Hub : Traits :

Average weekly fortified wine intake

1 significantly associated models · 1 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	19	45187302	45682026	1	1	9.9e-08	2e-06	0.26	94	APOC1P1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Alzheimer’s Disease (including proxy)	552.25	1	1	2.2	1	APOC1P1
Alzheimer’s Disease (in mother)	226.89	1	1	2.2	1	APOC1P1
Alzheimer’s Disease (in father)	87.53	1	1	2.2	1	APOC1P1
Loud music exposure frequency	13.89	1	0	0.0	1	APOC1P1
Illnesses of mother	12.21	1	0	0.0	1	APOC1P1
High cholesterol (Self-reported)	11.32	1	0	0.0	1	APOC1P1
Illnesses of father: None of the above (group 1)	8.90	1	0	0.0	1	APOC1P1
Cholesterol lowering medication	7.45	1	0	0.0	1	APOC1P1
Weight	6.80	1	1	2.2	1	APOC1P1
Wears glasses or contact lenses	6.37	1	0	0.0	1	APOC1P1
Arm predicted mass (left)	5.93	1	1	2.2	1	APOC1P1
Arm fat-free mass (left)	5.80	1	1	2.2	1	APOC1P1
Leg fat mass (left)	5.75	1	0	0.0	1	APOC1P1
BMI	5.70	1	1	2.2	1	APOC1P1
Back pain experienced in last month	5.69	1	0	0.0	1	APOC1P1
Basal metabolic rate	5.67	1	1	2.2	1	APOC1P1
Tinnitus: Yes, now most or all of the time	5.53	1	0	0.0	1	APOC1P1
Worrier / anxious feelings	5.46	1	0	0.0	1	APOC1P1
Leg fat mass (right)	5.37	1	0	0.0	1	APOC1P1
Relative age of first facial hair	5.34	1	0	0.0	1	APOC1P1
Trunk fat-free mass	5.31	1	1	2.2	1	APOC1P1
Trunk predicted mass	5.20	1	1	2.2	1	APOC1P1
Hand grip strength (left)	5.14	1	0	0.0	1	APOC1P1
Medication: Atorvastatin	5.14	1	0	0.0	1	APOC1P1
Whole body fat-free mass	5.03	1	1	2.2	1	APOC1P1
Whole body water mass	4.95	1	1	2.2	1	APOC1P1
Arm fat mass (right)	4.94	1	0	0.0	1	APOC1P1
Whole body fat mass	4.94	1	0	0.0	1	APOC1P1
Arm fat-free mass (right)	4.82	1	0	0.0	1	APOC1P1
Arm fat mass (left)	4.74	1	0	0.0	1	APOC1P1
Hand grip strength (right)	4.61	1	0	0.0	1	APOC1P1
Waist circumference	4.57	1	0	0.0	1	APOC1P1
Pulse rate	4.45	1	0	0.0	1	APOC1P1
Medication: Omeprazole (e.g. Zanprol)	4.33	1	0	0.0	1	APOC1P1
Leg predicted mass (left)	4.31	1	0	0.0	1	APOC1P1
Trunk fat mass	4.29	1	0	0.0	1	APOC1P1
Leg fat-free mass (left)	4.27	1	0	0.0	1	APOC1P1
Medication: Cholesterol lowering	4.24	1	0	0.0	1	APOC1P1
Medication: Simvastatin	4.22	1	0	0.0	1	APOC1P1
Leg predicted mass (right)	4.22	1	0	0.0	1	APOC1P1
Leg fat-free mass (right)	4.20	1	0	0.0	1	APOC1P1
Blood White Count	4.17	1	1	2.2	1	APOC1P1
Arm predicted mass (right)	4.17	1	0	0.0	1	APOC1P1
Ever had bowel cancer screening	4.17	1	0	0.0	1	APOC1P1
Birth weight	4.15	1	0	0.0	1	APOC1P1
Worry (Nagel 2018)	4.02	1	0	0.0	1	APOC1P1
Cardiovascular Disease	4.01	1	0	0.0	1	APOC1P1
Hip circumference	3.83	1	0	0.0	1	APOC1P1
Body mass index (BMI)	3.81	1	0	0.0	1	APOC1P1
Leg fat percentage (left)	3.76	1	0	0.0	1	APOC1P1
Medication: Omeprazole	3.73	1	0	0.0	1	APOC1P1
Father's age at death	3.71	1	0	0.0	1	APOC1P1
Average weekly spirits intake	3.33	1	0	0.0	1	APOC1P1
Leg fat percentage (right)	3.32	1	0	0.0	1	APOC1P1
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.27	1	0	0.0	1	APOC1P1
Mouth/teeth dental problems: Mouth ulcers	3.20	1	0	0.0	1	APOC1P1
Diabetes (mother)	3.16	1	0	0.0	1	APOC1P1
Allergy or Eczema	2.97	1	0	0.0	1	APOC1P1
Height	2.91	1	1	2.2	1	APOC1P1
Systolic Blood Pressure	2.90	1	0	0.0	1	APOC1P1
Crohns Disease (2012)	2.79	1	0	0.0	1	APOC1P1
Body fat percentage	2.79	1	0	0.0	1	APOC1P1
Peak expiratory flow (PEF)	2.62	1	0	0.0	1	APOC1P1
Fed-up feelings	2.61	1	0	0.0	1	APOC1P1
Arm fat percentage (right)	2.56	1	0	0.0	1	APOC1P1
Nervous feelings	2.55	1	0	0.0	1	APOC1P1
Trunk fat percentage	2.46	1	0	0.0	1	APOC1P1
Comparative height size at age 10	2.42	1	0	0.0	1	APOC1P1
Tense / 'highly strung'	2.37	1	0	0.0	1	APOC1P1
Arm fat percentage (left)	2.35	1	0	0.0	1	APOC1P1
Hypothyroidism/myxoedema (self-reported)	2.22	1	0	0.0	1	APOC1P1
Impedance of whole body	2.00	1	0	0.0	1	APOC1P1
Standing height	1.96	1	0	0.0	1	APOC1P1
Forced expiratory volume in 1-second (FEV1)	1.92	1	0	0.0	1	APOC1P1
Impedance of arm (left)	1.83	1	0	0.0	1	APOC1P1
Diastolic blood pressure, automated reading	1.70	1	0	0.0	1	APOC1P1
Pulse rate, automated reading	1.61	1	0	0.0	1	APOC1P1
Impedance of arm (right)	1.44	1	0	0.0	1	APOC1P1
Forced vital capacity (FVC)	1.34	1	0	0.0	1	APOC1P1
Impedance of leg (right)	1.07	1	0	0.0	1	APOC1P1
Lung FVC	0.95	1	0	0.0	1	APOC1P1
Impedance of leg (left)	0.89	1	0	0.0	1	APOC1P1
Blood Red Count	0.81	1	0	0.0	1	APOC1P1
Blood Platelet Count	0.38	1	0	0.0	1	APOC1P1
Hair Pigment	0.17	1	0	0.0	1	APOC1P1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Liver	0	0.000	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Pituitary	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adipose Visceral Omentum	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Coronary	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Frontal Cortex BA9	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Muscle Skeletal	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Thyroid	0	0.000	1.2
GTEx	Uterus	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1
GTEx	Cells Transformed fibroblasts	0	0.000	1.1
GTEx	Spleen	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
YFS	Blood	0	0.000	1.1
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.1
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.1