Hub : Traits :

Illnesses of mother

19 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 15 90730363 92135418 1 1 3.0e-12 4.5e-12 1.000 100 FES
2 17 37483599 38916313 1 1 1.7e-07 4.4e-03 0.035 45 MED24

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 7.50 1 1 2.2 0 1 FES
Schizophrenia (2018) 8.57 1 1 2.2 0 1 FES
Crohns Disease (2017) 3.07 1 0 0.0 0 1 FES
Irritable Bowel Disease (IBD) 2.68 1 0 0.0 0 1 FES
Major Depression (MDD) 7.03 1 0 0.0 0 1 FES
Breast Cancer 3.69 1 0 0.0 0 1 FES
Prostate Cancer 6.43 1 0 0.0 0 1 MED24
Coronary Artery Disease (CAD) 4.36 1 0 0.0 0 1 FES
Schizophrenia (2014) 8.94 1 1 2.2 0 1 FES
Blood Eosinophil Count 6.01 1 1 2.2 0 1 MED24
Blood Platelet Count 0.49 1 0 0.0 0 1 MED24
Blood Red Count 0.98 1 0 0.0 0 1 FES
Blood White Count 23.40 2 2 4.4 0 1 FES MED24
Height 0.69 2 0 0.0 0 1 FES MED24
Systolic Blood Pressure 25.59 1 1 2.2 0 1 FES
Smoking Status 4.06 1 0 0.0 0 1 FES
Allergy or Eczema 4.19 2 0 0.0 0 1 FES MED24
Cardiovascular Disease 19.25 1 1 2.2 0 1 FES
Respiratory disease 3.26 1 0 0.0 0 1 FES
Hair Pigment 0.77 1 1 2.2 0 1 FES
Hand grip strength (left) 2.15 1 0 0.0 0 1 FES
Number of treatments/medications taken 3.76 1 0 0.0 0 1 FES
Sensitivity / hurt feelings 5.16 1 0 0.0 0 1 FES
Other serious medical condition/disability diagnosed by doctor 4.58 1 0 0.0 0 1 MED24
Systolic blood pressure, automated reading 19.08 1 1 2.2 0 1 FES
Angina 12.06 1 1 2.2 0 1 FES
Impedance of leg (right) 2.87 1 1 2.2 0 1 FES
Leg fat-free mass (left) 1.16 1 0 0.0 0 1 FES
High blood pressure 21.58 1 1 2.2 0 1 FES
Medication: Atenolol 12.95 1 1 2.2 0 1 FES
Sitting height 0.82 1 0 0.0 0 1 FES
High blood pressure (mother) 32.16 1 1 2.2 0 1 FES
Impedance of leg (left) 2.68 1 0 0.0 0 1 FES
Leg predicted mass (left) 1.15 1 0 0.0 0 1 FES
Number of incorrect matches in round 3.52 1 0 0.0 0 1 FES
Alcohol usually taken with meals 3.86 1 0 0.0 0 1 FES
Heart attack 7.55 1 0 0.0 0 1 FES
Allergy 4.77 2 0 0.0 0 1 FES MED24
Medication: Ramipril 5.40 1 0 0.0 0 1 FES
Medication: Simvastatin 8.64 1 0 0.0 0 1 FES
Illnesses of siblings 8.55 1 0 0.0 0 1 FES
Impedance of arm (right) 1.28 1 0 0.0 0 1 MED24
Father's age at death 7.40 1 0 0.0 0 1 FES
Medication: Cholesterol lowering 10.35 1 1 2.2 0 1 FES
Impedance of arm (left) 1.03 1 0 0.0 0 1 MED24
Breastfed as a baby 5.20 1 0 0.0 0 1 FES
Hair/balding pattern: Pattern 4 2.62 1 0 0.0 0 1 FES
Birth weight of first child 10.65 1 1 2.2 0 1 FES
Headache pain in last month 3.04 1 0 0.0 0 1 FES
Medication for cholesterol, blood pressure or diabetes 19.26 1 1 2.2 0 1 FES
Medication: Amlodipine 8.67 1 0 0.0 0 1 FES
Birth weight 5.45 1 0 0.0 0 1 FES
High blood pressure (siblings) 11.71 1 1 2.2 0 1 FES
Wheeze or whistling in the chest in last year 5.86 1 0 0.0 0 1 MED24
Shortness of breath walking on level ground 6.41 1 0 0.0 0 1 MED24
Medication: Blood pressure 19.46 1 1 2.2 0 1 FES
Angina (self-reported) 13.02 1 1 2.2 0 1 FES
Mean time to correctly identify matches 2.71 1 0 0.0 0 1 FES
Heart disease (mother) 7.09 1 0 0.0 0 1 FES
Comparative height size at age 10 1.76 1 0 0.0 0 1 MED24
Chest pain or discomfort 6.11 1 0 0.0 0 1 MED24
Medication: Aspirin 8.98 1 0 0.0 0 1 FES
Knee pain experienced in last month 4.73 1 0 0.0 0 1 MED24
Hypertension (Self-reported) 22.31 1 1 2.2 0 1 FES
Illnesses of father: Heart disease 16.58 1 1 2.2 0 1 FES
Leg fat-free mass (right) 1.32 1 0 0.0 0 1 FES
Ever had stillbirth, spontaneous miscarriage or termination 5.92 1 0 0.0 0 1 FES
Medication: Aspirin 10.38 1 1 2.2 0 1 FES
Illnesses of father: None of the above (group 1) 13.24 1 1 2.2 0 1 FES
Whole body water mass 0.92 1 0 0.0 0 1 FES
Leg predicted mass (right) 1.38 1 0 0.0 0 1 FES
Number of self-reported non-cancer illnesses 2.94 1 0 0.0 0 1 FES
Medication: Blood pressure 14.28 1 1 2.2 0 1 FES
Supplements: Fish oil (including cod liver oil) 5.00 1 0 0.0 0 1 MED24
High cholesterol (Self-reported) 3.90 1 0 0.0 0 1 FES
Medication: Bendroflumethiazide 5.70 1 0 0.0 0 1 FES
Medication: Lisinopril 3.71 1 0 0.0 0 1 FES
Illnesses of father: High blood pressure 17.86 1 1 2.2 0 1 FES
Ever smoked 3.09 1 0 0.0 0 1 FES
Age started oral contraceptive pill 3.77 1 0 0.0 0 1 FES
Diastolic blood pressure, automated reading 15.67 1 1 2.2 0 1 FES
Vascular/heart problems diagnosed by doctor 24.15 1 1 2.2 0 1 FES
Pain experienced in last month 4.97 1 0 0.0 0 1 MED24
Heart attack/myocardial infarction (self-reported) 8.09 1 0 0.0 0 1 FES
Heart disease (siblings) 7.65 1 0 0.0 0 1 FES
Impedance of whole body 1.58 1 0 0.0 0 1 FES

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 1 0.049 1.3
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.3
GTEx Artery Coronary 0 0.000 1.3
GTEx Artery Tibial 1 0.027 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.2
GTEx Brain Cerebellum 0 0.000 1.3
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.1
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.1
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.3
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 1 0.024 1.3
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.3
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.1
GTEx Lung 1 0.035 1.2
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.3
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 1 0.027 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.2
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 1 0.025 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 1 0.050 1.3
METSIM Adipose 1 0.022 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 1 0.023 1.3
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 1 0.091 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 1 0.040 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 1 0.063 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 1 0.022 1.3
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.3
The Cancer Genome Atlas Thyroid Carcinoma 1 0.019 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2