Hub : Traits :

Mean Putamen Volume

6 significantly associated models · 4 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	11	82478824	86036955	2	1	3.6e-08	2.9e-08	1.0e+00	100	AP003026.1
2	14	55781054	56293564	1	1	2.4e-09	5.6e-24	6.6e-17	32	C14orf33
3	20	29833609	30922399	1	1	8.1e-08	2.4e-09	1.0e+00	100	COX4I2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Commuting to job workplace: Public transport	6.82	1	0	0.0	1	COX4I2
Long-standing illness, disability or infirmity	6.79	1	1	2.2	1	AP003026.1
Blood Platelet Count	6.61	3	1	2.2	1	AP003026.1 C14orf33 COX4I2
Illnesses of father: None of the above (group 1)	5.54	2	0	0.0	1	AP003026.1 COX4I2
Mother's age at death	5.18	2	0	0.0	1	AP003026.1 C14orf33
Schizophrenia (2018)	5.01	2	0	0.0	1	AP003026.1 C14orf33
High blood pressure (mother)	4.43	1	0	0.0	1	C14orf33
Loneliness, isolation	4.34	2	0	0.0	1	AP003026.1 COX4I2
Sitting height	4.19	1	1	2.2	1	COX4I2
Health satisfaction	4.09	1	0	0.0	1	AP003026.1
Falls in the last year	4.03	1	0	0.0	1	C14orf33
Depressed Affect (Nagel 2018)	3.93	1	0	0.0	1	AP003026.1
Rheumatoid Arthritis	3.83	1	0	0.0	1	C14orf33
Unable to work because of sickness or disability	3.76	1	0	0.0	1	AP003026.1
Depression (Nagel 2018)	3.73	1	0	0.0	1	AP003026.1
Emphysema/chronic bronchitis	3.62	1	0	0.0	1	C14orf33
Fed-up feelings	3.60	1	0	0.0	1	AP003026.1
Lung FVC	3.57	1	1	2.2	1	COX4I2
Commuting to job workplace: Car/motor vehicle	3.44	1	0	0.0	1	COX4I2
Number of incorrect matches in round	3.43	1	0	0.0	1	AP003026.1
Back pain experienced in last month	3.43	1	0	0.0	1	COX4I2
Wheeze or whistling in the chest in last year	3.40	1	0	0.0	1	AP003026.1
Noisy workplace	3.37	1	0	0.0	1	C14orf33
Overall health rating	3.33	1	0	0.0	1	AP003026.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.23	1	0	0.0	1	COX4I2
Bipolar Disorder (2011)	3.12	1	0	0.0	1	AP003026.1
Gout (self-reported)	3.08	1	0	0.0	1	COX4I2
Neuroticism	3.07	1	0	0.0	1	AP003026.1
Medication: Omeprazole	3.06	1	0	0.0	1	AP003026.1
Medication: Blood pressure	2.86	1	0	0.0	1	COX4I2
Taking other prescription medications	2.84	1	0	0.0	1	AP003026.1
Schizophrenia vs Biploar Disorder	2.78	1	0	0.0	1	C14orf33
Blood Red Count	2.78	1	1	2.2	1	COX4I2
Shortness of breath walking on level ground	2.74	1	0	0.0	1	AP003026.1
Vascular/heart problems diagnosed by doctor	2.69	2	0	0.0	1	AP003026.1 COX4I2
Respiratory disease	2.66	1	0	0.0	1	COX4I2
Bipolar Disorder or Schizophrenia	2.64	1	0	0.0	1	AP003026.1
Hypertension (Self-reported)	2.62	1	0	0.0	1	COX4I2
High blood pressure	2.58	1	0	0.0	1	COX4I2
Neuroticism score	2.58	1	0	0.0	1	AP003026.1
Mood swings	2.58	1	0	0.0	1	AP003026.1
Medication: Ventolin 100micrograms inhaler	2.51	1	0	0.0	1	COX4I2
Pain type(s) experienced in last month: Hip pain	2.50	1	0	0.0	1	AP003026.1
Medication: Paracetamol	2.44	1	0	0.0	1	COX4I2
Type 2 Diabetes (T2D) (2012)	2.37	1	0	0.0	1	AP003026.1
Medication: Gliclazide	2.36	1	0	0.0	1	COX4I2
Asthma	2.34	1	0	0.0	1	COX4I2
Neuroticism (2016)	2.33	1	0	0.0	1	C14orf33
Ever used hormone-replacement therapy (HRT)	2.31	1	0	0.0	1	COX4I2
Prostate Cancer	2.30	1	0	0.0	1	C14orf33
Asthma (self-reported)	2.29	1	0	0.0	1	COX4I2
Diastolic blood pressure, automated reading	2.28	2	0	0.0	1	AP003026.1 COX4I2
Frequency of depressed mood in last 2 weeks	2.26	1	0	0.0	1	AP003026.1
Hair/balding pattern: Pattern 3	2.26	1	0	0.0	1	C14orf33
Cardiovascular Disease	2.24	1	0	0.0	1	COX4I2
Illnesses of siblings	2.20	1	0	0.0	1	AP003026.1
Mouth/teeth dental problems: Dentures	2.18	1	0	0.0	1	COX4I2
Medication for pain relief, constipation, heartburn	2.12	1	0	0.0	1	COX4I2
Schizophrenia (2014)	2.09	1	0	0.0	1	AP003026.1
Neuroticism (Nagel 2018)	1.99	1	0	0.0	1	AP003026.1
Hearing difficulty/problems: Yes	1.88	1	0	0.0	1	COX4I2
Frequency of tenseness / restlessness in last 2 weeks	1.87	1	0	0.0	1	AP003026.1
Birth weight of first child	1.83	1	0	0.0	1	AP003026.1
Worrier / anxious feelings	1.80	1	0	0.0	1	AP003026.1
High cholesterol (Self-reported)	1.76	1	0	0.0	1	COX4I2
Reaction Time	1.73	1	0	0.0	1	AP003026.1
Number of self-reported non-cancer illnesses	1.55	1	0	0.0	1	AP003026.1
Smoking Status	1.45	1	0	0.0	1	COX4I2
Heel T-Score	1.40	2	0	0.0	1	AP003026.1 COX4I2
Standing height	1.22	1	1	2.2	1	COX4I2
Blood Eosinophil Count	1.03	1	0	0.0	1	COX4I2
Systolic Blood Pressure	1.03	1	0	0.0	1	COX4I2
Height	1.01	2	1	2.2	1	C14orf33 COX4I2
Impedance of arm (left)	0.65	1	0	0.0	1	C14orf33
Blood White Count	0.57	1	0	0.0	1	AP003026.1
Tanning	0.46	1	0	0.0	1	C14orf33
Hair Pigment	0.45	1	1	2.2	1	COX4I2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Nucleus accumbens basal ganglia	1	0.116	1.4
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Stomach	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	1	0.066	1.2
GTEx	Liver	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	2	0.055	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	1	0.062	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.060	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.1
GTEx	Artery Coronary	0	0.000	1.1
GTEx	Artery Tibial	0	0.000	1.1
GTEx	Brain Caudate basal ganglia	0	0.000	1.1
GTEx	Brain Cortex	0	0.000	1.1
GTEx	Brain Frontal Cortex BA9	0	0.000	1.1
GTEx	Brain Putamen basal ganglia	0	0.000	1.1
GTEx	Nerve Tibial	0	0.000	1.1
GTEx	Testis	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
NTR	Blood	0	0.000	1.1
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.1
YFS	Blood	0	0.000	1.1
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.1