Hub : Traits :

Illnesses of mother

19 significantly associated models · 2 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	15	90730363	92135418	1	1	3.0e-12	4.5e-12	1.000	100	FES
2	17	37483599	38916313	1	1	1.7e-07	4.4e-03	0.035	45	MED24

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
High blood pressure (mother)	32.16	1	1	2.2	1	FES
Systolic Blood Pressure	25.59	1	1	2.2	1	FES
Vascular/heart problems diagnosed by doctor	24.15	1	1	2.2	1	FES
Blood White Count	23.40	2	2	4.4	1	FES MED24
Hypertension (Self-reported)	22.31	1	1	2.2	1	FES
High blood pressure	21.58	1	1	2.2	1	FES
Medication: Blood pressure	19.46	1	1	2.2	1	FES
Medication for cholesterol, blood pressure or diabetes	19.26	1	1	2.2	1	FES
Cardiovascular Disease	19.25	1	1	2.2	1	FES
Systolic blood pressure, automated reading	19.08	1	1	2.2	1	FES
Illnesses of father: High blood pressure	17.86	1	1	2.2	1	FES
Illnesses of father: Heart disease	16.58	1	1	2.2	1	FES
Diastolic blood pressure, automated reading	15.67	1	1	2.2	1	FES
Medication: Blood pressure	14.28	1	1	2.2	1	FES
Illnesses of father: None of the above (group 1)	13.24	1	1	2.2	1	FES
Angina (self-reported)	13.02	1	1	2.2	1	FES
Medication: Atenolol	12.95	1	1	2.2	1	FES
Angina	12.06	1	1	2.2	1	FES
High blood pressure (siblings)	11.71	1	1	2.2	1	FES
Birth weight of first child	10.65	1	1	2.2	1	FES
Medication: Aspirin	10.38	1	1	2.2	1	FES
Medication: Cholesterol lowering	10.35	1	1	2.2	1	FES
Medication: Aspirin	8.98	1	0	0.0	1	FES
Schizophrenia (2014)	8.94	1	1	2.2	1	FES
Medication: Amlodipine	8.67	1	0	0.0	1	FES
Medication: Simvastatin	8.64	1	0	0.0	1	FES
Schizophrenia (2018)	8.57	1	1	2.2	1	FES
Illnesses of siblings	8.55	1	0	0.0	1	FES
Heart attack/myocardial infarction (self-reported)	8.09	1	0	0.0	1	FES
Heart disease (siblings)	7.65	1	0	0.0	1	FES
Heart attack	7.55	1	0	0.0	1	FES
Bipolar Disorder or Schizophrenia	7.50	1	1	2.2	1	FES
Father's age at death	7.40	1	0	0.0	1	FES
Heart disease (mother)	7.09	1	0	0.0	1	FES
Major Depression (MDD)	7.03	1	0	0.0	1	FES
Prostate Cancer	6.43	1	0	0.0	1	MED24
Shortness of breath walking on level ground	6.41	1	0	0.0	1	MED24
Chest pain or discomfort	6.11	1	0	0.0	1	MED24
Blood Eosinophil Count	6.01	1	1	2.2	1	MED24
Ever had stillbirth, spontaneous miscarriage or termination	5.92	1	0	0.0	1	FES
Wheeze or whistling in the chest in last year	5.86	1	0	0.0	1	MED24
Medication: Bendroflumethiazide	5.70	1	0	0.0	1	FES
Birth weight	5.45	1	0	0.0	1	FES
Medication: Ramipril	5.40	1	0	0.0	1	FES
Breastfed as a baby	5.20	1	0	0.0	1	FES
Sensitivity / hurt feelings	5.16	1	0	0.0	1	FES
Supplements: Fish oil (including cod liver oil)	5.00	1	0	0.0	1	MED24
Pain experienced in last month	4.97	1	0	0.0	1	MED24
Allergy	4.77	2	0	0.0	1	FES MED24
Knee pain experienced in last month	4.73	1	0	0.0	1	MED24
Other serious medical condition/disability diagnosed by doctor	4.58	1	0	0.0	1	MED24
Coronary Artery Disease (CAD)	4.36	1	0	0.0	1	FES
Allergy or Eczema	4.19	2	0	0.0	1	FES MED24
Smoking Status	4.06	1	0	0.0	1	FES
High cholesterol (Self-reported)	3.90	1	0	0.0	1	FES
Alcohol usually taken with meals	3.86	1	0	0.0	1	FES
Age started oral contraceptive pill	3.77	1	0	0.0	1	FES
Number of treatments/medications taken	3.76	1	0	0.0	1	FES
Medication: Lisinopril	3.71	1	0	0.0	1	FES
Breast Cancer	3.69	1	0	0.0	1	FES
Number of incorrect matches in round	3.52	1	0	0.0	1	FES
Respiratory disease	3.26	1	0	0.0	1	FES
Ever smoked	3.09	1	0	0.0	1	FES
Crohns Disease (2017)	3.07	1	0	0.0	1	FES
Headache pain in last month	3.04	1	0	0.0	1	FES
Number of self-reported non-cancer illnesses	2.94	1	0	0.0	1	FES
Impedance of leg (right)	2.87	1	1	2.2	1	FES
Mean time to correctly identify matches	2.71	1	0	0.0	1	FES
Irritable Bowel Disease (IBD)	2.68	1	0	0.0	1	FES
Impedance of leg (left)	2.68	1	0	0.0	1	FES
Hair/balding pattern: Pattern 4	2.62	1	0	0.0	1	FES
Hand grip strength (left)	2.15	1	0	0.0	1	FES
Comparative height size at age 10	1.76	1	0	0.0	1	MED24
Impedance of whole body	1.58	1	0	0.0	1	FES
Leg predicted mass (right)	1.38	1	0	0.0	1	FES
Leg fat-free mass (right)	1.32	1	0	0.0	1	FES
Impedance of arm (right)	1.28	1	0	0.0	1	MED24
Leg fat-free mass (left)	1.16	1	0	0.0	1	FES
Leg predicted mass (left)	1.15	1	0	0.0	1	FES
Impedance of arm (left)	1.03	1	0	0.0	1	MED24
Blood Red Count	0.98	1	0	0.0	1	FES
Whole body water mass	0.92	1	0	0.0	1	FES
Sitting height	0.82	1	0	0.0	1	FES
Hair Pigment	0.77	1	1	2.2	1	FES
Height	0.69	2	0	0.0	1	FES MED24
Blood Platelet Count	0.49	1	0	0.0	1	MED24

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Adipose Visceral Omentum	1	0.049	1.3
GTEx	Artery Aorta	0	0.000	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	1	0.027	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	1	0.024	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	1	0.027	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Thyroid	1	0.025	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Whole Blood	1	0.050	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	1	0.023	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.3
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	1	0.040	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	1	0.022	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	1	0.019	1.3
GTEx	Adipose Subcutaneous	0	0.000	1.2
GTEx	Adrenal Gland	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.2
GTEx	Brain Cortex	0	0.000	1.2
GTEx	Brain Hypothalamus	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Colon Sigmoid	0	0.000	1.2
GTEx	Colon Transverse	0	0.000	1.2
GTEx	Heart Atrial Appendage	0	0.000	1.2
GTEx	Heart Left Ventricle	0	0.000	1.2
GTEx	Lung	1	0.035	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Pancreas	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.2
GTEx	Spleen	0	0.000	1.2
GTEx	Stomach	0	0.000	1.2
GTEx	Testis	0	0.000	1.2
GTEx	Vagina	0	0.000	1.2
METSIM	Adipose	1	0.022	1.2
NTR	Blood	0	0.000	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.2
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.2
GTEx	Brain Hippocampus	0	0.000	1.1
GTEx	Brain Putamen basal ganglia	0	0.000	1.1
GTEx	Liver	0	0.000	1.1
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.1