Hub : Traits :

Breastfed as a baby

12 significantly associated models · 7 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 752566 2261222 7 2 1e-07 3.1e-07 0.058 86 PUSL1 RP4-758J18.13

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Heel T-Score 1.18 1 0 0.0 0 1 PUSL1
Height 0.61 1 0 0.0 0 1 PUSL1
Systolic Blood Pressure 11.27 2 2 6.1 0 1 PUSL1 RP4-758J18.13
Cardiovascular Disease 1.67 1 0 0.0 0 1 PUSL1
Hypothyroidism (self reported) 6.69 1 0 0.0 0 1 PUSL1
Hair Pigment 0.45 2 0 0.0 0 1 PUSL1 RP4-758J18.13
Systolic blood pressure, automated reading 9.84 2 1 3.0 0 1 PUSL1 RP4-758J18.13
Leg fat-free mass (left) 1.28 1 0 0.0 0 1 PUSL1
Fed-up feelings 2.96 1 0 0.0 0 1 PUSL1
Medication: Levothyroxine sodium 11.39 1 1 3.0 0 1 PUSL1
Sitting height 0.67 1 0 0.0 0 1 RP4-758J18.13
Leg predicted mass (left) 1.27 1 0 0.0 0 1 PUSL1
Weight 1.25 1 0 0.0 0 1 PUSL1
Trunk fat-free mass 1.66 1 0 0.0 0 1 PUSL1
Hip circumference 1.41 1 0 0.0 0 1 PUSL1
Arm fat mass (right) 1.48 1 0 0.0 0 1 PUSL1
Trunk predicted mass 1.65 1 0 0.0 0 1 PUSL1
Birth weight of first child 9.57 2 0 0.0 0 1 PUSL1 RP4-758J18.13
Peak expiratory flow (PEF) 8.55 1 1 3.0 0 1 PUSL1
Hypothyroidism/myxoedema (self-reported) 7.37 1 0 0.0 0 1 PUSL1
Arm fat-free mass (right) 1.51 1 0 0.0 0 1 PUSL1
Arm predicted mass (right) 1.38 1 0 0.0 0 1 PUSL1
Whole body fat-free mass 1.53 1 0 0.0 0 1 PUSL1
Leg fat-free mass (right) 1.15 1 0 0.0 0 1 PUSL1
Whole body water mass 1.63 1 0 0.0 0 1 PUSL1
Leg predicted mass (right) 1.29 1 0 0.0 0 1 PUSL1
Arm fat mass (left) 1.43 1 0 0.0 0 1 PUSL1
Basal metabolic rate 1.61 1 0 0.0 0 1 PUSL1
Arm fat-free mass (left) 1.40 1 0 0.0 0 1 PUSL1
Arm predicted mass (left) 1.36 1 0 0.0 0 1 PUSL1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 1 0.0286 1.26
GTEx Adipose Visceral Omentum 0 0.0000 1.21
GTEx Adrenal Gland 0 0.0000 1.12
GTEx Artery Aorta 0 0.0000 1.31
GTEx Artery Coronary 0 0.0000 1.16
GTEx Artery Tibial 0 0.0000 1.31
GTEx Brain Caudate basal ganglia 0 0.0000 1.32
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.32
GTEx Brain Cerebellum 0 0.0000 1.26
GTEx Brain Cortex 0 0.0000 1.35
GTEx Brain Frontal Cortex BA9 0 0.0000 1.24
GTEx Brain Hippocampus 0 0.0000 1.14
GTEx Brain Hypothalamus 0 0.0000 1.15
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.19
GTEx Brain Putamen basal ganglia 0 0.0000 1.24
GTEx Breast Mammary Tissue 0 0.0000 1.24
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.23
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.22
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.17
GTEx Cells Transformed fibroblasts 1 0.0238 1.24
GTEx Colon Sigmoid 0 0.0000 1.27
GTEx Colon Transverse 2 0.0969 1.25
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.24
GTEx Esophagus Mucosa 1 0.0301 1.20
GTEx Esophagus Muscularis 0 0.0000 1.25
GTEx Heart Atrial Appendage 0 0.0000 1.24
GTEx Heart Left Ventricle 0 0.0000 1.29
GTEx Liver 0 0.0000 1.20
GTEx Lung 0 0.0000 1.25
GTEx Muscle Skeletal 0 0.0000 1.29
GTEx Nerve Tibial 0 0.0000 1.26
GTEx Ovary 0 0.0000 1.25
GTEx Pancreas 0 0.0000 1.27
GTEx Pituitary 0 0.0000 1.20
GTEx Prostate 0 0.0000 1.21
GTEx Skin Not Sun Exposed Suprapubic 1 0.0407 1.30
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.26
GTEx Small Intestine Terminal Ileum 0 0.0000 1.22
GTEx Spleen 0 0.0000 1.21
GTEx Stomach 0 0.0000 1.25
GTEx Testis 1 0.0317 1.28
GTEx Thyroid 0 0.0000 1.29
GTEx Uterus 0 0.0000 1.14
GTEx Vagina 0 0.0000 1.32
GTEx Whole Blood 0 0.0000 1.18
METSIM Adipose 0 0.0000 1.23
NTR Blood 0 0.0000 1.26
ROSMAP Brain Pre-frontal Cortex 2 0.0455 1.29
YFS Blood 0 0.0000 1.22
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.23
TCGA Breast Tumor 0 0.0000 1.26
TCGA Breast Normal 1 0.0238 1.22
TCGA Ovarian Tumor 0 0.0000 1.16
TCGA Prostate Tumor 1 0.0289 1.26