Hub : Traits :

Lung cancer (father)

9 significantly associated models · 7 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 5 619022 2041665 1 1 2.0e-09 3e-10 0.036 89 CLPTM1L
2 15 78032707 79886142 6 1 1.4e-16 4e-15 0.120 96 PSMA4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Prostate Cancer 4.52 1 0 0 0 1 CLPTM1L
Schizophrenia 6.45 1 1 3 0 1 PSMA4
Blood Eosinophil Count 0.83 1 0 0 0 1 CLPTM1L
Blood Red Count 0.56 1 0 0 0 1 PSMA4
Blood White Count 0.75 1 0 0 0 1 PSMA4
Systolic Blood Pressure 1.16 1 0 0 0 1 CLPTM1L
Allergy or Eczema 4.47 1 0 0 0 1 PSMA4
Cardiovascular Disease 1.65 1 0 0 0 1 CLPTM1L
Lung FEV1/FVC ratio 3.41 1 1 3 0 1 PSMA4
Lung FVC 4.64 2 1 3 0 1 CLPTM1L PSMA4
Hair Pigment 0.28 1 0 0 0 1 CLPTM1L
Pack years adult smoking proportion 107.15 1 1 3 0 1 PSMA4
Impedance of leg (right) 0.96 1 0 0 0 1 CLPTM1L
Current tobacco smoking 4.05 1 0 0 0 1 PSMA4
Maternal smoking around birth 8.90 1 0 0 0 1 PSMA4
Age when periods started (menarche) 2.52 1 0 0 0 1 PSMA4
Qualifications: CSEs or equivalent 3.57 1 0 0 0 1 PSMA4
High blood pressure 2.31 1 0 0 0 1 CLPTM1L
Hayfever, allergic rhinitis or eczema 3.55 1 0 0 0 1 PSMA4
Multivitamins +/- minerals 3.91 1 0 0 0 1 PSMA4
Chronic bronchitis/emphysema (father) 21.37 1 1 3 0 1 PSMA4
Body mass index (BMI) 1.19 1 0 0 0 1 CLPTM1L
Impedance of leg (left) 1.42 1 0 0 0 1 CLPTM1L
Forced vital capacity (FVC) 4.43 2 1 3 0 1 CLPTM1L PSMA4
Father's age at death 16.52 1 1 3 0 1 PSMA4
Number of live births 6.45 2 0 0 0 1 CLPTM1L PSMA4
Forced expiratory volume in 1-second (FEV1) 7.63 1 1 3 0 1 PSMA4
Mouth/teeth dental problems: Dentures 6.86 1 0 0 0 1 PSMA4
Depression (self-reported) 6.98 1 0 0 0 1 CLPTM1L
Forced expiratory volume in 1-second (FEV1), Best measure 8.87 2 1 3 0 1 CLPTM1L PSMA4
Peak expiratory flow (PEF) 4.15 1 0 0 0 1 PSMA4
Birth weight 2.51 1 0 0 0 1 PSMA4
Chronic bronchitis/emphysema (mother) 17.69 1 1 3 0 1 PSMA4
Forced vital capacity (FVC), Best measure 5.25 2 0 0 0 1 CLPTM1L PSMA4
Comparative body size at age 10 1.53 1 0 0 0 1 PSMA4
Wheeze or whistling in the chest in last year 4.59 1 0 0 0 1 PSMA4
Mouth/teeth dental problems: Loose teeth 3.82 1 0 0 0 1 PSMA4
Emphysema/chronic bronchitis 9.37 1 0 0 0 1 PSMA4
Heart disease (mother) 5.20 1 0 0 0 1 PSMA4
Alcohol intake frequency. 2.27 1 0 0 0 1 PSMA4
Overall health rating 5.46 1 0 0 0 1 PSMA4
Knee pain experienced in last month 2.90 1 0 0 0 1 PSMA4
Hypertension (Self-reported) 2.47 1 0 0 0 1 CLPTM1L
Smoking status: Previous 3.66 1 0 0 0 1 PSMA4
Average weekly red wine intake 2.78 1 0 0 0 1 PSMA4
Long-standing illness, disability or infirmity 2.97 1 0 0 0 1 PSMA4
Forced expiratory volume in 1-second (FEV1), predicted percentage 15.80 1 1 3 0 1 PSMA4
Average weekly champagne plus white wine intake 2.98 1 0 0 0 1 PSMA4
Mother's age at death 5.78 1 0 0 0 1 PSMA4
Medication: Atorvastatin 3.85 1 0 0 0 1 CLPTM1L
Alcohol drinker status: Never 3.91 1 0 0 0 1 CLPTM1L
Ever smoked 4.83 1 0 0 0 1 PSMA4
Risk taking 6.04 1 0 0 0 1 PSMA4
Ever had prostate specific antigen (PSA) test 10.59 1 0 0 0 1 CLPTM1L
Diastolic blood pressure, automated reading 1.57 1 0 0 0 1 CLPTM1L
Unable to work because of sickness or disability 3.87 1 0 0 0 1 PSMA4
Vascular/heart problems diagnosed by doctor 1.84 1 0 0 0 1 CLPTM1L
Basal cell carcinoma (self-reported) 13.11 1 1 3 0 1 CLPTM1L
Pack years of smoking 99.38 1 1 3 0 1 PSMA4
Impedance of whole body 1.06 1 0 0 0 1 CLPTM1L

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.17
GTEx Adipose Visceral Omentum 0 0.0000 1.17
GTEx Adrenal Gland 0 0.0000 1.20
GTEx Artery Aorta 0 0.0000 1.14
GTEx Artery Coronary 0 0.0000 1.22
GTEx Artery Tibial 0 0.0000 1.17
GTEx Brain Caudate basal ganglia 0 0.0000 1.24
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.20
GTEx Brain Cerebellum 0 0.0000 1.15
GTEx Brain Cortex 0 0.0000 1.25
GTEx Brain Frontal Cortex BA9 0 0.0000 1.23
GTEx Brain Hippocampus 0 0.0000 1.18
GTEx Brain Hypothalamus 0 0.0000 1.18
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.22
GTEx Brain Putamen basal ganglia 0 0.0000 1.33
GTEx Breast Mammary Tissue 0 0.0000 1.20
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.11
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.11
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.19
GTEx Cells Transformed fibroblasts 0 0.0000 1.18
GTEx Colon Sigmoid 0 0.0000 1.23
GTEx Colon Transverse 0 0.0000 1.15
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.19
GTEx Esophagus Mucosa 0 0.0000 1.18
GTEx Esophagus Muscularis 0 0.0000 1.21
GTEx Heart Atrial Appendage 0 0.0000 1.11
GTEx Heart Left Ventricle 0 0.0000 1.19
GTEx Liver 1 0.1395 1.20
GTEx Lung 0 0.0000 1.18
GTEx Muscle Skeletal 0 0.0000 1.22
GTEx Nerve Tibial 0 0.0000 1.19
GTEx Ovary 0 0.0000 1.20
GTEx Pancreas 0 0.0000 1.19
GTEx Pituitary 0 0.0000 1.12
GTEx Prostate 0 0.0000 1.21
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.19
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.19
GTEx Small Intestine Terminal Ileum 0 0.0000 1.22
GTEx Spleen 0 0.0000 1.19
GTEx Stomach 0 0.0000 1.10
GTEx Testis 1 0.0317 1.17
GTEx Thyroid 0 0.0000 1.15
GTEx Uterus 0 0.0000 1.21
GTEx Vagina 0 0.0000 1.25
GTEx Whole Blood 0 0.0000 1.17
METSIM Adipose 0 0.0000 1.14
NTR Blood 0 0.0000 1.18
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.16
YFS Blood 2 0.0433 1.16
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.16
TCGA Breast Tumor 1 0.1304 1.21
TCGA Breast Normal 0 0.0000 1.10
TCGA Ovarian Tumor 1 0.0342 1.18
TCGA Prostate Tumor 2 0.0578 1.24