Hub : Traits :

Mean Putamen Volume

6 significantly associated models · 4 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 11 82478824 86036955 2 1 3.6e-08 2.9e-08 1.0e+00 100 AP003026.1
2 14 55781054 56293564 1 1 2.4e-09 5.6e-24 6.6e-17 32 C14orf33
3 20 29833609 30922399 1 1 8.1e-08 2.4e-09 1.0e+00 100 COX4I2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 2.64 1 0 0.0 0 1 AP003026.1
Depressed Affect (Nagel 2018) 3.93 1 0 0.0 0 1 AP003026.1
Depression (Nagel 2018) 3.73 1 0 0.0 0 1 AP003026.1
Neuroticism (Nagel 2018) 1.99 1 0 0.0 0 1 AP003026.1
Schizophrenia (2018) 5.01 2 0 0.0 0 1 AP003026.1 C14orf33
Schizophrenia vs Biploar Disorder 2.78 1 0 0.0 0 1 C14orf33
Reaction Time 1.73 1 0 0.0 0 1 AP003026.1
Prostate Cancer 2.30 1 0 0.0 0 1 C14orf33
Bipolar Disorder (2011) 3.12 1 0 0.0 0 1 AP003026.1
Neuroticism (2016) 2.33 1 0 0.0 0 1 C14orf33
Rheumatoid Arthritis 3.83 1 0 0.0 0 1 C14orf33
Schizophrenia (2014) 2.09 1 0 0.0 0 1 AP003026.1
Type 2 Diabetes (T2D) (2012) 2.37 1 0 0.0 0 1 AP003026.1
Blood Eosinophil Count 1.03 1 0 0.0 0 1 COX4I2
Blood Platelet Count 6.61 3 1 2.2 0 1 AP003026.1 C14orf33 COX4I2
Blood Red Count 2.78 1 1 2.2 0 1 COX4I2
Blood White Count 0.57 1 0 0.0 0 1 AP003026.1
Heel T-Score 1.40 2 0 0.0 0 1 AP003026.1 COX4I2
Height 1.01 2 1 2.2 0 1 C14orf33 COX4I2
Systolic Blood Pressure 1.03 1 0 0.0 0 1 COX4I2
Smoking Status 1.45 1 0 0.0 0 1 COX4I2
Cardiovascular Disease 2.24 1 0 0.0 0 1 COX4I2
Respiratory disease 2.66 1 0 0.0 0 1 COX4I2
Lung FVC 3.57 1 1 2.2 0 1 COX4I2
Neuroticism 3.07 1 0 0.0 0 1 AP003026.1
Hair Pigment 0.45 1 1 2.2 0 1 COX4I2
Tanning 0.46 1 0 0.0 0 1 C14orf33
Frequency of depressed mood in last 2 weeks 2.26 1 0 0.0 0 1 AP003026.1
Hearing difficulty/problems: Yes 1.88 1 0 0.0 0 1 COX4I2
Ever used hormone-replacement therapy (HRT) 2.31 1 0 0.0 0 1 COX4I2
Fed-up feelings 3.60 1 0 0.0 0 1 AP003026.1
Taking other prescription medications 2.84 1 0 0.0 0 1 AP003026.1
High blood pressure 2.58 1 0 0.0 0 1 COX4I2
Sitting height 4.19 1 1 2.2 0 1 COX4I2
High blood pressure (mother) 4.43 1 0 0.0 0 1 C14orf33
Number of incorrect matches in round 3.43 1 0 0.0 0 1 AP003026.1
Frequency of tenseness / restlessness in last 2 weeks 1.87 1 0 0.0 0 1 AP003026.1
Illnesses of siblings 2.20 1 0 0.0 0 1 AP003026.1
Neuroticism score 2.58 1 0 0.0 0 1 AP003026.1
Worrier / anxious feelings 1.80 1 0 0.0 0 1 AP003026.1
Falls in the last year 4.03 1 0 0.0 0 1 C14orf33
Hair/balding pattern: Pattern 3 2.26 1 0 0.0 0 1 C14orf33
Noisy workplace 3.37 1 0 0.0 0 1 C14orf33
Mouth/teeth dental problems: Dentures 2.18 1 0 0.0 0 1 COX4I2
Asthma 2.34 1 0 0.0 0 1 COX4I2
Impedance of arm (left) 0.65 1 0 0.0 0 1 C14orf33
Standing height 1.22 1 1 2.2 0 1 COX4I2
Birth weight of first child 1.83 1 0 0.0 0 1 AP003026.1
Medication: Paracetamol 2.44 1 0 0.0 0 1 COX4I2
Gout (self-reported) 3.08 1 0 0.0 0 1 COX4I2
Medication: Ventolin 100micrograms inhaler 2.51 1 0 0.0 0 1 COX4I2
Wheeze or whistling in the chest in last year 3.40 1 0 0.0 0 1 AP003026.1
Health satisfaction 4.09 1 0 0.0 0 1 AP003026.1
Shortness of breath walking on level ground 2.74 1 0 0.0 0 1 AP003026.1
Emphysema/chronic bronchitis 3.62 1 0 0.0 0 1 C14orf33
Medication for pain relief, constipation, heartburn 2.12 1 0 0.0 0 1 COX4I2
Medication: Blood pressure 2.86 1 0 0.0 0 1 COX4I2
Medication: Omeprazole 3.06 1 0 0.0 0 1 AP003026.1
Overall health rating 3.33 1 0 0.0 0 1 AP003026.1
Commuting to job workplace: Car/motor vehicle 3.44 1 0 0.0 0 1 COX4I2
Hypertension (Self-reported) 2.62 1 0 0.0 0 1 COX4I2
Mood swings 2.58 1 0 0.0 0 1 AP003026.1
Loneliness, isolation 4.34 2 0 0.0 0 1 AP003026.1 COX4I2
Long-standing illness, disability or infirmity 6.79 1 1 2.2 0 1 AP003026.1
Back pain experienced in last month 3.43 1 0 0.0 0 1 COX4I2
Asthma (self-reported) 2.29 1 0 0.0 0 1 COX4I2
Medication: Gliclazide 2.36 1 0 0.0 0 1 COX4I2
Illnesses of father: None of the above (group 1) 5.54 2 0 0.0 0 1 AP003026.1 COX4I2
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.23 1 0 0.0 0 1 COX4I2
Number of self-reported non-cancer illnesses 1.55 1 0 0.0 0 1 AP003026.1
Mother's age at death 5.18 2 0 0.0 0 1 AP003026.1 C14orf33
Commuting to job workplace: Public transport 6.82 1 0 0.0 0 1 COX4I2
Pain type(s) experienced in last month: Hip pain 2.50 1 0 0.0 0 1 AP003026.1
High cholesterol (Self-reported) 1.76 1 0 0.0 0 1 COX4I2
Diastolic blood pressure, automated reading 2.28 2 0 0.0 0 1 AP003026.1 COX4I2
Unable to work because of sickness or disability 3.76 1 0 0.0 0 1 AP003026.1
Vascular/heart problems diagnosed by doctor 2.69 2 0 0.0 0 1 AP003026.1 COX4I2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.1
GTEx Artery Coronary 0 0.000 1.1
GTEx Artery Tibial 0 0.000 1.1
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.1
GTEx Brain Frontal Cortex BA9 0 0.000 1.1
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 1 0.116 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.1
GTEx Breast Mammary Tissue 0 0.000 1.3
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 1 0.066 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.1
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 2 0.055 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.3
GTEx Testis 0 0.000 1.1
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.1
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.1
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 1 0.062 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.060 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1