Hub : Traits :

Alzheimer’s Disease (in mother)

34 significantly associated models · 18 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	127113672	128561279	1	1	1.5e-09	1.4e-11	2.8e-06	52	BIN1
2	19	44190626	46190531	16	15	6.4e-68	5.5e-89	NaN	NaN	APOC1P1 APOC2 APOC4 CEACAM19 GEMIN7 NKPD1 PVRL2 TOMM40 ZNF229

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Alzheimer’s Disease (including proxy)	149.90	10	10	22.2	0.99	3.2e-15	APOC1P1 APOC2 APOC4 BIN1 CEACAM19 GEMIN7 NKPD1 PVRL2 TOMM40 ZNF229
LDL Cholesterol	36.36	8	7	15.6	0.88	7.1e-04	APOC2 APOC4 CEACAM19 GEMIN7 NKPD1 PVRL2 TOMM40 ZNF229
Alzheimer’s Disease (in father)	30.87	9	5	11.1	0.99	5.2e-12	APOC1P1 APOC2 APOC4 CEACAM19 GEMIN7 NKPD1 PVRL2 TOMM40 ZNF229
High cholesterol (Self-reported)	14.47	7	5	11.1	0.95	2.9e-04	APOC2 APOC4 CEACAM19 GEMIN7 PVRL2 TOMM40 ZNF229
Cholesterol lowering medication	8.63	5	3	6.7	0.94	1.8e-02	APOC2 APOC4 PVRL2 TOMM40 ZNF229
Medication: Simvastatin	8.45	6	3	6.7	0.93	8.1e-03	APOC2 CEACAM19 GEMIN7 PVRL2 TOMM40 ZNF229
Medication: Cholesterol lowering	7.70	6	4	8.9	0.96	2.6e-03	APOC2 CEACAM19 NKPD1 PVRL2 TOMM40 ZNF229
Medication: Atorvastatin	6.08	4	2	4.4	0.98	2.3e-02	APOC4 PVRL2 TOMM40 ZNF229
HDL Cholesterol	4.50	4	0	0.0	-0.62	2.7e-01	APOC2 APOC4 PVRL2 TOMM40
Triglycerides	4.07	3	1	2.2	0.52	4.8e-01	APOC2 APOC4 PVRL2
Illnesses of mother	3.78	1	0	0.0	0.00	1.0e+00	APOC4
Average weekly fortified wine intake	3.28	2	0	0.0	0.00	1.0e+00	APOC1P1 TOMM40
Cardiovascular Disease	3.12	4	3	6.7	0.93	7.5e-02	APOC4 PVRL2 TOMM40 ZNF229
Illnesses of father: None of the above (group 1)	2.81	2	0	0.0	0.00	1.0e+00	APOC1P1 TOMM40
Health satisfaction	2.21	1	0	0.0	0.00	1.0e+00	APOC4
Loud music exposure frequency	2.15	1	0	0.0	0.00	1.0e+00	TOMM40
Supplements: Vitamin C	2.15	1	0	0.0	0.00	1.0e+00	PVRL2
Medication for cholesterol	2.12	2	0	0.0	0.00	1.0e+00	PVRL2 TOMM40
High blood pressure (siblings)	2.09	1	0	0.0	0.00	1.0e+00	APOC4
Medication for cholesterol, blood pressure or diabetes	2.02	2	0	0.0	0.00	1.0e+00	PVRL2 TOMM40
Angina	1.97	1	0	0.0	0.00	1.0e+00	APOC2
Hand grip strength (left)	1.96	3	0	0.0	-0.47	5.3e-01	APOC1P1 PVRL2 TOMM40
Allergy or Eczema	1.95	2	0	0.0	0.00	1.0e+00	APOC2 PVRL2
Hand grip strength (right)	1.89	2	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2
Medication: Aspirin	1.84	1	0	0.0	0.00	1.0e+00	TOMM40
Medication: Aspirin	1.79	1	0	0.0	0.00	1.0e+00	TOMM40
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.77	1	0	0.0	0.00	1.0e+00	CEACAM19
Diabetes (mother)	1.75	1	0	0.0	0.00	1.0e+00	PVRL2
Hayfever, allergic rhinitis or eczema	1.75	1	0	0.0	0.00	1.0e+00	PVRL2
Angina (self-reported)	1.75	1	0	0.0	0.00	1.0e+00	APOC2
Diabetes diagnosed by doctor	1.69	1	0	0.0	0.00	1.0e+00	PVRL2
Illnesses of father: Heart disease	1.63	1	0	0.0	0.00	1.0e+00	APOC2
Number of treatments/medications taken	1.54	1	0	0.0	0.00	1.0e+00	TOMM40
Birth weight	1.54	2	0	0.0	0.00	1.0e+00	PVRL2 TOMM40
Forced expiratory volume in 1-second (FEV1), predicted	1.38	1	0	0.0	0.00	1.0e+00	CEACAM19
Blood Eosinophil Count	1.37	3	3	6.7	0.53	4.7e-01	APOC2 APOC4 TOMM40
Pulse wave Arterial Stiffness index	1.34	1	0	0.0	0.00	1.0e+00	TOMM40
Worry (Nagel 2018)	1.33	1	0	0.0	0.00	1.0e+00	ZNF229
Bipolar Disorder or Schizophrenia	1.29	1	0	0.0	0.00	1.0e+00	APOC4
Weight	1.28	4	0	0.0	-0.87	2.3e-02	APOC4 PVRL2 TOMM40 ZNF229
Maternal smoking around birth	1.21	1	0	0.0	0.00	1.0e+00	PVRL2
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.21	1	0	0.0	0.00	1.0e+00	PVRL2
Blood Platelet Count	1.20	6	1	2.2	-0.54	2.1e-01	APOC2 APOC4 CEACAM19 NKPD1 PVRL2 TOMM40
Respiratory disease	1.19	1	0	0.0	0.00	1.0e+00	PVRL2
Leg fat mass (left)	1.19	3	0	0.0	0.00	1.0e+00	APOC4 PVRL2 TOMM40
BMI	1.18	3	0	0.0	0.00	1.0e+00	APOC4 TOMM40 ZNF229
Arm predicted mass (left)	1.16	1	1	2.2	0.00	1.0e+00	APOC4
Systolic Blood Pressure	1.15	3	0	0.0	0.00	1.0e+00	APOC4 BIN1 TOMM40
Trunk fat-free mass	1.12	2	1	2.2	0.56	4.4e-01	APOC2 APOC4
Basal metabolic rate	1.12	1	1	2.2	0.00	1.0e+00	APOC4
Trunk predicted mass	1.11	2	1	2.2	0.55	4.5e-01	APOC2 APOC4
Leg fat mass (right)	1.11	3	0	0.0	0.00	1.0e+00	APOC4 PVRL2 TOMM40
Arm fat-free mass (left)	1.09	1	1	2.2	0.00	1.0e+00	APOC4
Arm fat mass (right)	1.07	2	0	0.0	0.00	1.0e+00	APOC4 PVRL2
Whole body fat-free mass	1.06	2	1	2.2	0.55	4.5e-01	APOC2 APOC4
Waist circumference	1.03	1	0	0.0	0.00	1.0e+00	PVRL2
Whole body fat mass	1.03	2	0	0.0	0.00	1.0e+00	APOC4 PVRL2
Whole body water mass	1.03	1	1	2.2	0.00	1.0e+00	APOC4
Body mass index (BMI)	1.02	1	0	0.0	0.00	1.0e+00	PVRL2
Trunk fat mass	1.01	2	0	0.0	0.00	1.0e+00	APOC4 PVRL2
Arm fat mass (left)	1.00	1	0	0.0	0.00	1.0e+00	PVRL2
Verbal and Numeric Reasoning (VNR)	0.99	1	0	0.0	0.00	1.0e+00	PVRL2
Forced expiratory volume in 1-second (FEV1)	0.99	1	0	0.0	0.00	1.0e+00	PVRL2
Leg fat percentage (left)	0.99	1	0	0.0	0.00	1.0e+00	PVRL2
Blood White Count	0.98	4	1	2.2	-0.85	6.8e-02	APOC1P1 APOC4 PVRL2 TOMM40
Leg fat-free mass (right)	0.97	1	1	2.2	0.00	1.0e+00	APOC4
Forced expiratory volume in 1-second (FEV1), Best measure	0.96	1	0	0.0	0.00	1.0e+00	PVRL2
Leg predicted mass (left)	0.95	1	0	0.0	0.00	1.0e+00	APOC4
Leg predicted mass (right)	0.95	1	0	0.0	0.00	1.0e+00	APOC4
Leg fat-free mass (left)	0.94	1	0	0.0	0.00	1.0e+00	APOC4
Arm fat-free mass (right)	0.93	1	0	0.0	0.00	1.0e+00	APOC4
Breast Cancer	0.91	1	0	0.0	0.00	1.0e+00	APOC2
Forced vital capacity (FVC), Best measure	0.91	2	0	0.0	0.00	1.0e+00	GEMIN7 PVRL2
Leg fat percentage (right)	0.89	1	0	0.0	0.00	1.0e+00	PVRL2
Pulse rate, automated reading	0.89	1	0	0.0	0.00	1.0e+00	APOC2
Forced vital capacity (FVC)	0.87	1	0	0.0	0.00	1.0e+00	PVRL2
Crohns Disease (2017)	0.85	1	0	0.0	0.00	1.0e+00	BIN1
Standing height	0.84	3	1	2.2	0.67	2.2e-01	APOC2 APOC4 CEACAM19
Qualifications: College or University degree	0.83	1	0	0.0	0.00	1.0e+00	NKPD1
Lung FVC	0.82	2	0	0.0	0.00	1.0e+00	APOC1P1 PVRL2
Hip circumference	0.82	2	0	0.0	0.00	1.0e+00	APOC4 PVRL2
Body fat percentage	0.82	1	0	0.0	0.00	1.0e+00	PVRL2
Arm predicted mass (right)	0.82	1	0	0.0	0.00	1.0e+00	APOC4
Diastolic blood pressure, automated reading	0.78	1	0	0.0	0.00	1.0e+00	BIN1
Trunk fat percentage	0.77	1	0	0.0	0.00	1.0e+00	PVRL2
Comparative height size at age 10	0.77	1	0	0.0	0.00	1.0e+00	APOC4
Arm fat percentage (left)	0.77	1	0	0.0	0.00	1.0e+00	PVRL2
Arm fat percentage (right)	0.76	1	0	0.0	0.00	1.0e+00	PVRL2
Systolic blood pressure, automated reading	0.73	1	0	0.0	0.00	1.0e+00	BIN1
Height	0.72	6	2	4.4	-0.30	4.8e-01	APOC2 APOC4 CEACAM19 GEMIN7 TOMM40 ZNF229
Alcohol intake frequency.	0.62	1	0	0.0	0.00	1.0e+00	PVRL2
Impedance of arm (left)	0.59	1	0	0.0	0.00	1.0e+00	GEMIN7
Impedance of whole body	0.57	1	0	0.0	0.00	1.0e+00	GEMIN7
Age when periods started (menarche)	0.56	1	0	0.0	0.00	1.0e+00	APOC4
Impedance of arm (right)	0.54	1	0	0.0	0.00	1.0e+00	GEMIN7
Impedance of leg (left)	0.40	1	0	0.0	0.00	1.0e+00	GEMIN7
Sitting height	0.39	1	0	0.0	0.00	1.0e+00	APOC2
Heel T-Score	0.36	1	0	0.0	0.00	1.0e+00	TOMM40
Blood Red Count	0.32	2	0	0.0	0.00	1.0e+00	APOC4 PVRL2
Hair Pigment	0.08	1	0	0.0	0.00	1.0e+00	TOMM40

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.097	1.4
GTEx	Liver	1	0.139	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	2	0.080	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	1	0.093	1.3
GTEx	Adipose Subcutaneous	1	0.029	1.2
GTEx	Adipose Visceral Omentum	1	0.049	1.2
GTEx	Artery Aorta	0	0.000	1.2
GTEx	Artery Tibial	0	0.000	1.2
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Cerebellum	0	0.000	1.2
GTEx	Brain Putamen basal ganglia	0	0.000	1.2
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.2
GTEx	Cells Transformed fibroblasts	1	0.024	1.2
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.2
GTEx	Esophagus Mucosa	0	0.000	1.2
GTEx	Esophagus Muscularis	0	0.000	1.2
GTEx	Lung	0	0.000	1.2
GTEx	Nerve Tibial	0	0.000	1.2
GTEx	Ovary	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
GTEx	Skin Not Sun Exposed Suprapubic	1	0.041	1.2
GTEx	Stomach	1	0.069	1.2
GTEx	Thyroid	1	0.025	1.2
GTEx	Whole Blood	0	0.000	1.2
NTR	Blood	1	0.042	1.2
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.2
YFS	Blood	2	0.043	1.2
CommonMind	Brain Pre-frontal Cortex	2	0.037	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.2
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	1	0.049	1.2
The Cancer Genome Atlas	Brain Lower Grade Glioma	2	0.046	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	2	0.043	1.2
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	3	0.058	1.2
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.195	1.2
GTEx	Adrenal Gland	0	0.000	1.1
GTEx	Artery Coronary	0	0.000	1.1
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.1
GTEx	Brain Cortex	0	0.000	1.1
GTEx	Brain Frontal Cortex BA9	0	0.000	1.1
GTEx	Brain Hippocampus	0	0.000	1.1
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.1
GTEx	Breast Mammary Tissue	0	0.000	1.1
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.1
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.1
GTEx	Colon Sigmoid	0	0.000	1.1
GTEx	Colon Transverse	0	0.000	1.1
GTEx	Heart Atrial Appendage	0	0.000	1.1
GTEx	Heart Left Ventricle	0	0.000	1.1
GTEx	Muscle Skeletal	0	0.000	1.1
GTEx	Pancreas	0	0.000	1.1
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.1
GTEx	Small Intestine Terminal Ileum	0	0.000	1.1
GTEx	Spleen	0	0.000	1.1
GTEx	Testis	0	0.000	1.1
GTEx	Uterus	0	0.000	1.1
GTEx	Vagina	0	0.000	1.1
METSIM	Adipose	0	0.000	1.1
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.1
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.1
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.1
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.1
GTEx	Brain Hypothalamus	0	0.000	1.0