Hub : Traits :

Age at last live birth

122 significantly associated models · 18 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 3 48702606 51043528 17 1 2.4e-15 2.1e-14 0.43 99 MST1R
2 18 32870015 34346308 1 1 2.2e-07 5.2e-07 0.60 99 RPRD1A

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Crohns Disease (2017) 7.06 1 1 3 0 1 MST1R
Irritable Bowel Disease (IBD) 12.11 1 1 3 0 1 MST1R
Ulcerative Colitis (UC) 12.80 1 1 3 0 1 MST1R
Major Depression (MDD) 5.97 1 0 0 0 1 MST1R
Verbal and Numeric Reasoning (VNR) 16.16 1 1 3 0 1 MST1R
Prostate Cancer 5.68 1 0 0 0 1 MST1R
Age at First Birth 24.10 1 1 3 0 1 MST1R
Coronary Artery Disease (CAD) 5.43 1 0 0 0 1 MST1R
Crohns Disease (2012) 6.80 1 0 0 0 1 MST1R
Ulcerative Colitis 8.77 1 0 0 0 1 MST1R
Blood Eosinophil Count 1.17 1 0 0 0 1 MST1R
Blood White Count 6.11 1 1 3 0 1 MST1R
Heel T-Score 1.70 1 1 3 0 1 MST1R
BMI 17.64 1 1 3 0 1 MST1R
Height 0.68 1 0 0 0 1 RPRD1A
Smoking Status 4.76 1 0 0 0 1 MST1R
Respiratory disease 5.39 1 0 0 0 1 MST1R
Type 2 Diabetes (T2D) 4.69 1 0 0 0 1 MST1R
Lung FVC 2.69 1 0 0 0 1 MST1R
Neuroticism 4.30 1 0 0 0 1 MST1R
Number of treatments/medications taken 13.61 1 1 3 0 1 MST1R
Systolic blood pressure, automated reading 2.25 1 0 0 0 1 MST1R
Medication: Co-codamol 10.41 1 0 0 0 1 MST1R
Impedance of leg (right) 6.17 1 1 3 0 1 MST1R
Leg fat-free mass (left) 7.62 1 1 3 0 1 MST1R
Trunk fat percentage 8.13 1 1 3 0 1 MST1R
Maternal smoking around birth 6.16 1 0 0 0 1 MST1R
Fed-up feelings 9.42 1 1 3 0 1 MST1R
Taking other prescription medications 14.64 1 1 3 0 1 MST1R
Age when periods started (menarche) 5.21 1 0 0 0 1 MST1R
Qualifications: CSEs or equivalent 6.56 1 0 0 0 1 MST1R
Body mass index (BMI) 20.18 1 1 3 0 1 MST1R
Impedance of leg (left) 6.66 1 1 3 0 1 MST1R
Leg predicted mass (left) 7.55 1 1 3 0 1 MST1R
Trunk fat mass 10.44 1 1 3 0 1 MST1R
Waist circumference 10.67 1 1 3 0 1 MST1R
Frequency of tenseness / restlessness in last 2 weeks 6.61 1 0 0 0 1 MST1R
Forced vital capacity (FVC) 2.54 1 0 0 0 1 MST1R
Ever unenthusiastic/disinterested for a whole week 7.53 1 0 0 0 1 MST1R
Qualifications: None of the above 16.66 2 1 3 0 1 MST1R RPRD1A
Pain all over the body in last month 8.01 1 0 0 0 1 MST1R
Diabetes (self-reported) 5.71 1 0 0 0 1 MST1R
Fluid intelligence score 16.88 1 1 3 0 1 MST1R
Neuroticism score 4.57 1 0 0 0 1 MST1R
Weight 12.90 1 1 3 0 1 MST1R
Impedance of arm (right) 14.45 1 1 3 0 1 MST1R
Arm fat percentage (right) 11.16 1 1 3 0 1 MST1R
Trunk fat-free mass 6.22 1 1 3 0 1 MST1R
Hip circumference 8.22 1 1 3 0 1 MST1R
Alcohol intake versus 10 years previously 9.24 1 1 3 0 1 MST1R
Father's age at death 5.33 1 0 0 0 1 MST1R
Number of live births 4.75 1 0 0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1) 3.59 1 0 0 0 1 MST1R
Qualifications: A levels/AS levels or equivalent 26.36 1 1 3 0 1 MST1R
Mouth/teeth dental problems: Dentures 9.45 1 1 3 0 1 MST1R
Asthma 3.69 1 0 0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1), Best measure 3.93 1 0 0 0 1 MST1R
Impedance of arm (left) 14.48 1 1 3 0 1 MST1R
Arm fat mass (right) 15.29 1 1 3 0 1 MST1R
Trunk predicted mass 6.08 1 1 3 0 1 MST1R
Exposure to tobacco smoke at home 10.41 1 0 0 0 1 MST1R
Ever highly irritable/argumentative for 2 days 11.26 1 1 3 0 1 MST1R
Qualifications: O levels/GCSEs or equivalent 8.14 1 0 0 0 1 MST1R
Medication for cholesterol, blood pressure or diabetes 4.21 1 0 0 0 1 MST1R
Chronic bronchitis/emphysema (mother) 7.81 1 0 0 0 1 MST1R
Forced vital capacity (FVC), Best measure 3.04 1 0 0 0 1 MST1R
Body fat percentage 10.89 1 1 3 0 1 MST1R
Leg fat percentage (right) 16.35 1 1 3 0 1 MST1R
Arm fat-free mass (right) 9.78 1 1 3 0 1 MST1R
Exposure to tobacco smoke outside home 7.38 1 0 0 0 1 MST1R
Wheeze or whistling in the chest in last year 14.10 1 1 3 0 1 MST1R
Age at first live birth 24.19 2 1 3 0 1 MST1R RPRD1A
Health satisfaction 5.85 1 0 0 0 1 MST1R
Qualifications: College or University degree 27.79 2 1 3 0 1 MST1R RPRD1A
Neck or shoulder pain in last month 4.65 1 0 0 0 1 MST1R
Medication: Seretide 50 evohaler 7.01 1 0 0 0 1 MST1R
Whole body fat mass 14.11 1 1 3 0 1 MST1R
Leg fat mass (right) 18.16 1 1 3 0 1 MST1R
Arm predicted mass (right) 10.00 1 1 3 0 1 MST1R
Alcohol intake frequency. 6.82 1 1 3 0 1 MST1R
Overall health rating 15.23 1 1 3 0 1 MST1R
Chest pain or discomfort 6.23 1 0 0 0 1 MST1R
Leg pain on walking 13.84 1 0 0 0 1 MST1R
Qualifications: NVQ or HND or HNC or equivalent 5.25 1 0 0 0 1 MST1R
Knee pain experienced in last month 7.74 1 0 0 0 1 MST1R
Whole body fat-free mass 7.17 1 1 3 0 1 MST1R
Leg fat-free mass (right) 6.46 1 1 3 0 1 MST1R
Arm fat percentage (left) 11.30 1 1 3 0 1 MST1R
Mood swings 9.21 1 1 3 0 1 MST1R
Loneliness, isolation 5.55 1 0 0 0 1 MST1R
Diabetes diagnosed by doctor 4.50 1 0 0 0 1 MST1R
Qualifications: nursing, teaching 7.07 1 0 0 0 1 MST1R
Asthma (self-reported) 3.52 1 0 0 0 1 MST1R
Osteoarthritis (self-reported) 6.32 1 0 0 0 1 MST1R
Forced expiratory volume in 1-second (FEV1), predicted percentage 4.74 1 0 0 0 1 MST1R
Whole body water mass 7.41 1 1 3 0 1 MST1R
Leg predicted mass (right) 6.40 1 1 3 0 1 MST1R
Arm fat mass (left) 14.99 1 1 3 0 1 MST1R
Number of self-reported non-cancer illnesses 4.10 1 0 0 0 1 MST1R
Miserableness 14.14 1 1 3 0 1 MST1R
Guilty feelings 4.24 1 0 0 0 1 MST1R
Financial situation satisfaction 7.44 1 0 0 0 1 MST1R
Medication: Paracetamol 6.51 1 0 0 0 1 MST1R
Basal metabolic rate 8.79 1 1 3 0 1 MST1R
Leg fat percentage (left) 16.39 1 1 3 0 1 MST1R
Arm fat-free mass (left) 10.68 1 1 3 0 1 MST1R
Number of operations (self-reported) 5.93 1 0 0 0 1 MST1R
Average weekly beer plus cider intake 11.20 1 1 3 0 1 MST1R
Age started oral contraceptive pill 6.01 1 0 0 0 1 MST1R
Diastolic blood pressure, automated reading 4.86 1 1 3 0 1 MST1R
Pain experienced in last month 8.89 1 1 3 0 1 MST1R
Impedance of whole body 11.84 1 1 3 0 1 MST1R
Leg fat mass (left) 18.40 1 1 3 0 1 MST1R
Arm predicted mass (left) 10.83 1 1 3 0 1 MST1R

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 2 0.0573 1.53
GTEx Adipose Visceral Omentum 3 0.1473 1.56
GTEx Adrenal Gland 1 0.0686 1.55
GTEx Artery Aorta 3 0.1008 1.45
GTEx Artery Coronary 1 0.0845 1.52
GTEx Artery Tibial 5 0.1329 1.53
GTEx Brain Caudate basal ganglia 2 0.2174 1.65
GTEx Brain Cerebellar Hemisphere 4 0.2686 1.55
GTEx Brain Cerebellum 5 0.2523 1.52
GTEx Brain Cortex 2 0.1932 1.64
GTEx Brain Frontal Cortex BA9 3 0.3247 1.63
GTEx Brain Hippocampus 0 0.0000 1.65
GTEx Brain Hypothalamus 0 0.0000 1.51
GTEx Brain Nucleus accumbens basal ganglia 1 0.1156 1.55
GTEx Brain Putamen basal ganglia 1 0.1603 1.66
GTEx Breast Mammary Tissue 2 0.1013 1.57
GTEx Breast Mammary Tissue (Male) 0 0.0000 1.43
GTEx Breast Mammary Tissue (Female) 1 0.0608 1.48
GTEx Cells EBV-transformed lymphocytes 1 0.0703 1.55
GTEx Cells Transformed fibroblasts 4 0.0953 1.49
GTEx Colon Sigmoid 3 0.2052 1.68
GTEx Colon Transverse 2 0.0969 1.49
GTEx Esophagus Gastroesophageal Junction 3 0.2076 1.57
GTEx Esophagus Mucosa 4 0.1205 1.49
GTEx Esophagus Muscularis 4 0.1238 1.54
GTEx Heart Atrial Appendage 3 0.1900 1.55
GTEx Heart Left Ventricle 2 0.1307 1.47
GTEx Liver 1 0.1395 1.61
GTEx Lung 4 0.1392 1.50
GTEx Muscle Skeletal 2 0.0692 1.45
GTEx Nerve Tibial 3 0.0694 1.47
GTEx Ovary 1 0.1101 1.57
GTEx Pancreas 1 0.0613 1.54
GTEx Pituitary 2 0.1794 1.56
GTEx Prostate 1 0.1198 1.59
GTEx Skin Not Sun Exposed Suprapubic 4 0.1627 1.53
GTEx Skin Sun Exposed Lower leg 5 0.1374 1.48
GTEx Small Intestine Terminal Ileum 1 0.2169 1.85
GTEx Spleen 3 0.2126 1.56
GTEx Stomach 2 0.1376 1.51
GTEx Testis 2 0.0634 1.46
GTEx Thyroid 4 0.1000 1.53
GTEx Uterus 0 0.0000 1.63
GTEx Vagina 1 0.1575 1.60
GTEx Whole Blood 2 0.1004 1.50
METSIM Adipose 3 0.0651 1.37
NTR Blood 2 0.0833 1.35
ROSMAP Brain Pre-frontal Cortex 5 0.1139 1.44
YFS Blood 2 0.0433 1.29
CommonMind Brain Pre-frontal Cortex 3 0.0558 1.38
TCGA Breast Tumor 0 0.0000 1.41
TCGA Breast Normal 3 0.0713 1.30
TCGA Ovarian Tumor 1 0.0342 1.44
TCGA Prostate Tumor 2 0.0578 1.42