Hub : Traits :

Medication: Lisinopril

2 significantly associated models · 2 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	9	99707397	101087286	1	1	2.2e-07	8.3e-07	0.79	100	TSTD2
2	11	573554	1068900	1	1	1.3e-07	2.4e-05	0.27	93	PNPLA2

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Impedance of leg (left)	5.89	2	1	2.2	1	PNPLA2 TSTD2
Impedance of leg (right)	5.45	2	1	2.2	1	PNPLA2 TSTD2
Vitamin and mineral supplements	5.07	2	0	0.0	1	PNPLA2 TSTD2
Lung FEV1/FVC ratio	4.88	2	1	2.2	1	PNPLA2 TSTD2
Ulcerative Colitis (UC)	4.82	1	0	0.0	1	PNPLA2
Impedance of whole body	4.56	2	1	2.2	1	PNPLA2 TSTD2
Loud music exposure frequency	4.42	1	0	0.0	1	TSTD2
Pulse wave peak to peak time	4.26	1	0	0.0	1	PNPLA2
Pulse wave Arterial Stiffness index	4.23	1	0	0.0	1	PNPLA2
Fasting Glucose	3.99	1	0	0.0	1	TSTD2
Number of children fathered	3.70	1	0	0.0	1	PNPLA2
Leg fat-free mass (right)	3.62	1	1	2.2	1	PNPLA2
Leg predicted mass (right)	3.62	1	1	2.2	1	PNPLA2
Leg fat-free mass (left)	3.58	1	1	2.2	1	PNPLA2
Leg predicted mass (left)	3.56	1	1	2.2	1	PNPLA2
High blood pressure (mother)	3.43	1	0	0.0	1	TSTD2
Multivitamins +/- minerals	3.42	1	0	0.0	1	PNPLA2
Ever depressed for a whole week	3.26	1	0	0.0	1	PNPLA2
Birth weight of first child	3.24	1	0	0.0	1	TSTD2
Waist Hip Ratio (WHR)	3.18	1	1	2.2	1	PNPLA2
Diabetes (mother)	3.17	1	0	0.0	1	TSTD2
Medication: Blood pressure	3.17	1	0	0.0	1	TSTD2
Medication: Simvastatin	3.10	1	0	0.0	1	TSTD2
Breast cancer (self-reported)	2.96	1	0	0.0	1	PNPLA2
Medication: Co-codamol	2.95	1	0	0.0	1	PNPLA2
Had menopause	2.95	1	0	0.0	1	TSTD2
Whole body water mass	2.92	1	1	2.2	1	PNPLA2
Basal metabolic rate	2.92	1	1	2.2	1	PNPLA2
Whole body fat-free mass	2.89	1	1	2.2	1	PNPLA2
Hypothyroidism (self reported)	2.87	1	0	0.0	1	TSTD2
Diabetes (self-reported)	2.80	1	0	0.0	1	TSTD2
BMI	2.78	1	1	2.2	1	PNPLA2
High blood pressure	2.78	1	0	0.0	1	TSTD2
Hip circumference	2.76	1	0	0.0	1	PNPLA2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.66	1	0	0.0	1	PNPLA2
Mean Putamen Volume	2.52	1	0	0.0	1	PNPLA2
Arm fat-free mass (left)	2.51	1	0	0.0	1	PNPLA2
Arm predicted mass (left)	2.50	1	0	0.0	1	PNPLA2
Relative age voice broke	2.49	1	0	0.0	1	PNPLA2
Medication: Levothyroxine sodium	2.48	1	0	0.0	1	TSTD2
Hypertension (Self-reported)	2.42	1	0	0.0	1	TSTD2
Medication for cholesterol, blood pressure or diabetes	2.40	1	0	0.0	1	TSTD2
Medication for pain relief, constipation, heartburn	2.40	1	0	0.0	1	PNPLA2
Illnesses of mother	2.39	1	0	0.0	1	TSTD2
Body mass index (BMI)	2.35	1	0	0.0	1	PNPLA2
Vascular/heart problems diagnosed by doctor	2.34	1	0	0.0	1	TSTD2
Comparative body size at age 10	2.31	1	0	0.0	1	PNPLA2
Trunk predicted mass	2.24	1	0	0.0	1	PNPLA2
Average weekly beer plus cider intake	2.24	1	0	0.0	1	TSTD2
Trunk fat-free mass	2.22	1	0	0.0	1	PNPLA2
Medication: Metformin	2.20	1	0	0.0	1	TSTD2
Weight	2.20	1	0	0.0	1	PNPLA2
Diabetes diagnosed by doctor	2.18	1	0	0.0	1	TSTD2
Impedance of arm (left)	2.17	1	0	0.0	1	PNPLA2
Arm fat mass (right)	2.13	1	0	0.0	1	PNPLA2
Medication: Cholesterol lowering	2.08	1	0	0.0	1	TSTD2
Myopia	2.04	1	0	0.0	1	TSTD2
Arm predicted mass (right)	2.00	1	0	0.0	1	PNPLA2
Hypothyroidism/myxoedema (self-reported)	1.95	1	0	0.0	1	TSTD2
Irritable Bowel Disease (IBD)	1.93	1	0	0.0	1	PNPLA2
Arm fat-free mass (right)	1.93	1	0	0.0	1	PNPLA2
Age when periods started (menarche)	1.90	1	0	0.0	1	PNPLA2
Breast Cancer	1.84	1	0	0.0	1	PNPLA2
Ever smoked	1.83	1	0	0.0	1	PNPLA2
Arm fat mass (left)	1.82	1	0	0.0	1	PNPLA2
Type 2 Diabetes (T2D) (2018)	1.71	1	0	0.0	1	TSTD2
Relative age of first facial hair	1.71	1	0	0.0	1	PNPLA2
Headache pain in last month	1.58	1	0	0.0	1	PNPLA2
Impedance of arm (right)	1.54	1	0	0.0	1	PNPLA2
Forced expiratory volume in 1-second (FEV1), predicted	1.47	1	0	0.0	1	PNPLA2
Arm fat percentage (right)	1.25	1	0	0.0	1	PNPLA2
Blood Platelet Count	1.22	2	0	0.0	1	PNPLA2 TSTD2
Systolic blood pressure, automated reading	1.17	1	0	0.0	1	TSTD2
Whole body fat mass	1.08	1	0	0.0	1	PNPLA2
Arm fat percentage (left)	1.03	1	0	0.0	1	PNPLA2
Waist circumference	0.99	1	0	0.0	1	PNPLA2
Leg fat mass (left)	0.95	1	0	0.0	1	PNPLA2
Leg fat mass (right)	0.91	1	0	0.0	1	PNPLA2
Trunk fat mass	0.85	1	0	0.0	1	PNPLA2
Sitting height	0.41	1	0	0.0	1	PNPLA2
Hair Pigment	0.15	1	0	0.0	1	TSTD2

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Visceral Omentum	1	0.049	1.4
GTEx	Artery Aorta	0	0.000	1.4
GTEx	Artery Coronary	0	0.000	1.4
GTEx	Brain Caudate basal ganglia	0	0.000	1.4
GTEx	Brain Cerebellum	0	0.000	1.4
GTEx	Brain Frontal Cortex BA9	0	0.000	1.4
GTEx	Brain Hippocampus	0	0.000	1.4
GTEx	Brain Hypothalamus	0	0.000	1.4
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.4
GTEx	Breast Mammary Tissue	0	0.000	1.4
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.4
GTEx	Colon Sigmoid	0	0.000	1.4
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.4
GTEx	Lung	0	0.000	1.4
GTEx	Ovary	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Pituitary	0	0.000	1.4
GTEx	Prostate	0	0.000	1.4
GTEx	Stomach	0	0.000	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Tibial	0	0.000	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Transverse	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Atrial Appendage	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.3
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.3
GTEx	Small Intestine Terminal Ileum	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Uterus	0	0.000	1.3
GTEx	Vagina	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
METSIM	Adipose	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	1	0.037	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.3
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.2
NTR	Blood	0	0.000	1.2
YFS	Blood	0	0.000	1.2
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.2
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.2