Hub : Traits :

Medication: Ventolin 100micrograms inhaler

72 significantly associated models · 24 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 102118712 103767612 3 3 8.7e-11 1.6e-17 1.3e-06 68 IL18R1 IL1RL2
2 2 241978472 243048760 7 2 3.8e-09 1.3e-08 7.9e-01 100 AC093642.3 D2HGDH
3 9 5833337 7345304 1 1 2.2e-10 7.0e-21 2.1e-12 44 GLDC
4 13 40440805 41928314 1 1 3.0e-07 1.4e-05 7.7e-01 100 FOXO1
5 17 37083464 39048774 12 1 9.0e-14 3.1e-14 1.0e+00 100 GSDMB

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 4.60 1 1 3.0 0.00 1.0e+00 GSDMB
Irritable Bowel Disease (IBD) 5.81 1 1 3.0 0.00 1.0e+00 GSDMB
Ulcerative Colitis (UC) 4.23 1 1 3.0 0.00 1.0e+00 GSDMB
Crohns Disease (2012) 3.73 1 1 3.0 0.00 1.0e+00 GSDMB
HDL Cholesterol 4.36 1 1 3.0 0.00 1.0e+00 GSDMB
Lupus 2.55 1 0 0.0 0.00 1.0e+00 GSDMB
Primary Biliary Cirrhosis 5.97 1 1 3.0 0.00 1.0e+00 GSDMB
Rheumatoid Arthritis 3.62 1 0 0.0 0.00 1.0e+00 GSDMB
Ulcerative Colitis 4.87 1 1 3.0 0.00 1.0e+00 GSDMB
Blood Eosinophil Count 45.53 6 6 18.2 -0.97 4.3e-04 AC093642.3 D2HGDH FOXO1 GLDC IL18R1 IL1RL2
Blood Platelet Count 1.51 2 2 6.1 0.00 1.0e+00 FOXO1 GSDMB
Blood Red Count 0.97 2 1 3.0 0.00 1.0e+00 FOXO1 GSDMB
Blood White Count 12.53 1 1 3.0 0.00 1.0e+00 GSDMB
Heel T-Score 0.41 1 0 0.0 0.00 1.0e+00 GLDC
Height 0.23 1 0 0.0 0.00 1.0e+00 FOXO1
Allergy or Eczema 35.81 7 7 21.2 -0.97 6.9e-05 AC093642.3 D2HGDH FOXO1 GLDC GSDMB IL18R1 IL1RL2
Respiratory disease 49.21 7 6 18.2 -0.98 3.8e-05 AC093642.3 D2HGDH FOXO1 GLDC GSDMB IL18R1 IL1RL2
Lung FEV1/FVC ratio 4.26 7 2 6.1 0.98 9.5e-05 AC093642.3 D2HGDH FOXO1 GLDC GSDMB IL18R1 IL1RL2
Lung FVC 0.64 1 0 0.0 0.00 1.0e+00 GSDMB
Number of treatments/medications taken 2.80 1 0 0.0 0.00 1.0e+00 IL1RL2
Leg fat-free mass (left) 0.53 1 0 0.0 0.00 1.0e+00 FOXO1
Taking other prescription medications 6.71 4 0 0.0 1.00 4.0e-03 AC093642.3 D2HGDH GSDMB IL1RL2
Hayfever, allergic rhinitis or eczema 31.84 7 7 21.2 0.97 5.4e-05 AC093642.3 D2HGDH FOXO1 GLDC GSDMB IL18R1 IL1RL2
Supplements: Glucosamine 1.62 1 0 0.0 0.00 1.0e+00 GLDC
Medication: Atenolol 3.04 1 0 0.0 0.00 1.0e+00 IL18R1
Body mass index (BMI) 0.50 1 0 0.0 0.00 1.0e+00 FOXO1
Leg predicted mass (left) 0.54 1 0 0.0 0.00 1.0e+00 FOXO1
Trunk fat mass 0.43 1 0 0.0 0.00 1.0e+00 FOXO1
Waist circumference 0.78 1 0 0.0 0.00 1.0e+00 FOXO1
Past tobacco smoking 1.83 1 0 0.0 0.00 1.0e+00 GLDC
Allergy 46.99 7 7 21.2 -0.99 3.6e-06 AC093642.3 D2HGDH FOXO1 GLDC GSDMB IL18R1 IL1RL2
Hayfever/allergic rhinitis (self-reported) 22.80 6 6 18.2 0.99 3.8e-05 AC093642.3 D2HGDH GLDC GSDMB IL18R1 IL1RL2
Weight 0.58 1 0 0.0 0.00 1.0e+00 FOXO1
Impedance of arm (right) 0.53 1 0 0.0 0.00 1.0e+00 GSDMB
Arm fat percentage (right) 0.54 1 0 0.0 0.00 1.0e+00 FOXO1
Trunk fat-free mass 0.41 1 0 0.0 0.00 1.0e+00 FOXO1
Hip circumference 0.61 1 0 0.0 0.00 1.0e+00 FOXO1
Mouth/teeth dental problems: Dentures 1.17 1 0 0.0 0.00 1.0e+00 GSDMB
Asthma 49.40 7 6 18.2 0.97 5.6e-05 AC093642.3 D2HGDH FOXO1 GLDC GSDMB IL18R1 IL1RL2
Impedance of arm (left) 0.62 1 0 0.0 0.00 1.0e+00 GSDMB
Arm fat mass (right) 0.64 1 0 0.0 0.00 1.0e+00 FOXO1
Trunk predicted mass 0.42 1 0 0.0 0.00 1.0e+00 FOXO1
Gout (self-reported) 3.45 2 0 0.0 0.00 1.0e+00 GSDMB IL1RL2
Wheeze or whistling in the chest in last year 20.29 6 6 18.2 1.00 3.4e-06 AC093642.3 D2HGDH GLDC GSDMB IL18R1 IL1RL2
Qualifications: College or University degree 0.67 1 0 0.0 0.00 1.0e+00 GSDMB
Medication: Seretide 50 evohaler 9.80 2 0 0.0 0.00 1.0e+00 D2HGDH IL18R1
Whole body fat mass 0.59 1 0 0.0 0.00 1.0e+00 FOXO1
Leg fat mass (right) 0.60 1 0 0.0 0.00 1.0e+00 FOXO1
Chest pain or discomfort 3.93 1 0 0.0 0.00 1.0e+00 GSDMB
Supplements: Vitamin C 2.59 1 0 0.0 0.00 1.0e+00 GSDMB
Whole body fat-free mass 0.46 1 0 0.0 0.00 1.0e+00 FOXO1
Leg fat-free mass (right) 0.44 1 0 0.0 0.00 1.0e+00 FOXO1
Arm fat percentage (left) 0.41 1 0 0.0 0.00 1.0e+00 FOXO1
Average weekly red wine intake 1.64 1 0 0.0 0.00 1.0e+00 GSDMB
Mouth/teeth dental problems: Mouth ulcers 2.16 1 0 0.0 0.00 1.0e+00 GSDMB
Asthma (self-reported) 50.14 7 6 18.2 0.97 6.0e-05 AC093642.3 D2HGDH FOXO1 GLDC GSDMB IL18R1 IL1RL2
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.69 2 0 0.0 0.00 1.0e+00 GSDMB IL18R1
Whole body water mass 0.43 1 0 0.0 0.00 1.0e+00 FOXO1
Leg predicted mass (right) 0.43 1 0 0.0 0.00 1.0e+00 FOXO1
Arm fat mass (left) 0.59 1 0 0.0 0.00 1.0e+00 FOXO1
Number of self-reported non-cancer illnesses 6.90 3 1 3.0 0.00 1.0e+00 D2HGDH GSDMB IL1RL2
Ever smoked 1.90 1 0 0.0 0.00 1.0e+00 GLDC
Basal metabolic rate 0.50 1 0 0.0 0.00 1.0e+00 FOXO1
Arm fat-free mass (left) 0.54 1 0 0.0 0.00 1.0e+00 FOXO1
Myopia 2.58 1 0 0.0 0.00 1.0e+00 GSDMB
Leg fat mass (left) 0.54 1 0 0.0 0.00 1.0e+00 FOXO1
Arm predicted mass (left) 0.58 1 0 0.0 0.00 1.0e+00 FOXO1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.28
GTEx Adipose Visceral Omentum 0 0.0000 1.29
GTEx Adrenal Gland 0 0.0000 1.31
GTEx Artery Aorta 0 0.0000 1.28
GTEx Artery Coronary 0 0.0000 1.22
GTEx Artery Tibial 2 0.0532 1.33
GTEx Brain Caudate basal ganglia 0 0.0000 1.32
GTEx Brain Cerebellar Hemisphere 1 0.0672 1.28
GTEx Brain Cerebellum 0 0.0000 1.28
GTEx Brain Cortex 0 0.0000 1.39
GTEx Brain Frontal Cortex BA9 1 0.1082 1.40
GTEx Brain Hippocampus 0 0.0000 1.25
GTEx Brain Hypothalamus 1 0.1695 1.34
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.49
GTEx Brain Putamen basal ganglia 0 0.0000 1.37
GTEx Breast Mammary Tissue 1 0.0507 1.27
GTEx Breast Mammary Tissue (Male) 2 0.1676 1.29
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.22
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.19
GTEx Cells Transformed fibroblasts 3 0.0714 1.35
GTEx Colon Sigmoid 0 0.0000 1.26
GTEx Colon Transverse 4 0.1938 1.30
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.27
GTEx Esophagus Mucosa 4 0.1205 1.29
GTEx Esophagus Muscularis 1 0.0309 1.29
GTEx Heart Atrial Appendage 2 0.1267 1.30
GTEx Heart Left Ventricle 0 0.0000 1.23
GTEx Liver 1 0.1395 1.23
GTEx Lung 2 0.0696 1.28
GTEx Muscle Skeletal 2 0.0692 1.30
GTEx Nerve Tibial 1 0.0231 1.30
GTEx Ovary 0 0.0000 1.20
GTEx Pancreas 4 0.2451 1.33
GTEx Pituitary 0 0.0000 1.16
GTEx Prostate 1 0.1198 1.20
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.27
GTEx Skin Sun Exposed Lower leg 2 0.0549 1.29
GTEx Small Intestine Terminal Ileum 0 0.0000 1.32
GTEx Spleen 2 0.1417 1.37
GTEx Stomach 0 0.0000 1.24
GTEx Testis 3 0.0951 1.34
GTEx Thyroid 2 0.0500 1.33
GTEx Uterus 1 0.1764 1.20
GTEx Vagina 0 0.0000 1.20
GTEx Whole Blood 5 0.2509 1.32
METSIM Adipose 3 0.0651 1.27
NTR Blood 3 0.1249 1.37
ROSMAP Brain Pre-frontal Cortex 3 0.0683 1.31
YFS Blood 4 0.0866 1.29
CommonMind Brain Pre-frontal Cortex 2 0.0372 1.27
TCGA Breast Tumor 0 0.0000 1.33
TCGA Breast Normal 1 0.0238 1.18
TCGA Ovarian Tumor 2 0.0684 1.21
TCGA Prostate Tumor 3 0.0867 1.28