Hub : Traits :

Medication: Ramipril

8 significantly associated models · 6 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	11	99859184	101559718	2	1	8.8e-09	9.9e-09	1.0000	100	ARHGAP42
2	12	132663423	133778796	1	1	9.0e-08	2.2e-06	0.0089	69	GOLGA3
3	15	74402161	75930199	2	1	6.3e-08	2.0e-08	0.1160	92	CSK

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr P	genes
Systolic Blood Pressure	39.23	3	2	4.4	1	ARHGAP42 CSK GOLGA3
Hypertension (Self-reported)	31.71	3	2	4.4	1	ARHGAP42 CSK GOLGA3
High blood pressure	31.69	3	2	4.4	1	ARHGAP42 CSK GOLGA3
Vascular/heart problems diagnosed by doctor	31.69	3	2	4.4	1	ARHGAP42 CSK GOLGA3
Cardiovascular Disease	31.18	3	2	4.4	1	ARHGAP42 CSK GOLGA3
Diastolic blood pressure, automated reading	30.06	2	2	4.4	1	ARHGAP42 CSK
Systolic blood pressure, automated reading	25.50	3	2	4.4	1	ARHGAP42 CSK GOLGA3
Medication: Blood pressure	23.49	3	2	4.4	1	ARHGAP42 CSK GOLGA3
Medication: Blood pressure	21.88	2	2	4.4	1	ARHGAP42 CSK
Medication for cholesterol, blood pressure or diabetes	19.18	3	2	4.4	1	ARHGAP42 CSK GOLGA3
Medication: Bendroflumethiazide	14.42	3	2	4.4	1	ARHGAP42 CSK GOLGA3
Medication: Amlodipine	11.60	2	1	2.2	1	ARHGAP42 CSK
Medication: Lisinopril	10.28	2	0	0.0	1	ARHGAP42 CSK
Medication: Atenolol	9.75	2	0	0.0	1	ARHGAP42 CSK
Medication: Cholesterol lowering	9.46	2	0	0.0	1	ARHGAP42 CSK
High blood pressure (siblings)	9.28	3	0	0.0	1	ARHGAP42 CSK GOLGA3
High blood pressure (mother)	8.20	2	0	0.0	1	ARHGAP42 CSK
Medication for cholesterol	8.17	2	1	2.2	1	ARHGAP42 CSK
Number of treatments/medications taken	7.67	2	0	0.0	1	ARHGAP42 GOLGA3
Illnesses of mother	6.98	2	0	0.0	1	ARHGAP42 CSK
Illnesses of siblings	6.52	1	0	0.0	1	ARHGAP42
High cholesterol (Self-reported)	6.28	1	0	0.0	1	ARHGAP42
Fasting Glucose	5.95	2	0	0.0	1	CSK GOLGA3
Number of self-reported non-cancer illnesses	5.58	3	0	0.0	1	ARHGAP42 CSK GOLGA3
Illnesses of father: High blood pressure	5.49	1	0	0.0	1	ARHGAP42
Medication: Ibuprofen (e.g. Nurofen)	5.38	1	0	0.0	1	CSK
Supplements: Glucosamine	5.26	1	0	0.0	1	CSK
Medication: Simvastatin	5.14	1	0	0.0	1	ARHGAP42
Medication: Ibuprofen	5.11	1	0	0.0	1	CSK
Hearing difficulty/problems with background noise	5.06	1	0	0.0	1	CSK
Medication: Aspirin	5.03	1	0	0.0	1	CSK
Father's age at death	5.01	1	0	0.0	1	CSK
Osteoarthritis (self-reported)	4.69	1	0	0.0	1	CSK
Lupus	4.59	1	0	0.0	1	CSK
Medication: Aspirin	4.58	1	0	0.0	1	GOLGA3
Breast Cancer	4.53	1	0	0.0	1	CSK
Illnesses of father: Heart disease	4.49	1	0	0.0	1	ARHGAP42
Other serious medical condition/disability diagnosed by doctor	4.42	1	0	0.0	1	CSK
Birth weight of first child	4.31	1	0	0.0	1	CSK
Blood Red Count	3.88	2	1	2.2	1	CSK GOLGA3
Lung FEV1/FVC ratio	3.70	2	1	2.2	1	ARHGAP42 CSK
Had other major operations	3.66	1	0	0.0	1	ARHGAP42
Bipolar Disorder (2018)	3.51	1	0	0.0	1	CSK
LDL Cholesterol	3.37	1	0	0.0	1	CSK
Medication: Paracetamol	3.36	1	0	0.0	1	CSK
Qualifications: O levels/GCSEs or equivalent	3.29	1	0	0.0	1	CSK
Average weekly red wine intake	3.25	1	0	0.0	1	CSK
Mouth/teeth dental problems	3.13	1	0	0.0	1	CSK
Allergy or Eczema	3.11	2	0	0.0	1	ARHGAP42 CSK
Hair/balding pattern: Pattern 3	3.04	1	0	0.0	1	CSK
Angina	3.03	1	0	0.0	1	ARHGAP42
Forced expiratory volume in 1-second (FEV1)	3.00	2	0	0.0	1	ARHGAP42 GOLGA3
Hayfever, allergic rhinitis or eczema	2.94	1	0	0.0	1	CSK
Neuroticism (2016)	2.82	1	0	0.0	1	GOLGA3
Financial difficulties in last 2 years	2.81	1	0	0.0	1	CSK
Angina (self-reported)	2.80	1	0	0.0	1	ARHGAP42
Peak expiratory flow (PEF)	2.77	1	0	0.0	1	CSK
Illnesses of father: None of the above (group 1)	2.76	1	0	0.0	1	ARHGAP42
Mouth/teeth dental problems: Loose teeth	2.70	1	0	0.0	1	CSK
Bipolar Disorder or Schizophrenia	2.67	1	0	0.0	1	CSK
Medication: Paracetamol	2.63	1	0	0.0	1	CSK
Qualifications: A levels/AS levels or equivalent	2.61	1	0	0.0	1	CSK
Taking other prescription medications	2.53	1	0	0.0	1	GOLGA3
Forced vital capacity (FVC)	2.41	2	0	0.0	1	ARHGAP42 GOLGA3
Overall health rating	2.37	1	0	0.0	1	GOLGA3
Heel bone mineral density (BMD) T-score, automated (left)	2.36	1	0	0.0	1	ARHGAP42
Heel bone mineral density (BMD) T-score, automated (right)	2.33	1	0	0.0	1	ARHGAP42
Hearing difficulty/problems: Yes	2.24	1	0	0.0	1	CSK
Birth weight	2.19	1	0	0.0	1	ARHGAP42
Forced expiratory volume in 1-second (FEV1), Best measure	2.05	1	0	0.0	1	ARHGAP42
Allergy	1.96	1	0	0.0	1	CSK
Alcohol intake frequency.	1.95	1	0	0.0	1	CSK
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.95	1	0	0.0	1	ARHGAP42
Wheeze or whistling in the chest in last year	1.89	1	0	0.0	1	CSK
Blood Platelet Count	1.73	3	0	0.0	1	ARHGAP42 CSK GOLGA3
Intelligence (Savage-Jansen 2018)	1.66	1	0	0.0	1	CSK
Impedance of leg (right)	1.63	1	0	0.0	1	ARHGAP42
Leg fat-free mass (right)	1.62	2	0	0.0	1	ARHGAP42 CSK
Forced vital capacity (FVC), Best measure	1.61	1	0	0.0	1	GOLGA3
Waist circumference	1.59	1	0	0.0	1	CSK
Impedance of leg (left)	1.57	1	0	0.0	1	ARHGAP42
Schizophrenia (2014)	1.55	1	0	0.0	1	CSK
Leg predicted mass (right)	1.55	1	0	0.0	1	ARHGAP42
Heel T-Score	1.53	1	1	2.2	1	ARHGAP42
Impedance of whole body	1.49	1	0	0.0	1	ARHGAP42
Leg fat-free mass (left)	1.48	1	0	0.0	1	ARHGAP42
Leg predicted mass (left)	1.48	1	0	0.0	1	ARHGAP42
Whole body fat-free mass	1.42	2	0	0.0	1	ARHGAP42 CSK
Whole body water mass	1.40	1	0	0.0	1	ARHGAP42
Arm fat-free mass (right)	1.39	2	0	0.0	1	ARHGAP42 CSK
Blood White Count	1.38	1	0	0.0	1	ARHGAP42
Waist Hip Ratio (WHR)	1.38	1	0	0.0	1	CSK
Arm predicted mass (left)	1.36	2	0	0.0	1	ARHGAP42 CSK
Arm predicted mass (right)	1.32	2	0	0.0	1	ARHGAP42 CSK
Basal metabolic rate	1.32	2	0	0.0	1	ARHGAP42 CSK
Trunk fat-free mass	1.29	1	0	0.0	1	ARHGAP42
Impedance of arm (right)	1.28	1	0	0.0	1	CSK
Trunk predicted mass	1.23	1	0	0.0	1	ARHGAP42
Impedance of arm (left)	1.20	1	0	0.0	1	CSK
Arm fat-free mass (left)	1.15	1	0	0.0	1	CSK
BMI	0.97	1	0	0.0	1	CSK
Comparative body size at age 10	0.96	1	0	0.0	1	CSK
Weight	0.90	1	0	0.0	1	CSK
Leg fat mass (left)	0.85	1	0	0.0	1	CSK
Body mass index (BMI)	0.83	1	0	0.0	1	CSK
Blood Eosinophil Count	0.80	1	0	0.0	1	GOLGA3
Leg fat mass (right)	0.74	1	0	0.0	1	CSK
Tanning	0.67	2	0	0.0	1	ARHGAP42 CSK
Height	0.63	2	0	0.0	1	ARHGAP42 GOLGA3
Arm fat mass (right)	0.62	1	0	0.0	1	CSK
Sitting height	0.51	1	0	0.0	1	ARHGAP42
Standing height	0.42	1	0	0.0	1	ARHGAP42
Hair Pigment	0.24	1	0	0.0	1	ARHGAP42

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Visceral Omentum	0	0.000	1.4
GTEx	Colon Transverse	0	0.000	1.4
GTEx	Heart Atrial Appendage	0	0.000	1.4
GTEx	Pancreas	0	0.000	1.4
GTEx	Skin Not Sun Exposed Suprapubic	0	0.000	1.4
GTEx	Skin Sun Exposed Lower leg	0	0.000	1.4
GTEx	Small Intestine Terminal Ileum	0	0.000	1.4
GTEx	Stomach	0	0.000	1.4
GTEx	Uterus	0	0.000	1.4
GTEx	Vagina	1	0.157	1.4
GTEx	Adipose Subcutaneous	0	0.000	1.3
GTEx	Adrenal Gland	0	0.000	1.3
GTEx	Artery Aorta	1	0.034	1.3
GTEx	Artery Coronary	0	0.000	1.3
GTEx	Artery Tibial	2	0.053	1.3
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.3
GTEx	Brain Cerebellum	0	0.000	1.3
GTEx	Brain Cortex	0	0.000	1.3
GTEx	Brain Frontal Cortex BA9	0	0.000	1.3
GTEx	Brain Hippocampus	0	0.000	1.3
GTEx	Brain Hypothalamus	0	0.000	1.3
GTEx	Brain Putamen basal ganglia	0	0.000	1.3
GTEx	Breast Mammary Tissue	0	0.000	1.3
GTEx	Breast Mammary Tissue (Female)	0	0.000	1.3
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.3
GTEx	Cells Transformed fibroblasts	0	0.000	1.3
GTEx	Colon Sigmoid	0	0.000	1.3
GTEx	Esophagus Gastroesophageal Junction	0	0.000	1.3
GTEx	Esophagus Mucosa	0	0.000	1.3
GTEx	Esophagus Muscularis	0	0.000	1.3
GTEx	Heart Left Ventricle	0	0.000	1.3
GTEx	Liver	0	0.000	1.3
GTEx	Lung	1	0.035	1.3
GTEx	Muscle Skeletal	0	0.000	1.3
GTEx	Nerve Tibial	0	0.000	1.3
GTEx	Ovary	0	0.000	1.3
GTEx	Spleen	0	0.000	1.3
GTEx	Testis	0	0.000	1.3
GTEx	Thyroid	0	0.000	1.3
GTEx	Whole Blood	0	0.000	1.3
NTR	Blood	0	0.000	1.3
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.3
YFS	Blood	1	0.022	1.3
CommonMind	Brain Pre-frontal Cortex	1	0.019	1.3
The Cancer Genome Atlas	Breast Invasive Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Colon Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.3
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.3
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	0	0.000	1.3
The Cancer Genome Atlas	Lung Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.3
The Cancer Genome Atlas	Prostate Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.3
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.3
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.3
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.3
GTEx	Brain Caudate basal ganglia	0	0.000	1.2
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.2
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.2
GTEx	Pituitary	0	0.000	1.2
GTEx	Prostate	0	0.000	1.2
METSIM	Adipose	0	0.000	1.2
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	0	0.000	1.2
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Stomach Adenocarcinoma	0	0.000	1.2
The Cancer Genome Atlas	Testicular Germ Cell Tumors	0	0.000	1.2
The Cancer Genome Atlas	Thyroid Carcinoma	0	0.000	1.2