Hub : Traits :

Medication: Gliclazide

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 185112300 185786406 1 1 1.1e-08 1.7e-09 5.1e-02 90 IGF2BP2
2 10 114018656 115622375 1 1 2.0e-16 1.0e-53 2.8e-41 24 TCF7L2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depression (Nagel 2018) 1.72 1 0 0.0 0 1 IGF2BP2
Crohns Disease (2017) 1.33 1 0 0.0 0 1 IGF2BP2
Verbal and Numeric Reasoning (VNR) 2.01 1 0 0.0 0 1 TCF7L2
Breast Cancer 12.79 2 1 2.2 0 1 IGF2BP2 TCF7L2
Body Mass Index (BMI) (2010) 5.32 1 0 0.0 0 1 TCF7L2
Fasting Glucose 8.13 2 0 0.0 0 1 IGF2BP2 TCF7L2
Primary Biliary Cirrhosis 2.82 1 0 0.0 0 1 IGF2BP2
Type 2 Diabetes (T2D) (2012) 28.78 2 2 4.4 0 1 IGF2BP2 TCF7L2
Blood Platelet Count 4.65 2 1 2.2 0 1 IGF2BP2 TCF7L2
Blood Red Count 1.51 2 0 0.0 0 1 IGF2BP2 TCF7L2
Blood White Count 0.74 1 0 0.0 0 1 IGF2BP2
Heel T-Score 3.38 2 1 2.2 0 1 IGF2BP2 TCF7L2
BMI 3.85 1 1 2.2 0 1 TCF7L2
Height 0.27 1 0 0.0 0 1 TCF7L2
Waist Hip Ratio (WHR) 11.94 2 2 4.4 0 1 IGF2BP2 TCF7L2
Systolic Blood Pressure 3.06 1 1 2.2 0 1 TCF7L2
Cardiovascular Disease 2.51 1 0 0.0 0 1 IGF2BP2
Hypothyroidism (self reported) 3.86 1 0 0.0 0 1 IGF2BP2
Type 2 Diabetes (T2D) (2018) 98.23 2 2 4.4 0 1 IGF2BP2 TCF7L2
Lung FEV1/FVC ratio 3.87 2 1 2.2 0 1 IGF2BP2 TCF7L2
Lung FVC 2.61 1 0 0.0 0 1 IGF2BP2
Chronotype (morning person) 2.96 2 0 0.0 0 1 IGF2BP2 TCF7L2
Number of treatments/medications taken 4.05 1 0 0.0 0 1 IGF2BP2
Ever used hormone-replacement therapy (HRT) 2.24 1 0 0.0 0 1 IGF2BP2
Ever had hysterectomy (womb removed) 2.87 1 0 0.0 0 1 IGF2BP2
Eye problems/disorders: Diabetes related eye disease 18.91 2 0 0.0 0 1 IGF2BP2 TCF7L2
Medication: Metformin 67.16 2 2 4.4 0 1 IGF2BP2 TCF7L2
Diabetes (father) 67.47 2 2 4.4 0 1 IGF2BP2 TCF7L2
Diabetes (mother) 49.37 2 2 4.4 0 1 IGF2BP2 TCF7L2
Impedance of leg (right) 1.48 1 0 0.0 0 1 TCF7L2
Leg fat-free mass (left) 1.18 1 0 0.0 0 1 TCF7L2
Trunk fat percentage 1.46 1 0 0.0 0 1 TCF7L2
Hand grip strength (right) 1.44 1 0 0.0 0 1 TCF7L2
Townsend deprivation index at recruitment 2.99 1 0 0.0 0 1 IGF2BP2
Taking other prescription medications 2.16 1 0 0.0 0 1 IGF2BP2
Bilateral oophorectomy (both ovaries removed) 2.96 1 0 0.0 0 1 IGF2BP2
Heel bone mineral density (BMD) T-score, automated (left) 2.71 1 0 0.0 0 1 TCF7L2
High blood pressure 2.14 1 0 0.0 0 1 IGF2BP2
Medication: Levothyroxine sodium 2.07 1 0 0.0 0 1 IGF2BP2
Sitting height 0.42 1 0 0.0 0 1 IGF2BP2
Body mass index (BMI) 4.01 1 1 2.2 0 1 TCF7L2
Impedance of leg (left) 1.29 2 0 0.0 0 1 IGF2BP2 TCF7L2
Leg predicted mass (left) 1.19 1 0 0.0 0 1 TCF7L2
Trunk fat mass 1.91 1 0 0.0 0 1 TCF7L2
Waist circumference 2.56 1 0 0.0 0 1 TCF7L2
Alcohol usually taken with meals 2.44 1 0 0.0 0 1 TCF7L2
Had other major operations 2.71 1 0 0.0 0 1 IGF2BP2
Forced vital capacity (FVC) 1.51 1 0 0.0 0 1 IGF2BP2
Heel bone mineral density (BMD) T-score, automated (right) 2.43 1 0 0.0 0 1 TCF7L2
Diabetes (self-reported) 77.30 2 2 4.4 0 1 IGF2BP2 TCF7L2
Medication: Ramipril 2.89 1 0 0.0 0 1 IGF2BP2
Medication: Simvastatin 8.43 2 0 0.0 0 1 IGF2BP2 TCF7L2
Illnesses of siblings 5.19 1 0 0.0 0 1 IGF2BP2
Weight 2.31 1 0 0.0 0 1 TCF7L2
Impedance of arm (right) 2.34 1 0 0.0 0 1 TCF7L2
Arm fat percentage (right) 2.69 1 0 0.0 0 1 TCF7L2
Trunk fat-free mass 0.54 1 0 0.0 0 1 TCF7L2
Hip circumference 7.54 1 1 2.2 0 1 TCF7L2
Worrier / anxious feelings 5.08 2 0 0.0 0 1 IGF2BP2 TCF7L2
Frequency of tiredness / lethargy in last 2 weeks 1.88 1 0 0.0 0 1 IGF2BP2
Falls in the last year 2.08 1 0 0.0 0 1 TCF7L2
Forced expiratory volume in 1-second (FEV1) 3.35 1 0 0.0 0 1 IGF2BP2
Medication: Cholesterol lowering 12.03 2 0 0.0 0 1 IGF2BP2 TCF7L2
Illnesses of mother 8.93 2 0 0.0 0 1 IGF2BP2 TCF7L2
Forced expiratory volume in 1-second (FEV1), Best measure 2.74 1 0 0.0 0 1 IGF2BP2
Pulse wave Arterial Stiffness index 2.70 1 0 0.0 0 1 IGF2BP2
Impedance of arm (left) 2.41 1 0 0.0 0 1 TCF7L2
Arm fat mass (right) 3.12 1 0 0.0 0 1 TCF7L2
Trunk predicted mass 0.58 1 0 0.0 0 1 TCF7L2
Standing height 0.31 1 0 0.0 0 1 TCF7L2
Birth weight of first child 5.02 2 0 0.0 0 1 IGF2BP2 TCF7L2
Peak expiratory flow (PEF) 5.65 1 0 0.0 0 1 IGF2BP2
Medication for cholesterol, blood pressure or diabetes 7.82 2 0 0.0 0 1 IGF2BP2 TCF7L2
Hypothyroidism/myxoedema (self-reported) 3.41 1 0 0.0 0 1 IGF2BP2
Birth weight 3.38 1 0 0.0 0 1 TCF7L2
High blood pressure (siblings) 3.20 1 0 0.0 0 1 IGF2BP2
Forced vital capacity (FVC), Best measure 0.82 1 0 0.0 0 1 IGF2BP2
Body fat percentage 2.68 1 0 0.0 0 1 TCF7L2
Leg fat percentage (right) 4.60 1 1 2.2 0 1 TCF7L2
Arm fat-free mass (right) 1.02 1 0 0.0 0 1 TCF7L2
Comparative body size at age 10 0.98 1 0 0.0 0 1 TCF7L2
Wheeze or whistling in the chest in last year 2.76 1 0 0.0 0 1 IGF2BP2
Pulse wave peak to peak time 2.29 1 0 0.0 0 1 IGF2BP2
Medication for pain relief, constipation, heartburn 3.53 1 0 0.0 0 1 IGF2BP2
Medication: Blood pressure 2.37 1 0 0.0 0 1 IGF2BP2
Reproduciblity of spirometry measurement using ERS/ATS criteria 5.04 1 0 0.0 0 1 TCF7L2
Whole body fat mass 2.93 1 0 0.0 0 1 TCF7L2
Leg fat mass (right) 4.28 1 1 2.2 0 1 TCF7L2
Arm predicted mass (right) 0.93 1 0 0.0 0 1 TCF7L2
Pulse rate, automated reading 1.73 1 0 0.0 0 1 TCF7L2
Overall health rating 2.86 1 0 0.0 0 1 IGF2BP2
Medication: Aspirin 9.65 2 0 0.0 0 1 IGF2BP2 TCF7L2
Hypertension (Self-reported) 2.10 1 0 0.0 0 1 IGF2BP2
Illnesses of siblings: Diabetes 32.09 2 2 4.4 0 1 IGF2BP2 TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted 1.72 1 0 0.0 0 1 TCF7L2
Whole body fat-free mass 0.86 1 0 0.0 0 1 TCF7L2
Leg fat-free mass (right) 1.05 1 0 0.0 0 1 TCF7L2
Arm fat percentage (left) 2.83 1 0 0.0 0 1 TCF7L2
Long-standing illness, disability or infirmity 7.88 2 0 0.0 0 1 IGF2BP2 TCF7L2
Diabetes diagnosed by doctor 87.39 2 2 4.4 0 1 IGF2BP2 TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination 5.01 1 0 0.0 0 1 TCF7L2
Qualifications: nursing, teaching 4.56 1 0 0.0 0 1 TCF7L2
Breast cancer (self-reported) 4.89 1 0 0.0 0 1 TCF7L2
Medication: Aspirin 11.27 2 0 0.0 0 1 IGF2BP2 TCF7L2
Illnesses of father: None of the above (group 1) 4.76 1 0 0.0 0 1 TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.83 1 0 0.0 0 1 IGF2BP2
Whole body water mass 0.86 1 0 0.0 0 1 TCF7L2
Leg predicted mass (right) 1.08 1 0 0.0 0 1 TCF7L2
Arm fat mass (left) 2.89 1 0 0.0 0 1 TCF7L2
Number of self-reported non-cancer illnesses 4.34 1 0 0.0 0 1 IGF2BP2
Average weekly champagne plus white wine intake 3.59 1 0 0.0 0 1 TCF7L2
High cholesterol (Self-reported) 3.53 1 0 0.0 0 1 TCF7L2
Medication: Atorvastatin 12.00 2 0 0.0 0 1 IGF2BP2 TCF7L2
Basal metabolic rate 1.20 1 0 0.0 0 1 TCF7L2
Leg fat percentage (left) 4.89 1 1 2.2 0 1 TCF7L2
Arm fat-free mass (left) 1.21 1 0 0.0 0 1 TCF7L2
Diastolic blood pressure, automated reading 2.03 1 0 0.0 0 1 TCF7L2
Unable to work because of sickness or disability 2.22 1 0 0.0 0 1 IGF2BP2
Myopia 2.71 1 0 0.0 0 1 TCF7L2
Vascular/heart problems diagnosed by doctor 2.79 1 0 0.0 0 1 IGF2BP2
Cholesterol lowering medication 9.69 2 0 0.0 0 1 IGF2BP2 TCF7L2
Heart attack/myocardial infarction (self-reported) 2.89 1 0 0.0 0 1 TCF7L2
Heart disease (siblings) 3.71 1 0 0.0 0 1 IGF2BP2
Impedance of whole body 1.88 1 0 0.0 0 1 TCF7L2
Leg fat mass (left) 4.43 1 1 2.2 0 1 TCF7L2
Arm predicted mass (left) 1.16 1 0 0.0 0 1 TCF7L2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.1
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 1 0.034 1.2
GTEx Artery Coronary 0 0.000 1.1
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 0 0.000 1.1
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.1
GTEx Brain Hippocampus 0 0.000 1.0
GTEx Brain Hypothalamus 0 0.000 1.0
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.0
GTEx Breast Mammary Tissue 0 0.000 1.1
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.1
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.1
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.1
GTEx Heart Left Ventricle 0 0.000 1.1
GTEx Liver 0 0.000 1.1
GTEx Lung 0 0.000 1.1
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.1
GTEx Ovary 0 0.000 1.1
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.1
GTEx Prostate 0 0.000 1.1
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.2
GTEx Spleen 0 0.000 1.1
GTEx Stomach 0 0.000 1.1
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.0
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.1
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.1
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.1
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.1
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.1
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.0
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2