Hub : Traits :

Commuting to job workplace: Public transport

3 significantly associated models · 3 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 231030554 232441175 1 1 3.9e-08 1.2e-03 0.0059 28 ITM2C
2 20 29833609 30922399 2 1 1.6e-07 1.3e-07 0.0968 90 HM13-AS1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Mean Putamen Volume 4.87 1 0 0 0 1 HM13-AS1
Type 2 Diabetes (T2D) 3.76 1 0 0 0 1 ITM2C
Blood Eosinophil Count 1.14 1 0 0 0 1 HM13-AS1
Blood Platelet Count 4.21 1 1 3 0 1 HM13-AS1
Blood Red Count 5.57 1 1 3 0 1 HM13-AS1
Heel T-Score 2.98 1 1 3 0 1 HM13-AS1
BMI 1.73 1 0 0 0 1 HM13-AS1
Height 1.00 1 1 3 0 1 HM13-AS1
Systolic Blood Pressure 0.74 1 0 0 0 1 HM13-AS1
Smoking Status 2.95 1 0 0 0 1 HM13-AS1
Cardiovascular Disease 2.19 1 0 0 0 1 HM13-AS1
Lung FVC 1.51 1 0 0 0 1 HM13-AS1
Hair Pigment 0.31 1 0 0 0 1 HM13-AS1
Hearing difficulty/problems: Yes 2.66 1 0 0 0 1 HM13-AS1
Townsend deprivation index at recruitment 2.42 1 0 0 0 1 HM13-AS1
Maternal smoking around birth 5.77 2 0 0 0 1 HM13-AS1 ITM2C
Frequency of unenthusiasm / disinterest in last 2 weeks 3.38 1 0 0 0 1 ITM2C
Heel bone mineral density (BMD) T-score, automated (left) 3.67 1 0 0 0 1 HM13-AS1
Tinnitus: Yes, but not now, but have in the past 3.13 1 0 0 0 1 ITM2C
High blood pressure 3.21 1 0 0 0 1 HM13-AS1
Sitting height 4.82 1 1 3 0 1 HM13-AS1
Body mass index (BMI) 0.86 1 0 0 0 1 HM13-AS1
Heel bone mineral density (BMD) T-score, automated (right) 3.99 1 0 0 0 1 HM13-AS1
Medication: Simvastatin 2.71 1 0 0 0 1 HM13-AS1
Arm fat percentage (right) 1.10 1 0 0 0 1 HM13-AS1
Standing height 1.39 1 1 3 0 1 HM13-AS1
Tense / 'highly strung' 4.22 1 0 0 0 1 ITM2C
Headache pain in last month 2.30 1 0 0 0 1 ITM2C
Medication for cholesterol, blood pressure or diabetes 2.76 1 0 0 0 1 HM13-AS1
Glaucoma (self-reported) 3.62 1 0 0 0 1 ITM2C
Seen a psychiatrist for nerves, anxiety, tension or depression 6.01 2 0 0 0 1 HM13-AS1 ITM2C
Medication for pain relief, constipation, heartburn 2.42 1 0 0 0 1 HM13-AS1
Medication: Blood pressure 4.85 1 0 0 0 1 HM13-AS1
Pulse rate, automated reading 1.37 1 0 0 0 1 HM13-AS1
Comparative height size at age 10 0.66 1 0 0 0 1 HM13-AS1
Commuting to job workplace: Car/motor vehicle 8.96 2 0 0 0 1 HM13-AS1 ITM2C
Hypertension (Self-reported) 3.19 1 0 0 0 1 HM13-AS1
Arm fat percentage (left) 0.95 1 0 0 0 1 HM13-AS1
Average weekly red wine intake 3.11 1 0 0 0 1 HM13-AS1
Commuting to job workplace: Walk 4.02 1 0 0 0 1 ITM2C
Back pain experienced in last month 3.03 1 0 0 0 1 HM13-AS1
Osteoarthritis (self-reported) 2.52 1 0 0 0 1 ITM2C
Medication: Gliclazide 3.38 1 0 0 0 1 HM13-AS1
Illnesses of father: None of the above (group 1) 3.16 1 0 0 0 1 HM13-AS1
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.47 1 0 0 0 1 HM13-AS1
Supplements: Fish oil (including cod liver oil) 2.62 1 0 0 0 1 ITM2C
High cholesterol (Self-reported) 1.76 1 0 0 0 1 HM13-AS1
Fractured/broken bones in last 5 years 2.87 1 0 0 0 1 HM13-AS1
Diastolic blood pressure, automated reading 2.77 1 0 0 0 1 HM13-AS1
Vascular/heart problems diagnosed by doctor 3.58 1 0 0 0 1 HM13-AS1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.19
GTEx Adipose Visceral Omentum 0 0.0000 1.20
GTEx Adrenal Gland 0 0.0000 1.20
GTEx Artery Aorta 0 0.0000 1.18
GTEx Artery Coronary 0 0.0000 1.20
GTEx Artery Tibial 0 0.0000 1.22
GTEx Brain Caudate basal ganglia 0 0.0000 1.23
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.27
GTEx Brain Cerebellum 0 0.0000 1.26
GTEx Brain Cortex 0 0.0000 1.25
GTEx Brain Frontal Cortex BA9 0 0.0000 1.25
GTEx Brain Hippocampus 0 0.0000 1.21
GTEx Brain Hypothalamus 0 0.0000 1.25
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.22
GTEx Brain Putamen basal ganglia 0 0.0000 1.25
GTEx Breast Mammary Tissue 0 0.0000 1.16
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.30
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.24
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.22
GTEx Cells Transformed fibroblasts 0 0.0000 1.20
GTEx Colon Sigmoid 0 0.0000 1.26
GTEx Colon Transverse 0 0.0000 1.24
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.25
GTEx Esophagus Mucosa 0 0.0000 1.27
GTEx Esophagus Muscularis 0 0.0000 1.20
GTEx Heart Atrial Appendage 0 0.0000 1.28
GTEx Heart Left Ventricle 0 0.0000 1.30
GTEx Liver 0 0.0000 1.30
GTEx Lung 0 0.0000 1.17
GTEx Muscle Skeletal 1 0.0346 1.24
GTEx Nerve Tibial 1 0.0231 1.17
GTEx Ovary 0 0.0000 1.22
GTEx Pancreas 0 0.0000 1.25
GTEx Pituitary 0 0.0000 1.18
GTEx Prostate 0 0.0000 1.26
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.19
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.20
GTEx Small Intestine Terminal Ileum 0 0.0000 1.18
GTEx Spleen 0 0.0000 1.20
GTEx Stomach 0 0.0000 1.20
GTEx Testis 0 0.0000 1.21
GTEx Thyroid 0 0.0000 1.21
GTEx Uterus 0 0.0000 1.20
GTEx Vagina 0 0.0000 1.25
GTEx Whole Blood 0 0.0000 1.18
METSIM Adipose 0 0.0000 1.19
NTR Blood 0 0.0000 1.19
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.20
YFS Blood 0 0.0000 1.13
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.20
TCGA Breast Tumor 0 0.0000 1.25
TCGA Breast Normal 0 0.0000 1.14
TCGA Ovarian Tumor 0 0.0000 1.19
TCGA Prostate Tumor 0 0.0000 1.17