Hub : Genes

RPRD1A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.142	0.0450	5.4e-06	0.111	NA	0.126	NA	0.140	2.2e-09	NA	1.9e-10	NA	1.7e-11
2	GTEx	Adipose Visceral Omentum	0.122	0.0540	6.2e-03	0.087	NA	0.070	NA	0.113	3.0e-05	NA	1.7e-04	NA	1.8e-06
3	GTEx	Cells Transformed fibroblasts	0.082	0.0350	6.0e-03	0.027	NA	0.019	NA	0.023	3.7e-03	NA	1.4e-02	NA	6.7e-03
4	METSIM	Adipose	0.122	0.0349	3.2e-08	0.090	0.074	0.086	0.084	0.088	2.0e-13	3.6e-11	8.9e-13	1.4e-12	3.8e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.8	1.3	1.5	-1.0	-1.2	1.2	-1.1
Bipolar Disorder or Schizophrenia	1.2	2.9	5.5	-1.3	-1.5	2.3	-1.4
Depressed Affect (Nagel 2018)	0.3	0.7	1.6	0.1	0.7	-1.2	0.7
Depression (Nagel 2018)	1.6	2.4	4.4	-2.1	-1.5	0.5	-1.6
Intelligence (Savage-Jansen 2018)	2.1	6.4	10.9	2.6	3.3	-0.3	2.8
Neuroticism (Nagel 2018)	0.2	0.5	1.1	0.1	1.0	-0.4	1.0
Schizophrenia (2018)	0.8	1.7	4.2	-0.9	-0.9	2.0	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.3	0.4	0.4	0.5	0.6	0.7
Worry (Nagel 2018)	0.5	1.1	2.0	0.8	1.4	-0.4	1.3
Alzheimer’s Disease (in mother)	1.4	1.7	2.1	1.4	1.3	-1.1	1.3
Alzheimer’s Disease (in father)	0.1	0.2	0.4	0.6	0.1	0.1	0.5
Alzheimer’s Disease (including proxy)	1.3	1.8	2.4	1.6	1.2	-1.3	1.3
Crohns Disease (2017)	1.2	2.7	3.8	-1.8	-2.0	0.8	-1.8
Irritable Bowel Disease (IBD)	3.0	7.2	10.6	-2.9	-3.0	-0.9	-3.3
Ulcerative Colitis (UC)	3.7	7.0	9.2	-3.0	-2.9	-1.3	-3.0
Major Depression (MDD)	1.8	2.2	3.5	-1.9	-1.4	0.8	-1.6
Reaction Time	1.4	2.6	4.3	-1.5	-1.1	-1.7	-2.1
Verbal and Numeric Reasoning (VNR)	2.3	5.5	8.9	2.7	3.0	-0.5	2.4
Breast Cancer	0.5	1.3	2.1	1.1	1.4	-0.7	1.1
Ovarian Cancer	0.9	1.2	2.8	-1.0	-0.9	1.7	-0.4
Prostate Cancer	0.3	0.4	1.0	-0.5	-1.0	-0.1	-0.6
Age at First Birth	2.6	3.8	5.4	2.1	2.1	-1.1	2.3
Bipolar Disorder (2011)	0.2	0.2	0.4	-0.1	-0.6	-0.4	-0.4
Body Mass Index (BMI) (2010)	0.5	0.7	1.2	0.8	1.1	0.1	1.1
Coronary Artery Disease (CAD)	0.2	0.2	0.5	-0.3	-0.2	0.7	-0.5
Crohns Disease (2012)	0.3	0.4	0.9	-0.3	-0.7	1.0	-0.5
Mean Putamen Volume	0.3	0.3	0.7	0.4	0.8	-0.3	0.6
Fasting Glucose	2.6	3.1	4.7	2.2	1.9	-0.7	1.9
HbA1C	0.5	0.5	0.8	-0.8	-0.6	0.9	-0.4
HDL Cholesterol	0.3	0.5	1.6	-0.2	-0.3	-1.2	-0.5
LDL Cholesterol	0.4	0.6	2.2	-0.2	-0.4	1.5	0.1
Lupus	0.2	0.4	0.6	-0.3	-0.4	0.7	-0.8
Neuroticism (2016)	0.3	0.4	1.1	0.3	1.0	-0.4	0.7
Primary Biliary Cirrhosis	0.1	0.2	0.4	0.3	-0.1	-0.6	-0.4
Rheumatoid Arthritis	1.0	1.4	2.8	-0.5	-1.7	1.1	-1.1
Schizophrenia (2014)	1.6	3.5	7.1	-1.5	-1.6	2.7	-1.5
Triglycerides	0.1	0.2	0.6	-0.4	-0.4	0.8	0.0
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.1	-0.6	-0.6	0.4	-1.1
Ulcerative Colitis	1.8	2.6	3.5	-1.6	-1.3	-1.6	-1.9
Blood Eosinophil Count	0.1	0.7	1.9	-0.6	-0.1	1.4	-0.6
Blood Platelet Count	0.4	4.2	7.0	-2.2	-1.9	-1.2	-2.6
Blood Red Count	0.3	3.0	7.1	-0.5	-1.1	-2.7	-1.8
Blood White Count	1.1	7.8	14.9	-2.8	-2.5	-1.5	-3.9
Heel T-Score	0.1	0.6	1.1	-1.1	0.4	0.7	-0.7
BMI	0.5	2.8	4.7	-2.0	-1.5	-0.3	-2.2
Height	1.0	19.8	36.5	4.8	4.3	0.6	6.0
Waist Hip Ratio (WHR)	0.8	3.7	5.9	2.2	2.0	-0.2	2.4
Systolic Blood Pressure	0.1	0.4	1.0	1.0	0.6	0.3	-0.1
Smoking Status	1.5	3.5	3.9	-1.9	-1.8	2.0	-1.9
Allergy or Eczema	0.8	2.2	3.5	1.9	1.6	0.6	1.5
Cardiovascular Disease	0.3	0.9	3.4	-0.5	-0.3	1.9	-0.1
Hypothyroidism (self reported)	0.2	0.5	1.5	-0.1	1.2	0.3	0.8
Respiratory disease	2.4	5.3	10.6	3.3	2.1	-0.8	2.4
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.7	-0.5	-0.0	1.3	-0.4
Lung FEV1/FVC ratio	0.1	0.5	0.8	0.9	0.8	-0.4	0.7
Lung FVC	1.4	7.1	10.3	-3.2	-2.0	2.8	-2.5
Neuroticism	0.3	0.7	1.4	0.3	1.2	-0.8	0.7
Chronotype (morning person)	0.1	0.2	0.4	0.2	-0.3	-0.4	-0.6
Hair Pigment	0.2	5.9	7.3	2.1	2.7	-2.7	2.2
Tanning	0.1	1.2	2.5	-0.7	-1.6	1.1	-0.7
Hand grip strength (left)	0.6	1.5	5.9	0.3	0.4	2.4	0.2
Number of treatments/medications taken	1.2	2.2	3.7	-1.3	-1.9	1.6	-0.9
Average weekly spirits intake	0.3	0.3	0.6	-0.2	-0.8	0.5	-0.6
Sensitivity / hurt feelings	0.2	0.3	0.7	0.2	0.5	-0.8	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.2	-1.5	-0.3	-0.6	-0.6
Hearing difficulty/problems: Yes	0.4	0.7	1.2	-1.1	-0.6	0.2	-1.0
Relative age of first facial hair	0.0	0.1	0.1	0.2	-0.4	0.4	0.1
Other serious medical condition/disability diagnosed by doctor	0.0	0.0	0.1	0.1	0.1	-0.2	0.3
Ever used hormone-replacement therapy (HRT)	0.0	0.0	0.2	0.0	-0.0	0.4	0.0
Ever had hysterectomy (womb removed)	1.5	1.7	2.4	-1.3	-1.3	1.1	-1.6
Systolic blood pressure, automated reading	0.1	0.2	0.4	0.7	-0.2	-0.1	-0.6
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.8	-0.9	-0.9	-0.4	-0.7
Angina	0.2	0.2	0.5	0.5	0.3	-0.7	0.3
Medication for hormone replacement therapy	0.7	0.8	1.0	0.9	1.0	-0.9	0.8
Vitamin and mineral supplements	2.3	3.2	5.1	-1.9	-1.7	1.0	-2.3
Supplements: Zinc	1.0	1.1	3.9	-0.7	-0.3	2.0	-0.2
Medication: Co-codamol	0.1	0.2	0.4	0.2	-0.6	0.4	-0.1
Medication: Metformin	0.1	0.1	0.3	0.0	0.5	0.5	0.1
Diabetes (father)	0.3	0.3	0.8	-0.0	-0.2	0.6	-0.9
Diabetes (mother)	0.8	1.0	1.7	-1.1	-0.1	1.3	-1.1
Severe depression (siblings)	0.1	0.1	0.3	-0.6	0.3	-0.1	-0.1
Pack years adult smoking proportion	2.2	3.4	5.1	-2.2	-1.8	-0.0	-2.3
Impedance of leg (right)	0.1	0.3	1.0	0.1	-0.1	-1.0	-0.2
Leg fat-free mass (left)	0.0	0.2	0.3	0.3	0.2	0.4	0.6
Trunk fat percentage	1.9	7.5	11.7	-2.9	-3.1	-0.4	-3.4
Hand grip strength (right)	0.5	1.5	5.1	0.1	0.8	2.2	0.4
Townsend deprivation index at recruitment	3.2	4.5	5.6	-2.4	-2.3	1.4	-2.3
Current tobacco smoking	2.3	3.7	5.4	-2.0	-2.2	0.9	-2.3
Average weekly fortified wine intake	1.7	2.0	2.8	1.5	1.6	-0.4	1.7
Maternal smoking around birth	0.7	1.0	1.5	-0.6	-0.9	1.2	-1.2
Fed-up feelings	0.6	1.1	1.6	-1.3	-1.0	-0.9	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	2.0	2.7	5.8	-2.4	-1.3	0.5	-1.7
Relative age voice broke	0.2	0.3	0.6	0.6	0.4	-0.1	0.8
Taking other prescription medications	0.5	0.8	2.7	0.3	0.1	1.6	0.6
Age when periods started (menarche)	0.4	1.1	1.9	-0.8	-1.4	-0.6	-1.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.3	0.1	0.3	-0.6	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.5	-0.6	-0.3	-0.1	-0.7
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.7	-0.1	0.4	-1.3	-0.8
Qualifications: CSEs or equivalent	1.6	2.1	4.0	-1.4	-0.9	2.0	-1.2
Serious illness, injury or assault to yourself	0.6	0.7	1.1	-0.7	-0.7	-0.8	-1.1
High blood pressure	0.3	0.9	1.5	1.2	0.8	0.7	0.9
Hayfever, allergic rhinitis or eczema	1.0	2.1	2.7	1.7	1.5	1.1	1.5
Multivitamins +/- minerals	2.7	3.4	4.0	2.0	1.5	-1.9	2.0
Stomach or abdominal pain in last month	6.2	7.8	11.3	-3.2	-2.8	1.3	-3.4
Supplements: Glucosamine	4.0	5.3	9.4	2.6	1.1	-3.1	2.0
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	0.6	0.7	1.1	0.5
Medication: Atenolol	1.7	2.1	2.2	-1.5	-1.4	1.5	-1.4
Medication: Levothyroxine sodium	0.3	0.5	1.7	-0.3	0.4	1.3	0.2
Sitting height	0.9	6.4	10.4	3.2	2.1	-1.3	3.0
Chronic bronchitis/emphysema (father)	0.9	1.0	3.6	-0.6	-0.2	1.9	-0.2
High blood pressure (mother)	0.7	1.0	1.6	0.3	1.3	1.0	1.1
Body mass index (BMI)	1.0	4.3	6.9	-2.3	-2.2	0.2	-2.6
Impedance of leg (left)	0.0	0.1	0.3	0.1	-0.2	-0.6	-0.1
Leg predicted mass (left)	0.0	0.2	0.4	0.4	0.3	0.3	0.6
Trunk fat mass	0.8	3.6	5.5	-2.0	-2.2	-0.4	-2.4
Waist circumference	0.2	0.8	1.1	-1.1	-1.0	0.2	-1.0
Number of incorrect matches in round	1.6	2.6	6.0	1.5	0.9	-2.4	1.0
Past tobacco smoking	0.4	0.7	2.6	0.4	0.3	-1.6	0.0
Alcohol usually taken with meals	0.5	0.9	3.3	0.3	-0.2	-1.8	0.1
Nervous feelings	0.1	0.2	0.4	-0.4	0.5	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.4	-0.6	0.6	0.2	0.3
Hearing difficulty/problems with background noise	0.6	0.9	2.6	-0.7	-0.7	1.6	-0.3
Hair/balding pattern: Pattern 2	2.4	3.1	4.2	1.9	1.7	-1.3	2.0
Had menopause	1.5	1.9	3.0	-1.6	-1.7	0.4	-1.4
Had other major operations	0.2	0.3	0.5	0.2	-0.0	-0.7	-0.7
Forced vital capacity (FVC)	0.2	0.6	2.0	-0.4	0.5	1.4	0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	0.6	-0.7	-0.5	0.8	-0.6
Ever unenthusiastic/disinterested for a whole week	4.0	4.8	8.3	-2.9	-2.0	0.8	-2.5
Qualifications: None of the above	3.3	7.0	12.7	-2.5	-3.6	0.3	-3.0
Financial difficulties in last 2 years	0.5	0.7	1.2	0.6	1.0	-1.1	0.4
Mouth/teeth dental problems	0.3	0.5	1.5	0.3	0.7	-1.2	0.0
Heart attack	0.5	0.6	1.8	-0.8	-0.0	-1.3	-0.4
Allergy	1.7	3.9	7.4	-2.7	-1.8	-0.7	-2.1
Pain all over the body in last month	0.2	0.2	0.3	-0.5	-0.5	-0.4	-0.5
Diabetes (self-reported)	0.1	0.2	0.3	0.0	0.5	0.5	0.6
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	3.1	1.4	1.7	0.2	1.3
Medication: Ramipril	0.6	0.8	2.3	0.3	-0.3	-1.5	-0.9
Medication: Simvastatin	0.3	0.4	1.4	0.4	-0.0	-1.2	-0.3
Fluid intelligence score	3.1	6.5	9.3	2.8	3.0	-0.3	3.1
Illnesses of siblings	1.2	1.8	2.9	0.9	1.7	1.2	1.4
Neuroticism score	0.2	0.4	0.8	0.0	0.9	-0.5	0.7
Weight	0.0	0.2	0.4	-0.4	-0.6	-0.1	-0.4
Impedance of arm (right)	0.1	0.4	1.3	0.3	0.6	-1.1	0.2
Arm fat percentage (right)	1.3	5.0	8.8	-2.5	-2.1	-0.5	-3.0
Trunk fat-free mass	1.0	5.6	8.9	2.8	2.3	-0.6	3.0
Hip circumference	0.4	1.8	3.1	-1.4	-1.5	-0.1	-1.8
Time employed in main current job	0.1	0.1	0.5	-0.7	-0.0	0.3	0.1
Alcohol intake versus 10 years previously	0.3	0.5	1.0	-0.9	-0.3	-0.0	-1.0
Father’s age at death	0.1	0.1	0.3	0.5	0.3	-0.0	0.3
Worrier / anxious feelings	2.4	4.5	6.5	2.2	2.5	-0.4	2.5
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.9	-1.2	-0.5	1.4	-0.4
Falls in the last year	0.6	0.8	1.2	0.9	1.1	0.2	1.1
Hair/balding pattern: Pattern 3	0.4	0.5	0.8	0.9	0.7	-0.2	0.9
Number of live births	0.4	0.5	0.8	0.6	0.8	-0.9	0.5
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.4	-0.6	0.3	1.2	-0.0
Pulse rate	2.4	4.1	4.9	-2.2	-2.1	1.6	-2.1
Happiness	0.4	0.5	0.8	-0.9	-0.6	0.5	-0.6
Noisy workplace	0.3	0.3	0.7	0.1	0.9	0.7	0.0
Qualifications: A levels/AS levels or equivalent	4.2	9.4	12.9	3.5	3.5	-0.0	3.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.3	-0.5	-0.1	-0.5	-0.4
Mouth/teeth dental problems: Dentures	0.4	0.7	1.1	-0.5	-1.1	-0.8	-0.9
Asthma	1.7	3.3	7.9	2.8	1.3	-0.5	1.9
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.1	2.3	-1.5	-1.4	1.5	-1.4
Medication: Cholesterol lowering	0.1	0.1	0.4	0.2	0.1	-0.7	-0.0
Depression (self-reported)	0.8	1.0	1.4	-1.1	-1.1	-0.2	-1.2
Medication: Lansoprazole	0.1	0.1	0.2	-0.1	-0.4	0.1	-0.2
Prospective memory result	0.6	0.7	1.0	-0.7	-1.0	0.9	-0.8
Lung cancer (father)	4.4	5.1	7.3	-2.3	-2.6	1.1	-2.7
Illnesses of mother	0.5	0.7	1.3	-0.4	-1.1	-0.2	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	1.9	-1.4	-0.0	1.2	-0.6
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.0	-0.4	0.1	-0.5
Impedance of arm (left)	0.1	0.3	1.3	-0.2	-0.0	-1.1	-0.2
Arm fat mass (right)	0.9	3.6	5.8	-2.2	-2.0	-0.3	-2.4
Trunk predicted mass	1.0	5.5	8.7	2.7	2.3	-0.5	3.0
Standing height	1.1	11.4	19.6	3.9	3.1	-1.0	4.4
Length of working week for main job	0.7	0.8	1.4	-1.0	-0.8	1.2	-0.6
Exposure to tobacco smoke at home	1.3	1.5	3.4	-1.0	-1.0	1.9	-0.8
Breastfed as a baby	0.5	0.7	2.3	0.6	0.2	-1.5	0.2
Tense / ‘highly strung’	0.4	0.6	1.3	-1.1	-0.5	0.5	-0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.1	5.1	-2.3	-1.6	1.3	-1.7
Hair/balding pattern: Pattern 4	0.5	1.3	3.0	-1.7	-0.9	0.7	-0.9
Birth weight of first child	0.4	0.7	2.0	-0.7	-0.6	1.4	-0.2
Peak expiratory flow (PEF)	0.0	0.1	0.3	0.1	0.5	0.4	-0.0
Pulse wave reflection index	0.2	0.2	0.7	0.5	0.1	-0.8	-0.1
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.2	-1.2	-0.9	0.4	-1.5
Loud music exposure frequency	2.7	3.0	6.2	-1.8	-0.8	2.5	-1.3
Qualifications: O levels/GCSEs or equivalent	1.9	3.0	5.0	1.6	2.2	-0.8	2.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	1.6	-1.0	-0.9	1.3	-0.8
Blood clot in the leg (DVT)	2.7	3.4	4.2	-1.7	-1.7	1.9	-2.1
Medication: Paracetamol	3.2	5.3	7.2	-2.7	-2.4	1.9	-2.2
Headache pain in last month	0.1	0.1	0.4	0.0	-0.2	0.6	-0.2
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	0.9	-0.3	-0.0	1.0	-0.1
Glaucoma (self-reported)	0.5	0.6	1.6	0.7	1.3	0.0	0.5
Gout (self-reported)	1.9	2.6	4.2	-1.6	-2.0	-0.0	-1.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-0.1	0.9	-0.0	0.8
Medication: Amlodipine	0.8	1.2	2.2	1.5	1.1	0.2	1.1
Medication: Ventolin 100micrograms inhaler	1.9	2.4	4.4	2.1	1.6	-0.8	1.4
Birth weight	0.2	0.4	1.0	0.5	0.5	0.4	1.0
Chronic bronchitis/emphysema (mother)	0.6	0.8	2.3	-0.4	-1.5	-0.0	-0.7
High blood pressure (siblings)	0.4	0.6	0.8	-0.9	-0.9	-0.2	-0.9
Forced vital capacity (FVC), Best measure	0.2	0.7	1.6	-0.8	0.6	1.3	0.1
Body fat percentage	1.9	7.6	12.0	-3.0	-3.0	-0.4	-3.5
Leg fat percentage (right)	2.4	8.7	14.3	-3.2	-3.2	0.0	-3.8
Arm fat-free mass (right)	0.2	0.8	1.7	1.0	0.6	0.3	1.3
Exposure to tobacco smoke outside home	0.1	0.1	0.1	-0.2	0.1	0.4	0.4
Comparative body size at age 10	1.2	3.3	5.0	1.9	2.2	-0.0	2.2
Number of full brothers	1.2	1.5	3.4	-1.3	-0.8	1.8	-0.5
Worry too long after embarrassment	0.1	0.1	0.4	-0.1	0.6	-0.1	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.5	-0.7	-0.2	0.6	-0.2
Wheeze or whistling in the chest in last year	0.6	1.0	2.0	1.4	1.0	0.5	0.9
Number of children fathered	0.1	0.1	0.4	-0.3	-0.3	0.0	-0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.5	1.2	0.5	-0.6	0.7
Age at first live birth	8.1	14.4	18.0	4.1	4.2	-2.6	4.0
Pulse wave peak to peak time	0.2	0.2	0.5	0.1	0.5	-0.2	0.7
Health satisfaction	0.1	0.2	0.3	0.4	0.4	0.5	0.5
Shortness of breath walking on level ground	1.0	1.1	2.0	-0.8	-1.2	1.4	-0.6
Qualifications: College or University degree	4.0	12.6	17.6	4.0	4.1	-0.5	4.2
Eye problems/disorders: None of the above	2.1	2.4	3.6	1.9	1.7	0.1	1.9
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.3	-0.2	0.4	-0.6	0.1
Emphysema/chronic bronchitis	0.3	0.4	0.7	0.7	0.5	0.8	0.3
Medication for pain relief, constipation, heartburn	1.1	1.9	2.1	1.4	1.4	-1.4	1.3
Neck or shoulder pain in last month	0.6	0.8	1.5	-0.7	-0.4	-1.0	-1.2
Medication: Blood pressure	0.1	0.3	0.5	0.7	-0.3	-0.6	0.1
Angina (self-reported)	0.1	0.2	0.6	0.3	0.0	-0.8	0.1
Migraine (self-reported)	0.4	0.5	1.5	-0.3	-0.2	1.2	-0.5
Medication: Ibuprofen	2.1	2.5	3.3	-1.8	-1.8	0.8	-1.7
Medication: Allopurinol	2.7	3.6	5.4	-2.0	-2.3	0.8	-2.1
Medication: Omeprazole	1.0	1.2	2.8	-0.6	-1.7	-0.8	-1.0
Medication: Seretide 50 evohaler	1.1	1.3	1.6	1.3	1.0	1.1	1.1
Mean time to correctly identify matches	1.7	3.3	5.7	-1.6	-1.7	-1.4	-2.4
Heart disease (mother)	0.2	0.2	0.8	0.3	0.1	0.9	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.6	0.1	0.5	0.8	0.2
Whole body fat mass	0.8	3.5	5.1	-2.1	-2.1	-0.5	-2.3
Leg fat mass (right)	1.2	4.5	6.9	-2.4	-2.3	-0.1	-2.6
Arm predicted mass (right)	0.2	0.9	2.1	1.0	0.5	0.6	1.4
Pulse rate, automated reading	0.5	1.5	2.6	-0.8	-1.3	1.6	-1.0
Alcohol intake frequency.	2.2	5.1	7.2	-2.7	-2.3	1.5	-2.5
Comparative height size at age 10	1.4	7.5	11.3	3.0	2.8	-1.3	3.4
Number of full sisters	1.0	1.2	2.2	-0.9	-1.0	1.5	-0.8
Suffer from ‘nerves’	0.3	0.5	1.6	-0.3	0.4	-1.3	0.2
Overall health rating	0.7	1.5	1.9	-1.4	-1.1	1.2	-1.2
Chest pain or discomfort	0.9	1.3	2.1	1.4	1.2	0.7	1.0
Had major operations	0.6	0.7	0.9	0.9	0.9	-0.6	0.9
Age at last live birth	14.0	20.3	26.8	4.9	5.2	-2.8	4.8
Family relationship satisfaction	0.3	0.3	0.9	-1.0	-0.4	0.4	-0.4
Leg pain on walking	4.7	5.9	9.4	-2.5	-3.1	0.9	-2.7
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.2	0.4	0.1	-0.1
Commuting to job workplace: Car/motor vehicle	1.2	1.4	1.5	1.2	1.2	-1.2	1.0
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	-0.4	-0.9	1.2	-0.2
Medication: Aspirin	0.4	0.5	1.1	-0.5	-0.7	-0.2	-1.1
Supplements: Vitamin C	0.8	0.9	1.7	0.8	1.1	0.3	1.3
Knee pain experienced in last month	2.0	3.1	6.3	-1.4	-2.5	0.4	-2.0
Hypertension (Self-reported)	0.4	1.0	1.6	1.3	1.1	0.4	1.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.2	0.5	-0.0	-0.3	0.7	0.1
Illnesses of father: Heart disease	0.4	0.6	1.0	0.6	0.9	-0.1	1.0
Illnesses of siblings: Diabetes	0.6	0.8	1.2	-0.9	-1.1	-0.5	-0.9
Smoking status: Previous	0.3	0.5	1.7	0.0	0.2	1.3	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.5	3.1	4.7	1.4	1.9	1.5	2.2
Whole body fat-free mass	0.4	2.1	3.8	1.7	1.4	-0.2	1.9
Leg fat-free mass (right)	0.1	0.5	1.0	0.6	0.6	0.5	1.0
Arm fat percentage (left)	1.4	5.6	9.4	-2.6	-2.4	-0.4	-3.1
Average weekly red wine intake	0.3	0.5	0.8	0.9	0.6	-0.6	0.7
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.6	-0.5	-0.8	1.3	-0.8
Mood swings	0.2	0.3	0.6	-0.6	0.4	-0.8	0.3
Loneliness, isolation	0.4	0.5	1.4	0.4	0.7	-0.3	1.2
Long-standing illness, disability or infirmity	0.1	0.1	0.4	-0.1	-0.2	0.6	-0.4
Ever had bowel cancer screening	0.0	0.0	0.1	-0.2	-0.1	0.1	-0.3
Diabetes diagnosed by doctor	0.2	0.4	1.1	0.1	0.5	1.1	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	1.1	0.9	1.1	-0.7	1.0
Friendships satisfaction	0.1	0.1	0.2	0.4	0.4	0.1	0.4
Qualifications: nursing, teaching	1.5	2.4	3.3	1.6	1.8	0.3	1.8
Commuting to job workplace: Walk	0.3	0.3	0.6	-0.8	-0.0	-0.2	-0.8
Eye problems/disorders: Cataract	1.3	1.6	2.8	-1.2	-1.7	-0.0	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	4.2	1.9	1.3	0.6	2.0
Medication for cholesterol	0.0	0.0	0.1	-0.2	0.0	-0.3	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	-0.0	0.0	-0.9	-0.2
Back pain experienced in last month	0.3	0.4	1.2	0.3	0.2	-1.1	0.6
Mineral and other dietary supplements	3.6	4.8	6.2	-2.5	-1.9	2.0	-2.3
Breast cancer (self-reported)	0.4	0.5	1.9	-0.1	-0.2	-1.4	-0.5
Asthma (self-reported)	1.1	2.1	5.4	2.3	0.9	-0.3	1.4
Osteoporosis (self-reported)	0.1	0.1	0.2	0.4	-0.1	-0.1	0.5
Osteoarthritis (self-reported)	1.4	1.9	2.7	-1.2	-1.7	1.1	-1.5
Medication: Aspirin	0.3	0.4	0.8	-0.3	-0.3	-0.9	-0.7
Medication: Gliclazide	0.2	0.2	0.9	0.2	0.2	0.9	0.2
Illnesses of father: None of the above (group 1)	0.1	0.1	0.3	0.2	0.1	-0.5	0.4
Smoking status: Current	2.1	3.4	4.5	-1.9	-2.0	1.1	-2.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	5.2	8.1	-2.4	-2.4	1.0	-2.8
Whole body water mass	0.4	2.0	3.6	1.6	1.4	0.0	1.9
Leg predicted mass (right)	0.1	0.5	0.9	0.6	0.5	0.5	1.0
Arm fat mass (left)	0.7	3.0	4.8	-1.9	-1.8	-0.5	-2.2
Number of self-reported non-cancer illnesses	0.2	0.4	1.4	0.0	-0.3	1.2	-0.1
Average weekly champagne plus white wine intake	0.6	0.8	1.7	1.3	0.8	0.3	0.9
Miserableness	0.8	1.4	3.1	0.9	1.8	-0.1	1.3
Guilty feelings	0.2	0.3	1.1	-1.0	-0.3	-0.0	-0.3
Wears glasses or contact lenses	0.2	0.3	0.9	0.1	-0.1	1.0	0.4
Ever taken oral contraceptive pill	2.6	2.9	4.3	2.0	1.7	-0.3	2.1
Hearing aid user	0.1	0.1	0.2	-0.3	-0.0	0.4	-0.3
Mother’s age at death	2.5	3.2	4.8	2.2	1.6	-1.0	2.0
Financial situation satisfaction	0.2	0.3	0.5	-0.1	0.5	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.1	0.4	0.4	-0.3	0.4
Commuting to job workplace: Public transport	0.7	0.8	1.4	-0.6	-1.0	-0.8	-1.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.3	0.0	0.5	-0.3	-0.0
Medication: Blood pressure	0.1	0.3	0.9	0.4	0.0	1.0	0.2
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.2	-0.6	-1.1	0.4	-1.0
Supplements: Fish oil (including cod liver oil)	2.9	3.8	5.6	2.2	1.9	-1.1	2.4
High cholesterol (Self-reported)	0.5	0.8	1.0	-1.0	-1.0	0.6	-0.9
Medication: Bendroflumethiazide	0.2	0.3	1.0	1.0	-0.0	0.3	0.4
Medication: Paracetamol	4.0	6.2	8.1	-2.8	-2.6	2.0	-2.4
Medication: Lisinopril	0.4	0.6	0.8	0.7	0.9	-0.6	0.7
Medication: Atorvastatin	0.3	0.3	0.8	-0.9	-0.5	0.3	-0.3
Illnesses of father: High blood pressure	0.7	0.9	3.5	-0.4	0.1	1.9	-0.3
Alcohol drinker status: Never	1.3	1.5	2.5	-1.2	-1.6	0.4	-1.4
Ever smoked	0.1	0.2	0.3	0.5	0.2	0.5	0.4
Basal metabolic rate	0.2	0.9	1.7	1.1	0.8	-0.1	1.3
Leg fat percentage (left)	2.4	8.6	13.8	-3.1	-3.3	0.2	-3.7
Arm fat-free mass (left)	0.1	0.7	1.4	0.9	0.6	0.5	1.2
Number of operations (self-reported)	0.5	0.8	2.4	-0.3	-0.6	1.5	-0.7
Average weekly beer plus cider intake	0.4	0.6	1.3	-1.1	-0.9	-0.1	-0.7
Irritability	1.1	1.9	2.8	0.5	1.5	1.5	1.7
Risk taking	0.2	0.3	0.8	0.3	0.5	0.5	0.9
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.6	-0.5	-0.8	0.3	-0.4
Fractured/broken bones in last 5 years	0.8	1.0	1.9	1.3	0.7	0.0	1.4
Age started oral contraceptive pill	0.6	0.7	1.3	1.1	0.7	-0.4	1.0
Diastolic blood pressure, automated reading	0.3	0.8	1.2	-0.2	-1.0	1.0	-1.1
Ever depressed for a whole week	5.7	7.1	10.6	-3.3	-2.4	1.7	-3.0
Unable to work because of sickness or disability	3.2	4.1	6.1	-2.5	-2.2	-0.3	-2.3
Commuting to job workplace: Cycle	0.5	0.6	0.9	0.6	0.9	-0.9	0.7
Myopia	3.5	5.1	6.6	2.5	2.2	-1.7	2.6
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.9	-0.9	-0.7	-0.2	-0.7
Cholesterol lowering medication	0.2	0.2	0.4	-0.4	-0.6	0.3	-0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	2.2	-0.4	-1.5	-0.6	-0.9
Pain experienced in last month	1.2	2.0	3.0	1.1	1.4	1.3	1.7
Supplements: Calcium	1.5	1.7	2.7	1.6	1.3	0.0	1.5
Basal cell carcinoma (self-reported)	0.7	0.9	2.2	0.8	0.7	-1.5	0.3
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	-0.7	-0.0	-1.0	-0.4
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	3.6	-1.5	-1.4	1.9	-1.7
Heart disease (siblings)	2.6	3.2	4.8	-2.2	-1.9	0.5	-2.1
Alcohol drinker status: Previous	1.3	1.5	2.7	-1.6	-1.3	1.0	-0.9
Pack years of smoking	2.7	3.9	6.1	-2.4	-2.0	-0.1	-2.5
Impedance of whole body	0.0	0.2	0.5	-0.1	-0.4	-0.7	-0.3
Leg fat mass (left)	1.2	4.6	7.0	-2.4	-2.4	0.1	-2.7
Arm predicted mass (left)	0.1	0.7	1.3	1.0	0.5	0.3	1.2