Hub : Traits :

Average weekly fortified wine intake

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 19 45187302 45682026 1 1 9.9e-08 2e-06 0.26 94 APOC1P1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Worry (Nagel 2018) 4.02 1 0 0.0 0 1 APOC1P1
Alzheimer’s Disease (in mother) 226.89 1 1 2.2 0 1 APOC1P1
Alzheimer’s Disease (in father) 87.53 1 1 2.2 0 1 APOC1P1
Alzheimer’s Disease (including proxy) 552.25 1 1 2.2 0 1 APOC1P1
Crohns Disease (2012) 2.79 1 0 0.0 0 1 APOC1P1
Blood Platelet Count 0.38 1 0 0.0 0 1 APOC1P1
Blood Red Count 0.81 1 0 0.0 0 1 APOC1P1
Blood White Count 4.17 1 1 2.2 0 1 APOC1P1
BMI 5.70 1 1 2.2 0 1 APOC1P1
Height 2.91 1 1 2.2 0 1 APOC1P1
Systolic Blood Pressure 2.90 1 0 0.0 0 1 APOC1P1
Allergy or Eczema 2.97 1 0 0.0 0 1 APOC1P1
Cardiovascular Disease 4.01 1 0 0.0 0 1 APOC1P1
Lung FVC 0.95 1 0 0.0 0 1 APOC1P1
Hair Pigment 0.17 1 0 0.0 0 1 APOC1P1
Hand grip strength (left) 5.14 1 0 0.0 0 1 APOC1P1
Average weekly spirits intake 3.33 1 0 0.0 0 1 APOC1P1
Relative age of first facial hair 5.34 1 0 0.0 0 1 APOC1P1
Diabetes (mother) 3.16 1 0 0.0 0 1 APOC1P1
Impedance of leg (right) 1.07 1 0 0.0 0 1 APOC1P1
Leg fat-free mass (left) 4.27 1 0 0.0 0 1 APOC1P1
Trunk fat percentage 2.46 1 0 0.0 0 1 APOC1P1
Hand grip strength (right) 4.61 1 0 0.0 0 1 APOC1P1
Fed-up feelings 2.61 1 0 0.0 0 1 APOC1P1
Body mass index (BMI) 3.81 1 0 0.0 0 1 APOC1P1
Impedance of leg (left) 0.89 1 0 0.0 0 1 APOC1P1
Leg predicted mass (left) 4.31 1 0 0.0 0 1 APOC1P1
Trunk fat mass 4.29 1 0 0.0 0 1 APOC1P1
Waist circumference 4.57 1 0 0.0 0 1 APOC1P1
Nervous feelings 2.55 1 0 0.0 0 1 APOC1P1
Forced vital capacity (FVC) 1.34 1 0 0.0 0 1 APOC1P1
Medication: Simvastatin 4.22 1 0 0.0 0 1 APOC1P1
Weight 6.80 1 1 2.2 0 1 APOC1P1
Impedance of arm (right) 1.44 1 0 0.0 0 1 APOC1P1
Arm fat percentage (right) 2.56 1 0 0.0 0 1 APOC1P1
Trunk fat-free mass 5.31 1 1 2.2 0 1 APOC1P1
Hip circumference 3.83 1 0 0.0 0 1 APOC1P1
Father's age at death 3.71 1 0 0.0 0 1 APOC1P1
Worrier / anxious feelings 5.46 1 0 0.0 0 1 APOC1P1
Forced expiratory volume in 1-second (FEV1) 1.92 1 0 0.0 0 1 APOC1P1
Pulse rate 4.45 1 0 0.0 0 1 APOC1P1
Medication: Cholesterol lowering 4.24 1 0 0.0 0 1 APOC1P1
Illnesses of mother 12.21 1 0 0.0 0 1 APOC1P1
Impedance of arm (left) 1.83 1 0 0.0 0 1 APOC1P1
Arm fat mass (right) 4.94 1 0 0.0 0 1 APOC1P1
Trunk predicted mass 5.20 1 1 2.2 0 1 APOC1P1
Standing height 1.96 1 0 0.0 0 1 APOC1P1
Tense / 'highly strung' 2.37 1 0 0.0 0 1 APOC1P1
Peak expiratory flow (PEF) 2.62 1 0 0.0 0 1 APOC1P1
Loud music exposure frequency 13.89 1 0 0.0 0 1 APOC1P1
Hypothyroidism/myxoedema (self-reported) 2.22 1 0 0.0 0 1 APOC1P1
Birth weight 4.15 1 0 0.0 0 1 APOC1P1
Body fat percentage 2.79 1 0 0.0 0 1 APOC1P1
Leg fat percentage (right) 3.32 1 0 0.0 0 1 APOC1P1
Arm fat-free mass (right) 4.82 1 0 0.0 0 1 APOC1P1
Medication: Omeprazole 3.73 1 0 0.0 0 1 APOC1P1
Whole body fat mass 4.94 1 0 0.0 0 1 APOC1P1
Leg fat mass (right) 5.37 1 0 0.0 0 1 APOC1P1
Arm predicted mass (right) 4.17 1 0 0.0 0 1 APOC1P1
Pulse rate, automated reading 1.61 1 0 0.0 0 1 APOC1P1
Comparative height size at age 10 2.42 1 0 0.0 0 1 APOC1P1
Whole body fat-free mass 5.03 1 1 2.2 0 1 APOC1P1
Leg fat-free mass (right) 4.20 1 0 0.0 0 1 APOC1P1
Arm fat percentage (left) 2.35 1 0 0.0 0 1 APOC1P1
Ever had bowel cancer screening 4.17 1 0 0.0 0 1 APOC1P1
Mouth/teeth dental problems: Mouth ulcers 3.20 1 0 0.0 0 1 APOC1P1
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.27 1 0 0.0 0 1 APOC1P1
Back pain experienced in last month 5.69 1 0 0.0 0 1 APOC1P1
Illnesses of father: None of the above (group 1) 8.90 1 0 0.0 0 1 APOC1P1
Whole body water mass 4.95 1 1 2.2 0 1 APOC1P1
Leg predicted mass (right) 4.22 1 0 0.0 0 1 APOC1P1
Arm fat mass (left) 4.74 1 0 0.0 0 1 APOC1P1
Wears glasses or contact lenses 6.37 1 0 0.0 0 1 APOC1P1
Tinnitus: Yes, now most or all of the time 5.53 1 0 0.0 0 1 APOC1P1
High cholesterol (Self-reported) 11.32 1 0 0.0 0 1 APOC1P1
Medication: Atorvastatin 5.14 1 0 0.0 0 1 APOC1P1
Basal metabolic rate 5.67 1 1 2.2 0 1 APOC1P1
Leg fat percentage (left) 3.76 1 0 0.0 0 1 APOC1P1
Arm fat-free mass (left) 5.80 1 1 2.2 0 1 APOC1P1
Diastolic blood pressure, automated reading 1.70 1 0 0.0 0 1 APOC1P1
Cholesterol lowering medication 7.45 1 0 0.0 0 1 APOC1P1
Medication: Omeprazole (e.g. Zanprol) 4.33 1 0 0.0 0 1 APOC1P1
Impedance of whole body 2.00 1 0 0.0 0 1 APOC1P1
Leg fat mass (left) 5.75 1 0 0.0 0 1 APOC1P1
Arm predicted mass (left) 5.93 1 1 2.2 0 1 APOC1P1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.1
GTEx Brain Caudate basal ganglia 0 0.000 1.3
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.2
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.1
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.4
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.1
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.1
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 1 0.024 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3