Hub : Traits :

Medication: Lisinopril

1 significantly associated models · 1 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 9 99707397 101087286 1 1 2.2e-07 8.3e-07 0.79 100 TSTD2

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2012) 2.90 1 0 0 0 1 TSTD2
Fasting Glucose 6.19 1 0 0 0 1 TSTD2
Blood Platelet Count 1.17 1 0 0 0 1 TSTD2
Blood Red Count 0.41 1 0 0 0 1 TSTD2
Hypothyroidism (self reported) 4.28 1 0 0 0 1 TSTD2
Type 2 Diabetes (T2D) 3.39 1 0 0 0 1 TSTD2
Lung FEV1/FVC ratio 8.56 1 1 3 0 1 TSTD2
Hair Pigment 0.26 1 0 0 0 1 TSTD2
Systolic blood pressure, automated reading 1.91 1 0 0 0 1 TSTD2
Vitamin and mineral supplements 4.73 1 0 0 0 1 TSTD2
Medication: Metformin 4.37 1 0 0 0 1 TSTD2
Diabetes (mother) 6.28 1 0 0 0 1 TSTD2
Impedance of leg (right) 1.62 1 0 0 0 1 TSTD2
High blood pressure 5.18 1 0 0 0 1 TSTD2
Medication: Levothyroxine sodium 4.41 1 0 0 0 1 TSTD2
High blood pressure (mother) 4.15 1 0 0 0 1 TSTD2
Impedance of leg (left) 2.04 1 0 0 0 1 TSTD2
Had menopause 5.86 1 0 0 0 1 TSTD2
Diabetes (self-reported) 4.90 1 0 0 0 1 TSTD2
Medication: Simvastatin 4.44 1 0 0 0 1 TSTD2
Medication: Cholesterol lowering 3.38 1 0 0 0 1 TSTD2
Illnesses of mother 4.56 1 0 0 0 1 TSTD2
Birth weight of first child 6.45 1 0 0 0 1 TSTD2
Loud music exposure frequency 6.77 1 0 0 0 1 TSTD2
Medication for cholesterol, blood pressure or diabetes 4.57 1 0 0 0 1 TSTD2
Hypothyroidism/myxoedema (self-reported) 3.47 1 0 0 0 1 TSTD2
Medication: Blood pressure 5.90 1 0 0 0 1 TSTD2
Comparative height size at age 10 0.77 1 0 0 0 1 TSTD2
Hypertension (Self-reported) 4.60 1 0 0 0 1 TSTD2
Diabetes diagnosed by doctor 3.25 1 0 0 0 1 TSTD2
Hearing aid user 3.61 1 0 0 0 1 TSTD2
Medication: Blood pressure 2.44 1 0 0 0 1 TSTD2
Average weekly beer plus cider intake 4.20 1 0 0 0 1 TSTD2
Myopia 3.79 1 0 0 0 1 TSTD2
Vascular/heart problems diagnosed by doctor 4.07 1 0 0 0 1 TSTD2
Impedance of whole body 1.01 1 0 0 0 1 TSTD2

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 0 0.0000 1.31
GTEx Adipose Visceral Omentum 1 0.0491 1.37
GTEx Adrenal Gland 0 0.0000 1.33
GTEx Artery Aorta 0 0.0000 1.37
GTEx Artery Coronary 0 0.0000 1.39
GTEx Artery Tibial 0 0.0000 1.34
GTEx Brain Caudate basal ganglia 0 0.0000 1.39
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.32
GTEx Brain Cerebellum 0 0.0000 1.37
GTEx Brain Cortex 0 0.0000 1.28
GTEx Brain Frontal Cortex BA9 0 0.0000 1.39
GTEx Brain Hippocampus 0 0.0000 1.39
GTEx Brain Hypothalamus 0 0.0000 1.45
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.43
GTEx Brain Putamen basal ganglia 0 0.0000 1.33
GTEx Breast Mammary Tissue 0 0.0000 1.36
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.32
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.38
GTEx Cells EBV-transformed lymphocytes 0 0.0000 1.35
GTEx Cells Transformed fibroblasts 0 0.0000 1.33
GTEx Colon Sigmoid 0 0.0000 1.39
GTEx Colon Transverse 0 0.0000 1.35
GTEx Esophagus Gastroesophageal Junction 0 0.0000 1.40
GTEx Esophagus Mucosa 0 0.0000 1.30
GTEx Esophagus Muscularis 0 0.0000 1.35
GTEx Heart Atrial Appendage 0 0.0000 1.34
GTEx Heart Left Ventricle 0 0.0000 1.33
GTEx Liver 0 0.0000 1.32
GTEx Lung 0 0.0000 1.36
GTEx Muscle Skeletal 0 0.0000 1.33
GTEx Nerve Tibial 0 0.0000 1.25
GTEx Ovary 0 0.0000 1.43
GTEx Pancreas 0 0.0000 1.36
GTEx Pituitary 0 0.0000 1.37
GTEx Prostate 0 0.0000 1.44
GTEx Skin Not Sun Exposed Suprapubic 0 0.0000 1.29
GTEx Skin Sun Exposed Lower leg 0 0.0000 1.29
GTEx Small Intestine Terminal Ileum 0 0.0000 1.31
GTEx Spleen 0 0.0000 1.32
GTEx Stomach 0 0.0000 1.38
GTEx Testis 0 0.0000 1.32
GTEx Thyroid 0 0.0000 1.30
GTEx Uterus 0 0.0000 1.31
GTEx Vagina 0 0.0000 1.28
GTEx Whole Blood 0 0.0000 1.29
METSIM Adipose 0 0.0000 1.27
NTR Blood 0 0.0000 1.25
ROSMAP Brain Pre-frontal Cortex 0 0.0000 1.27
YFS Blood 0 0.0000 1.22
CommonMind Brain Pre-frontal Cortex 0 0.0000 1.24
TCGA Breast Tumor 0 0.0000 1.46
TCGA Breast Normal 0 0.0000 1.23
TCGA Ovarian Tumor 0 0.0000 1.14
TCGA Prostate Tumor 0 0.0000 1.26