Hub : Traits :

Ever had bowel cancer screening

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 6 41058968 42450682 2 2 2.7e-07 5.7e-06 0.19 92 CCND3 PRICKLE4

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Neuroticism (Nagel 2018) 1.43 1 0 0.0 0 1 CCND3
Ulcerative Colitis (UC) 2.68 1 0 0.0 0 1 CCND3
Blood Eosinophil Count 1.18 1 0 0.0 0 1 CCND3
Blood Platelet Count 0.76 1 0 0.0 0 1 CCND3
Blood Red Count 119.95 2 2 4.4 0 1 CCND3 PRICKLE4
Blood White Count 1.64 1 0 0.0 0 1 CCND3
Height 1.40 2 1 2.2 0 1 CCND3 PRICKLE4
Waist Hip Ratio (WHR) 1.78 1 0 0.0 0 1 PRICKLE4
Smoking Status 4.24 2 0 0.0 0 1 CCND3 PRICKLE4
Allergy or Eczema 2.31 1 0 0.0 0 1 PRICKLE4
Lung FVC 2.15 2 0 0.0 0 1 CCND3 PRICKLE4
Chronotype (morning person) 8.03 1 1 2.2 0 1 PRICKLE4
Tanning 0.43 1 0 0.0 0 1 CCND3
Frequency of depressed mood in last 2 weeks 3.65 1 0 0.0 0 1 PRICKLE4
Relative age of first facial hair 8.64 1 1 2.2 0 1 PRICKLE4
Other serious medical condition/disability diagnosed by doctor 8.98 2 0 0.0 0 1 CCND3 PRICKLE4
Vitamin and mineral supplements 5.49 1 0 0.0 0 1 PRICKLE4
Supplements: Zinc 5.44 1 0 0.0 0 1 PRICKLE4
Pack years adult smoking proportion 4.19 1 0 0.0 0 1 PRICKLE4
Trunk fat percentage 0.98 1 0 0.0 0 1 PRICKLE4
Current tobacco smoking 2.38 1 0 0.0 0 1 PRICKLE4
Relative age voice broke 4.24 1 0 0.0 0 1 PRICKLE4
Age when periods started (menarche) 8.69 1 1 2.2 0 1 PRICKLE4
Hayfever, allergic rhinitis or eczema 2.54 2 0 0.0 0 1 CCND3 PRICKLE4
Multivitamins +/- minerals 2.08 1 0 0.0 0 1 PRICKLE4
Stomach or abdominal pain in last month 8.18 2 0 0.0 0 1 CCND3 PRICKLE4
Supplements: Glucosamine 4.78 1 0 0.0 0 1 PRICKLE4
Diverticular disease/diverticulitis (self-reported) 2.79 1 0 0.0 0 1 CCND3
Sitting height 1.02 1 0 0.0 0 1 PRICKLE4
Trunk fat mass 0.69 1 0 0.0 0 1 PRICKLE4
Number of incorrect matches in round 2.62 1 0 0.0 0 1 CCND3
Past tobacco smoking 4.38 2 0 0.0 0 1 CCND3 PRICKLE4
Alcohol usually taken with meals 5.21 1 0 0.0 0 1 PRICKLE4
Had menopause 6.45 2 0 0.0 0 1 CCND3 PRICKLE4
Ever unenthusiastic/disinterested for a whole week 2.38 1 0 0.0 0 1 PRICKLE4
Qualifications: None of the above 3.74 2 0 0.0 0 1 CCND3 PRICKLE4
Diabetes (self-reported) 1.97 1 0 0.0 0 1 PRICKLE4
Hayfever/allergic rhinitis (self-reported) 4.29 1 0 0.0 0 1 CCND3
Illnesses of siblings 5.79 1 0 0.0 0 1 PRICKLE4
Impedance of arm (right) 1.91 2 0 0.0 0 1 CCND3 PRICKLE4
Number of live births 5.07 1 0 0.0 0 1 PRICKLE4
Pulse rate 2.27 1 0 0.0 0 1 PRICKLE4
Qualifications: A levels/AS levels or equivalent 2.07 1 0 0.0 0 1 PRICKLE4
Mouth/teeth dental problems: Dentures 5.51 1 0 0.0 0 1 PRICKLE4
Impedance of arm (left) 2.20 2 0 0.0 0 1 CCND3 PRICKLE4
Standing height 0.95 2 0 0.0 0 1 CCND3 PRICKLE4
Pulse wave reflection index 2.69 1 0 0.0 0 1 PRICKLE4
Loud music exposure frequency 6.85 2 0 0.0 0 1 CCND3 PRICKLE4
Qualifications: O levels/GCSEs or equivalent 5.63 1 0 0.0 0 1 PRICKLE4
High blood pressure (siblings) 2.46 1 0 0.0 0 1 PRICKLE4
Exposure to tobacco smoke outside home 5.53 1 0 0.0 0 1 PRICKLE4
Neck or shoulder pain in last month 2.28 1 0 0.0 0 1 PRICKLE4
Migraine (self-reported) 2.59 1 0 0.0 0 1 PRICKLE4
Medication: Omeprazole 4.45 1 0 0.0 0 1 PRICKLE4
Mean time to correctly identify matches 2.12 1 0 0.0 0 1 PRICKLE4
Pulse rate, automated reading 3.45 1 0 0.0 0 1 PRICKLE4
Comparative height size at age 10 0.69 1 0 0.0 0 1 PRICKLE4
Chest pain or discomfort 1.94 1 0 0.0 0 1 PRICKLE4
Supplements: Vitamin C 11.43 2 0 0.0 0 1 CCND3 PRICKLE4
Knee pain experienced in last month 1.80 1 0 0.0 0 1 CCND3
Illnesses of father: Heart disease 4.95 1 0 0.0 0 1 PRICKLE4
Smoking status: Previous 5.17 2 0 0.0 0 1 CCND3 PRICKLE4
Forced expiratory volume in 1-second (FEV1), predicted 1.93 1 0 0.0 0 1 PRICKLE4
Average weekly red wine intake 5.74 1 0 0.0 0 1 PRICKLE4
Long-standing illness, disability or infirmity 4.99 1 0 0.0 0 1 PRICKLE4
Diabetes diagnosed by doctor 1.79 1 0 0.0 0 1 PRICKLE4
Friendships satisfaction 3.71 1 0 0.0 0 1 PRICKLE4
Qualifications: nursing, teaching 3.13 1 0 0.0 0 1 PRICKLE4
Mineral and other dietary supplements 9.72 1 0 0.0 0 1 PRICKLE4
Osteoporosis (self-reported) 6.40 2 0 0.0 0 1 CCND3 PRICKLE4
Illnesses of father: None of the above (group 1) 6.07 1 0 0.0 0 1 PRICKLE4
Smoking status: Current 1.95 1 0 0.0 0 1 PRICKLE4
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.58 2 0 0.0 0 1 CCND3 PRICKLE4
Wears glasses or contact lenses 3.64 1 0 0.0 0 1 PRICKLE4
Ever taken oral contraceptive pill 7.43 2 0 0.0 0 1 CCND3 PRICKLE4
Pain type(s) experienced in last month: Hip pain 3.78 1 0 0.0 0 1 PRICKLE4
Supplements: Fish oil (including cod liver oil) 4.02 1 0 0.0 0 1 PRICKLE4
Illnesses of father: High blood pressure 5.76 2 0 0.0 0 1 CCND3 PRICKLE4
Alcohol drinker status: Never 7.35 2 0 0.0 0 1 CCND3 PRICKLE4
Ever smoked 4.47 2 0 0.0 0 1 CCND3 PRICKLE4
Average weekly beer plus cider intake 6.98 1 0 0.0 0 1 PRICKLE4
Fractured/broken bones in last 5 years 3.95 1 0 0.0 0 1 CCND3
Medication: Omeprazole (e.g. Zanprol) 8.50 2 0 0.0 0 1 CCND3 PRICKLE4
Pain experienced in last month 2.00 1 0 0.0 0 1 CCND3
Supplements: Calcium 5.20 1 0 0.0 0 1 PRICKLE4
Pack years of smoking 2.39 1 0 0.0 0 1 PRICKLE4
Impedance of whole body 1.19 2 0 0.0 0 1 CCND3 PRICKLE4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.029 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.2
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.1
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.1
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.0
GTEx Brain Hypothalamus 0 0.000 1.0
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.2
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.2
GTEx Breast Mammary Tissue (Female) 0 0.000 1.2
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.2
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.1
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 0 0.000 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.2
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.3
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.2
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.4
GTEx Vagina 0 0.000 1.2
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.1
NTR Blood 0 0.000 1.1
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.1
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.1
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Brain Lower Grade Glioma 1 0.023 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.2
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.2
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.2
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.2