2.0	9.4	-0.7	-0.1	0.3	-3.1	-0.3
Leg pain on walking	0.9	1.1	2.6	0.4	1.5	0.1	-1.6	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.0	2.1	-1.1	-0.3	-1.1	-0.8	-1.4
Commuting to job workplace: Car/motor vehicle	2.7	3.1	11.3	-0.1	-3.4	-0.2	-1.2	1.6
Illness, injury, bereavement, stress in last 2 years	1.1	1.3	3.2	0.6	-1.6	0.0	0.6	1.8
Medication: Aspirin	0.4	0.6	2.6	0.1	0.1	1.6	0.1	0.4
Supplements: Vitamin C	0.6	0.7	2.0	-0.5	1.4	0.6	0.3	0.8
Knee pain experienced in last month	0.5	0.7	2.1	-1.0	-0.1	0.0	0.7	1.4
Hypertension (Self-reported)	0.5	1.3	3.7	0.7	-1.3	-0.0	0.8	-1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	1.0	2.5	-1.4	0.3	-0.7	1.6	-0.0
Illnesses of father: Heart disease	1.2	1.7	3.6	1.3	-0.1	-0.8	-1.6	-1.9
Illnesses of siblings: Diabetes	1.7	2.1	5.5	1.0	-0.0	-1.8	0.8	-2.4
Smoking status: Previous	1.1	1.7	3.2	-1.8	-0.2	1.0	-1.4	1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	4.6	0.7	-0.5	0.9	0.1	2.1
Whole body fat-free mass	0.5	2.6	5.4	-0.7	-1.0	2.2	-1.1	2.3
Leg fat-free mass (right)	0.3	1.7	3.3	-0.3	-0.4	1.8	-1.5	1.6
Arm fat percentage (left)	0.1	0.5	1.0	-0.1	0.9	1.0	-0.6	-0.5
Average weekly red wine intake	0.3	0.4	1.0	1.0	-0.9	0.3	0.0	0.1
Handedness (chirality/laterality): Left-handed	0.6	0.8	2.2	-1.5	-0.3	-0.6	1.1	-0.2
Mood swings	0.7	1.2	2.0	1.0	0.9	-0.8	-1.4	-1.3
Loneliness, isolation	1.0	1.3	3.2	0.1	-0.1	-1.0	-1.8	-1.5
Long-standing illness, disability or infirmity	1.2	1.8	6.0	-0.9	-0.9	-1.2	0.1	-2.4
Ever had bowel cancer screening	0.4	0.5	1.0	0.1	0.7	-0.6	-1.0	0.9
Diabetes diagnosed by doctor	0.6	1.0	1.6	0.7	-1.3	1.1	-1.0	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.8	0.2	-2.0	-1.1	1.4	1.1
Friendships satisfaction	1.5	1.9	4.6	-0.3	-2.0	-0.9	-2.2	-0.1
Qualifications: nursing, teaching	1.5	2.3	8.9	1.1	-0.3	0.7	-3.0	0.8
Commuting to job workplace: Walk	1.9	2.0	7.1	0.3	2.7	1.0	1.3	0.4
Eye problems/disorders: Cataract	2.5	2.9	6.4	1.1	0.8	2.5	-1.3	2.1
Mouth/teeth dental problems: Mouth ulcers	0.7	1.2	2.8	1.7	1.1	0.1	-1.0	0.8
Medication for cholesterol	0.2	0.4	0.9	-0.7	0.5	1.0	-0.4	0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.4	1.6	3.5	-0.3	-1.5	-1.9	-1.4	-0.1
Back pain experienced in last month	0.4	0.5	1.4	-0.6	-0.4	0.0	-0.9	1.2
Mineral and other dietary supplements	0.6	0.8	1.3	0.6	-1.1	-1.1	0.7	-0.9
Breast cancer (self-reported)	0.1	0.2	0.5	0.7	-0.3	-0.0	0.2	-0.4
Asthma (self-reported)	0.7	1.4	4.8	0.9	-0.0	-1.1	-2.2	0.1
Osteoporosis (self-reported)	0.3	0.3	1.1	0.1	0.4	-1.0	0.7	-0.1
Osteoarthritis (self-reported)	1.3	1.7	6.2	0.3	2.5	0.7	1.3	0.1
Medication: Aspirin	0.4	0.5	1.6	0.7	-0.1	1.3	-0.1	0.4
Medication: Gliclazide	0.7	0.8	2.7	0.7	1.0	0.1	-0.2	-1.6
Illnesses of father: None of the above (group 1)	1.9	2.4	6.2	0.1	0.5	1.0	2.1	2.5
Smoking status: Current	0.3	0.5	1.3	-0.4	0.7	1.2	0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	6.1	2.5	0.4	1.2	0.1	0.9
Whole body water mass	0.4	2.5	5.1	-0.7	-0.9	2.2	-1.1	2.3
Leg predicted mass (right)	0.3	1.6	3.3	-0.3	-0.3	1.8	-1.4	1.7
Arm fat mass (left)	0.1	0.5	1.7	-0.3	0.3	1.3	-0.8	0.4
Number of self-reported non-cancer illnesses	0.4	0.7	3.2	0.3	-0.5	0.3	-0.3	-1.8
Average weekly champagne plus white wine intake	0.8	1.2	3.2	0.6	-1.8	0.4	-0.9	1.1
Miserableness	0.3	0.5	1.0	-0.2	1.0	-1.0	0.2	-0.6
Guilty feelings	1.2	1.9	4.8	1.2	1.0	-0.9	-1.2	-2.2
Wears glasses or contact lenses	0.1	0.1	0.2	-0.3	0.3	-0.4	-0.4	0.2
Ever taken oral contraceptive pill	0.3	0.4	0.8	0.4	-0.7	0.1	0.9	0.7
Hearing aid user	0.6	0.7	2.1	-0.7	-0.5	-0.7	-1.4	-0.4
Mother’s age at death	2.4	3.0	5.4	2.0	1.8	0.6	-2.3	1.4
Financial situation satisfaction	2.9	3.6	12.3	-0.3	1.1	1.8	-1.0	3.5
Tinnitus: Yes, now most or all of the time	2.1	2.4	5.0	-0.6	2.2	0.8	-1.3	2.1
Commuting to job workplace: Public transport	5.2	6.2	30.2	0.7	5.5	0.3	-0.2	-0.5
Eye problems/disorders: Glaucoma	1.0	1.2	4.4	0.5	2.1	-0.2	-1.1	0.1
Medication: Blood pressure	0.4	0.8	2.3	0.3	0.3	-0.9	1.5	-0.7
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.9	-1.7	1.4	-0.3	0.9	-0.4
Supplements: Fish oil (including cod liver oil)	2.1	2.7	6.7	0.3	2.4	2.6	0.0	0.8
High cholesterol (Self-reported)	0.2	0.3	0.6	0.4	0.3	0.8	0.2	0.7
Medication: Bendroflumethiazide	0.7	1.1	2.7	-0.7	-1.1	0.3	1.6	-0.9
Medication: Paracetamol	0.4	0.6	1.1	-1.1	-0.4	0.9	0.9	-0.4
Medication: Lisinopril	0.6	0.7	3.1	-0.5	-0.1	-0.4	1.8	-0.3
Medication: Atorvastatin	0.5	0.6	1.9	1.4	-0.6	-0.5	0.8	-0.1
Illnesses of father: High blood pressure	1.1	1.4	2.8	-0.5	-1.0	0.5	-1.7	-1.6
Alcohol drinker status: Never	0.7	0.9	3.2	1.8	-0.1	0.6	0.9	-0.3
Ever smoked	0.8	1.4	4.3	-2.1	-1.3	0.2	-0.3	1.0
Basal metabolic rate	0.4	2.2	4.3	-0.7	-0.8	2.1	-1.2	2.0
Leg fat percentage (left)	0.1	0.5	2.2	0.1	0.5	1.5	0.4	-0.1
Arm fat-free mass (left)	0.5	2.6	5.9	-0.8	-1.1	2.4	-0.5	2.2
Number of operations (self-reported)	0.4	0.7	1.9	-0.0	-0.8	0.8	-1.4	-0.3
Average weekly beer plus cider intake	1.1	1.5	3.9	-1.4	2.0	0.5	1.2	0.5
Irritability	1.2	2.0	5.2	0.4	-1.3	1.2	-2.3	1.2
Risk taking	1.1	1.6	5.4	-0.4	-0.8	-0.1	-1.4	2.3
Ever had prostate specific antigen (PSA) test	0.5	0.5	1.1	-0.5	1.0	-0.5	-1.1	-0.5
Fractured/broken bones in last 5 years	0.4	0.5	1.1	0.2	1.0	0.8	0.1	1.0
Age started oral contraceptive pill	0.2	0.2	0.5	-0.7	0.5	-0.2	-0.1	0.4
Diastolic blood pressure, automated reading	0.1	0.2	0.5	0.7	0.4	-0.3	0.2	-0.7
Ever depressed for a whole week	0.3	0.4	1.0	0.1	0.5	0.1	-1.0	0.9
Unable to work because of sickness or disability	0.5	0.6	1.0	-1.0	-0.9	-1.0	0.1	-0.5
Commuting to job workplace: Cycle	0.9	1.1	2.1	-1.0	-0.6	-0.8	1.4	-1.1
Myopia	0.9	1.2	2.7	-1.6	0.0	-1.6	-0.8	0.6
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.4	-0.3	1.0	0.3	-0.5	1.5
Cholesterol lowering medication	0.5	0.8	3.3	1.8	0.7	-0.2	-0.0	-0.3
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	5.0	-2.2	-0.0	-0.9	1.6	-0.4
Pain experienced in last month	0.5	0.9	1.5	1.2	1.1	0.2	-0.5	-1.1
Supplements: Calcium	0.9	0.9	1.8	0.3	-1.3	-0.3	-1.0	-1.3
Basal cell carcinoma (self-reported)	0.2	0.3	0.6	0.2	-0.2	-0.8	0.6	0.4
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.9	0.1	1.0	-0.3	-0.1	0.4
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.3	0.6	0.6	1.5	0.9	1.1
Heart disease (siblings)	1.0	1.2	3.3	0.7	1.8	1.5	0.1	0.3
Alcohol drinker status: Previous	0.8	0.9	2.4	1.2	0.7	-1.6	-0.2	0.2
Pack years of smoking	0.6	0.9	1.9	-0.9	-1.4	-0.1	0.9	-1.0
Impedance of whole body	0.3	1.5	3.2	0.8	1.8	-1.4	0.2	-1.4
Leg fat mass (left)	0.1	0.5	2.2	-0.4	0.1	1.5	0.1	0.6
Arm predicted mass (left)	0.5	2.5	5.9	-0.5	-0.8	2.4	-0.8	2.3