Hub : Traits :

Medication: Co-codamol

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 49244657 50620043 1 1 9.1e-08 2.7e-06 0.074 86 MST1R

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Bipolar Disorder (2018) 2.90 1 0 0.0 0 1 MST1R
Depressed Affect (Nagel 2018) 15.93 1 1 2.2 0 1 MST1R
Depression (Nagel 2018) 2.70 1 0 0.0 0 1 MST1R
Intelligence (Savage-Jansen 2018) 30.63 1 1 2.2 0 1 MST1R
Neuroticism (Nagel 2018) 6.25 1 0 0.0 0 1 MST1R
Schizophrenia vs Biploar Disorder 10.08 1 0 0.0 0 1 MST1R
Crohns Disease (2017) 12.37 1 1 2.2 0 1 MST1R
Irritable Bowel Disease (IBD) 22.44 1 1 2.2 0 1 MST1R
Ulcerative Colitis (UC) 23.29 1 1 2.2 0 1 MST1R
Major Depression (MDD) 8.38 1 0 0.0 0 1 MST1R
Verbal and Numeric Reasoning (VNR) 25.81 1 1 2.2 0 1 MST1R
Breast Cancer 1.96 1 0 0.0 0 1 MST1R
Prostate Cancer 9.53 1 0 0.0 0 1 MST1R
Age at First Birth 45.60 1 1 2.2 0 1 MST1R
Body Mass Index (BMI) (2010) 8.32 1 0 0.0 0 1 MST1R
Coronary Artery Disease (CAD) 10.74 1 0 0.0 0 1 MST1R
Crohns Disease (2012) 15.53 1 0 0.0 0 1 MST1R
HbA1C 5.32 1 0 0.0 0 1 MST1R
HDL Cholesterol 3.12 1 0 0.0 0 1 MST1R
Neuroticism (2016) 5.17 1 0 0.0 0 1 MST1R
Ulcerative Colitis 18.55 1 1 2.2 0 1 MST1R
Blood Eosinophil Count 0.65 1 0 0.0 0 1 MST1R
Blood White Count 5.54 1 1 2.2 0 1 MST1R
Heel T-Score 1.92 1 0 0.0 0 1 MST1R
BMI 28.24 1 1 2.2 0 1 MST1R
Height 2.48 1 1 2.2 0 1 MST1R
Waist Hip Ratio (WHR) 1.16 1 0 0.0 0 1 MST1R
Systolic Blood Pressure 0.83 1 0 0.0 0 1 MST1R
Smoking Status 7.26 1 0 0.0 0 1 MST1R
Cardiovascular Disease 1.75 1 0 0.0 0 1 MST1R
Respiratory disease 5.56 1 0 0.0 0 1 MST1R
Type 2 Diabetes (T2D) (2018) 6.47 1 0 0.0 0 1 MST1R
Lung FEV1/FVC ratio 2.20 1 0 0.0 0 1 MST1R
Lung FVC 3.90 1 0 0.0 0 1 MST1R
Neuroticism 8.09 1 0 0.0 0 1 MST1R
Chronotype (morning person) 1.85 1 0 0.0 0 1 MST1R
Tanning 0.74 1 0 0.0 0 1 MST1R
Number of treatments/medications taken 17.25 1 1 2.2 0 1 MST1R
Average weekly spirits intake 3.74 1 0 0.0 0 1 MST1R
Frequency of depressed mood in last 2 weeks 3.65 1 0 0.0 0 1 MST1R
Relative age of first facial hair 3.78 1 0 0.0 0 1 MST1R
Ever had hysterectomy (womb removed) 6.67 1 0 0.0 0 1 MST1R
Systolic blood pressure, automated reading 2.50 1 0 0.0 0 1 MST1R
Medication: Metformin 3.98 1 0 0.0 0 1 MST1R
Diabetes (mother) 4.59 1 0 0.0 0 1 MST1R
Pack years adult smoking proportion 3.56 1 0 0.0 0 1 MST1R
Impedance of leg (right) 10.23 1 1 2.2 0 1 MST1R
Leg fat-free mass (left) 9.06 1 1 2.2 0 1 MST1R
Trunk fat percentage 10.19 1 1 2.2 0 1 MST1R
Hand grip strength (right) 2.32 1 0 0.0 0 1 MST1R
Current tobacco smoking 3.73 1 0 0.0 0 1 MST1R
Maternal smoking around birth 3.26 1 0 0.0 0 1 MST1R
Fed-up feelings 19.97 1 1 2.2 0 1 MST1R
Frequency of unenthusiasm / disinterest in last 2 weeks 7.07 1 0 0.0 0 1 MST1R
Taking other prescription medications 16.61 1 0 0.0 0 1 MST1R
Age when periods started (menarche) 5.49 1 0 0.0 0 1 MST1R
Bilateral oophorectomy (both ovaries removed) 8.62 1 0 0.0 0 1 MST1R
Heel bone mineral density (BMD) T-score, automated (left) 2.96 1 0 0.0 0 1 MST1R
Tinnitus: Yes, but not now, but have in the past 4.00 1 0 0.0 0 1 MST1R
Qualifications: CSEs or equivalent 12.62 1 0 0.0 0 1 MST1R
Chronic bronchitis/emphysema (father) 6.00 1 0 0.0 0 1 MST1R
Body mass index (BMI) 32.68 1 1 2.2 0 1 MST1R
Impedance of leg (left) 11.74 1 1 2.2 0 1 MST1R
Leg predicted mass (left) 8.91 1 1 2.2 0 1 MST1R
Trunk fat mass 13.77 1 1 2.2 0 1 MST1R
Waist circumference 15.22 1 1 2.2 0 1 MST1R
Past tobacco smoking 2.36 1 0 0.0 0 1 MST1R
Alcohol usually taken with meals 6.83 1 0 0.0 0 1 MST1R
Frequency of tenseness / restlessness in last 2 weeks 9.05 1 0 0.0 0 1 MST1R
Forced vital capacity (FVC) 5.42 1 0 0.0 0 1 MST1R
Ever unenthusiastic/disinterested for a whole week 10.92 1 0 0.0 0 1 MST1R
Qualifications: None of the above 27.18 1 1 2.2 0 1 MST1R
Financial difficulties in last 2 years 3.22 1 0 0.0 0 1 MST1R
Mouth/teeth dental problems 3.49 1 0 0.0 0 1 MST1R
Heart attack 6.33 1 0 0.0 0 1 MST1R
Pain all over the body in last month 14.84 1 0 0.0 0 1 MST1R
Diabetes (self-reported) 9.16 1 0 0.0 0 1 MST1R
Medication: Ramipril 3.70 1 0 0.0 0 1 MST1R
Fluid intelligence score 27.29 1 1 2.2 0 1 MST1R
Illnesses of siblings 6.58 1 0 0.0 0 1 MST1R
Neuroticism score 9.23 1 0 0.0 0 1 MST1R
Weight 16.26 1 1 2.2 0 1 MST1R
Impedance of arm (right) 24.10 1 1 2.2 0 1 MST1R
Arm fat percentage (right) 18.42 1 1 2.2 0 1 MST1R
Trunk fat-free mass 6.37 1 1 2.2 0 1 MST1R
Hip circumference 12.87 1 1 2.2 0 1 MST1R
Alcohol intake versus 10 years previously 13.44 1 0 0.0 0 1 MST1R
Father's age at death 7.43 1 0 0.0 0 1 MST1R
Worrier / anxious feelings 2.29 1 0 0.0 0 1 MST1R
Number of live births 7.86 1 0 0.0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1) 7.42 1 0 0.0 0 1 MST1R
Noisy workplace 5.78 1 0 0.0 0 1 MST1R
Qualifications: A levels/AS levels or equivalent 36.33 1 1 2.2 0 1 MST1R
Mouth/teeth dental problems: Dentures 12.82 1 0 0.0 0 1 MST1R
Asthma 4.90 1 0 0.0 0 1 MST1R
Medication: Ibuprofen (e.g. Nurofen) 3.57 1 0 0.0 0 1 MST1R
Medication: Cholesterol lowering 5.28 1 0 0.0 0 1 MST1R
Prospective memory result 3.72 1 0 0.0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1), Best measure 8.81 1 1 2.2 0 1 MST1R
Impedance of arm (left) 24.73 1 1 2.2 0 1 MST1R
Arm fat mass (right) 22.95 1 1 2.2 0 1 MST1R
Trunk predicted mass 6.23 1 1 2.2 0 1 MST1R
Standing height 2.18 1 0 0.0 0 1 MST1R
Exposure to tobacco smoke at home 18.69 1 0 0.0 0 1 MST1R
Breastfed as a baby 4.51 1 0 0.0 0 1 MST1R
Seen doctor (GP) for nerves, anxiety, tension or depression 6.14 1 0 0.0 0 1 MST1R
Peak expiratory flow (PEF) 5.15 1 0 0.0 0 1 MST1R
Pulse wave reflection index 3.47 1 0 0.0 0 1 MST1R
Ever highly irritable/argumentative for 2 days 23.14 1 1 2.2 0 1 MST1R
Qualifications: O levels/GCSEs or equivalent 9.74 1 0 0.0 0 1 MST1R
Medication: Paracetamol 5.32 1 0 0.0 0 1 MST1R
Medication for cholesterol, blood pressure or diabetes 10.21 1 0 0.0 0 1 MST1R
Medication: Ventolin 100micrograms inhaler 7.93 1 0 0.0 0 1 MST1R
Chronic bronchitis/emphysema (mother) 10.88 1 0 0.0 0 1 MST1R
High blood pressure (siblings) 5.87 1 0 0.0 0 1 MST1R
Forced vital capacity (FVC), Best measure 6.95 1 0 0.0 0 1 MST1R
Body fat percentage 14.94 1 1 2.2 0 1 MST1R
Leg fat percentage (right) 23.87 1 1 2.2 0 1 MST1R
Arm fat-free mass (right) 11.21 1 1 2.2 0 1 MST1R
Exposure to tobacco smoke outside home 12.77 1 0 0.0 0 1 MST1R
Comparative body size at age 10 3.62 1 0 0.0 0 1 MST1R
Number of full brothers 11.79 1 0 0.0 0 1 MST1R
Wheeze or whistling in the chest in last year 17.70 1 1 2.2 0 1 MST1R
Number of children fathered 3.78 1 0 0.0 0 1 MST1R
Reason for reducing amount of alcohol drunk: Health precaution 4.73 1 0 0.0 0 1 MST1R
Age at first live birth 32.10 1 1 2.2 0 1 MST1R
Health satisfaction 4.95 1 0 0.0 0 1 MST1R
Shortness of breath walking on level ground 5.01 1 0 0.0 0 1 MST1R
Qualifications: College or University degree 44.95 1 1 2.2 0 1 MST1R
Medication for pain relief, constipation, heartburn 4.04 1 0 0.0 0 1 MST1R
Neck or shoulder pain in last month 4.91 1 0 0.0 0 1 MST1R
Medication: Blood pressure 6.84 1 0 0.0 0 1 MST1R
Medication: Ibuprofen 4.52 1 0 0.0 0 1 MST1R
Medication: Omeprazole 5.08 1 0 0.0 0 1 MST1R
Medication: Seretide 50 evohaler 17.43 1 0 0.0 0 1 MST1R
Mean time to correctly identify matches 3.41 1 0 0.0 0 1 MST1R
Whole body fat mass 19.44 1 1 2.2 0 1 MST1R
Leg fat mass (right) 26.31 1 1 2.2 0 1 MST1R
Arm predicted mass (right) 12.14 1 1 2.2 0 1 MST1R
Alcohol intake frequency. 8.91 1 0 0.0 0 1 MST1R
Comparative height size at age 10 3.52 1 0 0.0 0 1 MST1R
Number of full sisters 7.25 1 0 0.0 0 1 MST1R
Overall health rating 25.39 1 1 2.2 0 1 MST1R
Chest pain or discomfort 6.45 1 0 0.0 0 1 MST1R
Had major operations 8.82 1 0 0.0 0 1 MST1R
Age at last live birth 37.93 1 1 2.2 0 1 MST1R
Leg pain on walking 9.23 1 0 0.0 0 1 MST1R
Qualifications: NVQ or HND or HNC or equivalent 8.99 1 0 0.0 0 1 MST1R
Commuting to job workplace: Car/motor vehicle 6.84 1 0 0.0 0 1 MST1R
Knee pain experienced in last month 9.31 1 0 0.0 0 1 MST1R
Illnesses of siblings: Diabetes 4.80 1 0 0.0 0 1 MST1R
Smoking status: Previous 2.81 1 0 0.0 0 1 MST1R
Whole body fat-free mass 7.97 1 1 2.2 0 1 MST1R
Leg fat-free mass (right) 7.08 1 1 2.2 0 1 MST1R
Arm fat percentage (left) 18.28 1 1 2.2 0 1 MST1R
Average weekly red wine intake 7.74 1 0 0.0 0 1 MST1R
Mood swings 15.57 1 1 2.2 0 1 MST1R
Loneliness, isolation 8.47 1 0 0.0 0 1 MST1R
Long-standing illness, disability or infirmity 2.76 1 0 0.0 0 1 MST1R
Ever had bowel cancer screening 8.17 1 0 0.0 0 1 MST1R
Diabetes diagnosed by doctor 6.79 1 0 0.0 0 1 MST1R
Qualifications: nursing, teaching 9.39 1 0 0.0 0 1 MST1R
Commuting to job workplace: Walk 4.98 1 0 0.0 0 1 MST1R
Asthma (self-reported) 5.14 1 0 0.0 0 1 MST1R
Osteoarthritis (self-reported) 6.39 1 0 0.0 0 1 MST1R
Smoking status: Current 2.86 1 0 0.0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.86 1 0 0.0 0 1 MST1R
Whole body water mass 8.28 1 1 2.2 0 1 MST1R
Leg predicted mass (right) 6.95 1 1 2.2 0 1 MST1R
Arm fat mass (left) 22.63 1 1 2.2 0 1 MST1R
Number of self-reported non-cancer illnesses 2.69 1 0 0.0 0 1 MST1R
Average weekly champagne plus white wine intake 3.01 1 0 0.0 0 1 MST1R
Miserableness 24.80 1 1 2.2 0 1 MST1R
Guilty feelings 14.75 1 0 0.0 0 1 MST1R
Ever taken oral contraceptive pill 4.92 1 0 0.0 0 1 MST1R
Mother's age at death 5.19 1 0 0.0 0 1 MST1R
Financial situation satisfaction 8.48 1 0 0.0 0 1 MST1R
Commuting to job workplace: Public transport 5.52 1 0 0.0 0 1 MST1R
Medication: Paracetamol 6.94 1 0 0.0 0 1 MST1R
Basal metabolic rate 10.41 1 1 2.2 0 1 MST1R
Leg fat percentage (left) 23.03 1 1 2.2 0 1 MST1R
Arm fat-free mass (left) 12.90 1 1 2.2 0 1 MST1R
Number of operations (self-reported) 12.03 1 0 0.0 0 1 MST1R
Average weekly beer plus cider intake 18.84 1 1 2.2 0 1 MST1R
Age started oral contraceptive pill 12.84 1 0 0.0 0 1 MST1R
Diastolic blood pressure, automated reading 5.51 1 0 0.0 0 1 MST1R
Ever depressed for a whole week 13.11 1 0 0.0 0 1 MST1R
Commuting to job workplace: Cycle 5.18 1 0 0.0 0 1 MST1R
Vascular/heart problems diagnosed by doctor 1.94 1 0 0.0 0 1 MST1R
Medication: Omeprazole (e.g. Zanprol) 3.73 1 0 0.0 0 1 MST1R
Pain experienced in last month 11.62 1 0 0.0 0 1 MST1R
Basal cell carcinoma (self-reported) 9.00 1 0 0.0 0 1 MST1R
Heart attack/myocardial infarction (self-reported) 5.15 1 0 0.0 0 1 MST1R
Alcohol drinker status: Previous 6.88 1 0 0.0 0 1 MST1R
Impedance of whole body 20.45 1 1 2.2 0 1 MST1R
Leg fat mass (left) 26.12 1 1 2.2 0 1 MST1R
Arm predicted mass (left) 13.10 1 1 2.2 0 1 MST1R

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.000 1.2
GTEx Adipose Visceral Omentum 0 0.000 1.2
GTEx Adrenal Gland 0 0.000 1.1
GTEx Artery Aorta 0 0.000 1.2
GTEx Artery Coronary 0 0.000 1.2
GTEx Artery Tibial 0 0.000 1.2
GTEx Brain Caudate basal ganglia 0 0.000 1.2
GTEx Brain Cerebellar Hemisphere 0 0.000 1.1
GTEx Brain Cerebellum 0 0.000 1.2
GTEx Brain Cortex 0 0.000 1.2
GTEx Brain Frontal Cortex BA9 0 0.000 1.2
GTEx Brain Hippocampus 0 0.000 1.1
GTEx Brain Hypothalamus 0 0.000 1.2
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.1
GTEx Brain Putamen basal ganglia 0 0.000 1.1
GTEx Breast Mammary Tissue 0 0.000 1.2
GTEx Breast Mammary Tissue (Male) 0 0.000 1.1
GTEx Breast Mammary Tissue (Female) 0 0.000 1.1
GTEx Cells EBV-transformed lymphocytes 0 0.000 1.1
GTEx Cells Transformed fibroblasts 0 0.000 1.2
GTEx Colon Sigmoid 0 0.000 1.2
GTEx Colon Transverse 0 0.000 1.2
GTEx Esophagus Gastroesophageal Junction 0 0.000 1.2
GTEx Esophagus Mucosa 0 0.000 1.2
GTEx Esophagus Muscularis 1 0.031 1.2
GTEx Heart Atrial Appendage 0 0.000 1.2
GTEx Heart Left Ventricle 0 0.000 1.1
GTEx Liver 0 0.000 1.2
GTEx Lung 0 0.000 1.2
GTEx Muscle Skeletal 0 0.000 1.2
GTEx Nerve Tibial 0 0.000 1.2
GTEx Ovary 0 0.000 1.2
GTEx Pancreas 0 0.000 1.2
GTEx Pituitary 0 0.000 1.1
GTEx Prostate 0 0.000 1.2
GTEx Skin Not Sun Exposed Suprapubic 0 0.000 1.2
GTEx Skin Sun Exposed Lower leg 0 0.000 1.2
GTEx Small Intestine Terminal Ileum 0 0.000 1.1
GTEx Spleen 0 0.000 1.1
GTEx Stomach 0 0.000 1.2
GTEx Testis 0 0.000 1.1
GTEx Thyroid 0 0.000 1.2
GTEx Uterus 0 0.000 1.2
GTEx Vagina 0 0.000 1.1
GTEx Whole Blood 0 0.000 1.2
METSIM Adipose 0 0.000 1.2
NTR Blood 0 0.000 1.2
ROSMAP Brain Pre-frontal Cortex 0 0.000 1.2
YFS Blood 0 0.000 1.2
CommonMind Brain Pre-frontal Cortex 0 0.000 1.2
The Cancer Genome Atlas Bladder Urothelial Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Breast Invasive Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Colon Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Esophageal Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.2
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Brain Lower Grade Glioma 0 0.000 1.2
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Pancreatic Adenocarcinoma 0 0.000 1.0
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 0 0.000 1.1
The Cancer Genome Atlas Prostate Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.2
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.1
The Cancer Genome Atlas Skin Cutaneous Melanoma 0 0.000 1.1
The Cancer Genome Atlas Stomach Adenocarcinoma 0 0.000 1.1
The Cancer Genome Atlas Testicular Germ Cell Tumors 0 0.000 1.1
The Cancer Genome Atlas Thyroid Carcinoma 0 0.000 1.1
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 0 0.000 1.1