Hub : Traits :

Qualifications: O levels/GCSEs or equivalent

103 significantly associated models · 18 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	43476957	45153116	3	1	7.8e-08	1.3e-09	0.00093	70	ST3GAL3
2	2	43899918	45698128	1	1	1.1e-09	4.3e-09	1.00000	100	CAMKMT
3	2	98921826	100468953	1	1	1.4e-07	4.5e-07	0.06370	86	TSGA10
4	3	48702606	50085153	1	1	5.9e-08	6.9e-07	0.11400	90	GPX1
5	12	122713991	124591385	11	1	1.4e-11	7.1e-11	0.62100	99	CDK2AP1
6	16	4049365	5441125	1	1	9.5e-08	1.5e-06	0.52700	98	NUDT16L1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Bipolar Disorder (2018)	3.07	1	0	0.0	0.00	1.0e+00	TSGA10
Bipolar Disorder or Schizophrenia	3.06	1	1	2.2	0.00	1.0e+00	CDK2AP1
Depressed Affect (Nagel 2018)	6.13	2	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1
Intelligence (Savage-Jansen 2018)	8.54	4	2	4.4	0.94	6.0e-02	CAMKMT CDK2AP1 GPX1 ST3GAL3
Neuroticism (Nagel 2018)	2.57	1	0	0.0	0.00	1.0e+00	GPX1
Schizophrenia (2018)	2.57	1	0	0.0	0.00	1.0e+00	CDK2AP1
Schizophrenia vs Biploar Disorder	5.12	1	0	0.0	0.00	1.0e+00	TSGA10
Crohns Disease (2017)	3.35	1	1	2.2	0.00	1.0e+00	GPX1
Irritable Bowel Disease (IBD)	4.76	1	1	2.2	0.00	1.0e+00	GPX1
Ulcerative Colitis (UC)	4.09	1	1	2.2	0.00	1.0e+00	GPX1
Major Depression (MDD)	4.57	1	0	0.0	0.00	1.0e+00	GPX1
Verbal and Numeric Reasoning (VNR)	6.65	3	2	4.4	0.00	1.0e+00	CDK2AP1 GPX1 ST3GAL3
Prostate Cancer	3.65	1	0	0.0	0.00	1.0e+00	GPX1
Age at First Birth	5.29	1	1	2.2	0.00	1.0e+00	GPX1
Neuroticism (2016)	3.09	1	0	0.0	0.00	1.0e+00	GPX1
Schizophrenia (2014)	3.00	1	1	2.2	0.00	1.0e+00	CDK2AP1
Ulcerative Colitis	3.51	1	1	2.2	0.00	1.0e+00	GPX1
Blood Eosinophil Count	3.07	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 TSGA10
Blood Platelet Count	3.99	2	2	4.4	0.00	1.0e+00	CDK2AP1 NUDT16L1
Blood Red Count	0.87	1	0	0.0	0.00	1.0e+00	CAMKMT
Blood White Count	1.36	2	0	0.0	0.00	1.0e+00	GPX1 NUDT16L1
Heel T-Score	2.47	1	1	2.2	0.00	1.0e+00	CDK2AP1
BMI	3.79	3	2	4.4	0.00	1.0e+00	CAMKMT GPX1 ST3GAL3
Height	4.98	5	4	8.9	0.97	7.4e-03	CAMKMT CDK2AP1 GPX1 NUDT16L1 TSGA10
Waist Hip Ratio (WHR)	5.44	2	2	4.4	0.00	1.0e+00	CDK2AP1 GPX1
Systolic Blood Pressure	3.30	2	1	2.2	0.00	1.0e+00	GPX1 NUDT16L1
Smoking Status	3.67	2	1	2.2	0.00	1.0e+00	GPX1 TSGA10
Allergy or Eczema	2.52	1	0	0.0	0.00	1.0e+00	CDK2AP1
Cardiovascular Disease	2.19	1	0	0.0	0.00	1.0e+00	NUDT16L1
Respiratory disease	2.20	1	0	0.0	0.00	1.0e+00	CDK2AP1
Type 2 Diabetes (T2D) (2018)	2.69	1	0	0.0	0.00	1.0e+00	CDK2AP1
Lung FEV1/FVC ratio	1.72	1	1	2.2	0.00	1.0e+00	TSGA10
Lung FVC	1.70	1	0	0.0	0.00	1.0e+00	GPX1
Neuroticism	3.23	1	1	2.2	0.00	1.0e+00	GPX1
Chronotype (morning person)	2.84	2	0	0.0	0.00	1.0e+00	CAMKMT GPX1
Hair Pigment	0.34	1	1	2.2	0.00	1.0e+00	CDK2AP1
Hand grip strength (left)	2.02	1	0	0.0	0.00	1.0e+00	NUDT16L1
Number of treatments/medications taken	5.73	2	0	0.0	0.00	1.0e+00	GPX1 NUDT16L1
Systolic blood pressure, automated reading	4.16	2	2	4.4	0.00	1.0e+00	GPX1 NUDT16L1
Medication: Co-codamol	3.23	1	0	0.0	0.00	1.0e+00	GPX1
Pack years adult smoking proportion	3.87	1	0	0.0	0.00	1.0e+00	GPX1
Impedance of leg (right)	1.49	2	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1
Leg fat-free mass (left)	2.68	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Trunk fat percentage	2.08	3	0	0.0	0.00	1.0e+00	CAMKMT GPX1 NUDT16L1
Hand grip strength (right)	1.95	1	0	0.0	0.00	1.0e+00	TSGA10
Current tobacco smoking	3.71	1	0	0.0	0.00	1.0e+00	GPX1
Fed-up feelings	7.09	2	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1
Frequency of unenthusiasm / disinterest in last 2 weeks	3.34	1	0	0.0	0.00	1.0e+00	GPX1
Taking other prescription medications	4.23	1	0	0.0	0.00	1.0e+00	GPX1
Age when periods started (menarche)	3.30	1	1	2.2	0.00	1.0e+00	GPX1
Heel bone mineral density (BMD) T-score, automated (left)	1.58	1	0	0.0	0.00	1.0e+00	CDK2AP1
Qualifications: CSEs or equivalent	5.04	1	0	0.0	0.00	1.0e+00	ST3GAL3
High blood pressure	2.89	1	1	2.2	0.00	1.0e+00	NUDT16L1
Hayfever, allergic rhinitis or eczema	2.39	1	0	0.0	0.00	1.0e+00	CDK2AP1
Sitting height	6.48	4	1	2.2	1.00	3.0e-03	CAMKMT CDK2AP1 NUDT16L1 TSGA10
Body mass index (BMI)	4.41	2	1	2.2	0.00	1.0e+00	CAMKMT GPX1
Impedance of leg (left)	1.70	2	0	0.0	0.00	1.0e+00	CDK2AP1 GPX1
Leg predicted mass (left)	2.64	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Trunk fat mass	2.27	2	0	0.0	0.00	1.0e+00	GPX1 NUDT16L1
Waist circumference	2.11	2	0	0.0	0.00	1.0e+00	GPX1 NUDT16L1
Frequency of tenseness / restlessness in last 2 weeks	3.95	1	0	0.0	0.00	1.0e+00	GPX1
Had menopause	4.33	1	0	0.0	0.00	1.0e+00	CDK2AP1
Forced vital capacity (FVC)	3.38	2	1	2.2	0.00	1.0e+00	GPX1 NUDT16L1
Qualifications: None of the above	16.51	6	4	8.9	-1.00	2.1e-05	CAMKMT CDK2AP1 GPX1 NUDT16L1 ST3GAL3 TSGA10
Allergy	3.03	1	1	2.2	0.00	1.0e+00	CDK2AP1
Pain all over the body in last month	4.19	1	0	0.0	0.00	1.0e+00	GPX1
Fluid intelligence score	8.32	4	1	2.2	0.97	3.2e-02	CAMKMT CDK2AP1 GPX1 ST3GAL3
Illnesses of siblings	4.42	1	0	0.0	0.00	1.0e+00	ST3GAL3
Neuroticism score	3.59	1	1	2.2	0.00	1.0e+00	GPX1
Weight	2.81	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Impedance of arm (right)	3.34	1	1	2.2	0.00	1.0e+00	GPX1
Arm fat percentage (right)	3.11	2	1	2.2	0.00	1.0e+00	CAMKMT GPX1
Trunk fat-free mass	2.98	2	1	2.2	0.00	1.0e+00	CDK2AP1 NUDT16L1
Hip circumference	3.28	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Alcohol intake versus 10 years previously	6.14	3	0	0.0	0.00	1.0e+00	CAMKMT CDK2AP1 ST3GAL3
Father's age at death	6.57	2	0	0.0	0.00	1.0e+00	CDK2AP1 GPX1
Frequency of tiredness / lethargy in last 2 weeks	3.27	1	0	0.0	0.00	1.0e+00	GPX1
Forced expiratory volume in 1-second (FEV1)	3.02	2	1	2.2	0.00	1.0e+00	GPX1 NUDT16L1
Qualifications: A levels/AS levels or equivalent	16.48	5	4	8.9	0.99	4.4e-04	CAMKMT CDK2AP1 GPX1 NUDT16L1 ST3GAL3
Mouth/teeth dental problems: Dentures	3.20	1	0	0.0	0.00	1.0e+00	GPX1
Asthma	1.81	1	0	0.0	0.00	1.0e+00	CDK2AP1
Prospective memory result	3.85	1	0	0.0	0.00	1.0e+00	CAMKMT
Lung cancer (father)	2.20	1	0	0.0	0.00	1.0e+00	GPX1
Forced expiratory volume in 1-second (FEV1), Best measure	3.45	2	1	2.2	0.00	1.0e+00	GPX1 NUDT16L1
Impedance of arm (left)	3.70	1	1	2.2	0.00	1.0e+00	GPX1
Arm fat mass (right)	3.17	3	1	2.2	0.00	1.0e+00	CAMKMT GPX1 NUDT16L1
Trunk predicted mass	2.97	2	1	2.2	0.00	1.0e+00	CDK2AP1 NUDT16L1
Standing height	4.77	5	4	8.9	0.97	5.5e-03	CAMKMT CDK2AP1 GPX1 NUDT16L1 TSGA10
Exposure to tobacco smoke at home	3.98	1	0	0.0	0.00	1.0e+00	GPX1
Breastfed as a baby	3.68	1	0	0.0	0.00	1.0e+00	CDK2AP1
Seen doctor (GP) for nerves, anxiety, tension or depression	3.40	1	0	0.0	0.00	1.0e+00	GPX1
Ever highly irritable/argumentative for 2 days	4.47	2	0	0.0	0.00	1.0e+00	CDK2AP1 GPX1
Medication: Paracetamol	5.72	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 ST3GAL3
Forced vital capacity (FVC), Best measure	3.99	4	1	2.2	0.99	1.5e-02	CAMKMT GPX1 NUDT16L1 ST3GAL3
Body fat percentage	2.93	2	1	2.2	0.00	1.0e+00	CAMKMT GPX1
Leg fat percentage (right)	4.82	2	1	2.2	0.00	1.0e+00	CAMKMT GPX1
Arm fat-free mass (right)	2.67	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Number of full brothers	3.99	1	0	0.0	0.00	1.0e+00	GPX1
Wheeze or whistling in the chest in last year	2.49	1	0	0.0	0.00	1.0e+00	GPX1
Age at first live birth	6.84	1	1	2.2	0.00	1.0e+00	GPX1
Health satisfaction	2.42	1	0	0.0	0.00	1.0e+00	GPX1
Qualifications: College or University degree	12.93	5	3	6.7	0.96	1.0e-02	CAMKMT CDK2AP1 GPX1 ST3GAL3 TSGA10
Medication for pain relief, constipation, heartburn	7.08	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Neck or shoulder pain in last month	3.25	1	0	0.0	0.00	1.0e+00	GPX1
Whole body fat mass	2.86	2	1	2.2	0.00	1.0e+00	GPX1 NUDT16L1
Leg fat mass (right)	3.68	1	1	2.2	0.00	1.0e+00	GPX1
Arm predicted mass (right)	2.59	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Pulse rate, automated reading	2.20	2	0	0.0	0.00	1.0e+00	GPX1 NUDT16L1
Alcohol intake frequency.	3.94	1	1	2.2	0.00	1.0e+00	CDK2AP1
Comparative height size at age 10	4.98	4	2	4.4	0.98	1.5e-02	CAMKMT CDK2AP1 GPX1 NUDT16L1
Overall health rating	6.56	1	1	2.2	0.00	1.0e+00	GPX1
Chest pain or discomfort	2.52	1	0	0.0	0.00	1.0e+00	GPX1
Had major operations	2.57	1	0	0.0	0.00	1.0e+00	GPX1
Age at last live birth	6.30	1	1	2.2	0.00	1.0e+00	GPX1
Hypertension (Self-reported)	2.84	1	1	2.2	0.00	1.0e+00	NUDT16L1
Illnesses of siblings: Diabetes	5.10	1	0	0.0	0.00	1.0e+00	TSGA10
Forced expiratory volume in 1-second (FEV1), predicted	3.35	1	0	0.0	0.00	1.0e+00	NUDT16L1
Whole body fat-free mass	2.83	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Leg fat-free mass (right)	2.65	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Arm fat percentage (left)	2.97	2	1	2.2	0.00	1.0e+00	CAMKMT GPX1
Average weekly red wine intake	7.45	2	1	2.2	0.00	1.0e+00	CAMKMT CDK2AP1
Mood swings	6.19	1	1	2.2	0.00	1.0e+00	GPX1
Loneliness, isolation	4.01	1	1	2.2	0.00	1.0e+00	GPX1
Qualifications: nursing, teaching	8.46	3	1	2.2	0.00	1.0e+00	CDK2AP1 NUDT16L1 ST3GAL3
Medication for cholesterol	5.32	1	1	2.2	0.00	1.0e+00	NUDT16L1
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.62	1	0	0.0	0.00	1.0e+00	GPX1
Asthma (self-reported)	2.10	1	0	0.0	0.00	1.0e+00	CDK2AP1
Whole body water mass	2.89	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Leg predicted mass (right)	2.62	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Arm fat mass (left)	3.07	3	1	2.2	0.00	1.0e+00	CAMKMT GPX1 NUDT16L1
Number of self-reported non-cancer illnesses	4.88	1	0	0.0	0.00	1.0e+00	NUDT16L1
Miserableness	7.27	1	1	2.2	0.00	1.0e+00	GPX1
Guilty feelings	2.61	1	0	0.0	0.00	1.0e+00	GPX1
Financial situation satisfaction	6.00	1	1	2.2	0.00	1.0e+00	GPX1
Medication: Blood pressure	3.96	1	1	2.2	0.00	1.0e+00	NUDT16L1
Medication: Paracetamol	5.20	2	0	0.0	0.00	1.0e+00	GPX1 ST3GAL3
Ever smoked	3.63	1	0	0.0	0.00	1.0e+00	CDK2AP1
Basal metabolic rate	2.93	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Leg fat percentage (left)	5.17	3	2	4.4	0.00	1.0e+00	CAMKMT CDK2AP1 GPX1
Arm fat-free mass (left)	2.93	3	2	4.4	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Number of operations (self-reported)	2.62	1	0	0.0	0.00	1.0e+00	GPX1
Irritability	2.99	1	0	0.0	0.00	1.0e+00	GPX1
Age started oral contraceptive pill	3.56	1	0	0.0	0.00	1.0e+00	GPX1
Diastolic blood pressure, automated reading	6.23	3	1	2.2	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1
Vascular/heart problems diagnosed by doctor	3.67	1	1	2.2	0.00	1.0e+00	NUDT16L1
Cholesterol lowering medication	3.07	1	0	0.0	0.00	1.0e+00	NUDT16L1
Pain experienced in last month	5.23	1	1	2.2	0.00	1.0e+00	GPX1
Pack years of smoking	3.17	1	0	0.0	0.00	1.0e+00	GPX1
Impedance of whole body	2.76	1	1	2.2	0.00	1.0e+00	GPX1
Leg fat mass (left)	3.91	2	1	2.2	0.00	1.0e+00	CAMKMT GPX1
Arm predicted mass (left)	2.90	3	2	4.4	0.00	1.0e+00	CDK2AP1 GPX1 NUDT16L1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Adipose Subcutaneous	2	0.057	1.7
GTEx	Adipose Visceral Omentum	3	0.147	1.7
GTEx	Adrenal Gland	0	0.000	1.5
GTEx	Artery Aorta	4	0.134	1.7
GTEx	Artery Coronary	0	0.000	1.6
GTEx	Artery Tibial	3	0.080	1.7
GTEx	Brain Caudate basal ganglia	0	0.000	1.6
GTEx	Brain Cerebellar Hemisphere	0	0.000	1.7
GTEx	Brain Cerebellum	0	0.000	1.7
GTEx	Brain Cortex	0	0.000	1.6
GTEx	Brain Frontal Cortex BA9	1	0.108	1.6
GTEx	Brain Hippocampus	0	0.000	1.6
GTEx	Brain Hypothalamus	0	0.000	1.6
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.5
GTEx	Brain Putamen basal ganglia	0	0.000	1.5
GTEx	Breast Mammary Tissue	2	0.101	1.7
GTEx	Breast Mammary Tissue (Male)	0	0.000	1.5
GTEx	Breast Mammary Tissue (Female)	3	0.182	1.7
GTEx	Cells EBV-transformed lymphocytes	0	0.000	1.6
GTEx	Cells Transformed fibroblasts	6	0.143	1.7
GTEx	Colon Sigmoid	1	0.068	1.7
GTEx	Colon Transverse	3	0.145	1.7
GTEx	Esophagus Gastroesophageal Junction	1	0.069	1.7
GTEx	Esophagus Mucosa	3	0.090	1.7
GTEx	Esophagus Muscularis	4	0.124	1.7
GTEx	Heart Atrial Appendage	0	0.000	1.7
GTEx	Heart Left Ventricle	2	0.131	1.6
GTEx	Liver	0	0.000	1.6
GTEx	Lung	3	0.104	1.7
GTEx	Muscle Skeletal	2	0.069	1.6
GTEx	Nerve Tibial	5	0.116	1.7
GTEx	Ovary	0	0.000	1.6
GTEx	Pancreas	4	0.245	1.8
GTEx	Pituitary	0	0.000	1.6
GTEx	Prostate	0	0.000	1.5
GTEx	Skin Not Sun Exposed Suprapubic	3	0.122	1.6
GTEx	Skin Sun Exposed Lower leg	4	0.110	1.6
GTEx	Small Intestine Terminal Ileum	1	0.217	1.6
GTEx	Spleen	0	0.000	1.7
GTEx	Stomach	1	0.069	1.7
GTEx	Testis	3	0.095	1.6
GTEx	Thyroid	4	0.100	1.7
GTEx	Uterus	0	0.000	1.6
GTEx	Vagina	0	0.000	1.5
GTEx	Whole Blood	0	0.000	1.5
METSIM	Adipose	4	0.087	1.6
NTR	Blood	0	0.000	1.5
ROSMAP	Brain Pre-frontal Cortex	0	0.000	1.7
YFS	Blood	2	0.043	1.5
CommonMind	Brain Pre-frontal Cortex	0	0.000	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	2	0.121	1.6
The Cancer Genome Atlas	Breast Invasive Carcinoma	2	0.045	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	1	0.091	1.6
The Cancer Genome Atlas	Colon Adenocarcinoma	2	0.097	1.6
The Cancer Genome Atlas	Esophageal Carcinoma	0	0.000	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.6
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	2	0.073	1.6
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	1	0.024	1.5
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	3	0.146	1.6
The Cancer Genome Atlas	Brain Lower Grade Glioma	0	0.000	1.6
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	1	0.090	1.7
The Cancer Genome Atlas	Lung Adenocarcinoma	1	0.034	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	3	0.120	1.6
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	1	0.063	1.6
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	1	0.060	1.5
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	0	0.000	1.7
The Cancer Genome Atlas	Prostate Adenocarcinoma	3	0.065	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.6
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.5
The Cancer Genome Atlas	Skin Cutaneous Melanoma	0	0.000	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	1	0.059	1.6
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.6
The Cancer Genome Atlas	Thyroid Carcinoma	4	0.078	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	0	0.000	1.5