Hub : Traits :

Had menopause

97 significantly associated models · 26 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 26592429 28607344 13 1 2.0e-11 1.9e-11 1.000 100 IFT172
2 4 83635581 85216227 4 1 1.4e-08 6.4e-09 1.000 100 MRPS18C
3 5 175611678 177138298 4 1 5.9e-17 1.5e-16 1.000 100 UIMC1
4 12 56435412 57844049 1 1 5.8e-11 2.9e-11 1.000 100 PRIM1
5 16 89094243 90172696 3 2 1.7e-08 1.1e-07 1.000 100 FANCA GAS8
6 17 40672739 42067365 1 1 4.0e-07 7.5e-06 0.082 85 TMEM106A

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 1.89 1 0 0.0 0.00 1.00 IFT172
Irritable Bowel Disease (IBD) 1.81 1 0 0.0 0.00 1.00 IFT172
Breast Cancer 3.23 2 0 0.0 0.00 1.00 FANCA GAS8
Fasting Glucose 4.36 1 1 3.0 0.00 1.00 IFT172
Triglycerides 15.37 1 1 3.0 0.00 1.00 IFT172
Blood Platelet Count 2.04 1 1 3.0 0.00 1.00 IFT172
Blood Red Count 0.86 1 1 3.0 0.00 1.00 PRIM1
Blood White Count 2.52 2 1 3.0 0.00 1.00 IFT172 PRIM1
Heel T-Score 1.94 3 1 3.0 0.00 1.00 FANCA GAS8 TMEM106A
BMI 0.74 1 0 0.0 0.00 1.00 FANCA
Height 2.69 6 5 15.2 -0.04 0.95 FANCA GAS8 IFT172 PRIM1 TMEM106A UIMC1
Waist Hip Ratio (WHR) 2.21 2 1 3.0 0.00 1.00 PRIM1 TMEM106A
Systolic Blood Pressure 1.18 1 0 0.0 0.00 1.00 IFT172
Allergy or Eczema 1.66 1 0 0.0 0.00 1.00 IFT172
Cardiovascular Disease 1.55 1 1 3.0 0.00 1.00 IFT172
Type 2 Diabetes (T2D) 2.55 1 0 0.0 0.00 1.00 IFT172
Hair Pigment 50.69 3 3 9.1 0.00 1.00 FANCA GAS8 IFT172
Tanning 9.94 3 2 6.1 0.00 1.00 FANCA GAS8 IFT172
Number of treatments/medications taken 2.01 1 0 0.0 0.00 1.00 IFT172
Relative age of first facial hair 2.35 1 0 0.0 0.00 1.00 GAS8
Ever used hormone-replacement therapy (HRT) 7.21 3 0 0.0 0.00 1.00 IFT172 PRIM1 UIMC1
Impedance of leg (right) 1.10 1 1 3.0 0.00 1.00 PRIM1
Leg fat-free mass (left) 2.30 2 1 3.0 0.00 1.00 IFT172 PRIM1
Trunk fat percentage 2.08 2 1 3.0 0.00 1.00 FANCA GAS8
Hayfever, allergic rhinitis or eczema 1.74 1 0 0.0 0.00 1.00 IFT172
Sitting height 1.57 3 0 0.0 0.00 1.00 FANCA IFT172 PRIM1
Impedance of leg (left) 1.17 1 1 3.0 0.00 1.00 PRIM1
Leg predicted mass (left) 2.31 2 1 3.0 0.00 1.00 IFT172 PRIM1
Trunk fat mass 2.04 2 1 3.0 0.00 1.00 FANCA GAS8
Waist circumference 1.34 2 0 0.0 0.00 1.00 FANCA GAS8
Forced vital capacity (FVC) 0.94 1 0 0.0 0.00 1.00 GAS8
Heel bone mineral density (BMD) T-score, automated (right) 1.48 1 0 0.0 0.00 1.00 GAS8
Diabetes (self-reported) 2.30 1 0 0.0 0.00 1.00 IFT172
Weight 2.15 3 0 0.0 0.00 1.00 FANCA GAS8 PRIM1
Impedance of arm (right) 1.20 1 1 3.0 0.00 1.00 PRIM1
Trunk fat-free mass 2.82 2 1 3.0 0.00 1.00 IFT172 PRIM1
Hip circumference 1.76 1 0 0.0 0.00 1.00 PRIM1
Alcohol intake versus 10 years previously 1.98 1 0 0.0 0.00 1.00 IFT172
Forced expiratory volume in 1-second (FEV1) 0.76 1 0 0.0 0.00 1.00 GAS8
Medication: Cholesterol lowering 1.82 1 0 0.0 0.00 1.00 IFT172
Impedance of arm (left) 1.33 1 1 3.0 0.00 1.00 PRIM1
Arm fat mass (right) 1.11 1 0 0.0 0.00 1.00 FANCA
Trunk predicted mass 2.83 2 2 6.1 0.00 1.00 IFT172 PRIM1
Standing height 2.10 5 2 6.1 0.01 0.98 FANCA GAS8 IFT172 PRIM1 UIMC1
Medication: Paracetamol 3.33 1 0 0.0 0.00 1.00 UIMC1
Gout (self-reported) 6.33 1 1 3.0 0.00 1.00 IFT172
Body fat percentage 1.55 2 0 0.0 0.00 1.00 FANCA GAS8
Arm fat-free mass (right) 2.90 2 2 6.1 0.00 1.00 IFT172 PRIM1
Comparative body size at age 10 2.45 1 0 0.0 0.00 1.00 UIMC1
Medication: Allopurinol 4.53 1 1 3.0 0.00 1.00 IFT172
Whole body fat mass 1.61 2 0 0.0 0.00 1.00 FANCA GAS8
Leg fat mass (right) 1.34 2 0 0.0 0.00 1.00 FANCA GAS8
Arm predicted mass (right) 2.68 2 1 3.0 0.00 1.00 IFT172 PRIM1
Pulse rate, automated reading 1.43 1 1 3.0 0.00 1.00 IFT172
Alcohol intake frequency. 2.57 1 1 3.0 0.00 1.00 IFT172
Comparative height size at age 10 1.99 3 1 3.0 0.00 1.00 IFT172 PRIM1 UIMC1
Whole body fat-free mass 2.65 2 1 3.0 0.00 1.00 IFT172 PRIM1
Leg fat-free mass (right) 2.18 1 1 3.0 0.00 1.00 PRIM1
Arm fat percentage (left) 0.81 1 0 0.0 0.00 1.00 GAS8
Diabetes diagnosed by doctor 2.59 1 0 0.0 0.00 1.00 IFT172
Whole body water mass 2.67 2 1 3.0 0.00 1.00 IFT172 PRIM1
Leg predicted mass (right) 2.21 1 1 3.0 0.00 1.00 PRIM1
Arm fat mass (left) 1.19 1 0 0.0 0.00 1.00 GAS8
High cholesterol (Self-reported) 3.10 1 1 3.0 0.00 1.00 IFT172
Medication: Bendroflumethiazide 1.38 1 0 0.0 0.00 1.00 TMEM106A
Medication: Paracetamol 3.15 1 0 0.0 0.00 1.00 UIMC1
Medication: Atorvastatin 2.56 1 0 0.0 0.00 1.00 IFT172
Basal metabolic rate 2.57 3 1 3.0 0.00 1.00 FANCA IFT172 PRIM1
Arm fat-free mass (left) 2.81 3 1 3.0 0.00 1.00 FANCA IFT172 PRIM1
Impedance of whole body 1.42 1 1 3.0 0.00 1.00 PRIM1
Leg fat mass (left) 1.31 2 0 0.0 0.00 1.00 FANCA GAS8
Arm predicted mass (left) 2.75 2 1 3.0 0.00 1.00 IFT172 PRIM1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 4 0.1146 1.30
GTEx Adipose Visceral Omentum 4 0.1965 1.34
GTEx Adrenal Gland 1 0.0686 1.23
GTEx Artery Aorta 2 0.0672 1.24
GTEx Artery Coronary 1 0.0845 1.27
GTEx Artery Tibial 4 0.1064 1.31
GTEx Brain Caudate basal ganglia 0 0.0000 1.17
GTEx Brain Cerebellar Hemisphere 0 0.0000 1.31
GTEx Brain Cerebellum 1 0.0505 1.27
GTEx Brain Cortex 1 0.0966 1.28
GTEx Brain Frontal Cortex BA9 0 0.0000 1.25
GTEx Brain Hippocampus 0 0.0000 1.26
GTEx Brain Hypothalamus 0 0.0000 1.25
GTEx Brain Nucleus accumbens basal ganglia 0 0.0000 1.20
GTEx Brain Putamen basal ganglia 0 0.0000 1.24
GTEx Breast Mammary Tissue 0 0.0000 1.29
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.22
GTEx Breast Mammary Tissue (Female) 0 0.0000 1.29
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.28
GTEx Cells Transformed fibroblasts 5 0.1191 1.25
GTEx Colon Sigmoid 1 0.0684 1.33
GTEx Colon Transverse 2 0.0969 1.36
GTEx Esophagus Gastroesophageal Junction 2 0.1384 1.24
GTEx Esophagus Mucosa 2 0.0602 1.27
GTEx Esophagus Muscularis 4 0.1238 1.29
GTEx Heart Atrial Appendage 0 0.0000 1.23
GTEx Heart Left Ventricle 0 0.0000 1.28
GTEx Liver 0 0.0000 1.22
GTEx Lung 2 0.0696 1.26
GTEx Muscle Skeletal 2 0.0692 1.27
GTEx Nerve Tibial 6 0.1389 1.29
GTEx Ovary 1 0.1101 1.32
GTEx Pancreas 1 0.0613 1.33
GTEx Pituitary 0 0.0000 1.34
GTEx Prostate 1 0.1198 1.33
GTEx Skin Not Sun Exposed Suprapubic 2 0.0813 1.29
GTEx Skin Sun Exposed Lower leg 4 0.1099 1.28
GTEx Small Intestine Terminal Ileum 0 0.0000 1.36
GTEx Spleen 0 0.0000 1.30
GTEx Stomach 0 0.0000 1.30
GTEx Testis 6 0.1902 1.28
GTEx Thyroid 7 0.1750 1.34
GTEx Uterus 0 0.0000 1.20
GTEx Vagina 1 0.1575 1.36
GTEx Whole Blood 1 0.0502 1.23
METSIM Adipose 3 0.0651 1.21
NTR Blood 0 0.0000 1.21
ROSMAP Brain Pre-frontal Cortex 7 0.1594 1.24
YFS Blood 5 0.1083 1.20
CommonMind Brain Pre-frontal Cortex 7 0.1302 1.24
TCGA Breast Tumor 0 0.0000 1.26
TCGA Breast Normal 3 0.0713 1.19
TCGA Ovarian Tumor 1 0.0342 1.17
TCGA Prostate Tumor 2 0.0578 1.27