Hub : Traits :

Alzheimer’s Disease (in mother)

34 significantly associated models · 18 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 127113672 128561279 1 1 1.5e-09 1.4e-11 2.8e-06 52 BIN1
2 19 44190626 46190531 16 15 6.4e-68 5.5e-89 NaN NaN APOC1P1 APOC2 APOC4 CEACAM19 GEMIN7 NKPD1 PVRL2 TOMM40 ZNF229

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder or Schizophrenia 1.29 1 0 0.0 0.00 1.0e+00 APOC4
Worry (Nagel 2018) 1.33 1 0 0.0 0.00 1.0e+00 ZNF229
Alzheimer’s Disease (in father) 30.87 9 5 11.1 0.99 5.2e-12 APOC1P1 APOC2 APOC4 CEACAM19 GEMIN7 NKPD1 PVRL2 TOMM40 ZNF229
Alzheimer’s Disease (including proxy) 149.90 10 10 22.2 0.99 3.2e-15 APOC1P1 APOC2 APOC4 BIN1 CEACAM19 GEMIN7 NKPD1 PVRL2 TOMM40 ZNF229
Crohns Disease (2017) 0.85 1 0 0.0 0.00 1.0e+00 BIN1
Verbal and Numeric Reasoning (VNR) 0.99 1 0 0.0 0.00 1.0e+00 PVRL2
Breast Cancer 0.91 1 0 0.0 0.00 1.0e+00 APOC2
HDL Cholesterol 4.50 4 0 0.0 -0.62 2.7e-01 APOC2 APOC4 PVRL2 TOMM40
LDL Cholesterol 36.36 8 7 15.6 0.88 7.1e-04 APOC2 APOC4 CEACAM19 GEMIN7 NKPD1 PVRL2 TOMM40 ZNF229
Triglycerides 4.07 3 1 2.2 0.52 4.8e-01 APOC2 APOC4 PVRL2
Blood Eosinophil Count 1.37 3 3 6.7 0.53 4.7e-01 APOC2 APOC4 TOMM40
Blood Platelet Count 1.20 6 1 2.2 -0.54 2.1e-01 APOC2 APOC4 CEACAM19 NKPD1 PVRL2 TOMM40
Blood Red Count 0.32 2 0 0.0 0.00 1.0e+00 APOC4 PVRL2
Blood White Count 0.98 4 1 2.2 -0.85 6.8e-02 APOC1P1 APOC4 PVRL2 TOMM40
Heel T-Score 0.36 1 0 0.0 0.00 1.0e+00 TOMM40
BMI 1.18 3 0 0.0 0.00 1.0e+00 APOC4 TOMM40 ZNF229
Height 0.72 6 2 4.4 -0.30 4.8e-01 APOC2 APOC4 CEACAM19 GEMIN7 TOMM40 ZNF229
Systolic Blood Pressure 1.15 3 0 0.0 0.00 1.0e+00 APOC4 BIN1 TOMM40
Allergy or Eczema 1.95 2 0 0.0 0.00 1.0e+00 APOC2 PVRL2
Cardiovascular Disease 3.12 4 3 6.7 0.93 7.5e-02 APOC4 PVRL2 TOMM40 ZNF229
Respiratory disease 1.19 1 0 0.0 0.00 1.0e+00 PVRL2
Lung FVC 0.82 2 0 0.0 0.00 1.0e+00 APOC1P1 PVRL2
Hair Pigment 0.08 1 0 0.0 0.00 1.0e+00 TOMM40
Hand grip strength (left) 1.96 3 0 0.0 -0.47 5.3e-01 APOC1P1 PVRL2 TOMM40
Number of treatments/medications taken 1.54 1 0 0.0 0.00 1.0e+00 TOMM40
Systolic blood pressure, automated reading 0.73 1 0 0.0 0.00 1.0e+00 BIN1
Angina 1.97 1 0 0.0 0.00 1.0e+00 APOC2
Diabetes (mother) 1.75 1 0 0.0 0.00 1.0e+00 PVRL2
Leg fat-free mass (left) 0.94 1 0 0.0 0.00 1.0e+00 APOC4
Trunk fat percentage 0.77 1 0 0.0 0.00 1.0e+00 PVRL2
Hand grip strength (right) 1.89 2 0 0.0 0.00 1.0e+00 APOC1P1 PVRL2
Average weekly fortified wine intake 3.28 2 0 0.0 0.00 1.0e+00 APOC1P1 TOMM40
Maternal smoking around birth 1.21 1 0 0.0 0.00 1.0e+00 PVRL2
Age when periods started (menarche) 0.56 1 0 0.0 0.00 1.0e+00 APOC4
Hayfever, allergic rhinitis or eczema 1.75 1 0 0.0 0.00 1.0e+00 PVRL2
Sitting height 0.39 1 0 0.0 0.00 1.0e+00 APOC2
Body mass index (BMI) 1.02 1 0 0.0 0.00 1.0e+00 PVRL2
Impedance of leg (left) 0.40 1 0 0.0 0.00 1.0e+00 GEMIN7
Leg predicted mass (left) 0.95 1 0 0.0 0.00 1.0e+00 APOC4
Trunk fat mass 1.01 2 0 0.0 0.00 1.0e+00 APOC4 PVRL2
Waist circumference 1.03 1 0 0.0 0.00 1.0e+00 PVRL2
Forced vital capacity (FVC) 0.87 1 0 0.0 0.00 1.0e+00 PVRL2
Medication: Simvastatin 8.45 6 3 6.7 0.93 8.1e-03 APOC2 CEACAM19 GEMIN7 PVRL2 TOMM40 ZNF229
Weight 1.28 4 0 0.0 -0.87 2.3e-02 APOC4 PVRL2 TOMM40 ZNF229
Impedance of arm (right) 0.54 1 0 0.0 0.00 1.0e+00 GEMIN7
Arm fat percentage (right) 0.76 1 0 0.0 0.00 1.0e+00 PVRL2
Trunk fat-free mass 1.12 2 1 2.2 0.56 4.4e-01 APOC2 APOC4
Hip circumference 0.82 2 0 0.0 0.00 1.0e+00 APOC4 PVRL2
Forced expiratory volume in 1-second (FEV1) 0.99 1 0 0.0 0.00 1.0e+00 PVRL2
Medication: Cholesterol lowering 7.70 6 4 8.9 0.96 2.6e-03 APOC2 CEACAM19 NKPD1 PVRL2 TOMM40 ZNF229
Illnesses of mother 3.78 1 0 0.0 0.00 1.0e+00 APOC4
Forced expiratory volume in 1-second (FEV1), Best measure 0.96 1 0 0.0 0.00 1.0e+00 PVRL2
Pulse wave Arterial Stiffness index 1.34 1 0 0.0 0.00 1.0e+00 TOMM40
Impedance of arm (left) 0.59 1 0 0.0 0.00 1.0e+00 GEMIN7
Arm fat mass (right) 1.07 2 0 0.0 0.00 1.0e+00 APOC4 PVRL2
Trunk predicted mass 1.11 2 1 2.2 0.55 4.5e-01 APOC2 APOC4
Standing height 0.84 3 1 2.2 0.67 2.2e-01 APOC2 APOC4 CEACAM19
Loud music exposure frequency 2.15 1 0 0.0 0.00 1.0e+00 TOMM40
Medication for cholesterol, blood pressure or diabetes 2.02 2 0 0.0 0.00 1.0e+00 PVRL2 TOMM40
Birth weight 1.54 2 0 0.0 0.00 1.0e+00 PVRL2 TOMM40
High blood pressure (siblings) 2.09 1 0 0.0 0.00 1.0e+00 APOC4
Forced vital capacity (FVC), Best measure 0.91 2 0 0.0 0.00 1.0e+00 GEMIN7 PVRL2
Body fat percentage 0.82 1 0 0.0 0.00 1.0e+00 PVRL2
Leg fat percentage (right) 0.89 1 0 0.0 0.00 1.0e+00 PVRL2
Arm fat-free mass (right) 0.93 1 0 0.0 0.00 1.0e+00 APOC4
Health satisfaction 2.21 1 0 0.0 0.00 1.0e+00 APOC4
Qualifications: College or University degree 0.83 1 0 0.0 0.00 1.0e+00 NKPD1
Angina (self-reported) 1.75 1 0 0.0 0.00 1.0e+00 APOC2
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.77 1 0 0.0 0.00 1.0e+00 CEACAM19
Whole body fat mass 1.03 2 0 0.0 0.00 1.0e+00 APOC4 PVRL2
Leg fat mass (right) 1.11 3 0 0.0 0.00 1.0e+00 APOC4 PVRL2 TOMM40
Arm predicted mass (right) 0.82 1 0 0.0 0.00 1.0e+00 APOC4
Pulse rate, automated reading 0.89 1 0 0.0 0.00 1.0e+00 APOC2
Alcohol intake frequency. 0.62 1 0 0.0 0.00 1.0e+00 PVRL2
Comparative height size at age 10 0.77 1 0 0.0 0.00 1.0e+00 APOC4
Medication: Aspirin 1.84 1 0 0.0 0.00 1.0e+00 TOMM40
Supplements: Vitamin C 2.15 1 0 0.0 0.00 1.0e+00 PVRL2
Illnesses of father: Heart disease 1.63 1 0 0.0 0.00 1.0e+00 APOC2
Forced expiratory volume in 1-second (FEV1), predicted 1.38 1 0 0.0 0.00 1.0e+00 CEACAM19
Whole body fat-free mass 1.06 2 1 2.2 0.55 4.5e-01 APOC2 APOC4
Leg fat-free mass (right) 0.97 1 1 2.2 0.00 1.0e+00 APOC4
Arm fat percentage (left) 0.77 1 0 0.0 0.00 1.0e+00 PVRL2
Diabetes diagnosed by doctor 1.69 1 0 0.0 0.00 1.0e+00 PVRL2
Medication for cholesterol 2.12 2 0 0.0 0.00 1.0e+00 PVRL2 TOMM40
Medication: Aspirin 1.79 1 0 0.0 0.00 1.0e+00 TOMM40
Illnesses of father: None of the above (group 1) 2.81 2 0 0.0 0.00 1.0e+00 APOC1P1 TOMM40
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.21 1 0 0.0 0.00 1.0e+00 PVRL2
Whole body water mass 1.03 1 1 2.2 0.00 1.0e+00 APOC4
Leg predicted mass (right) 0.95 1 0 0.0 0.00 1.0e+00 APOC4
Arm fat mass (left) 1.00 1 0 0.0 0.00 1.0e+00 PVRL2
High cholesterol (Self-reported) 14.47 7 5 11.1 0.95 2.9e-04 APOC2 APOC4 CEACAM19 GEMIN7 PVRL2 TOMM40 ZNF229
Medication: Atorvastatin 6.08 4 2 4.4 0.98 2.3e-02 APOC4 PVRL2 TOMM40 ZNF229
Basal metabolic rate 1.12 1 1 2.2 0.00 1.0e+00 APOC4
Leg fat percentage (left) 0.99 1 0 0.0 0.00 1.0e+00 PVRL2
Arm fat-free mass (left) 1.09 1 1 2.2 0.00 1.0e+00 APOC4
Diastolic blood pressure, automated reading 0.78 1 0 0.0 0.00 1.0e+00 BIN1
Cholesterol lowering medication 8.63 5 3 6.7 0.94 1.8e-02 APOC2 APOC4 PVRL2 TOMM40 ZNF229
Impedance of whole body 0.57 1 0 0.0 0.00 1.0e+00 GEMIN7
Leg fat mass (left) 1.19 3 0 0.0 0.00 1.0e+00 APOC4 PVRL2 TOMM40
Arm predicted mass (left) 1.16 1 1 2.2 0.00 1.0e+00 APOC4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.2
GTEx Adipose Visceral Omentum 1 0.049 1.2
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.1
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.1
GTEx Brain Frontal Cortex BA9 0 0.000 1.1
GTEx Brain Hippocampus 0 0.000 1.1
GTEx Brain Hypothalamus 0 0.000 1.0
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.2
GTEx Breast Mammary Tissue 0 0.000 1.1
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 1 0.024 1.2
GTEx Colon Sigmoid 0 0.000 1.1
GTEx Colon Transverse 0 0.000 1.1
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.1
GTEx Heart Left Ventricle 0 0.000 1.1
GTEx Liver 1 0.139 1.3
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.1
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.1
GTEx Pituitary 0 0.000 1.2
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 1 0.041 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.1
GTEx Small Intestine Terminal Ileum 0 0.000 1.1
GTEx Spleen 0 0.000 1.1
GTEx Stomach 1 0.069 1.2
GTEx Testis 0 0.000 1.1
GTEx Thyroid 1 0.025 1.2
GTEx Uterus 0 0.000 1.1
GTEx Vagina 0 0.000 1.1
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 1 0.042 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 2 0.043 1.2
CommonMind Brain Pre-frontal Cortex 2 0.037 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.097 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 1 0.049 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 2 0.046 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 1 0.034 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 2 0.080 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 1 0.060 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 2 0.043 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 1 0.093 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 1 0.059 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.2
The Cancer Genome Atlas Thyroid Carcinoma 3 0.058 1.2
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.195 1.2