Hub : Traits :

Medication: Gliclazide

2 significantly associated models · 2 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	3	185112300	185786406	1	1	1.1e-08	1.7e-09	5.1e-02	90	IGF2BP2
2	10	114018656	115622375	1	1	2.0e-16	1.0e-53	2.8e-41	24	TCF7L2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Type 2 Diabetes (T2D) (2018)	98.23	2	2	4.4	1	IGF2BP2 TCF7L2
Diabetes diagnosed by doctor	87.39	2	2	4.4	1	IGF2BP2 TCF7L2
Diabetes (self-reported)	77.30	2	2	4.4	1	IGF2BP2 TCF7L2
Diabetes (father)	67.47	2	2	4.4	1	IGF2BP2 TCF7L2
Medication: Metformin	67.16	2	2	4.4	1	IGF2BP2 TCF7L2
Diabetes (mother)	49.37	2	2	4.4	1	IGF2BP2 TCF7L2
Illnesses of siblings: Diabetes	32.09	2	2	4.4	1	IGF2BP2 TCF7L2
Type 2 Diabetes (T2D) (2012)	28.78	2	2	4.4	1	IGF2BP2 TCF7L2
Eye problems/disorders: Diabetes related eye disease	18.91	2	0	0.0	1	IGF2BP2 TCF7L2
Breast Cancer	12.79	2	1	2.2	1	IGF2BP2 TCF7L2
Medication: Cholesterol lowering	12.03	2	0	0.0	1	IGF2BP2 TCF7L2
Medication: Atorvastatin	12.00	2	0	0.0	1	IGF2BP2 TCF7L2
Waist Hip Ratio (WHR)	11.94	2	2	4.4	1	IGF2BP2 TCF7L2
Medication: Aspirin	11.27	2	0	0.0	1	IGF2BP2 TCF7L2
Cholesterol lowering medication	9.69	2	0	0.0	1	IGF2BP2 TCF7L2
Medication: Aspirin	9.65	2	0	0.0	1	IGF2BP2 TCF7L2
Illnesses of mother	8.93	2	0	0.0	1	IGF2BP2 TCF7L2
Medication: Simvastatin	8.43	2	0	0.0	1	IGF2BP2 TCF7L2
Fasting Glucose	8.13	2	0	0.0	1	IGF2BP2 TCF7L2
Long-standing illness, disability or infirmity	7.88	2	0	0.0	1	IGF2BP2 TCF7L2
Medication for cholesterol, blood pressure or diabetes	7.82	2	0	0.0	1	IGF2BP2 TCF7L2
Hip circumference	7.54	1	1	2.2	1	TCF7L2
Peak expiratory flow (PEF)	5.65	1	0	0.0	1	IGF2BP2
Body Mass Index (BMI) (2010)	5.32	1	0	0.0	1	TCF7L2
Illnesses of siblings	5.19	1	0	0.0	1	IGF2BP2
Worrier / anxious feelings	5.08	2	0	0.0	1	IGF2BP2 TCF7L2
Reproduciblity of spirometry measurement using ERS/ATS criteria	5.04	1	0	0.0	1	TCF7L2
Birth weight of first child	5.02	2	0	0.0	1	IGF2BP2 TCF7L2
Ever had stillbirth, spontaneous miscarriage or termination	5.01	1	0	0.0	1	TCF7L2
Breast cancer (self-reported)	4.89	1	0	0.0	1	TCF7L2
Leg fat percentage (left)	4.89	1	1	2.2	1	TCF7L2
Forced expiratory volume in 1-second (FEV1), predicted percentage	4.83	1	0	0.0	1	IGF2BP2
Illnesses of father: None of the above (group 1)	4.76	1	0	0.0	1	TCF7L2
Blood Platelet Count	4.65	2	1	2.2	1	IGF2BP2 TCF7L2
Leg fat percentage (right)	4.60	1	1	2.2	1	TCF7L2
Qualifications: nursing, teaching	4.56	1	0	0.0	1	TCF7L2
Leg fat mass (left)	4.43	1	1	2.2	1	TCF7L2
Number of self-reported non-cancer illnesses	4.34	1	0	0.0	1	IGF2BP2
Leg fat mass (right)	4.28	1	1	2.2	1	TCF7L2
Number of treatments/medications taken	4.05	1	0	0.0	1	IGF2BP2
Body mass index (BMI)	4.01	1	1	2.2	1	TCF7L2
Lung FEV1/FVC ratio	3.87	2	1	2.2	1	IGF2BP2 TCF7L2
Hypothyroidism (self reported)	3.86	1	0	0.0	1	IGF2BP2
BMI	3.85	1	1	2.2	1	TCF7L2
Heart disease (siblings)	3.71	1	0	0.0	1	IGF2BP2
Average weekly champagne plus white wine intake	3.59	1	0	0.0	1	TCF7L2
Medication for pain relief, constipation, heartburn	3.53	1	0	0.0	1	IGF2BP2
High cholesterol (Self-reported)	3.53	1	0	0.0	1	TCF7L2
Hypothyroidism/myxoedema (self-reported)	3.41	1	0	0.0	1	IGF2BP2
Heel T-Score	3.38	2	1	2.2	1	IGF2BP2 TCF7L2
Birth weight	3.38	1	0	0.0	1	TCF7L2
Forced expiratory volume in 1-second (FEV1)	3.35	1	0	0.0	1	IGF2BP2
High blood pressure (siblings)	3.20	1	0	0.0	1	IGF2BP2
Arm fat mass (right)	3.12	1	0	0.0	1	TCF7L2
Systolic Blood Pressure	3.06	1	1	2.2	1	TCF7L2
Townsend deprivation index at recruitment	2.99	1	0	0.0	1	IGF2BP2
Chronotype (morning person)	2.96	2	0	0.0	1	IGF2BP2 TCF7L2
Bilateral oophorectomy (both ovaries removed)	2.96	1	0	0.0	1	IGF2BP2
Whole body fat mass	2.93	1	0	0.0	1	TCF7L2
Medication: Ramipril	2.89	1	0	0.0	1	IGF2BP2
Arm fat mass (left)	2.89	1	0	0.0	1	TCF7L2
Heart attack/myocardial infarction (self-reported)	2.89	1	0	0.0	1	TCF7L2
Ever had hysterectomy (womb removed)	2.87	1	0	0.0	1	IGF2BP2
Overall health rating	2.86	1	0	0.0	1	IGF2BP2
Arm fat percentage (left)	2.83	1	0	0.0	1	TCF7L2
Primary Biliary Cirrhosis	2.82	1	0	0.0	1	IGF2BP2
Vascular/heart problems diagnosed by doctor	2.79	1	0	0.0	1	IGF2BP2
Wheeze or whistling in the chest in last year	2.76	1	0	0.0	1	IGF2BP2
Forced expiratory volume in 1-second (FEV1), Best measure	2.74	1	0	0.0	1	IGF2BP2
Heel bone mineral density (BMD) T-score, automated (left)	2.71	1	0	0.0	1	TCF7L2
Had other major operations	2.71	1	0	0.0	1	IGF2BP2
Myopia	2.71	1	0	0.0	1	TCF7L2
Pulse wave Arterial Stiffness index	2.70	1	0	0.0	1	IGF2BP2
Arm fat percentage (right)	2.69	1	0	0.0	1	TCF7L2
Body fat percentage	2.68	1	0	0.0	1	TCF7L2
Lung FVC	2.61	1	0	0.0	1	IGF2BP2
Waist circumference	2.56	1	0	0.0	1	TCF7L2
Cardiovascular Disease	2.51	1	0	0.0	1	IGF2BP2
Alcohol usually taken with meals	2.44	1	0	0.0	1	TCF7L2
Heel bone mineral density (BMD) T-score, automated (right)	2.43	1	0	0.0	1	TCF7L2
Impedance of arm (left)	2.41	1	0	0.0	1	TCF7L2
Medication: Blood pressure	2.37	1	0	0.0	1	IGF2BP2
Impedance of arm (right)	2.34	1	0	0.0	1	TCF7L2
Weight	2.31	1	0	0.0	1	TCF7L2
Pulse wave peak to peak time	2.29	1	0	0.0	1	IGF2BP2
Ever used hormone-replacement therapy (HRT)	2.24	1	0	0.0	1	IGF2BP2
Unable to work because of sickness or disability	2.22	1	0	0.0	1	IGF2BP2
Taking other prescription medications	2.16	1	0	0.0	1	IGF2BP2
High blood pressure	2.14	1	0	0.0	1	IGF2BP2
Hypertension (Self-reported)	2.10	1	0	0.0	1	IGF2BP2
Falls in the last year	2.08	1	0	0.0	1	TCF7L2
Medication: Levothyroxine sodium	2.07	1	0	0.0	1	IGF2BP2
Diastolic blood pressure, automated reading	2.03	1	0	0.0	1	TCF7L2
Verbal and Numeric Reasoning (VNR)	2.01	1	0	0.0	1	TCF7L2
Trunk fat mass	1.91	1	0	0.0	1	TCF7L2
Frequency of tiredness / lethargy in last 2 weeks	1.88	1	0	0.0	1	IGF2BP2
Impedance of whole body	1.88	1	0	0.0	1	TCF7L2
Pulse rate, automated reading	1.73	1	0	0.0	1	TCF7L2
Depression (Nagel 2018)	1.72	1	0	0.0	1	IGF2BP2
Forced expiratory volume in 1-second (FEV1), predicted	1.72	1	0	0.0	1	TCF7L2
Blood Red Count	1.51	2	0	0.0	1	IGF2BP2 TCF7L2
Forced vital capacity (FVC)	1.51	1	0	0.0	1	IGF2BP2
Impedance of leg (right)	1.48	1	0	0.0	1	TCF7L2
Trunk fat percentage	1.46	1	0	0.0	1	TCF7L2
Hand grip strength (right)	1.44	1	0	0.0	1	TCF7L2
Crohns Disease (2017)	1.33	1	0	0.0	1	IGF2BP2
Impedance of leg (left)	1.29	2	0	0.0	1	IGF2BP2 TCF7L2
Arm fat-free mass (left)	1.21	1	0	0.0	1	TCF7L2
Basal metabolic rate	1.20	1	0	0.0	1	TCF7L2
Leg predicted mass (left)	1.19	1	0	0.0	1	TCF7L2
Leg fat-free mass (left)	1.18	1	0	0.0	1	TCF7L2
Arm predicted mass (left)	1.16	1	0	0.0	1	TCF7L2
Leg predicted mass (right)	1.08	1	0	0.0	1	TCF7L2
Leg fat-free mass (right)	1.05	1	0	0.0	1	TCF7L2
Arm fat-free mass (right)	1.02	1	0	0.0	1	TCF7L2
Comparative body size at age 10	0.98	1	0	0.0	1	TCF7L2
Arm predicted mass (right)	0.93	1	0	0.0	1	TCF7L2
Whole body fat-free mass	0.86	1	0	0.0	1	TCF7L2
Whole body water mass	0.86	1	0	0.0	1	TCF7L2
Forced vital capacity (FVC), Best measure	0.82	1	0	0.0	1	IGF2BP2
Blood White Count	0.74	1	0	0.0	1	IGF2BP2
Trunk predicted mass	0.58	1	0	0.0	1	TCF7L2
Trunk fat-free mass	0.54	1	0	0.0	1	TCF7L2
Sitting height	0.42	1	0	0.0	1	IGF2BP2
Standing height	0.31	1	0	0.0	1	TCF7L2
Height	0.27	1	0	0.0	1	TCF7L2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Artery Aorta	1	0.034	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Small Intestine Terminal Ileum	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.1
GTEx	Adrenal Gland	0	0.000	1.1
GTEx	Artery Coronary	0	0.000	1.1
GTEx	Brain Caudate basal ganglia	0	0.000	1.1
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.1
GTEx	Brain Cerebellum	0	0.000	1.1
GTEx	Brain Frontal Cortex BA9	0	0.000	1.1
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.1
GTEx	Breast Mammary Tissue	0	0.000	1.1
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.1
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.1
GTEx	Heart Atrial Appendage	0	0.000	1.1
GTEx	Heart Left Ventricle	0	0.000	1.1
GTEx	Liver	0	0.000	1.1
GTEx	Lung	0	0.000	1.1
GTEx	Nerve Tibial	0	0.000	1.1
GTEx	Ovary	0	0.000	1.1
GTEx	Pituitary	0	0.000	1.1
GTEx	Prostate	0	0.000	1.1
GTEx	Spleen	0	0.000	1.1
GTEx	Stomach	0	0.000	1.1
GTEx	Whole Blood	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
NTR	Blood	0	0.000	1.1
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.1
YFS	Blood	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.1
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.1
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.1
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.1
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.1
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.1
GTEx	Brain Hippocampus	0	0.000	1.0
GTEx	Brain Hypothalamus	0	0.000	1.0
GTEx	Brain Putamen basal ganglia	0	0.000	1.0
GTEx	Uterus	0	0.000	1.0
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.0