Hub : Traits :

Knee pain experienced in last month

43 significantly associated models · 13 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 20 32865844 34980465 13 1 6.7e-16 4e-18 0.0011 86 UQCC

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Heel T-Score 2.1 1 0 0 0 1 UQCC
Height 100.6 1 1 3 0 1 UQCC
Waist Hip Ratio (WHR) 13.6 1 1 3 0 1 UQCC
Systolic Blood Pressure 5.7 1 1 3 0 1 UQCC
Lung FEV1/FVC ratio 3.0 1 0 0 0 1 UQCC
Lung FVC 29.0 1 1 3 0 1 UQCC
Hair Pigment 24.2 1 1 3 0 1 UQCC
Tanning 52.4 1 1 3 0 1 UQCC
Hand grip strength (left) 41.4 1 1 3 0 1 UQCC
Relative age of first facial hair 5.3 1 0 0 0 1 UQCC
Impedance of leg (right) 19.3 1 1 3 0 1 UQCC
Leg fat-free mass (left) 75.4 1 1 3 0 1 UQCC
Hand grip strength (right) 52.6 1 1 3 0 1 UQCC
Relative age voice broke 12.0 1 0 0 0 1 UQCC
Sitting height 129.2 1 1 3 0 1 UQCC
Impedance of leg (left) 19.2 1 1 3 0 1 UQCC
Leg predicted mass (left) 75.3 1 1 3 0 1 UQCC
Trunk fat mass 9.7 1 1 3 0 1 UQCC
Waist circumference 3.0 1 0 0 0 1 UQCC
Forced vital capacity (FVC) 7.4 1 1 3 0 1 UQCC
Qualifications: None of the above 6.4 1 0 0 0 1 UQCC
Weight 39.1 1 1 3 0 1 UQCC
Impedance of arm (right) 3.2 1 0 0 0 1 UQCC
Trunk fat-free mass 92.1 1 1 3 0 1 UQCC
Hip circumference 23.8 1 1 3 0 1 UQCC
Forced expiratory volume in 1-second (FEV1) 5.7 1 0 0 0 1 UQCC
Qualifications: A levels/AS levels or equivalent 8.6 1 0 0 0 1 UQCC
Medication: Lansoprazole 10.6 1 0 0 0 1 UQCC
Forced expiratory volume in 1-second (FEV1), Best measure 6.8 1 0 0 0 1 UQCC
Impedance of arm (left) 3.4 1 0 0 0 1 UQCC
Arm fat mass (right) 4.8 1 0 0 0 1 UQCC
Trunk predicted mass 92.5 1 1 3 0 1 UQCC
Standing height 102.7 1 1 3 0 1 UQCC
Peak expiratory flow (PEF) 26.1 1 1 3 0 1 UQCC
Qualifications: O levels/GCSEs or equivalent 7.0 1 0 0 0 1 UQCC
Birth weight 5.1 1 0 0 0 1 UQCC
Forced vital capacity (FVC), Best measure 9.6 1 1 3 0 1 UQCC
Leg fat percentage (right) 10.6 1 1 3 0 1 UQCC
Arm fat-free mass (right) 74.2 1 1 3 0 1 UQCC
Qualifications: College or University degree 5.9 1 0 0 0 1 UQCC
Whole body fat mass 6.4 1 1 3 0 1 UQCC
Arm predicted mass (right) 74.0 1 1 3 0 1 UQCC
Comparative height size at age 10 91.0 1 1 3 0 1 UQCC
Forced expiratory volume in 1-second (FEV1), predicted 47.9 1 1 3 0 1 UQCC
Whole body fat-free mass 87.6 1 1 3 0 1 UQCC
Leg fat-free mass (right) 79.7 1 1 3 0 1 UQCC
Forced expiratory volume in 1-second (FEV1), predicted percentage 8.5 1 0 0 0 1 UQCC
Whole body water mass 85.4 1 1 3 0 1 UQCC
Leg predicted mass (right) 79.4 1 1 3 0 1 UQCC
Arm fat mass (left) 4.8 1 0 0 0 1 UQCC
Basal metabolic rate 76.6 1 1 3 0 1 UQCC
Leg fat percentage (left) 9.6 1 1 3 0 1 UQCC
Arm fat-free mass (left) 72.7 1 1 3 0 1 UQCC
Impedance of whole body 9.1 1 1 3 0 1 UQCC
Arm predicted mass (left) 73.3 1 1 3 0 1 UQCC

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.60
GTEx Adipose Visceral Omentum 1 0.0491 1.60
GTEx Adrenal Gland 1 0.0686 1.70
GTEx Artery Aorta 0 0.0000 1.58
GTEx Artery Coronary 0 0.0000 1.54
GTEx Artery Tibial 0 0.0000 1.53
GTEx Brain Caudate basal ganglia 1 0.1087 1.49
GTEx Brain Cerebellar Hemisphere 2 0.1343 1.70
GTEx Brain Cerebellum 2 0.1009 1.69
GTEx Brain Cortex 2 0.1932 1.58
GTEx Brain Frontal Cortex BA9 2 0.2165 1.75
GTEx Brain Hippocampus 0 0.0000 1.62
GTEx Brain Hypothalamus 1 0.1695 1.63
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.58
GTEx Brain Putamen basal ganglia 0 0.0000 1.58
GTEx Breast Mammary Tissue 0 0.0000 1.58
GTEx Breast Mammary Tissue (Male) 1 0.0838 1.61
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.54
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.49
GTEx Cells Transformed fibroblasts 2 0.0476 1.59
GTEx Colon Sigmoid 0 0.0000 1.59
GTEx Colon Transverse 0 0.0000 1.58
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.60
GTEx Esophagus Mucosa 2 0.0602 1.58
GTEx Esophagus Muscularis 0 0.0000 1.58
GTEx Heart Atrial Appendage 0 0.0000 1.57
GTEx Heart Left Ventricle 0 0.0000 1.61
GTEx Liver 0 0.0000 1.56
GTEx Lung 1 0.0348 1.57
GTEx Muscle Skeletal 3 0.1038 1.57
GTEx Nerve Tibial 1 0.0231 1.59
GTEx Ovary 0 0.0000 1.63
GTEx Pancreas 1 0.0613 1.67
GTEx Pituitary 0 0.0000 1.58
GTEx Prostate 0 0.0000 1.69
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.61
GTEx Skin Sun Exposed Lower leg 1 0.0275 1.64
GTEx Small Intestine Terminal Ileum 0 0.0000 1.52
GTEx Spleen 0 0.0000 1.60
GTEx Stomach 1 0.0688 1.52
GTEx Testis 0 0.0000 1.54
GTEx Thyroid 0 0.0000 1.59
GTEx Uterus 0 0.0000 1.68
GTEx Vagina 0 0.0000 1.60
GTEx Whole Blood 0 0.0000 1.55
METSIM Adipose 2 0.0434 1.54
NTR Blood 1 0.0416 1.51
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.60
YFS Blood 3 0.0650 1.45
CommonMind Brain Pre-frontal Cortex 1 0.0186 1.50
TCGA Breast Tumor 0 0.0000 1.70
TCGA Breast Normal 1 0.0238 1.42
TCGA Ovarian Tumor 2 0.0684 1.45
TCGA Prostate Tumor 3 0.0867 1.54