Hub : Traits :

Medication: Lisinopril

2 significantly associated models · 2 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 9 99707397 101087286 1 1 2.2e-07 8.3e-07 0.79 100 TSTD2
2 11 573554 1068900 1 1 1.3e-07 2.4e-05 0.27 93 PNPLA2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Irritable Bowel Disease (IBD) 1.93 1 0 0.0 0 1 PNPLA2
Ulcerative Colitis (UC) 4.82 1 0 0.0 0 1 PNPLA2
Breast Cancer 1.84 1 0 0.0 0 1 PNPLA2
Mean Putamen Volume 2.52 1 0 0.0 0 1 PNPLA2
Fasting Glucose 3.99 1 0 0.0 0 1 TSTD2
Blood Platelet Count 1.22 2 0 0.0 0 1 PNPLA2 TSTD2
BMI 2.78 1 1 2.2 0 1 PNPLA2
Waist Hip Ratio (WHR) 3.18 1 1 2.2 0 1 PNPLA2
Hypothyroidism (self reported) 2.87 1 0 0.0 0 1 TSTD2
Type 2 Diabetes (T2D) (2018) 1.71 1 0 0.0 0 1 TSTD2
Lung FEV1/FVC ratio 4.88 2 1 2.2 0 1 PNPLA2 TSTD2
Hair Pigment 0.15 1 0 0.0 0 1 TSTD2
Relative age of first facial hair 1.71 1 0 0.0 0 1 PNPLA2
Systolic blood pressure, automated reading 1.17 1 0 0.0 0 1 TSTD2
Vitamin and mineral supplements 5.07 2 0 0.0 0 1 PNPLA2 TSTD2
Medication: Co-codamol 2.95 1 0 0.0 0 1 PNPLA2
Medication: Metformin 2.20 1 0 0.0 0 1 TSTD2
Diabetes (mother) 3.17 1 0 0.0 0 1 TSTD2
Impedance of leg (right) 5.45 2 1 2.2 0 1 PNPLA2 TSTD2
Leg fat-free mass (left) 3.58 1 1 2.2 0 1 PNPLA2
Relative age voice broke 2.49 1 0 0.0 0 1 PNPLA2
Age when periods started (menarche) 1.90 1 0 0.0 0 1 PNPLA2
High blood pressure 2.78 1 0 0.0 0 1 TSTD2
Multivitamins +/- minerals 3.42 1 0 0.0 0 1 PNPLA2
Medication: Levothyroxine sodium 2.48 1 0 0.0 0 1 TSTD2
Sitting height 0.41 1 0 0.0 0 1 PNPLA2
High blood pressure (mother) 3.43 1 0 0.0 0 1 TSTD2
Body mass index (BMI) 2.35 1 0 0.0 0 1 PNPLA2
Impedance of leg (left) 5.89 2 1 2.2 0 1 PNPLA2 TSTD2
Leg predicted mass (left) 3.56 1 1 2.2 0 1 PNPLA2
Trunk fat mass 0.85 1 0 0.0 0 1 PNPLA2
Waist circumference 0.99 1 0 0.0 0 1 PNPLA2
Had menopause 2.95 1 0 0.0 0 1 TSTD2
Diabetes (self-reported) 2.80 1 0 0.0 0 1 TSTD2
Medication: Simvastatin 3.10 1 0 0.0 0 1 TSTD2
Weight 2.20 1 0 0.0 0 1 PNPLA2
Impedance of arm (right) 1.54 1 0 0.0 0 1 PNPLA2
Arm fat percentage (right) 1.25 1 0 0.0 0 1 PNPLA2
Trunk fat-free mass 2.22 1 0 0.0 0 1 PNPLA2
Hip circumference 2.76 1 0 0.0 0 1 PNPLA2
Medication: Cholesterol lowering 2.08 1 0 0.0 0 1 TSTD2
Illnesses of mother 2.39 1 0 0.0 0 1 TSTD2
Pulse wave Arterial Stiffness index 4.23 1 0 0.0 0 1 PNPLA2
Impedance of arm (left) 2.17 1 0 0.0 0 1 PNPLA2
Arm fat mass (right) 2.13 1 0 0.0 0 1 PNPLA2
Trunk predicted mass 2.24 1 0 0.0 0 1 PNPLA2
Birth weight of first child 3.24 1 0 0.0 0 1 TSTD2
Loud music exposure frequency 4.42 1 0 0.0 0 1 TSTD2
Headache pain in last month 1.58 1 0 0.0 0 1 PNPLA2
Medication for cholesterol, blood pressure or diabetes 2.40 1 0 0.0 0 1 TSTD2
Hypothyroidism/myxoedema (self-reported) 1.95 1 0 0.0 0 1 TSTD2
Arm fat-free mass (right) 1.93 1 0 0.0 0 1 PNPLA2
Comparative body size at age 10 2.31 1 0 0.0 0 1 PNPLA2
Number of children fathered 3.70 1 0 0.0 0 1 PNPLA2
Pulse wave peak to peak time 4.26 1 0 0.0 0 1 PNPLA2
Medication for pain relief, constipation, heartburn 2.40 1 0 0.0 0 1 PNPLA2
Medication: Blood pressure 3.17 1 0 0.0 0 1 TSTD2
Whole body fat mass 1.08 1 0 0.0 0 1 PNPLA2
Leg fat mass (right) 0.91 1 0 0.0 0 1 PNPLA2
Arm predicted mass (right) 2.00 1 0 0.0 0 1 PNPLA2
Hypertension (Self-reported) 2.42 1 0 0.0 0 1 TSTD2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.66 1 0 0.0 0 1 PNPLA2
Forced expiratory volume in 1-second (FEV1), predicted 1.47 1 0 0.0 0 1 PNPLA2
Whole body fat-free mass 2.89 1 1 2.2 0 1 PNPLA2
Leg fat-free mass (right) 3.62 1 1 2.2 0 1 PNPLA2
Arm fat percentage (left) 1.03 1 0 0.0 0 1 PNPLA2
Diabetes diagnosed by doctor 2.18 1 0 0.0 0 1 TSTD2
Breast cancer (self-reported) 2.96 1 0 0.0 0 1 PNPLA2
Whole body water mass 2.92 1 1 2.2 0 1 PNPLA2
Leg predicted mass (right) 3.62 1 1 2.2 0 1 PNPLA2
Arm fat mass (left) 1.82 1 0 0.0 0 1 PNPLA2
Ever smoked 1.83 1 0 0.0 0 1 PNPLA2
Basal metabolic rate 2.92 1 1 2.2 0 1 PNPLA2
Arm fat-free mass (left) 2.51 1 0 0.0 0 1 PNPLA2
Average weekly beer plus cider intake 2.24 1 0 0.0 0 1 TSTD2
Ever depressed for a whole week 3.26 1 0 0.0 0 1 PNPLA2
Myopia 2.04 1 0 0.0 0 1 TSTD2
Vascular/heart problems diagnosed by doctor 2.34 1 0 0.0 0 1 TSTD2
Impedance of whole body 4.56 2 1 2.2 0 1 PNPLA2 TSTD2
Leg fat mass (left) 0.95 1 0 0.0 0 1 PNPLA2
Arm predicted mass (left) 2.50 1 0 0.0 0 1 PNPLA2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.3
GTEx Adipose Visceral Omentum 1 0.049 1.4
GTEx Adrenal Gland 0 0.000 1.3
GTEx Artery Aorta 0 0.000 1.4
GTEx Artery Coronary 0 0.000 1.4
GTEx Artery Tibial 0 0.000 1.3
GTEx Brain Caudate basal ganglia 0 0.000 1.4
GTEx Brain Cerebellar Hemisphere 0 0.000 1.3
GTEx Brain Cerebellum 0 0.000 1.4
GTEx Brain Cortex 0 0.000 1.3
GTEx Brain Frontal Cortex BA9 0 0.000 1.4
GTEx Brain Hippocampus 0 0.000 1.4
GTEx Brain Hypothalamus 0 0.000 1.4
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.4
GTEx Brain Putamen basal ganglia 0 0.000 1.3
GTEx Breast Mammary Tissue 0 0.000 1.4
GTEx Breast Mammary Tissue (Male) 0 0.000 1.3
GTEx Breast Mammary Tissue (Female) 0 0.000 1.4
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.3
GTEx Cells Transformed fibroblasts 0 0.000 1.3
GTEx Colon Sigmoid 0 0.000 1.4
GTEx Colon Transverse 0 0.000 1.3
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.4
GTEx Esophagus Mucosa 0 0.000 1.3
GTEx Esophagus Muscularis 0 0.000 1.3
GTEx Heart Atrial Appendage 0 0.000 1.3
GTEx Heart Left Ventricle 0 0.000 1.3
GTEx Liver 0 0.000 1.3
GTEx Lung 0 0.000 1.4
GTEx Muscle Skeletal 0 0.000 1.3
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.4
GTEx Pancreas 0 0.000 1.4
GTEx Pituitary 0 0.000 1.4
GTEx Prostate 0 0.000 1.4
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.3
GTEx Skin Sun Exposed Lower leg 0 0.000 1.3
GTEx Small Intestine Terminal Ileum 0 0.000 1.3
GTEx Spleen 0 0.000 1.3
GTEx Stomach 0 0.000 1.4
GTEx Testis 0 0.000 1.3
GTEx Thyroid 0 0.000 1.3
GTEx Uterus 0 0.000 1.3
GTEx Vagina 0 0.000 1.3
GTEx Whole Blood 0 0.000 1.3
METSIM Adipose 0 0.000 1.3
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.3
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.3
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 1 0.037 1.3
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.3
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.3
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.3
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.2
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.3
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.3
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.3
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.3